BR112018069578A2 - compostos de heteroaril-1,2,4-triazol e heteroaril-tetrazol para controlar ectoparasitas - Google Patents

compostos de heteroaril-1,2,4-triazol e heteroaril-tetrazol para controlar ectoparasitas

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Publication number
BR112018069578A2
BR112018069578A2 BR112018069578A BR112018069578A BR112018069578A2 BR 112018069578 A2 BR112018069578 A2 BR 112018069578A2 BR 112018069578 A BR112018069578 A BR 112018069578A BR 112018069578 A BR112018069578 A BR 112018069578A BR 112018069578 A2 BR112018069578 A2 BR 112018069578A2
Authority
BR
Brazil
Prior art keywords
heteroaryl
triazole
alkoxy
alkyl
optionally substituted
Prior art date
Application number
BR112018069578A
Other languages
English (en)
Other versions
BR112018069578B1 (pt
Inventor
Wach Jean-Yves
Tosatti Paolo
Original Assignee
Elanco Tiergesundheit Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Tiergesundheit Ag filed Critical Elanco Tiergesundheit Ag
Publication of BR112018069578A2 publication Critical patent/BR112018069578A2/pt
Publication of BR112018069578B1 publication Critical patent/BR112018069578B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

a presente invenção refere-se a compostos da fórmula: (i) em que: x é o ou s; q1 e q2 são independentemente cr5 ou n, contanto que pelo menos um dentre q1 e q2 seja n; y é uma ligação direta ou ch2; r1 é h, alquila, alquenila, alquinila, cicloalquilalquila, benzila opcionalmente substituídas ou oxetan-3-il-ch2-; r2 é fenila, piridina, pirimidina, pirazina ou piridazina opcionalmente substituída; r3 é alquila ou haloalquila; r4 é piridina, pirimidina, pirazina ou piridazina opcionalmen-te substituída; r5 é h, alquila, haloalquila, cicloalquila, alcóxi, alcó-xic(o)- ou (alcóxi)2ch-; ou um sal dos mesmos. os compostos são úteis para controlar ectoparasitas em animais.
BR112018069578-5A 2016-05-05 2017-04-28 Compostos de heteroaril-1,2,4-triazol e heteroariltetrazol para controlar ectoparasitas, seus usos, e formulação BR112018069578B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662332004P 2016-05-05 2016-05-05
US62/332,004 2016-05-05
PCT/US2017/030082 WO2017192385A1 (en) 2016-05-05 2017-04-28 Heteroaryl-1,2,4-triazole and heteroaryl-tetrazole compounds for controlling ectoparasites

Publications (2)

Publication Number Publication Date
BR112018069578A2 true BR112018069578A2 (pt) 2019-01-22
BR112018069578B1 BR112018069578B1 (pt) 2024-02-06

Family

ID=58672822

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018069578-5A BR112018069578B1 (pt) 2016-05-05 2017-04-28 Compostos de heteroaril-1,2,4-triazol e heteroariltetrazol para controlar ectoparasitas, seus usos, e formulação

Country Status (20)

Country Link
US (2) US10287276B2 (pt)
EP (1) EP3452460B1 (pt)
JP (1) JP6370504B2 (pt)
KR (1) KR102174828B1 (pt)
CN (1) CN109311841B (pt)
AR (1) AR108222A1 (pt)
AU (1) AU2017261187B2 (pt)
BR (1) BR112018069578B1 (pt)
CA (1) CA3023208C (pt)
CL (1) CL2018003021A1 (pt)
CO (1) CO2018011825A2 (pt)
DK (1) DK3452460T3 (pt)
EA (1) EA036478B1 (pt)
ES (1) ES2776850T3 (pt)
MX (1) MX373315B (pt)
NZ (1) NZ746361A (pt)
PL (1) PL3452460T3 (pt)
PT (1) PT3452460T (pt)
TW (2) TWI679197B (pt)
WO (1) WO2017192385A1 (pt)

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MX2018012951A (es) 2019-01-21
PL3452460T3 (pl) 2020-06-01
CL2018003021A1 (es) 2019-02-15
CO2018011825A2 (es) 2018-11-22
DK3452460T3 (da) 2020-03-16
BR112018069578B1 (pt) 2024-02-06
CN109311841B (zh) 2021-04-27
NZ746361A (en) 2020-04-24
EP3452460A1 (en) 2019-03-13
WO2017192385A1 (en) 2017-11-09
US20180186778A1 (en) 2018-07-05
EP3452460B1 (en) 2020-02-12
ES2776850T3 (es) 2020-08-03
EA036478B1 (ru) 2020-11-16
US20190256501A1 (en) 2019-08-22
KR20180132100A (ko) 2018-12-11
TWI696615B (zh) 2020-06-21
CA3023208A1 (en) 2017-11-09
MX373315B (es) 2020-04-30
PT3452460T (pt) 2020-03-24
US10287276B2 (en) 2019-05-14
EA201892191A1 (ru) 2019-04-30
JP2018517716A (ja) 2018-07-05
CN109311841A (zh) 2019-02-05
TW201938548A (zh) 2019-10-01
JP6370504B2 (ja) 2018-08-08
AR108222A1 (es) 2018-08-01
KR102174828B1 (ko) 2020-11-06
TW201803863A (zh) 2018-02-01
TWI679197B (zh) 2019-12-11
AU2017261187B2 (en) 2019-04-18
AU2017261187A1 (en) 2018-10-04
CA3023208C (en) 2020-11-03
US10981897B2 (en) 2021-04-20

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