BR9915475A - Derivados da quinolina-4-carboxamida comoantagonistas dos receptores de nk-3 e nk-2 - Google Patents

Derivados da quinolina-4-carboxamida comoantagonistas dos receptores de nk-3 e nk-2

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Publication number
BR9915475A
BR9915475A BR9915475-7A BR9915475A BR9915475A BR 9915475 A BR9915475 A BR 9915475A BR 9915475 A BR9915475 A BR 9915475A BR 9915475 A BR9915475 A BR 9915475A
Authority
BR
Brazil
Prior art keywords
alkyl
optionally substituted
aryl
group
cycloalkyl
Prior art date
Application number
BR9915475-7A
Other languages
English (en)
Inventor
Carlo Farina
Giuseppe Giardina
Mario Grugni
Marcel Morvan
Guy Marguerite Marie Gerard Nadler
Luca Francesco Raveglia
Original Assignee
Smithkline Beecham Spa
Smithkline Beecham Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9825552.4A external-priority patent/GB9825552D0/en
Priority claimed from GBGB9825553.2A external-priority patent/GB9825553D0/en
Application filed by Smithkline Beecham Spa, Smithkline Beecham Lab filed Critical Smithkline Beecham Spa
Publication of BR9915475A publication Critical patent/BR9915475A/pt

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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

"DERIVADOS DA QUINOLINA-4-CARBOXAMIDA COMOANTAGONISTAS DOS RECEPTORES DE NK-3 E NK-2".Trata-se de um composto, ou um solvato ou um sal delesproveniente, de fórmula (I): onde, Ar é um grupo arila ou um grupocicloalcadienila C~ 5-7~ opcionalmente substituídos, ou um grupocicloalquila C~ 5-7~ OPcionalmente substituído, ou um grupoaromático heterocíclico de anel único ou fundido opcionalmentesubstituído; R é hidrogênio, alquila C~ 1-6~, cicloalquila C~ 3-7~,cicloalquilalquila C~ 3-7~, lineares ou ramificadas; R~ 1~,representa hidrogênio ou até três substituíntes opcionaisselecionados a partir da lista consistindo de: alquila C~ 1-6~,alquenila C~ 1-6~, arila, alcoxila C~ 1-6~, hidroxila, halogênio, nitro,ciano, carboxila, carboxamido, sulfonamido, alcoxicarbonila C~1-6~, trifluorometila, aciloxila, amino ou mono- e di-alquilamino C~1-6~; R~ 2~ representa uma fração -(CH~ 2~)~ n~-NY~ 1~Y~ 2~onde n é um inteiro na faixa de 1 a 9, Y~ 1~ e Y~ 2~ sãoindependentemente selecionados a partir de alquila C~ 1-6~;alquila C~ 1-6~ substituída com hidroxila, alcoxila, alquilamino C~1-6~ ou bis (alquil C~ 1-6~) amino; cicloalquila C~ 3-6~;azobicicloalquila C~ 4-6~; alquenila C~ 1-6~; arila ou aril-alquila-C~1-6~ ou Y~ 1~ e Y~ 2~ juntamente com o átomo de nitrogênio aoqual eles estão ligados representam um grupo heterocíclico deanel único ou fundido N-articulado opcionalmente substituído; R~3~ é alquila C~ 1-6~, cicloalquila C~ 3-7~, cicloalquilalquila C~4-7~, lineares ou ramificadas, arila opcionalmente substituída, ouum grupo aromático heterocíclico de anel único ou fundidoopcionalmente substituído; e R~ 4~ representa hidrogênio oualquila C~ 1-6~; R~ 5~ representa hidrogênio ou halogênio; umprocesso para a preparação de tais compostos, uma composiçãofarmacêutica contendo tais compostos e o uso de tais compostos ecomposições em medicina.
BR9915475-7A 1998-11-20 1999-11-19 Derivados da quinolina-4-carboxamida comoantagonistas dos receptores de nk-3 e nk-2 BR9915475A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9825552.4A GB9825552D0 (en) 1998-11-20 1998-11-20 Novel compounds
GBGB9825553.2A GB9825553D0 (en) 1998-11-20 1998-11-20 Novel Compounds
PCT/EP1999/009115 WO2000031037A1 (en) 1998-11-20 1999-11-19 Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

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BR9915475A true BR9915475A (pt) 2001-12-18

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BR9915475-7A BR9915475A (pt) 1998-11-20 1999-11-19 Derivados da quinolina-4-carboxamida comoantagonistas dos receptores de nk-3 e nk-2

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EP (1) EP1131295A1 (pt)
JP (1) JP2002530377A (pt)
KR (1) KR20010075726A (pt)
CN (1) CN1406225A (pt)
AR (2) AR021354A1 (pt)
AU (1) AU768708B2 (pt)
BR (1) BR9915475A (pt)
CA (1) CA2351865A1 (pt)
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HU (1) HUP0104959A3 (pt)
IL (1) IL143137A0 (pt)
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NO (1) NO20012473L (pt)
NZ (1) NZ511777A (pt)
PL (1) PL347721A1 (pt)
TR (1) TR200101412T2 (pt)
WO (1) WO2000031037A1 (pt)

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