BR9713237A - Comprimido de liberação controlada de cloridrato de alfuzosina - Google Patents

Comprimido de liberação controlada de cloridrato de alfuzosina

Info

Publication number
BR9713237A
BR9713237A BR9713237-3A BR9713237A BR9713237A BR 9713237 A BR9713237 A BR 9713237A BR 9713237 A BR9713237 A BR 9713237A BR 9713237 A BR9713237 A BR 9713237A
Authority
BR
Brazil
Prior art keywords
layer
alfuzosin hydrochloride
hydrophilic polymers
release
swell
Prior art date
Application number
BR9713237-3A
Other languages
English (en)
Other versions
BR9713237B1 (pt
Inventor
Lauretta Maggi
Ubaldo Conte
Pascal Grenier
Guy Vergnault
Alain Dufour
Francois Xavier Jarreau
Clemence Rauch-Desanti
Original Assignee
Synthelabo
Jagotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26232935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9713237(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR9610551A external-priority patent/FR2752737B1/fr
Application filed by Synthelabo, Jagotec Ag filed Critical Synthelabo
Publication of BR9713237A publication Critical patent/BR9713237A/pt
Publication of BR9713237B1 publication Critical patent/BR9713237B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção:<"COMPRIMIDO DE LIBERAçãO CONTROLADA DE CLORIDRATO DE ALFUZOSINA".>Comprimido farmacêutico destinado à via oral para a liberação controlada de cloridrato de alfuzosina ao nível dos segmentos proximais do trato gastrintestinal, caracterizado pelo fato de ser constituído por: a) uma primeira camada (1) com a propriedade de inchar acentuada e rapidamente em contato com líquidos biológicos aquosos, a dita camada sendo produzida pela compressão de uma mistura ou de um granulado compreendendo polímeros hidrofílicos que constituem de 5,0 a 90%, de preferência de 10 a 85% do peso da camada, b) uma segunda camada (2) adjacente ou superposta à primeira camada, em que o cloridrato de alfuzosina é veiculado, essa camada sendo formulada com polímeros hidrofílicos e com outras substâncias auxiliares para conferir à preparação propriedades de compressibilidade convenientes e par permitir a liberação do cloridrato de alfuzosina em um intervalo de tempo predeterminado, c) e eventualmente uma terceira camada (3), obtida por compressão e aplicada sobre a camada (2), genericamente constituída particularmente por polímeros hidrofílicos que formem um gel e/ou inchem, depois possam eventualmente se erodir, e com a função de barreira moduladora da liberação do cloridrato de alfuzosina da camada (2), a camada (3) sendo inicialmente muito pouco permeável à passagem da substância ativa. Composição farmacêutica.
BRPI9713237-3A 1996-08-29 1997-08-22 comprimido de liberaÇço controlada de cloridrato de alfuzosina e composiÇço farmacÊutica compreendendo o mesmo. BR9713237B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9610551A FR2752737B1 (fr) 1996-08-29 1996-08-29 Comprime a liberation controlee de chlorhydrate d'alfuzosine
FR9704386 1997-04-10
PCT/FR1997/001515 WO1998008515A1 (fr) 1996-08-29 1997-08-22 Comprime a liberation controlee de chlorhydrate d'alfuzosine

Publications (2)

Publication Number Publication Date
BR9713237A true BR9713237A (pt) 2000-04-04
BR9713237B1 BR9713237B1 (pt) 2009-01-13

Family

ID=26232935

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9713237-3A BR9713237B1 (pt) 1996-08-29 1997-08-22 comprimido de liberaÇço controlada de cloridrato de alfuzosina e composiÇço farmacÊutica compreendendo o mesmo.

