BR9810896A - Processo de preparação de derivados aminas de alquiloxifuranona, compostos provenientes desse processo e utilização desses compostos - Google Patents

Processo de preparação de derivados aminas de alquiloxifuranona, compostos provenientes desse processo e utilização desses compostos

Info

Publication number
BR9810896A
BR9810896A BR9810896-4A BR9810896A BR9810896A BR 9810896 A BR9810896 A BR 9810896A BR 9810896 A BR9810896 A BR 9810896A BR 9810896 A BR9810896 A BR 9810896A
Authority
BR
Brazil
Prior art keywords
compounds
alkyloxifuranone
preparation
formula
amine derivatives
Prior art date
Application number
BR9810896-4A
Other languages
English (en)
Inventor
Raphael Bouchet
Francis Brion
Collete Colladant
Jacques Lagoudart
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of BR9810896A publication Critical patent/BR9810896A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO DE PREPARAçãO DE DERIVADOS AMINAS DE ALQUILOXIFURANONA, COMPOSTOS PROVENIENTES DESSE PROCESSO E UTILIZAçãO DESSES COMPOSTOS"<D>. A invenção tem como objetivo um novo processo de preparação de compostos de fórmula (IV) ou (I) a partir de alquiloxifuranona racêmica de fórmula (II), R~ 1~ e R~ 2~ sendo tais como definidos na descrição, os compostos novos de fórmula (IV) assim como os compostos intermediários desse processo, e a utilização dos compostos de fórmula (IV) ou (I) no processo de síntese de compostos inibidores da enzima de conversão da interleucina-1beta.
BR9810896-4A 1997-07-15 1998-07-09 Processo de preparação de derivados aminas de alquiloxifuranona, compostos provenientes desse processo e utilização desses compostos BR9810896A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr) 1997-07-15 1998-07-09 Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (1)

Publication Number Publication Date
BR9810896A true BR9810896A (pt) 2000-09-26

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810896-4A BR9810896A (pt) 1997-07-15 1998-07-09 Processo de preparação de derivados aminas de alquiloxifuranona, compostos provenientes desse processo e utilização desses compostos

Country Status (34)

Country Link
US (1) US6235899B1 (pt)
EP (1) EP0998470B1 (pt)
JP (1) JP4450987B2 (pt)
KR (1) KR100519691B1 (pt)
CN (1) CN100363355C (pt)
AP (1) AP1071A (pt)
AR (1) AR015924A1 (pt)
AT (1) ATE239713T1 (pt)
AU (1) AU744272B2 (pt)
BG (1) BG64050B1 (pt)
BR (1) BR9810896A (pt)
CA (1) CA2296742C (pt)
CZ (1) CZ295312B6 (pt)
DE (1) DE69814395T2 (pt)
DK (1) DK0998470T3 (pt)
EA (1) EA002883B1 (pt)
EE (1) EE03873B1 (pt)
ES (1) ES2197489T3 (pt)
FR (1) FR2766188B1 (pt)
HR (1) HRP20000027B1 (pt)
HU (1) HU230148B1 (pt)
ID (1) ID23784A (pt)
IL (1) IL134031A (pt)
ME (1) ME01708B (pt)
NO (1) NO324508B1 (pt)
NZ (1) NZ502338A (pt)
PL (1) PL200820B1 (pt)
PT (1) PT998470E (pt)
RS (1) RS49832B (pt)
SK (1) SK284168B6 (pt)
TR (1) TR200000117T2 (pt)
UA (1) UA66364C2 (pt)
WO (1) WO1999003852A1 (pt)
ZA (1) ZA986203B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) * 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
CA2402128A1 (en) 2000-04-24 2001-11-01 Vertex Pharmaceuticals Incorporated Process and intermediates for making substituted aspartic acid acetals
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
JPWO2002055478A1 (ja) * 2001-01-16 2004-05-13 鐘淵化学工業株式会社 光学活性アミノラクトン誘導体の製造法およびその中間体
EP1718639A2 (en) 2004-02-27 2006-11-08 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
SG150547A1 (en) * 2004-03-12 2009-03-30 Vertex Pharma Processes and intermediates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
PL338035A1 (en) 2000-09-25
HRP20000027B1 (en) 2006-07-31
KR20010021834A (ko) 2001-03-15
CZ295312B6 (cs) 2005-07-13
ME01708B (me) 2008-08-07
CN100363355C (zh) 2008-01-23
EE200000024A (et) 2000-10-16
NO20000182D0 (no) 2000-01-14
SK302000A3 (en) 2000-11-07
CZ200065A3 (cs) 2000-07-12
RS49832B (sr) 2008-08-07
FR2766188A1 (fr) 1999-01-22
AR015924A1 (es) 2001-05-30
EP0998470B1 (fr) 2003-05-07
AP2000001732A0 (en) 2000-03-31
EP0998470A1 (fr) 2000-05-10
PT998470E (pt) 2003-09-30
US6235899B1 (en) 2001-05-22
EE03873B1 (et) 2002-10-15
KR100519691B1 (ko) 2005-10-13
AP1071A (en) 2002-05-20
JP4450987B2 (ja) 2010-04-14
PL200820B1 (pl) 2009-02-27
NO324508B1 (no) 2007-11-05
EA200000127A1 (ru) 2000-08-28
DK0998470T3 (da) 2003-09-01
WO1999003852A1 (fr) 1999-01-28
HUP0003857A3 (en) 2002-08-28
BG64050B1 (bg) 2003-11-28
TR200000117T2 (tr) 2000-07-21
UA66364C2 (uk) 2004-05-17
ATE239713T1 (de) 2003-05-15
EA002883B1 (ru) 2002-10-31
ES2197489T3 (es) 2004-01-01
CN1269795A (zh) 2000-10-11
JP2001510191A (ja) 2001-07-31
YU1500A (sh) 2002-10-18
BG104073A (en) 2001-05-31
NO20000182L (no) 2000-03-07
SK284168B6 (sk) 2004-10-05
HU230148B1 (hu) 2015-09-28
IL134031A0 (en) 2001-04-30
ID23784A (id) 2000-05-11
CA2296742C (fr) 2009-12-08
ZA986203B (en) 1999-08-18
AU744272B2 (en) 2002-02-21
AU8633398A (en) 1999-02-10
DE69814395T2 (de) 2003-12-11
DE69814395D1 (de) 2003-06-12
IL134031A (en) 2004-06-01
FR2766188B1 (fr) 2000-02-11
NZ502338A (en) 2001-09-28
CA2296742A1 (fr) 1999-01-28
HRP20000027A2 (en) 2000-10-31
HUP0003857A2 (hu) 2001-04-28

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: AVENTIS PHARMA S.A. (FR)

Free format text: TRANSFERIDO POR FUSAO DE: HOECHST MARION ROUSSEL

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.