ES2159400T3 - Comprimido con liberacion controlada de clorhidrato de alfuzosina - Google Patents

Comprimido con liberacion controlada de clorhidrato de alfuzosina

Info

Publication number
ES2159400T3
ES2159400T3 ES97937651T ES97937651T ES2159400T3 ES 2159400 T3 ES2159400 T3 ES 2159400T3 ES 97937651 T ES97937651 T ES 97937651T ES 97937651 T ES97937651 T ES 97937651T ES 2159400 T3 ES2159400 T3 ES 2159400T3
Authority
ES
Spain
Prior art keywords
layer
polymers
chlorhydrate
hydrophyl
controlled release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97937651T
Other languages
English (en)
Inventor
Lauretta Maggi
Ubaldo Conte
Pascal Grenier
Guy Vergnault
Alain Dufour
Francois Xavier Jarreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jagotec AG
Sanofi Aventis France
Original Assignee
Jagotec AG
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26232935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2159400(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR9610551A external-priority patent/FR2752737B1/fr
Application filed by Jagotec AG, Sanofi Synthelabo SA filed Critical Jagotec AG
Application granted granted Critical
Publication of ES2159400T3 publication Critical patent/ES2159400T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPRIMIDO FARMACEUTICO DESTINADO A ADMINISTRACION POR VIA ORAL, PARA LA LIBERACION CONTROLADA DE CLORHIDRATO DE ALFUZOSINA EN SEGMENTOS PROXIMALES DEL TRACTO GASTROINTESTINAL, COMPRIMIDO CARACTERIZADO PORQUE ESTA CONSTITUIDO POR A) UNA PRIMERA CAPA (1) QUE TIENE LA PROPIEDAD DE INFLARSE NOTABLE Y RAPIDAMENTE EN CONTACTO CON LOS LIQUIDOS BIOLOGICOS ACUOSOS, PRODUCIENDOSE DICHA CAPA POR COMPRESION DE UNA MEZCLA O DE UN GRANULADO QUE COMPRENDE POLIMEROS HIDROFILOS QUE CONSTITUYEN ENTRE UN 0,50 Y UN 90 % Y PREFERENTEMENTE ENTRE UN 10 Y UN 85 % DE PESO DE LA CAPA, B) UNA SEGUNDA CAPA (2) ADYACENTE O SUPERPUESTA A LA PRIMERA CAPA, EN LA QUE EL CLORHIDRATO DE ALFUZASINA ES VEHICULADO, ESTANDO ESTA CAPA FORMULADA CON POLIMEROS HIDROFILOS Y CON OTRAS SUSTANCIAS AUXILIARES, PARA DAR A LA PREPARACION PROPIEDADES DE COMPRESIBILIDAD ADECUADA Y PARA PERMITIR LA LIBERACION DE CLORHIDRATO DE ALFUZOSINA EN UN INTERVALO DE TIEMPO PREDETERMINADO, C) Y OPCIONALMENTE UNA TERCERA CAPA (3) OBTENIDA POR COMPRESION Y APLICADA EN LA CAPA (2), GENERALMENTE CONSTITUIDA EN PARTICULAR POR POLIMEROS HIDROFILOS QUE SE GELIFICAN Y/O SE INFLAN Y A CONTINUACION PUEDEN OPCIONALMENTE DESGASTAR Y QUE TIENEN UNA FUNCION DE BARRERA QUE MODULA LA LIBERACION DEL CHORHIDRATO DE ALFUZOSINA DE LA CAPA (2), SIENDO LA CAPA (3) EN UN PRIMER LUGAR MUY POCO PERMEABLE AL PASO DE LA SUSTANCIA ACTIVA. COMPOSICION FARMACEUTICA.
ES97937651T 1996-08-29 1997-08-22 Comprimido con liberacion controlada de clorhidrato de alfuzosina Expired - Lifetime ES2159400T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9610551A FR2752737B1 (fr) 1996-08-29 1996-08-29 Comprime a liberation controlee de chlorhydrate d'alfuzosine
FR9704386 1997-04-10

Publications (1)

Publication Number Publication Date
ES2159400T3 true ES2159400T3 (es) 2001-10-01

Family

ID=26232935

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97937651T Expired - Lifetime ES2159400T3 (es) 1996-08-29 1997-08-22 Comprimido con liberacion controlada de clorhidrato de alfuzosina

