BRPI0105509B8 - formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga - Google Patents

formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga

Info

Publication number
BRPI0105509B8
BRPI0105509B8 BRPI0105509A BRPI0105509A BRPI0105509B8 BR PI0105509 B8 BRPI0105509 B8 BR PI0105509B8 BR PI0105509 A BRPI0105509 A BR PI0105509A BR PI0105509 A BRPI0105509 A BR PI0105509A BR PI0105509 B8 BRPI0105509 B8 BR PI0105509B8
Authority
BR
Brazil
Prior art keywords
analogs
derivatives
angiotensin
liposomes
cyclodextrins
Prior art date
Application number
BRPI0105509A
Other languages
English (en)
Inventor
Paula Nadu Ana
Jean Georges Frezard Frederic
Augusto Souza Dos Santos Robson
Dario Sinisterra Millán Rubén
Original Assignee
Univ Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minas Gerais filed Critical Univ Minas Gerais
Priority to BRPI0105509A priority Critical patent/BRPI0105509B8/pt
Priority to CA2466232A priority patent/CA2466232C/en
Priority to AU2002349190A priority patent/AU2002349190A1/en
Priority to EP20110160834 priority patent/EP2356995A3/en
Priority to JP2003541528A priority patent/JP2005511577A/ja
Priority to KR10-2004-7006892A priority patent/KR20040089078A/ko
Priority to MXPA04004313A priority patent/MXPA04004313A/es
Priority to EP02780983.9A priority patent/EP1450842B1/en
Priority to PCT/BR2002/000156 priority patent/WO2003039434A2/en
Priority to KR1020107024591A priority patent/KR101246608B1/ko
Priority to CNB028240138A priority patent/CN100525830C/zh
Priority to US10/494,758 priority patent/US7723304B2/en
Publication of BR0105509A publication Critical patent/BR0105509A/pt
Priority to US12/715,363 priority patent/US20100158995A1/en
Priority to JP2010215646A priority patent/JP2011037868A/ja
Publication of BRPI0105509B1 publication Critical patent/BRPI0105509B1/pt
Publication of BRPI0105509B8 publication Critical patent/BRPI0105509B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/085—Angiotensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)

Abstract

processo de preparação de formulações do peptídeo angiotensina-(1-7)e seus análogos, agonistas e antagonistas usando as ciclidextrinas, seus derivados, lipossomas e os polímeros biodegradáveis e/ou misturas desses sistemas e/ou dos produtos derivados. a presente invenção caracteriza-se pelo processo de preparação de formulações do heptapeptídeo angiotensina-(1-7) e seus análogos usando preferencialmente as ciclodextrinas, seus derivados, lipossomas e os polímeros biodegradáveis e/ou misturas destes. a presente invenção caracteriza-se pela combinação de tecnologias diferentes, a de inclusão em ciclodextrinas, encapsulamento em lipossomas e o encapsulamento molecular dos pepeptídeos angiotensina-(1-7) e/ou seus análogos e/ou derivados, agonistas e/ou dos seus análogos e/ou derivados e antagonistas e/ou dos seus análogos e/ou derivados. caracteriza-se ainda pelo aumento na biodisponibilidade, liberação controlada e estabilização nas formulações dos peptídeos angiotensina-(1-7) e/ou seus análogos e/ou derivados, agonistas e/ou dos seus análogos e/ou derivados e antagonistas e/ou dos seus análogos e/ou derivados e seus análogos da presente invenção.
BRPI0105509A 2001-11-05 2001-11-05 formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga BRPI0105509B8 (pt)

Priority Applications (14)

