BR112012000769A2 - lupeol -tipo de derivados triterpenos como antivirais - Google Patents

lupeol -tipo de derivados triterpenos como antivirais

Info

Publication number: BR112012000769A2
Authority: BR; Brazil
Prior art keywords: lupeol; antivirals; type; triterpene derivatives; triterpene
Prior art date: 2009-07-14

Application number

BR112012000769A

Other languages

English (en)

Inventor

Bandi Parthasaradhi Reddy

Kura Rathnakar Reddy

Lanka Vl Subrahmanyam

Musku Madhanmohan Reddy

Nelli Yella Reddy

Vedula Manohar Sharma

Original Assignee

Hetero Research Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-14

Filing date

2010-07-05

Publication date

2016-02-23

2010-07-05 Application filed by Hetero Research Foundation filed Critical Hetero Research Foundation

2016-02-23 Publication of BR112012000769A2 publication Critical patent/BR112012000769A2/pt

Links

239000003443 antiviral agent Substances 0.000 title 1
229940121357 antivirals Drugs 0.000 title 1
PKGKOZOYXQMJNG-UHFFFAOYSA-N lupeol Natural products CC(=C)C1CC2C(C)(CCC3C4(C)CCC5C(C)(C)C(O)CCC5(C)C4CCC23C)C1 PKGKOZOYXQMJNG-UHFFFAOYSA-N 0.000 title 1
125000003177 lupeol group Chemical group 0.000 title 1
150000003648 triterpenes Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BR112012000769A 2009-07-14 2010-07-05 lupeol -tipo de derivados triterpenos como antivirais BR112012000769A2 (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IN1670CH2009		2009-07-14
US25193309P	2009-10-15	2009-10-15
IN587CH2010		2010-03-08
PCT/IB2010/001677 WO2011007230A2 (en)	2009-07-14	2010-07-05	Lupeol-type triterpene derivatives as antivirals

Publications (1)

Publication Number	Publication Date
BR112012000769A2 true BR112012000769A2 (pt)	2016-02-23

Family

ID=43449901

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112012000769A BR112012000769A2 (pt)	2009-07-14	2010-07-05	lupeol -tipo de derivados triterpenos como antivirais

Country Status (10)

Country	Link
US (1)	US9067966B2 (pt)
EP (1)	EP2454270B1 (pt)
KR (2)	KR20140016428A (pt)
CN (1)	CN102656180B (pt)
AP (1)	AP2012006081A0 (pt)
BR (1)	BR112012000769A2 (pt)
CA (1)	CA2767642C (pt)
MX (1)	MX2012000565A (pt)
RU (1)	RU2561604C2 (pt)
WO (1)	WO2011007230A2 (pt)

