BR9808290A - Composto, composição farmacêutica, processo de tratar infecções bacterianas em seres humanos e animais, uso de um composto, e, processo para sua preparação - Google Patents

Composto, composição farmacêutica, processo de tratar infecções bacterianas em seres humanos e animais, uso de um composto, e, processo para sua preparação

Info

Publication number: BR9808290A
Authority: BR; Brazil
Prior art keywords: compound; preparation; animals; pharmaceutical composition; bacterial infections
Prior art date: 1997-03-21

Application number

BR9808290-6A

Other languages

English (en)

Portuguese (pt)

Inventor

Ae Ri Kim

Jin Hwa Lee

Ki Sook Park

Jong Ryoo Choi

Tae Hee Lee

Jay Hyok Chang

Do Hyun Nam

Hoon Choi

Original Assignee

Lg Chemical Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-21

Filing date

1998-03-20

Publication date

2000-05-16

1998-03-20 Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd

2000-05-16 Publication of BR9808290A publication Critical patent/BR9808290A/pt

Links

238000000034 method Methods 0.000 title abstract 5
150000001875 compounds Chemical class 0.000 title abstract 4
239000008194 pharmaceutical composition Substances 0.000 title abstract 3
208000035143 Bacterial infection Diseases 0.000 title abstract 2
241001465754 Metazoa Species 0.000 title abstract 2
208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
JIYMVSQRGZEYAX-UHFFFAOYSA-N 7-[3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid;methanesulfonic acid Chemical compound CS(O)(=O)=O.C1C(CN)C(=NOC)CN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1CC1 JIYMVSQRGZEYAX-UHFFFAOYSA-N 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BR9808290-6A 1997-03-21 1998-03-20 Composto, composição farmacêutica, processo de tratar infecções bacterianas em seres humanos e animais, uso de um composto, e, processo para sua preparação BR9808290A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR19970009840		1997-03-21
PCT/KR1998/000051 WO1998042705A1 (en)	1997-03-21	1998-03-20	Salt of naphthyridine carboxylic acid derivative

Publications (1)

Publication Number	Publication Date
BR9808290A true BR9808290A (pt)	2000-05-16

Family

ID=19500439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9808290-6A BR9808290A (pt)	1997-03-21	1998-03-20	Composto, composição farmacêutica, processo de tratar infecções bacterianas em seres humanos e animais, uso de um composto, e, processo para sua preparação

Country Status (38)

