BR112012017458A2 - uso de um agente de modificação de hormônio adrenal - Google Patents

uso de um agente de modificação de hormônio adrenal

Info

Publication number
BR112012017458A2
BR112012017458A2 BR112012017458A BR112012017458A BR112012017458A2 BR 112012017458 A2 BR112012017458 A2 BR 112012017458A2 BR 112012017458 A BR112012017458 A BR 112012017458A BR 112012017458 A BR112012017458 A BR 112012017458A BR 112012017458 A2 BR112012017458 A2 BR 112012017458A2
Authority
BR
Brazil
Prior art keywords
hydrogen
aryl
modifying agent
hormone
halogen
Prior art date
Application number
BR112012017458A
Other languages
English (en)
Other versions
BR112012017458B1 (pt
Inventor
Schumacher Christoph
Meredith Erik
Ksander Gary
Papillon Julien
G Monovich Lauren
Hu Qi-Ying
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43735742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012017458(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112012017458A2 publication Critical patent/BR112012017458A2/pt
Publication of BR112012017458B1 publication Critical patent/BR112012017458B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

uso de um agente de modificação de hormônio adrenal a presente invenção refere-se a um método de tratamento de uma doença ou distúrbio caracterizado por níveis aumentados de hormônio de estresse e/ou níveis diminuídos de hormônio andrógeno em um indivíduo, compreendendo administrar ao indivíduo uma quantidades terapeuticamente efetiva de um composto representado pela fómula (l) em que n é 1 ou 3; r é hidrogênio ou --c(o)n(r~ a~)(r~ b~) em que r~ a~ e r~ b~ são independentemente --(c~1~-c~ 4~) alquila , ou --(c~ 1~-c~ 4~) alquila-(c~ 5~-c~ 7~) arila ,em que cada um de r~ a~ e r~ b~ é opcionalmente substituído por --(c~ 1~-c~ 4~) alcóxi; r~ 1~, r~ 2~ e r~ 3~ são independentemente hidrogênio, halogênio, ciano ou --(c~ 6~-c~ 10) arila, em que referida --(c~ 6~-c~ 10~) arila é opcionalmente substituída por halogênio, com a condição que não mais do que um de r~ 1~,r~ 2~ e r~ 3~ é hidrogênio; e r~ 4~ e r~ 5~ são hidrogênio ; ou um sal farmaceuticamente aceitável deste.
BR112012017458-4A 2010-01-14 2011-01-13 Uso de di-hidrogeno fosfato de 4-[(5r)-6,7-di-hidro-5h-pirrolo[1,2-c]imidazol-5-il]-3- flurorbenzonitrila BR112012017458B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29498010P 2010-01-14 2010-01-14
US61/294,980 2010-01-14
PCT/US2011/021100 WO2011088188A1 (en) 2010-01-14 2011-01-13 Use of an adrenal hormone-modifying agent

Publications (2)

Publication Number Publication Date
BR112012017458A2 true BR112012017458A2 (pt) 2017-12-19
BR112012017458B1 BR112012017458B1 (pt) 2020-10-20

Family

ID=43735742

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012017458-4A BR112012017458B1 (pt) 2010-01-14 2011-01-13 Uso de di-hidrogeno fosfato de 4-[(5r)-6,7-di-hidro-5h-pirrolo[1,2-c]imidazol-5-il]-3- flurorbenzonitrila

Country Status (33)