Application Number Priority Date Filing Date Title
BRPI0105509A BRPI0105509B8 (pt) 2001-11-05 2001-11-05 formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
EP02780983.9A EP1450842B1 (en) 2001-11-05 2002-11-05 Formulation comprising angiotensin-(1-7) analogues and cyclodextrin
PCT/BR2002/000156 WO2003039434A2 (en) 2001-11-05 2002-11-05 Process of preparation of formulations of the peptide angiotensin-(1-7) and its analogues, agonistic and antagonists using cyclodextrins, lipossomes and biodegradable polymers and/or mixtures and products thereof
EP20110160834 EP2356995A3 (en) 2001-11-05 2002-11-05 Process of preparation of formulations of the peptide Angiotensin-(1-7) and its analogues, agonists and antagonists using cyclodextrins, liposomes and biodegradable polymers and/or mixtures and products thereof
JP2003541528A JP2005511577A (ja) 2001-11-05 2002-11-05 シクロデキストリン、リポソーム及び生分解性ポリマー並びに／或いはそれらの混合物及び生成物を用いる、ペプチドアンギオテンシン−（１−７）並びにその類似体、作動薬及び拮抗薬の製剤の調製方法
KR10-2004-7006892A KR20040089078A (ko) 2001-11-05 2002-11-05 사이클로덱스트린, 리포솜 및 생분해성 중합체 및/또는그의 혼합물 및 생성물을 사용하는 펩티드안지오텐신-(1-7) 및 그의 동족체, 작용물질 및 길항물질제형의 제조 방법
MXPA04004313A MXPA04004313A (es) 2001-11-05 2002-11-05 PROCESO DE PREPARACION DE FORMULACIONES DE LA ANGIOTENSINA-(1-7) DE PEPTIDO Y SUS ANáLOGOS, AGONISTICOS Y ANTAGONSITAS UTILIZANDO CICLODEXTRINAS, LIPOSOMAS Y POLIMEROS BIODEGRADABLES Y/O MEZCLAS Y PRODUCTOS DE LOS MISMOS.
CA2466232A CA2466232C (en) 2001-11-05 2002-11-05 Systems for delivery and release of angiotensin-(1-7)
AU2002349190A AU2002349190A1 (en) 2001-11-05 2002-11-05 Process of preparation of formulations of the peptide angiotensin-(1-7) and its analogues, agonistic and antagonists using cyclodextrins, lipossomes and biodegradable polymers and/or mixtures and products thereof
KR1020107024591A KR101246608B1 (ko) 2001-11-05 2002-11-05 사이클로덱스트린, 리포솜 및 생분해성 중합체 및/또는 그의 혼합물 및 생성물을 사용하는 펩티드 안지오텐신-(1-7) 및 그의 동족체, 작용물질 및 길항물질 제형의 제조 방법
CNB028240138A CN100525830C (zh) 2001-11-05 2002-11-05 采用环糊精、脂质体和生物降解性聚合物和/或其混合物及其制品制备肽血管紧张素-(1-7)和类似物、激动剂和拮抗剂制剂的方法
US10/494,758 US7723304B2 (en) 2001-11-05 2002-11-05 Systems for delivery and release of angiotensin-(1-7)
US12/715,363 US20100158995A1 (en) 2001-11-05 2010-03-01 Systems for delivery and release of angiotensin-(1-7)
JP2010215646A JP2011037868A (ja) 2001-11-05 2010-09-27 シクロデキストリン、リポソーム及び生分解性ポリマー並びに／或いはそれらの混合物及び生成物を用いる、ペプチドアンギオテンシン−（１−７）並びにその類似体、作動薬及び拮抗薬の製剤の調製方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0105509A BRPI0105509B8 (pt) 2001-11-05 2001-11-05 formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga

Publications (3)

Publication Number Publication Date
BR0105509A BR0105509A (pt) 2007-05-22
BRPI0105509B1 BRPI0105509B1 (pt) 2016-01-05
BRPI0105509B8 true BRPI0105509B8 (pt) 2021-05-25

Family

ID=3948119

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0105509A BRPI0105509B8 (pt) 2001-11-05 2001-11-05 formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga

Country Status (10)