Country	Link
US (9)	US7700617B2 (2)
EP (2)	EP0981527B1 (2)
JP (3)	JP3759962B2 (2)
KR (1)	KR100266499B1 (2)
CN (1)	CN1131229C (2)
AP (1)	AP1331A (2)
AR (1)	AR012125A1 (2)
AT (2)	ATE257836T1 (2)
AU (1)	AU726634B2 (2)
BG (1)	BG63972B1 (2)
BR (1)	BR9808290A (2)
CA (1)	CA2283671C (2)
CZ (2)	CZ288673B6 (2)
DE (2)	DE69821147T2 (2)
DK (2)	DK1179533T3 (2)
DZ (1)	DZ2448A1 (2)
EA (1)	EA001674B1 (2)
ES (2)	ES2213669T3 (2)
HU (2)	HU225412B1 (2)
ID (1)	ID22681A (2)
IL (2)	IL131812A0 (2)
IN (1)	IN188178B (2)
IS (2)	IS2093B (2)
MA (1)	MA24500A1 (2)
MY (1)	MY137653A (2)
NO (1)	NO312515B1 (2)
NZ (1)	NZ337748A (2)
OA (1)	OA11161A (2)
PE (1)	PE67999A1 (2)
PL (1)	PL191815B1 (2)
PT (2)	PT981527E (2)
SA (1)	SA98181055B1 (2)
SI (2)	SI0981527T1 (2)
SK (1)	SK284107B6 (2)
TR (1)	TR199902313T2 (2)
UA (1)	UA56218C2 (2)
WO (1)	WO1998042705A1 (2)
ZA (1)	ZA982335B (2)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9820405D0 (en) *	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process
CA2366660A1 (en) *	1999-03-19	2000-09-28	Carl M. Mendel	Treatment of osteoarthritis
US6262071B1 (en)	1999-06-29	2001-07-17	Smithkline Beecham Corporation	Methods of use of antimicrobial compounds against pathogenic amycoplasma bacteria
US6331550B1 (en)	1999-06-29	2001-12-18	Smithkline Beecham Corporation	Methods of use of quinolone compounds against anaerobic pathogenic bacteria
CA2282066C (en)	1999-06-29	2010-09-07	Smithkline Beecham Corporation	Methods of use of quinolone compounds against atypical upper respiratory pathogenic bacteria
US6803376B1 (en)	1999-06-29	2004-10-12	Smithkline Beecham Corporation	Method of use of quinolone compounds against pneumococcal and haemophilus bacteria
GB9920917D0 (en) *	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel process
GB9920919D0 (en) *	1999-09-03	1999-11-10	Sb Pharmco Inc	Novel compound
JP2001097891A (ja) *	1999-09-24	2001-04-10	Smithkline Beecham Corp	呼吸器系病原菌に対するフルオロキノロン化合物の使用法
GR1003520B (el) *	1999-09-22	2001-01-22	Smithkline Beecham Plc	Μεθοδος χρησης ενωσεων φλουοροκινολονης εναντια σε νοσοκομειακα αρνητικα κατα gramμ παθογενων βακτηριδιων
JP2001097864A (ja) *	1999-09-24	2001-04-10	Smithkline Beecham Corp	呼吸管および尿路病原性細菌に対するフルオロキノリン化合物の使用方法
JP2001097863A (ja) *	1999-09-24	2001-04-10	Smithkline Beecham Corp	嫌気性病原菌に対するフルオロキノロン化合物の使用法
EP1242079A4 (en) *	1999-09-22	2003-01-22	Smithkline Beecham	Methods of anti-bacterial use of fluoroquinolonic compounds
GR1003521B (el) *	1999-09-23	2001-01-22	Smithkline Beecham Plc	Μεθοδοι χρησεως ενωσεων φλουοροκινολονης εναντια κατα gram θετικων παθογονων βακτηριδιων
KR20010091379A (ko) *	2000-03-15	2001-10-23	성재갑	7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
PT1412078E (pt)	2001-08-02	2009-01-08	Lg Life Sciences Ltd	Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
US7169792B2 (en) *	2001-11-30	2007-01-30	Lg Life Sciences Ltd.	Method of treating bacterial infections using gemifloxacin or a salt thereof and a β-lactam antibiotic
KR100517638B1 (ko) *	2002-04-08	2005-09-28	주식회사 엘지생명과학	게미플록사신 산염의 새로운 제조방법
AR043880A1 (es) *	2003-04-22	2005-08-17	Solvay Pharm Gmbh	Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas
EP1891037A1 (en) *	2005-06-15	2008-02-27	Hetero Drugs Limited	Gemifloxacin process and polymorphs
NZ570865A (en) *	2006-03-07	2010-11-26	Wockhardt Ltd	Alanine and valine prodrugs of nadifloxacin, S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
WO2010001408A2 (en) *	2008-06-06	2010-01-07	Matrix Laboratories Ltd.	Novel polymorphic forms of gemifloxacin mesylate
WO2010146594A1 (en) *	2009-06-16	2010-12-23	Hetero Research Foundation	Novel polymorphs of gemifloxacin mesylate
EP2491921A1 (en)	2011-02-25	2012-08-29	Deva Holding Anonim Sirketi	Conservation of anhydrous form of gemifloxacin
HRP20171620T1 (hr) *	2012-02-27	2017-12-01	Bristol-Myers Squibb Company	N- (5s, 6s, 9r) - 5 amino- 6 - (2, 3 - difluorofenil) -6, 7, 8, 9 - tetrahidro - 5h - ciklohepta [b]piridin-9 -il- 4 - (2 - okso-2, 3 - dihidro - 1h - imidazo [4, 5 -b]piridin - 1 - il) piperidin - 1 - karboksilat, hemisulfatna sol
CZ2016104A3 (cs) *	2016-02-24	2017-09-06	Zentiva, K.S.	Krystalické modifikace solí methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}fenyl)amino](fenyl)methyliden}-2-oxo-2,3-dihydro-1H-indol-6-karboxylátu a způsoby jejich přípravy

