ECSP12011977A - Derivados de etinilo - Google Patents

Derivados de etinilo

Info

Publication number
ECSP12011977A
ECSP12011977A ECSP12011977A ECSP12011977A EC SP12011977 A ECSP12011977 A EC SP12011977A EC SP12011977 A ECSP12011977 A EC SP12011977A EC SP12011977 A ECSP12011977 A EC SP12011977A
Authority
EC
Ecuador
Prior art keywords
ethylene derivatives
derivatives
ethylene
Prior art date
Application number
Other languages
English (en)
Inventor
Georg Jaeschke
Synese Jolidon
Heinz Stadler
Eric Vieira
Lothar Lindemann
Wolfgang Guba
Luke Green
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43446449&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011977(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP12011977A publication Critical patent/ECSP12011977A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ECSP12011977 2009-12-17 2012-06-15 Derivados de etinilo ECSP12011977A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09179719 2009-12-17

Publications (1)

Publication Number Publication Date
ECSP12011977A true ECSP12011977A (es) 2012-07-31

Family

ID=43446449

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011977 ECSP12011977A (es) 2009-12-17 2012-06-15 Derivados de etinilo

Country Status (27)

Country Link
US (2) US8586581B2 (es)
EP (1) EP2513102B1 (es)
JP (1) JP5763094B2 (es)
KR (1) KR101407856B1 (es)
CN (1) CN102686589B (es)
AR (1) AR079467A1 (es)
AU (1) AU2010332987B2 (es)
BR (1) BR112012014770A2 (es)
CA (1) CA2780155A1 (es)
CL (1) CL2012001596A1 (es)
CO (1) CO6531478A2 (es)
CR (1) CR20120269A (es)
EC (1) ECSP12011977A (es)
ES (1) ES2551582T3 (es)
IL (1) IL219371A (es)
MA (1) MA33802B1 (es)
MX (1) MX2012006789A (es)
MY (1) MY162998A (es)
NZ (1) NZ599553A (es)
PE (1) PE20121443A1 (es)
PH (1) PH12012500867A1 (es)
RU (1) RU2553461C2 (es)
SG (1) SG181779A1 (es)
TW (1) TWI448465B (es)
UA (1) UA107002C2 (es)
WO (1) WO2011073172A1 (es)
ZA (1) ZA201204429B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2636668T (pt) * 2010-11-05 2018-10-09 Oat Agrio Co Ltd Composto de etinilfenilamidina ou um seu sal, processo para a sua produção e fungicida para ser utilizado na agricultura e na horticultura
HRP20150555T1 (hr) 2011-04-26 2015-07-03 F. Hoffmann - La Roche Ag Derivati etinila kao pozitivni alosterijski modulatori za mglur5
US20130123254A1 (en) 2011-09-30 2013-05-16 Barbara Biemans Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
EP2900659B1 (en) * 2012-09-27 2016-08-24 F. Hoffmann-La Roche AG Arylethynyl derivatives
MY171517A (en) * 2012-10-18 2019-10-16 Hoffmann La Roche Ethynyl derivatives as modulators of mglur5 receptor activity
CN104768554B (zh) * 2012-11-07 2018-04-17 霍夫曼-拉罗奇有限公司 三唑并化合物
RS60199B1 (sr) 2015-06-03 2020-06-30 Hoffmann La Roche Derivati etinila
UA120463C2 (uk) 2015-07-15 2019-12-10 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як модулятори метаботропного рецептора глутамату
WO2018015235A1 (en) 2016-07-18 2018-01-25 F. Hoffmann-La Roche Ag Ethynyl derivatives
WO2026072192A1 (en) 2024-09-27 2026-04-02 Alto Neuroscience, Inc. Effective treatment of depression in patients having poor cognition or impaired learning and/or memory with a mglur5 positive allosteric modulator