Country Status (36)

Country Link
US (1) US6149940A (es)
EP (1) EP0938318B1 (es)
JP (1) JP3797388B2 (es)
KR (1) KR100364328B1 (es)
CN (2) CN1155382C (es)
AP (1) AP1107A (es)
AR (1) AR009312A1 (es)
AT (1) ATE200864T1 (es)
AU (1) AU724490B2 (es)
BG (1) BG63768B1 (es)
BR (1) BR9713237B1 (es)
CA (1) CA2264250C (es)
CO (1) CO4920217A1 (es)
CY (1) CY2284B1 (es)
CZ (1) CZ295066B6 (es)
DE (1) DE69704712T2 (es)
DK (1) DK0938318T3 (es)
EE (1) EE03855B1 (es)
ES (1) ES2159400T3 (es)
GR (1) GR3036291T3 (es)
HU (1) HU228007B1 (es)
IL (1) IL128146A (es)
IS (1) IS2091B (es)
MX (1) MXPA99001958A (es)
NO (1) NO326206B1 (es)
NZ (1) NZ334018A (es)
OA (1) OA10983A (es)
PL (1) PL191546B1 (es)
PT (1) PT938318E (es)
RU (1) RU2183459C2 (es)
SI (1) SI0938318T1 (es)
SK (1) SK284388B6 (es)
TR (1) TR199900289T2 (es)
TW (1) TW522023B (es)
UA (1) UA69374C2 (es)
WO (1) WO1998008515A1 (es)

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Also Published As

Publication number Publication date
PT938318E (pt) 2001-10-30
KR100364328B1 (ko) 2002-12-26
AP1107A (en) 2002-09-20
CN1228700A (zh) 1999-09-15
TW522023B (en) 2003-03-01
IS4964A (is) 1999-01-29
DK0938318T3 (da) 2001-08-20
NO990944D0 (no) 1999-02-26
IL128146A (en) 2001-01-11
AU4020197A (en) 1998-03-19
US6149940A (en) 2000-11-21
EP0938318B1 (fr) 2001-05-02
EE03855B1 (et) 2002-10-15
WO1998008515A1 (fr) 1998-03-05
SI0938318T1 (en) 2001-12-31
OA10983A (fr) 2003-03-04
UA69374C2 (uk) 2004-09-15
SK27099A3 (en) 1999-12-10
PL191546B1 (pl) 2006-06-30
EP0938318A1 (fr) 1999-09-01
EE9900090A (et) 1999-10-15
PL331862A1 (en) 1999-08-16
BG103138A (en) 1999-09-30
CO4920217A1 (es) 2000-05-29
MXPA99001958A (es) 2005-09-08
ATE200864T1 (de) 2001-05-15
CN1543954A (zh) 2004-11-10
NO326206B1 (no) 2008-10-20
AP9901470A0 (en) 1999-03-31
NO990944L (no) 1999-04-27
CA2264250C (en) 2005-07-05
CZ65599A3 (cs) 1999-06-16
JP3797388B2 (ja) 2006-07-19
RU2183459C2 (ru) 2002-06-20
BR9713237B1 (pt) 2009-01-13
CA2264250A1 (en) 1998-03-05
HK1020875A1 (en) 2000-05-26
AU724490B2 (en) 2000-09-21
HUP9903428A3 (en) 2000-04-28
HUP9903428A2 (hu) 2000-02-28
IL128146A0 (en) 1999-11-30
CY2284B1 (en) 2003-07-04
CN100335057C (zh) 2007-09-05
CN1155382C (zh) 2004-06-30
DE69704712D1 (de) 2001-06-07
BR9713237A (pt) 2000-04-04
KR20000035929A (ko) 2000-06-26
NZ334018A (en) 1999-06-29
CZ295066B6 (cs) 2005-05-18
AR009312A1 (es) 2000-04-12
TR199900289T2 (xx) 2000-12-21
BG63768B1 (bg) 2002-12-29
SK284388B6 (sk) 2005-02-04
JP2000514462A (ja) 2000-10-31
IS2091B (is) 2006-03-15
HU228007B1 (en) 2012-08-28
GR3036291T3 (en) 2001-10-31
DE69704712T2 (de) 2001-11-29

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