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US9067966B2 (en)	2009-07-14	2015-06-30	Hetero Research Foundation, Hetero Drugs Ltd.	Lupeol-type triterpene derivatives as antivirals
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CA2849475A1 (en)	2011-09-21	2013-03-28	Bristol-Myers Squibb Company	Novel betulinic acid derivatives with antiviral activity
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JO3387B1 (ar)	2011-12-16	2019-03-13	Glaxosmithkline Llc	مشتقات بيتولين
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EA027371B1 (ru)	2013-02-06	2017-07-31	Бристол-Майерс Сквибб Компани	C-19 модифицированные тритерпеноиды с ингибиторной активностью созревания вич
JP6186012B2 (ja)	2013-02-25	2017-08-23	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｃ−３アルキルおよびアルケニル修飾ベツリン酸誘導体
NZ724644A (en)	2014-04-11	2023-07-28	Viiv Healthcare Uk No 4 Ltd	Triterpenoids with hiv maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent
WO2015195776A1 (en)	2014-06-19	2015-12-23	Bristol-Myers Squibb Company	Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en)	2014-06-26	2017-05-11	Hetero Research Foundation	Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) *	2014-06-26	2015-12-30	Hetero Research Foundation	Novel betulinic proline substituted derivatives as hiv inhibitors
EP3197430A1 (en)	2014-09-26	2017-08-02	Glaxosmithkline Intellectual Property (No. 2) Limited	Long acting pharmaceutical compositions
BR112017009852A2 (pt)	2014-11-14	2018-01-16	Viiv Healthcare Uk No 5 Ltd	composto, composição, e, usos de um composto
EP3218387A1 (en)	2014-11-14	2017-09-20	VIIV Healthcare UK (No.5) Limited	Oxolupene derivatives
MA40886B1 (fr)	2015-02-09	2020-03-31	Hetero Research Foundation	Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en)	2015-03-16	2019-08-06	Hetero Labs Limited	C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
WO2017021922A1 (en) *	2015-08-05	2017-02-09	Hetero Research Foundation	Novel substituted amides of triterpene derivatives as hiv inhibitors
WO2017115329A1 (en) *	2015-12-30	2017-07-06	Hetero Research Foundation	C-3 novel triterpenone derivatives as hiv inhibitors
AR107512A1 (es)	2016-02-04	2018-05-09	VIIV HEALTHCARE UK Nº 5 LTD	Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018044853A1 (en) *	2016-08-31	2018-03-08	Viiv Healthcare Conpany	Combinations and uses and treatments thereof
US20190183901A1 (en) *	2016-08-31	2019-06-20	Viiv Healthcare Company	Combinations and uses and treatments thereof
RU2641900C1 (ru) *	2017-02-27	2018-01-23	Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ)	N-[3-оксолуп-20(29)-ен-28-оил]-2,2,6,6-тетраметилпиперидин-4-иламин, обладающий цитотоксической активностью в отношении опухолевых клеток человека
PL3924361T3 (pl)	2019-02-11	2024-03-18	Hetero Labs Limited	Nowe pochodne triterpenu jako inhibitory wirusa hiv
KR102601258B1 (ko) *	2020-02-25	2023-11-13	(주)지뉴인텍	코로나바이러스감염증-19(covid-19)에 대한 재조합 아데노바이러스 백신 및 이를 이용한 병용요법
CN119818507B (zh) *	2024-12-27	2025-12-19	广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院）	甲基美洲茶烷在制备具有抗肝纤维化作用的药物中的应用

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2010
- 2010-07-02 US US12/829,483 patent/US9067966B2/en not_active Expired - Fee Related
- 2010-07-05 WO PCT/IB2010/001677 patent/WO2011007230A2/en not_active Ceased
- 2010-07-05 CA CA2767642A patent/CA2767642C/en not_active Expired - Fee Related
- 2010-07-05 BR BR112012000769A patent/BR112012000769A2/pt not_active IP Right Cessation
- 2010-07-05 KR KR1020147000436A patent/KR20140016428A/ko not_active Ceased
- 2010-07-05 KR KR1020127003716A patent/KR101582856B1/ko not_active Expired - Fee Related
- 2010-07-05 EP EP10734556.3A patent/EP2454270B1/en not_active Not-in-force
- 2010-07-05 CN CN201080031744.XA patent/CN102656180B/zh not_active Expired - Fee Related
- 2010-07-05 AP AP2012006081A patent/AP2012006081A0/xx unknown
- 2010-07-05 MX MX2012000565A patent/MX2012000565A/es not_active Application Discontinuation
- 2010-07-05 RU RU2012104993/04A patent/RU2561604C2/ru not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN102656180A (zh)	2012-09-05
WO2011007230A3 (en)	2011-06-03
MX2012000565A (es)	2012-05-08
RU2012104993A (ru)	2013-08-20
CN102656180B (zh)	2016-04-20
KR101582856B1 (ko)	2016-01-07
EP2454270B1 (en)	2015-02-11
KR20140016428A (ko)	2014-02-07
WO2011007230A2 (en)	2011-01-20
RU2561604C2 (ru)	2015-08-27
CA2767642A1 (en)	2011-01-20
CA2767642C (en)	2014-11-18
KR20120037985A (ko)	2012-04-20
US9067966B2 (en)	2015-06-30
AP2012006081A0 (en)	2012-02-29
EP2454270A2 (en)	2012-05-23
US20110015196A1 (en)	2011-01-20

Legal Events

Date	Code	Title	Description
2016-09-06	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A ANUIDADE.
2016-12-20	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2383 DE 06-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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BR112012002810A2 (pt)	2015-09-15	derivados de n1-acil-5-fluoropirimidinona
DK2387580T3 (da)	2014-10-13	Deoxyactagardinderivater
PT2492266E (pt)	2015-11-18	Derivado de 5-hidroxipirimidino-4-carboxamida
ECSP12011977A (es)	2012-07-31	Derivados de etinilo
EP2401281A4 (en)	2012-08-15	PYRIMIDINPYRIMIDOINDAZOLDERIVAT