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID29095A (id) * 1998-10-02 2001-07-26 Novartis Ag Cs Antagonis mglur5 untuk pengobatan rasa sakit dan kegelisahan
CO5271680A1 (es) * 2000-02-21 2003-04-30 Smithkline Beecham Corp Compuestos
GB0027987D0 (en) * 2000-11-16 2001-01-03 Smithkline Beecham Plc Compounds
US6910976B2 (en) 2001-06-26 2005-06-28 Stx, Llc Multi-component lacrosse stick head
GB0127433D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
GB0127430D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
GB0413605D0 (en) 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
WO2006048771A1 (en) 2004-11-04 2006-05-11 Addex Pharmaceuticals Sa Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
US8178533B2 (en) * 2005-06-01 2012-05-15 Ucb Pharma, S.A. 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
ATE446294T1 (de) 2005-11-15 2009-11-15 Array Biopharma Inc N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten
TW200817391A (en) 2006-06-30 2008-04-16 Astrazeneca Ab Novel compounds
EP1972628A1 (en) 2007-03-21 2008-09-24 Schwarz Pharma Ag Indolizines and aza-analog derivatives thereof as CNS active compounds
KR20100019470A (ko) * 2007-04-30 2010-02-18 아보트 러보러터리즈 디아실글리세롤 o-아실트랜스퍼라제 타입 1 효소의 억제제
KR20100033981A (ko) 2007-06-03 2010-03-31 벤더르빌트 유니버시티 벤즈아미드 대사성 글루타민산염 수용체5 양성 알로스테릭 조절자 및 이의 제조 및 사용방법
TW201116532A (en) * 2009-08-05 2011-05-16 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators

Also Published As

Publication number Publication date
HK1171225A1 (en) 2013-03-22
AU2010332987B2 (en) 2015-08-13
JP2013514305A (ja) 2013-04-25
NZ599553A (en) 2014-05-30
US8586581B2 (en) 2013-11-19
CL2012001596A1 (es) 2013-01-04
RU2012128551A (ru) 2014-01-27
MY162998A (en) 2017-07-31
MX2012006789A (es) 2012-07-10
IL219371A (en) 2015-02-26
KR101407856B1 (ko) 2014-06-16
JP5763094B2 (ja) 2015-08-12
SG181779A1 (en) 2012-07-30
TWI448465B (zh) 2014-08-11
US8933094B2 (en) 2015-01-13
PH12012500867A1 (en) 2014-10-14
CO6531478A2 (es) 2012-09-28
US20140073638A1 (en) 2014-03-13
EP2513102A1 (en) 2012-10-24
TW201144314A (en) 2011-12-16
RU2553461C2 (ru) 2015-06-20
CN102686589B (zh) 2014-12-10
IL219371A0 (en) 2012-06-28
CN102686589A (zh) 2012-09-19
CR20120269A (es) 2012-07-04
KR20120095472A (ko) 2012-08-28
ES2551582T3 (es) 2015-11-20
PE20121443A1 (es) 2012-10-26
EP2513102B1 (en) 2015-08-19
BR112012014770A2 (pt) 2016-03-29
AR079467A1 (es) 2012-01-25
WO2011073172A1 (en) 2011-06-23
UA107002C2 (uk) 2014-11-10
MA33802B1 (fr) 2012-12-03
CA2780155A1 (en) 2011-06-23
US20110152257A1 (en) 2011-06-23
ZA201204429B (en) 2013-02-27
AU2010332987A1 (en) 2012-06-07

Similar Documents

Publication Publication Date Title
BRPI1013246A2 (pt) derivados de benzofuralina
BR112012002828A2 (pt) derivados de 5-fluorpirimidinona
BR112012002662A2 (pt) derivados de bis-benzimidazol
BR112012004969A2 (pt) derivados de bis-benzimidazol
ECSP12011999A (es) Derivados benzamida sustituidos
BRPI1013844A2 (pt) derivados de piridina-isoxazol
EP2433940A4 (en) SPIROIMIDAZOLONDERIVAT
BRPI1011694A2 (pt) similadores de categoria
BRPI1005525A2 (pt) compostos de azaazuleno
DK2397480T3 (da) Diazepindionderivat
BRPI1014077A2 (pt) Derivados de tiazolilperidina como fungicidas
BRPI1014454A2 (pt) derivados de isoxazol-pirazol
ECSP12011977A (es) Derivados de etinilo
BR112012002810A2 (pt) derivados de n1-acil-5-fluoropirimidinona
DK2387580T3 (da) Deoxyactagardinderivater
BRPI1007884A2 (pt) derivados de actagardina
EP2401281A4 (en) PYRIMIDINPYRIMIDOINDAZOLDERIVAT
BRPI1011416A2 (pt) derivados de antraquinova novos
EP2492266A4 (en) 5-hydroxypyrimidine-4-carboxamide
BRPI1016192A2 (pt) derivados de soxazol.
FR2947857B1 (fr) Agencement de deshuileur
EP2463290A4 (en) THIENOXAZEPINDERIVAT
BRPI1007893A2 (pt) derivado de cianopirimidina
BR112012001680A2 (pt) Derivados de tazaroteno
BRPI0923602A2 (pt) derivados de benzotiazolona