BRPI0014428B8 - composto, composição farmacêutica, e, uso de um composto para o tratamento ou prevenção da doença infecciosa do hiv - Google Patents

composto, composição farmacêutica, e, uso de um composto para o tratamento ou prevenção da doença infecciosa do hiv

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Publication number
BRPI0014428B8
BRPI0014428B8 BRPI0014428A BR0014428A BRPI0014428B8 BR PI0014428 B8 BRPI0014428 B8 BR PI0014428B8 BR PI0014428 A BRPI0014428 A BR PI0014428A BR 0014428 A BR0014428 A BR 0014428A BR PI0014428 B8 BRPI0014428 B8 BR PI0014428B8
Authority
BR
Brazil
Prior art keywords
substituted
compound
group
bond
heterocyclic group
Prior art date
Application number
BRPI0014428A
Other languages
English (en)
Other versions
BRPI0014428B1 (pt
BR0014428A (pt
Inventor
Baba Masanori
Kanzaki Naoyuki
Nishimura Osamu
Imamura Shinichi
Hashiguchi Shohei
Hattori Taeko
Sugihara Yoshihiro
Original Assignee
Takeda Chemical Industries Ltd
Tobira Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26554466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0014428(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd, Tobira Therapeutics Inc filed Critical Takeda Chemical Industries Ltd
Publication of BR0014428A publication Critical patent/BR0014428A/pt
Publication of BRPI0014428B1 publication Critical patent/BRPI0014428B1/pt
Publication of BRPI0014428B8 publication Critical patent/BRPI0014428B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"composto, pró medicamento de um composto, composição farmacêutica, uso de um composto, e, métodos para antagonizar ccr5, e, para produzir um composto". um composto da fórmula (i) (em que r^ 1^ é um átomo de hidrogênio, um grupo hidrocarboneto que pode ser substituído, um grupo heterocíclico não aromático que pode ser substituído, r^ 2^ é um grupo hidrocarboneto que pode ser substituído, um grupo heterocíclico não aromático que pode ser substituído ou r^ 1^ e r^ 2^ podem combinar um com o outro juntos com a para formar um grupo heterocíclico que pode ser substituído; a é n ou n^ +^-r^ 5^<sym>-y^ -^(r^ 5^ é um grupo hidrocarboneto; y^ -^ é um contra ânion); r^ 3^ é um grupo hidrocarboneto cíclico que pode ser substituído ou um grupo heterocíclico que pode ser substituído; n é 0 ou 1; r^ 4^ é um átomo de hidrogênio, um grupo hidrocarboneto que pode ser substituído, um grupo heterocíclico que pode ser substituído, um grupo alcóxi que pode ser substituído, um grupo arilóxi que pode ser substituído ou um grupo amino que pode ser substituído, e é um grupo hidrocarboneto alifático bivalente que pode ser substituído por grupo(s) outros que não oxo; g^ 1^ é uma ligação, co ou so~ 2~; g^ 2^ é co, so~ 2~, nhco, conh ou oco; j é metina ou um átomo de nitrogênio; e cada um de q e r é uma ligação ou um hidrocarboneto alifático bivalente c~ 1-3~ que pode ser substituído; contanto que j seja metina quando g^ 2^ é oco, que um de q e r não seja uma ligação quando o outro é uma ligação e que cada um de q e r não seja substituído por grupo(s) oxo quando g^ 1^ é uma ligação) ou um sal deste têm uma atividade antagonística ao ccr5 potente e podem ser vantajosamente usados para o tratamento ou a prevenção de doença infecciosa de vários hiv em seres humanos (por exemplo, a aids).
BRPI0014428A 1999-10-01 2000-09-29 composto, composição farmacêutica, e, uso de um composto para o tratamento ou prevenção da doença infecciosa do hiv BRPI0014428B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28208899 1999-10-01
JP2000046749 2000-02-18
PCT/JP2000/006755 WO2001025200A1 (en) 1999-10-01 2000-09-29 Cyclic amine compounds as ccr5 antagonists

Publications (3)

Publication Number Publication Date
BR0014428A BR0014428A (pt) 2002-06-11
BRPI0014428B1 BRPI0014428B1 (pt) 2016-08-02
BRPI0014428B8 true BRPI0014428B8 (pt) 2021-05-25

Family

ID=26554466

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0014428A BRPI0014428B8 (pt) 1999-10-01 2000-09-29 composto, composição farmacêutica, e, uso de um composto para o tratamento ou prevenção da doença infecciosa do hiv

Country Status (22)

Country Link
US (2) US6562978B1 (pt)
EP (2) EP1220842B1 (pt)
JP (2) JP3814136B2 (pt)
KR (1) KR20020060190A (pt)
CN (1) CN1390201A (pt)
AR (1) AR025884A1 (pt)
AT (1) ATE400555T1 (pt)
AU (1) AU7448700A (pt)
BR (1) BRPI0014428B8 (pt)
CA (2) CA2608807A1 (pt)
CO (1) CO5380013A1 (pt)
CY (1) CY1108403T1 (pt)
DE (1) DE60039446D1 (pt)
DK (1) DK1220842T3 (pt)
ES (1) ES2310173T3 (pt)
HU (1) HUP0300138A3 (pt)
NO (1) NO20021450L (pt)
PE (1) PE20010628A1 (pt)
PL (1) PL203984B1 (pt)
PT (1) PT1220842E (pt)
WO (1) WO2001025200A1 (pt)
ZA (1) ZA200202593B (pt)

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CA2608807A1 (en) 2001-04-12
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DE60039446D1 (de) 2008-08-21
EP1220842A1 (en) 2002-07-10
PL203984B1 (pl) 2009-11-30
US20030114443A1 (en) 2003-06-19
CA2385938C (en) 2010-02-16
EP1886994A1 (en) 2008-02-13
NO20021450L (no) 2002-06-03
PT1220842E (pt) 2008-10-17
HUP0300138A2 (en) 2003-05-28
CN1390201A (zh) 2003-01-08
PL356034A1 (en) 2004-06-14
PE20010628A1 (es) 2001-06-18
ATE400555T1 (de) 2008-07-15
ZA200202593B (en) 2003-04-03
KR20020060190A (ko) 2002-07-16
US6562978B1 (en) 2003-05-13
CA2385938A1 (en) 2001-04-12
BRPI0014428B1 (pt) 2016-08-02
DK1220842T3 (da) 2008-11-10
JP2003048880A (ja) 2003-02-21
AR025884A1 (es) 2002-12-18
CO5380013A1 (es) 2004-03-31
JP3814136B2 (ja) 2006-08-23
ES2310173T3 (es) 2009-01-01
EP1220842B1 (en) 2008-07-09
WO2001025200A1 (en) 2001-04-12
JP2001302633A (ja) 2001-10-31
US7348324B2 (en) 2008-03-25
BR0014428A (pt) 2002-06-11
HK1046905A1 (en) 2003-01-30
CY1108403T1 (el) 2014-02-12
HUP0300138A3 (en) 2003-06-30

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