Country Link
US (2) US8609862B2 (pt)
EP (2) EP3527208A1 (pt)
JP (4) JP5602250B2 (pt)
KR (1) KR101412206B1 (pt)
CN (2) CN102711916B (pt)
AU (1) AU2011205290C1 (pt)
BR (1) BR112012017458B1 (pt)
CA (1) CA2786443C (pt)
CL (1) CL2012001961A1 (pt)
CY (2) CY1121320T1 (pt)
DK (1) DK2523731T3 (pt)
ES (1) ES2707596T3 (pt)
HR (1) HRP20190064T1 (pt)
HU (2) HUE041967T2 (pt)
IL (1) IL220804A0 (pt)
LT (2) LT2523731T (pt)
LU (1) LUC00159I2 (pt)
MA (1) MA33904B1 (pt)
ME (1) ME03371B (pt)
MX (2) MX2012008212A (pt)
NL (1) NL301043I2 (pt)
NO (1) NO2020012I1 (pt)
NZ (1) NZ601077A (pt)
PH (1) PH12012501422B1 (pt)
PL (1) PL2523731T3 (pt)
PT (1) PT2523731T (pt)
RS (1) RS58234B1 (pt)
SG (1) SG182393A1 (pt)
SI (1) SI2523731T1 (pt)
TN (1) TN2012000352A1 (pt)
TR (1) TR201900515T4 (pt)
WO (1) WO2011088188A1 (pt)
ZA (1) ZA201205058B (pt)

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AU2011205290C1 (en) * 2010-01-14 2014-11-06 Recordati Ag Use of an adrenal hormone-modifying agent
JP2013528658A (ja) 2010-06-16 2013-07-11 エンベラ ニューロセラピューティクス,インコーポレイティド 依存、精神疾患、及び神経変性病の治療のための組成物と方法
AR086665A1 (es) 2011-06-14 2014-01-15 Lilly Co Eli Inhibidor de aldosterona sintasa y composiciones farmaceuticas
US20140235667A1 (en) 2011-09-22 2014-08-21 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
US9193724B2 (en) 2011-09-22 2015-11-24 Merck Sharp & Dohme Corp. Triazolopyridyl compounds as aldosterone synthase inhibitors
WO2013043521A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Pyrazolopyridyl compounds as aldosterone synthase inhibitors
IN2014DN06781A (pt) * 2012-01-17 2015-05-22 Novartis Ag
AU2013246908B2 (en) * 2012-04-12 2016-06-30 Novartis Ag Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors
EP2903615B1 (en) 2012-10-05 2021-04-07 Merck Sharp & Dohme Corp. 5-pyridin-3-yl-2,3-dihydro-1h-indole derivatives as aldosterone synthase (cyp11b2) inhibitors for the treatment of hypertension
JP2015093832A (ja) * 2013-11-08 2015-05-18 日本メジフィジックス株式会社 放射性ハロゲン標識化合物又はその塩、これを含む医薬
SI3166596T1 (sl) * 2014-07-07 2018-10-30 Novartis Ag Farmacevtske odmerne oblike
WO2016048984A1 (en) * 2014-09-25 2016-03-31 Cortendo Ab (Publ) Methods and compositions for the treatment of cushing's syndrome using 2s, 4r ketoconazole
HUE054248T2 (hu) 2015-01-29 2021-08-30 Recordati Ag Eljárás kondenzált imidazo-származékok elõállítására
US20160287565A1 (en) 2015-04-06 2016-10-06 Millendo Therapeutics, Inc. Combination therapy for treating disorders associated with excess cortisol production
US20180185375A1 (en) * 2015-06-22 2018-07-05 Embera Neurotherapeutics, Inc. Compositions and methods for the treatment of substance use disorders, addiction, and psychiatric disorders
WO2018165649A1 (en) 2017-03-10 2018-09-13 Embera Neurotherapeutics, Inc. Pharmaceutical compositions and uses thereof