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AR223983A1 (es)	1978-08-25	1981-10-15	Dainippon Pharmaceutical Co	Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
ES8304117A1 (es)	1981-06-11	1983-02-16	Warner Lambert Co	"un procedimiento para preparar sales de compuestos de naftiridina y quinoleina".
IN162769B (2)	1984-11-13	1988-07-09	Kyorin Seiyaku Kk
NZ222047A (en)	1986-10-08	1991-01-29	Bristol Myers Co	Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja)	1987-10-13	1989-04-18	Shionogi & Co Ltd	オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en)	1988-01-25	1990-04-24	Warner-Lambert Company	Antibacterial agents
US4931446A (en)	1988-03-23	1990-06-05	Abbott Laboratories	Antimicrobial for in-vitro diagnostic kits
US5286723A (en)	1988-08-31	1994-02-15	Daiichi Seiyaku Co., Ltd.	Spiro compound
CA1336090C (en)	1988-08-31	1995-06-27	Isao Hayakawa	Spiro-substituted cyclic amines of quinolone derivatives
RU2049777C1 (ru)	1989-08-16	1995-12-10	Пфайзер Инк.	Азабицикло-хинолон-карбоновые кислоты или их фармацевтически приемлемые кислотно-аддитивные соли и промежуточные продукты для их получения
EP0541086A1 (en)	1991-11-08	1993-05-12	Kaken Pharmaceutical Co., Ltd.	Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
WO1993025545A1 (en)	1992-06-09	1993-12-23	Korea Research Institute Of Chemical Technology	Novel quinoline derivatives and processes for preparing the same
US5776944A (en)	1994-06-16	1998-07-07	Lg Chemical Ltd.	7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
EP0688772B1 (en)	1994-06-16	1999-05-06	LG Chemical Limited	Quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime) pyrrolidine substituents and processes for their preparation
DE69531305T2 (de)	1994-10-20	2004-05-13	Wakunaga Seiyaku K.K.	Pyridoncarboxylat- derivate oder salze davon und antibakterielle zusammensetzungen die diese als aktiven bestandteil enthalten
KR100499366B1 (ko)	1995-01-30	2005-09-08	와쿠나가 세이야쿠 가부시키 가이샤	신규피리돈카르복실산유도체또는그염및그물질을유효성분으로하는항균제
JP3145715B2 (ja)	1995-06-06	2001-03-12	ファイザー・インコーポレーテッド	無水７−（［１α，５α，６α］−６−アミノ−３−アザビシクロ［３．１．０］ヘキサ−３−イル）−６−フルオロ−１−（２，４−ジフルオロフェニル）−１，４−ジヒドロ−４−オキソ−１，８−ナフチリディン−３−カルボン酸メタンスルホン酸塩の新規な結晶形態
US20020032216A1 (en) *	1997-03-21	2002-03-14	Lg Chemical Ltd.	Salt of naphthyridine carboxylic acid derivative
KR100286874B1 (ko)	1998-03-04	2001-04-16	성재갑	보호된 4-아미노메틸-피롤리딘-3-온의 제조방법
GB9820405D0 (en)	1998-09-18	1998-11-11	Smithkline Beecham Plc	Process