Country Link
US (2) US7723304B2 (pt)
EP (2) EP1450842B1 (pt)
JP (2) JP2005511577A (pt)
KR (2) KR20040089078A (pt)
CN (1) CN100525830C (pt)
AU (1) AU2002349190A1 (pt)
BR (1) BRPI0105509B8 (pt)
CA (1) CA2466232C (pt)
MX (1) MXPA04004313A (pt)
WO (1) WO2003039434A2 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
AU2003217783A1 (en) * 2002-02-27 2003-09-09 Wake Forest University Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
US20050119180A1 (en) * 2002-03-28 2005-06-02 Roks Antonius J.M. Use of angiotensin 1-7 for enhancing cardiac function
AU2004309419A1 (en) * 2003-12-23 2005-07-14 Arena Pharmaceuticals, Inc. Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof
EP1802361B1 (en) 2004-10-21 2009-11-18 Medtronic, Inc. Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function
BRPI0503122A (pt) * 2005-05-30 2007-05-02 Univ Minas Gerais composições farmacêuticas do peptìdeo angiotensina-(1-7) [ang-(1-7)] e seus análogos, agonistas e antagonistas usando as ciclodextrinas, seus derivados, e o polìmeros biodegradáveis e/ou dos produtos derivados para uso no controle das funções do sistema reprodutivo
BRPI0502497A (pt) * 2005-06-28 2007-02-06 Univ Minas Gerais uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças
BRPI0602366B1 (pt) * 2006-04-26 2017-12-12 Universidade Federal De Minas Gerais Use of agonists of the receptor coupled to protein g, but, in the treatment of metabolic syndrome, its components and their complications
FR2900576B1 (fr) * 2006-05-03 2008-09-19 Centre Nat Rech Scient Procede de concentration extemporanee et reversible de liposomes.
BRPI0602372B8 (pt) * 2006-05-18 2021-06-22 Einco Biomaterial Ltda processo de preparação de compósitos em base de biocerâmicas e polímeros biodegradáveis e produto derivado
WO2008052295A1 (en) * 2006-10-30 2008-05-08 Universidade Federal De Minas Gerais Process for the preparation of compounds of at1 receptor antagonists with angiotensin-(1-7), analogues thereof and/or mixtures of these systems, pharmaceutical compositions thereof and use of their derivative products
BRPI0806230A2 (pt) * 2007-01-26 2021-05-25 Universidade Federal De Minas Gerais - Ufmg composições farmacêuticas, método para tratar a disfunção erétil e método para restaurar a capacidade de ereção
BRPI0800585B8 (pt) * 2008-02-13 2021-05-25 Univ Minas Gerais composições farmacêuticas do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) e uso do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7)
WO2010124280A2 (en) * 2009-04-24 2010-10-28 New Century Pharmaceuticals, Inc. Human serum albumin-based topical ointment for treatment of acne, psoriasis, egfr-induced toxicity, premature skin aging and other skin conditions
US20130210726A1 (en) * 2012-02-10 2013-08-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of peripheral vascular disease
US8557958B1 (en) * 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
BR102013023224B1 (pt) * 2012-09-14 2023-02-07 Universidade Federal De Minas Gerais PEPTÍDEO (ARGº)N-ANGIOTENSINA-(1-7) E COMPOSIÇÕES FARMACÊUTICAS PARA TRATAMENTO DE DOENÇAS
US8633158B1 (en) 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
BR132012028005E2 (pt) * 2012-10-31 2014-11-18 Univ Minas Gerais Composições farmacêuticas contendo um agonista do receptor mas para o tratamento de doenças degenerativas musculares.
US20150313829A1 (en) * 2012-11-26 2015-11-05 Roberto Queiroga Lautner Topical formulations for the prevention and treatment of alopecia and inhibition of hair growth
US10793597B2 (en) 2013-03-01 2020-10-06 Stealth Biotherapeutics Corp Methods for the treatment of mitochondrial diseases associated with a mutation in SURF 1 or POLG gene resulting in a disruption of mitochondrial oxidative phosphorylation
EP3626252A1 (en) 2013-03-01 2020-03-25 Stealth Biotherapeutics Corp Methods and compositions for the prevention or treatment of barth syndrome
ES2834430T3 (es) * 2013-03-15 2021-06-17 Univ Southern California Procedimientos, compuestos y composiciones para el tratamiento de enfermedades relacionadas con la angiotensina
JP2016524593A (ja) 2013-04-29 2016-08-18 メモリアル スローン−ケタリング キャンサー センター セカンドメッセンジャーのシグナル伝達を変えるための組成物及び方法
AU2014259948B2 (en) * 2013-04-30 2019-04-18 University Of Southern California Accelerated healing of eye injuries by angiotensin peptides
US10047395B2 (en) 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
BR102017000331A2 (pt) * 2017-01-06 2018-07-24 Uniao Quim Farmaceutica Nacional S/A composição farmacêutica, processo para a produção da mesma, uso de um peptídeo, uso de uma composição farmacêutica e método de tratamento de doenças associadas à hipertensão intraocular ou glaucoma
US20200188473A1 (en) * 2017-05-02 2020-06-18 Beth Israel Deaconess Medical Center, Inc. Combination therapy for cancer
IL320076A (en) 2018-04-27 2025-06-01 Fresh Inset S A Preparations and articles containing complexes of 1-methylcyclopropane and alpha-cyclodextrin
CN108395543B (zh) * 2018-05-31 2020-09-22 华南理工大学 一种改性聚轮烷、基于聚轮烷的载药胶束及其制备方法与应用
US20200093884A1 (en) 2018-09-20 2020-03-26 Mark C. Manning Stable intranasal formulations of carbetocin
EP3852724A4 (en) 2018-09-20 2022-07-06 Levo Therapeutics, Inc. CARBETOCIN DRUG PRODUCT AND PROCESS FOR ITS MANUFACTURE
CA3170106A1 (en) 2020-02-03 2021-08-12 Fresh Inset S.A. Stable 1-methylcyclopropene compositions and uses thereof
EP4085921A1 (en) 2021-05-04 2022-11-09 CU-Pharmaceuticals UG Angiotensin-(1-7) in the treatment of sars-cov related diseases
EP4371556B1 (en) 2022-11-15 2026-08-05 Explicat Pharma GmbH Angiotensin(1-7) pharmaceutical compositions for inhalation
CN116763929B (zh) * 2023-07-20 2025-07-25 江苏省人民医院（南京医科大学第一附属医院） MrgD作为靶点在制备治疗和/或预防高血压药物中的应用