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GB0212412D0 (en) * 2002-05-29 2002-07-10 Novartis Ag Combination of organic compounds
JP5138875B2 (ja) 2005-07-19 2013-02-06 株式会社デンソー センサ装置
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RU2008150752A (ru) * 2006-05-26 2010-07-10 Новартис АГ (CH) Ингибиторы альдостеронсинтазы и/или 11-гидроксилазы
EP1886695A1 (en) 2006-06-27 2008-02-13 Speedel Experimenta AG Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
KR20090055595A (ko) * 2006-08-25 2009-06-02 노파르티스 아게 알도스테론 신타제 및/또는 11-베타-히드록실라제 및/또는 아로마타제에 의해 매개된 장애의 치료를 위한 융합 이미다졸 유도체
EA200900812A1 (ru) * 2006-12-18 2009-12-30 Новартис Аг Производные 4-имидазолил-1,2,3,4-тетрагидрохинолина и их применение в качестве ингибиторов альдостерон/11-бета-гидроксилазы
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AU2011205290C1 (en) * 2010-01-14 2014-11-06 Recordati Ag Use of an adrenal hormone-modifying agent
IN2014DN06781A (pt) * 2012-01-17 2015-05-22 Novartis Ag
AU2013246908B2 (en) * 2012-04-12 2016-06-30 Novartis Ag Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors

Also Published As

Publication number Publication date
NL301043I2 (nl) 2020-07-06
JP2018150326A (ja) 2018-09-27
KR101412206B1 (ko) 2014-06-25
HUE041967T2 (hu) 2019-06-28
TR201900515T4 (tr) 2019-02-21
JP6425688B2 (ja) 2018-11-21
EP2523731B1 (en) 2018-10-24
PH12012501422A1 (en) 2012-10-22
TN2012000352A1 (en) 2014-01-30
JP2015013859A (ja) 2015-01-22
KR20120116482A (ko) 2012-10-22
PT2523731T (pt) 2019-01-21
PH12012501422B1 (en) 2018-09-12
RU2012134510A (ru) 2014-02-20
US20140171392A1 (en) 2014-06-19
CA2786443A1 (en) 2011-07-21
LTPA2020512I1 (lt) 2020-07-27
US9434754B2 (en) 2016-09-06
CL2012001961A1 (es) 2013-03-22
EP3527208A1 (en) 2019-08-21
MA33904B1 (fr) 2013-01-02
PL2523731T3 (pl) 2019-04-30
NZ601077A (en) 2014-07-25
LTC2523731I2 (lt) 2022-05-10
SG182393A1 (en) 2012-08-30
CN102711916A (zh) 2012-10-03
US20120295888A1 (en) 2012-11-22
CN102711916B (zh) 2015-09-02
NL301043I1 (nl) 2020-06-17
JP6181610B2 (ja) 2017-08-16
AU2011205290B2 (en) 2014-06-26
RS58234B1 (sr) 2019-03-29
CY2020018I2 (el) 2020-11-25
HRP20190064T1 (hr) 2019-03-08
DK2523731T3 (en) 2019-02-04
AU2011205290C1 (en) 2014-11-06
EP2523731A1 (en) 2012-11-21
CY2020018I1 (el) 2020-11-25
IL220804A0 (en) 2012-08-30
JP5602250B2 (ja) 2014-10-08
CY1121320T1 (el) 2020-05-29
JP2013517280A (ja) 2013-05-16
CA2786443C (en) 2018-12-11
LT2523731T (lt) 2019-02-11
AU2011205290A1 (en) 2012-08-02
ME03371B (me) 2020-01-20
HUS2000018I1 (hu) 2020-07-28
ES2707596T3 (es) 2019-04-04
MX354022B (es) 2018-02-08
RU2598708C2 (ru) 2016-09-27
ZA201205058B (en) 2014-04-30
CN105440038A (zh) 2016-03-30
LUC00159I1 (pt) 2020-06-16
LUC00159I2 (pt) 2021-07-06
WO2011088188A1 (en) 2011-07-21
BR112012017458B1 (pt) 2020-10-20
US8609862B2 (en) 2013-12-17
MX2012008212A (es) 2012-08-03
NO2020012I1 (no) 2020-06-09
SI2523731T1 (sl) 2019-02-28
HUS000508I2 (hu) 2021-03-29
JP2017002063A (ja) 2017-01-05

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B25A Requested transfer of rights approved

Owner name: RECORDATI AG (CH)

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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/01/2011, OBSERVADAS AS CONDICOES LEGAIS.