1998
- 1998-03-17 MA MA25001A patent/MA24500A1/fr unknown
- 1998-03-18 DZ DZ980058A patent/DZ2448A1/xx active
- 1998-03-19 ZA ZA9802335A patent/ZA982335B/xx unknown
- 1998-03-20 AT AT01203507T patent/ATE257836T1/de active
- 1998-03-20 WO PCT/KR1998/000051 patent/WO1998042705A1/en not_active Ceased
- 1998-03-20 NZ NZ337748A patent/NZ337748A/xx not_active IP Right Cessation
- 1998-03-20 DE DE69821147T patent/DE69821147T2/de not_active Expired - Lifetime
- 1998-03-20 IL IL13181298A patent/IL131812A0/xx active IP Right Grant
- 1998-03-20 SI SI9830418T patent/SI0981527T1/xx unknown
- 1998-03-20 PE PE1998000202A patent/PE67999A1/es not_active Application Discontinuation
- 1998-03-20 BR BR9808290-6A patent/BR9808290A/pt not_active Application Discontinuation
- 1998-03-20 AU AU66366/98A patent/AU726634B2/en not_active Expired
- 1998-03-20 PT PT98908300T patent/PT981527E/pt unknown
- 1998-03-20 CA CA002283671A patent/CA2283671C/en not_active Expired - Lifetime
- 1998-03-20 EP EP98908300A patent/EP0981527B1/en not_active Expired - Lifetime
- 1998-03-20 UA UA99095186A patent/UA56218C2/uk unknown
- 1998-03-20 EP EP01203507A patent/EP1179533B1/en not_active Expired - Lifetime
- 1998-03-20 HU HU0000728A patent/HU225412B1/hu unknown
- 1998-03-20 AR ARP980101268A patent/AR012125A1/es active IP Right Grant
- 1998-03-20 SI SI9830595T patent/SI1179533T1/ unknown
- 1998-03-20 PL PL335812A patent/PL191815B1/pl unknown
- 1998-03-20 DK DK01203507T patent/DK1179533T3/da active
- 1998-03-20 DK DK98908300T patent/DK0981527T3/da active
- 1998-03-20 ES ES01203507T patent/ES2213669T3/es not_active Expired - Lifetime
- 1998-03-20 CN CN98803576A patent/CN1131229C/zh not_active Expired - Lifetime
- 1998-03-20 ID IDW991044A patent/ID22681A/id unknown
- 1998-03-20 IL IL131812A patent/IL131812A/en not_active IP Right Cessation
- 1998-03-20 EA EA199900855A patent/EA001674B1/ru not_active IP Right Cessation
- 1998-03-20 PT PT01203507T patent/PT1179533E/pt unknown
- 1998-03-20 HU HU0600401A patent/HU227536B1/hu unknown
- 1998-03-20 KR KR1019980009717A patent/KR100266499B1/ko not_active Expired - Lifetime
- 1998-03-20 ES ES98908300T patent/ES2198697T3/es not_active Expired - Lifetime
- 1998-03-20 SK SK1236-99A patent/SK284107B6/sk not_active IP Right Cessation
- 1998-03-20 AP APAP/P/1999/001649A patent/AP1331A/en active
- 1998-03-20 DE DE69814378T patent/DE69814378T2/de not_active Expired - Lifetime
- 1998-03-20 AT AT98908300T patent/ATE239724T1/de active
- 1998-03-20 JP JP54550098A patent/JP3759962B2/ja not_active Expired - Lifetime
- 1998-03-20 CZ CZ19993282A patent/CZ288673B6/cs not_active IP Right Cessation
- 1998-03-20 TR TR1999/02313T patent/TR199902313T2/xx unknown
- 1998-03-21 MY MYPI98001236A patent/MY137653A/en unknown
- 1998-03-23 IN IN727DE1998 patent/IN188178B/en unknown
- 1998-03-25 SA SA98181055A patent/SA98181055B1/ar unknown
1999
- 1999-09-14 IS IS5181A patent/IS2093B/is unknown
- 1999-09-20 OA OA9900213A patent/OA11161A/fr unknown
- 1999-09-21 NO NO19994595A patent/NO312515B1/no not_active IP Right Cessation
- 1999-09-21 BG BG103750A patent/BG63972B1/bg unknown
2000
- 2000-10-03 CZ CZ20003641A patent/CZ288715B6/cs not_active IP Right Cessation
2003
- 2003-05-07 JP JP2003128650A patent/JP4781614B2/ja not_active Expired - Lifetime
2005
- 2005-07-21 IS IS7952A patent/IS2095B/is unknown
2006
- 2006-12-07 US US11/635,069 patent/US7700617B2/en not_active Expired - Fee Related
2008
- 2008-10-14 JP JP2008265345A patent/JP2009051851A/ja not_active Withdrawn
2009
- 2009-01-09 US US12/318,845 patent/US20090182006A1/en not_active Abandoned
2010
- 2010-06-02 US US12/791,957 patent/US20100240694A1/en not_active Abandoned
2011
- 2011-04-11 US US13/083,685 patent/US20110312987A1/en not_active Abandoned
2012
- 2012-06-26 US US13/533,383 patent/US20130065917A1/en not_active Abandoned
2013
- 2013-10-25 US US14/063,117 patent/US20140187576A1/en not_active Abandoned
2015
- 2015-02-13 US US14/621,689 patent/US20150291585A1/en not_active Abandoned
2016
- 2016-01-15 US US14/996,765 patent/US20160264569A1/en not_active Abandoned
2017
- 2017-01-20 US US15/411,030 patent/US20170253588A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MA24500A1 (fr)	1998-10-01
DE69821147D1 (de)	2004-02-19
JP4781614B2 (ja)	2011-09-28
US20090182006A1 (en)	2009-07-16
HUP0600401A3 (en)	2010-05-28
EP1179533A2 (en)	2002-02-13
DE69821147T2 (de)	2004-11-11
IL131812A (en)	2006-04-10
US20130065917A1 (en)	2013-03-14
KR19980080504A (ko)	1998-11-25
EP1179533A3 (en)	2002-03-20
ES2213669T3 (es)	2004-09-01
OA11161A (en)	2003-04-25
IN188178B (2)	2002-08-31
EA001674B1 (ru)	2001-06-25
IS2093B (is)	2006-04-12
NO994595D0 (no)	1999-09-21
JP2000510484A (ja)	2000-08-15
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