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054736A (en) * 1970-06-10 1977-10-18 Ono Pharmaceutical Co., Ltd. Clathrate compounds of prostaglandins or their analogues with cyclodextrin
US4078052A (en) 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
CH624011A5 (pt) 1977-08-05 1981-07-15 Battelle Memorial Institute
GB2008122B (en) 1977-10-25 1982-03-24 Searle & Co Sarcosine dehydrolanine angiotensin ii derivatives
US4204991A (en) 1977-10-25 1980-05-27 G. D. Searle & Co. Sarcosine1 dehydroalanine8 angiotensin II derivatives
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
IT1111367B (it) 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
US4310506A (en) 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
US4394372A (en) 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
FR2521565B1 (fr) 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4552803A (en) 1983-01-28 1985-11-12 Pearson Glenn A Fire retardant powders and methods
US5030453A (en) 1983-03-24 1991-07-09 The Liposome Company, Inc. Stable plurilamellar vesicles
US5169637A (en) 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4552802A (en) * 1983-07-15 1985-11-12 Mechin Jean Claude Self-adhesive product, process for its manufacture and application as a dressing, packing sheet or fixing tape
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US5059421A (en) 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
US4975282A (en) 1985-06-26 1990-12-04 The Liposome Company, Inc. Multilamellar liposomes having improved trapping efficiencies
IN166447B (pt) * 1985-11-27 1990-05-12 Ethicon Inc
US5236944A (en) * 1988-03-28 1993-08-17 Janssen Pharmaceutica N.V. Compounds, compositions and anti-neoplastic methods
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
GB8920135D0 (en) * 1989-09-06 1989-10-18 Erba Carlo Spa Use of dehydrated cyclodextrins for improving drug dissolution
CA2031469A1 (en) * 1989-12-28 1991-06-29 Larry A. Wheeler Use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension
NL9001681A (nl) * 1990-07-24 1992-02-17 Rijksuniversiteit Transmucosale geneesmiddelpreparaten en transmucosale toediening.
JPH05331192A (ja) * 1992-05-29 1993-12-14 Nippon Synthetic Chem Ind Co Ltd:The 新規ペプチド及びそれを製造する方法
JPH06247842A (ja) * 1993-02-23 1994-09-06 Green Cross Corp:The リポソーム組成物の製造方法
AU6818094A (en) * 1993-04-22 1994-11-08 Depotech Corporation Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use
JPH07241457A (ja) * 1994-03-04 1995-09-19 Shiseido Co Ltd 乳化組成物
JP3604782B2 (ja) * 1995-06-19 2004-12-22 日本ケミカルリサーチ株式会社 持続性注射剤
JP3569065B2 (ja) * 1996-02-08 2004-09-22 株式会社ノエビア 皮膚及び口腔用組成物
US5916883A (en) * 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
WO1999044590A1 (en) * 1998-03-04 1999-09-10 Takeda Chemical Industries, Ltd. Sustained-release preparation for aii antagonist, production and use thereof
GB9813100D0 (en) 1998-06-18 1998-08-19 Secr Defence Method of forming liposomes
WO2000062793A2 (en) * 1999-04-15 2000-10-26 Eli Lilly And Company Pseudomycin antifungal compositions and methods for their use
WO2001030320A1 (en) * 1999-10-22 2001-05-03 Amgen Inc. Biodegradable microparticles with novel erythropoietin stimulating protein
AU1792901A (en) * 1999-12-16 2001-06-25 University Of Southern California Methods for treating and preventing diabetic complications
WO2001055176A2 (en) 2000-01-27 2001-08-02 University Of Southern California Methods for inhibiting smooth muscle cell proliferation
WO2002008910A1 (en) 2000-07-20 2002-01-31 Silicon Graphics, Inc. Memory device storing data and directory information thereon, and method for providing the directory information and the data in the memory device
US6897196B1 (en) * 2001-02-07 2005-05-24 The Regents Of The University Of California pH sensitive lipids based on ortho ester linkers, composition and method
BR0102252B1 (pt) 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
BRPI0105509B8 (pt) 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga

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US20050069533A1 (en) 2005-03-31
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