BR112012000287B8 - composição farmacêutica para um inibidor de protease viral de hepatite c - Google Patents

composição farmacêutica para um inibidor de protease viral de hepatite c

Info

Publication number
BR112012000287B8
BR112012000287B8 BR112012000287A BR112012000287A BR112012000287B8 BR 112012000287 B8 BR112012000287 B8 BR 112012000287B8 BR 112012000287 A BR112012000287 A BR 112012000287A BR 112012000287 A BR112012000287 A BR 112012000287A BR 112012000287 B8 BR112012000287 B8 BR 112012000287B8
Authority
BR
Brazil
Prior art keywords
hepatitis
pharmaceutical composition
protease inhibitor
viral protease
semi
Prior art date
Application number
BR112012000287A
Other languages
English (en)
Other versions
BR112012000287A2 (pt
BR112012000287B1 (pt
Inventor
Chen Feng-Jing
J Schwabe Robert
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112012000287A2 publication Critical patent/BR112012000287A2/pt
Publication of BR112012000287B1 publication Critical patent/BR112012000287B1/pt
Publication of BR112012000287B8 publication Critical patent/BR112012000287B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

composição farmacêutica para um inibidor de protease viral de hepatite c. a presente invenção refere-se a uma composição farmacêutica de um inibidor de protease viral de hepatite c que é adequado para administração oral através de uma cápsula cheia de líquido ou semissólido e métodos de uso dessa composição para inibir a replicação do vírus da hepatite c (hcv) e para o tratamento de uma infecção por hcv. a composição farmacêutica líquida ou semissólida da presente invenção compreende um composto da fórmula i, ou um sal farmaceuticamente aceitável do mesmo, junto com um ou mais lipídios e tensoativos hidrofílicos farmaceuticamente aceitáveis.
BR112012000287A 2009-07-07 2010-07-01 composição farmacêutica para um inibidor de protease viral de hepatite c BR112012000287B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22350709P 2009-07-07 2009-07-07
US61/223,507 2009-07-07
PCT/US2010/040734 WO2011005646A2 (en) 2009-07-07 2010-07-01 Pharmaceutical composition for a hepatitis c viral protease inhibitor

Publications (3)

Publication Number Publication Date
BR112012000287A2 BR112012000287A2 (pt) 2016-02-23
BR112012000287B1 BR112012000287B1 (pt) 2020-12-08
BR112012000287B8 true BR112012000287B8 (pt) 2021-05-25

Family

ID=43245003

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012000287A BR112012000287B8 (pt) 2009-07-07 2010-07-01 composição farmacêutica para um inibidor de protease viral de hepatite c

Country Status (35)

Country Link
US (1) US9034831B2 (pt)
EP (1) EP2451438B8 (pt)
JP (1) JP5607736B2 (pt)
KR (1) KR101685941B1 (pt)
CN (1) CN102470103B (pt)
AP (1) AP2011005979A0 (pt)
AR (1) AR077393A1 (pt)
AU (1) AU2010270783B2 (pt)
BR (1) BR112012000287B8 (pt)
CA (1) CA2767692C (pt)
CL (1) CL2012000054A1 (pt)
CO (1) CO6480980A2 (pt)
DK (1) DK2451438T3 (pt)
EA (1) EA023433B1 (pt)
EC (1) ECSP12011624A (pt)
ES (1) ES2464367T3 (pt)
GE (1) GEP20146016B (pt)
HR (1) HRP20140445T1 (pt)
IL (1) IL216098A (pt)
MA (1) MA33491B1 (pt)
ME (1) ME01718B (pt)
MX (1) MX2011013824A (pt)
MY (1) MY154683A (pt)
NZ (1) NZ596928A (pt)
PE (1) PE20120322A1 (pt)
PL (1) PL2451438T3 (pt)
PT (1) PT2451438E (pt)
RS (1) RS53209B (pt)
SG (1) SG177569A1 (pt)
SI (1) SI2451438T1 (pt)
TN (1) TN2012000009A1 (pt)
TW (1) TWI490216B (pt)
UA (1) UA104195C2 (pt)
UY (1) UY32760A (pt)
WO (1) WO2011005646A2 (pt)

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Also Published As

Publication number Publication date
UA104195C2 (ru) 2014-01-10
EA201200096A1 (ru) 2012-08-30
RS53209B (sr) 2014-06-30
CN102470103B (zh) 2016-09-07
HRP20140445T1 (hr) 2014-06-20
US9034831B2 (en) 2015-05-19
SI2451438T1 (sl) 2014-04-30
GEP20146016B (en) 2014-01-27
EP2451438A2 (en) 2012-05-16
CN102470103A (zh) 2012-05-23
TN2012000009A1 (en) 2013-09-19
PT2451438E (pt) 2014-03-26
AP2011005979A0 (en) 2011-12-31
DK2451438T3 (da) 2014-03-10
IL216098A (en) 2016-02-29
JP5607736B2 (ja) 2014-10-15
TW201114766A (en) 2011-05-01
MA33491B1 (fr) 2012-08-01
UY32760A (es) 2011-02-28
CA2767692A1 (en) 2011-01-13
KR101685941B1 (ko) 2016-12-13
CA2767692C (en) 2017-03-07
MX2011013824A (es) 2012-01-30
US20110160149A1 (en) 2011-06-30
AR077393A1 (es) 2011-08-24
NZ596928A (en) 2013-05-31
ME01718B (me) 2014-09-20
BR112012000287A2 (pt) 2016-02-23
ECSP12011624A (es) 2012-02-29
CL2012000054A1 (es) 2012-10-12
AU2010270783B2 (en) 2013-06-27
EP2451438B8 (en) 2014-04-09
JP2012532192A (ja) 2012-12-13
ES2464367T3 (es) 2014-06-02
MY154683A (en) 2015-07-15
CO6480980A2 (es) 2012-07-16
WO2011005646A2 (en) 2011-01-13
BR112012000287B1 (pt) 2020-12-08
KR20120059481A (ko) 2012-06-08
AU2010270783A1 (en) 2011-12-15
TWI490216B (zh) 2015-07-01
PL2451438T3 (pl) 2014-07-31
IL216098A0 (en) 2012-01-31
SG177569A1 (en) 2012-03-29
PE20120322A1 (es) 2012-04-14
EA023433B1 (ru) 2016-06-30
WO2011005646A3 (en) 2011-12-22
EP2451438B1 (en) 2014-02-26

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