Country Status (36)

Country Link
US (1) US6149940A (pt)
EP (1) EP0938318B1 (pt)
JP (1) JP3797388B2 (pt)
KR (1) KR100364328B1 (pt)
CN (2) CN1155382C (pt)
AP (1) AP1107A (pt)
AR (1) AR009312A1 (pt)
AT (1) ATE200864T1 (pt)
AU (1) AU724490B2 (pt)
BG (1) BG63768B1 (pt)
BR (1) BR9713237B1 (pt)
CA (1) CA2264250C (pt)
CO (1) CO4920217A1 (pt)
CY (1) CY2284B1 (pt)
CZ (1) CZ295066B6 (pt)
DE (1) DE69704712T2 (pt)
DK (1) DK0938318T3 (pt)
EE (1) EE03855B1 (pt)
ES (1) ES2159400T3 (pt)
GR (1) GR3036291T3 (pt)
HU (1) HU228007B1 (pt)
IL (1) IL128146A (pt)
IS (1) IS2091B (pt)
MX (1) MXPA99001958A (pt)
NO (1) NO326206B1 (pt)
NZ (1) NZ334018A (pt)
OA (1) OA10983A (pt)
PL (1) PL191546B1 (pt)
PT (1) PT938318E (pt)
RU (1) RU2183459C2 (pt)
SI (1) SI0938318T1 (pt)
SK (1) SK284388B6 (pt)
TR (1) TR199900289T2 (pt)
TW (1) TW522023B (pt)
UA (1) UA69374C2 (pt)
WO (1) WO1998008515A1 (pt)

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Also Published As

Publication number Publication date
CA2264250C (en) 2005-07-05
AP1107A (en) 2002-09-20
PL191546B1 (pl) 2006-06-30
HUP9903428A2 (hu) 2000-02-28
BG63768B1 (bg) 2002-12-29
CZ295066B6 (cs) 2005-05-18
CZ65599A3 (cs) 1999-06-16
SK27099A3 (en) 1999-12-10
KR100364328B1 (ko) 2002-12-26
AU724490B2 (en) 2000-09-21
US6149940A (en) 2000-11-21
TW522023B (en) 2003-03-01
GR3036291T3 (en) 2001-10-31
UA69374C2 (uk) 2004-09-15
NO326206B1 (no) 2008-10-20
NO990944D0 (no) 1999-02-26
RU2183459C2 (ru) 2002-06-20
EP0938318B1 (fr) 2001-05-02
OA10983A (fr) 2003-03-04
PL331862A1 (en) 1999-08-16
ES2159400T3 (es) 2001-10-01
ATE200864T1 (de) 2001-05-15
EE9900090A (et) 1999-10-15
HU228007B1 (en) 2012-08-28
CN1155382C (zh) 2004-06-30
DE69704712D1 (de) 2001-06-07
SK284388B6 (sk) 2005-02-04
CY2284B1 (en) 2003-07-04
PT938318E (pt) 2001-10-30
WO1998008515A1 (fr) 1998-03-05
EP0938318A1 (fr) 1999-09-01
BG103138A (en) 1999-09-30
AR009312A1 (es) 2000-04-12
KR20000035929A (ko) 2000-06-26
IS4964A (is) 1999-01-29
CA2264250A1 (en) 1998-03-05
JP3797388B2 (ja) 2006-07-19
CN100335057C (zh) 2007-09-05
EE03855B1 (et) 2002-10-15
HK1020875A1 (en) 2000-05-26
IL128146A (en) 2001-01-11
DK0938318T3 (da) 2001-08-20
BR9713237B1 (pt) 2009-01-13
CO4920217A1 (es) 2000-05-29
TR199900289T2 (xx) 2000-12-21
SI0938318T1 (en) 2001-12-31
CN1543954A (zh) 2004-11-10
IL128146A0 (en) 1999-11-30
MXPA99001958A (es) 2005-09-08
NZ334018A (en) 1999-06-29
IS2091B (is) 2006-03-15
JP2000514462A (ja) 2000-10-31
AP9901470A0 (en) 1999-03-31
HUP9903428A3 (en) 2000-04-28
AU4020197A (en) 1998-03-19
CN1228700A (zh) 1999-09-15
NO990944L (no) 1999-04-27
DE69704712T2 (de) 2001-11-29

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