BRPI0206565A8 - Composições e seus usos, e processo de produção de um arranjo de antígeno ordenado e repetitivo, de ocorrência não-natural - Google Patents
Composições e seus usos, e processo de produção de um arranjo de antígeno ordenado e repetitivo, de ocorrência não-naturalInfo
- Publication number
- BRPI0206565A8 BRPI0206565A8 BRPI0206565A BR0206565A BRPI0206565A8 BR PI0206565 A8 BRPI0206565 A8 BR PI0206565A8 BR PI0206565 A BRPI0206565 A BR PI0206565A BR 0206565 A BR0206565 A BR 0206565A BR PI0206565 A8 BRPI0206565 A8 BR PI0206565A8
- Authority
- BR
- Brazil
- Prior art keywords
- ordered
- repetitive
- producing
- compositions
- naturally occurring
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5409—IL-5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5437—IL-13
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—DNA viruses
- C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/18011—Details ssRNA Bacteriophages positive-sense
- C12N2795/18111—Leviviridae
- C12N2795/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Wood Science & Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
Abstract
"ARRANJO DE ANTÍGENO MOLECULAR". A presente invenção diz respeito aos campos de biologia molecular, virologia, imunologia e medicina. A invenção fornece uma composição compreendendo um arranjo de antígeno ou determinante antigênico ordenado e repetitivo. A invenção também fornece um processo para produzir um antígeno ou determinante antigênico em um arranjo ordenado e repetitivo. O antígeno ou determinante antigênico ordenado e repetitivo é útil na produção de vacinas para o tratamento de doenças infecciosas, para o tratamento de alergias e como um fármaco para prevenir ou curar câncer e eficazmente induzir respostas imunes autoespecíficas, em particular respostas de anticorpos.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26237901P | 2001-01-19 | 2001-01-19 | |
| US28854901P | 2001-05-04 | 2001-05-04 | |
| US32699801P | 2001-10-05 | 2001-10-05 | |
| US33104501P | 2001-11-07 | 2001-11-07 | |
| PCT/IB2002/000168 WO2002056907A2 (en) | 2001-01-19 | 2002-01-21 | Molecular antigen array presenting amyloid beta |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0206565A BR0206565A (pt) | 2004-01-27 |
| BRPI0206565A8 true BRPI0206565A8 (pt) | 2017-10-03 |
Family
ID=27500737
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0206566-5A BR0206566A (pt) | 2001-01-19 | 2002-01-21 | Arranjo de antìgeno molecular |
| BRPI0206565A BRPI0206565A8 (pt) | 2001-01-19 | 2002-01-21 | Composições e seus usos, e processo de produção de um arranjo de antígeno ordenado e repetitivo, de ocorrência não-natural |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0206566-5A BR0206566A (pt) | 2001-01-19 | 2002-01-21 | Arranjo de antìgeno molecular |
Country Status (13)
| Country | Link |
|---|---|
| US (10) | US7320793B2 (pt) |
| EP (4) | EP2055312A1 (pt) |
| JP (6) | JP4489349B2 (pt) |
| CN (2) | CN1301133C (pt) |
| AT (1) | ATE421332T1 (pt) |
| AU (1) | AU2002226603B2 (pt) |
| BR (2) | BR0206566A (pt) |
| CA (2) | CA2433862C (pt) |
| DE (1) | DE60230963D1 (pt) |
| DK (1) | DK1353691T3 (pt) |
| ES (1) | ES2321382T3 (pt) |
| RU (2) | RU2295973C2 (pt) |
| WO (2) | WO2002056907A2 (pt) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8022270B2 (en) * | 2000-07-31 | 2011-09-20 | Biolex Therapeutics, Inc. | Expression of biologically active polypeptides in duckweed |
| US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| AU2002256423B2 (en) | 2001-04-30 | 2008-07-24 | Zystor Therapeutics, Inc. | Subcellular targeting of therapeutic proteins |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| AU2002347404A1 (en) * | 2001-09-14 | 2003-04-01 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| MXPA04002644A (es) | 2001-10-05 | 2004-07-08 | Cytos Biotechnology Ag | Conjugados que portan un peptido de angiotensina y usos de los mismos. |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| EP1494722A4 (en) * | 2002-03-25 | 2005-11-30 | THERAPEUTIC METHODS AGAINST INFLAMMATORY CONDITIONS RELATED TO EOTAXIN | |
| AU2003246690B2 (en) * | 2002-07-17 | 2010-03-11 | Cytos Biotechnology Ag | Molecular antigen arrays using a virus like particle derived from the AP205 coat protein |
| NZ537003A (en) | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| EP1524994B1 (en) * | 2002-07-19 | 2011-04-27 | Cytos Biotechnology AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| US20040076645A1 (en) * | 2002-07-19 | 2004-04-22 | Bachmann Martin F. | Ghrelin-carrier conjugates |
| WO2004016283A2 (en) * | 2002-08-14 | 2004-02-26 | Avidis Sa | Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use |
| DK2261249T3 (en) | 2002-09-12 | 2015-02-16 | Oncotherapy Science Inc | KDR peptides and vaccines comprising the same |
| NZ539218A (en) * | 2002-09-18 | 2008-03-28 | Univ Montreal Ct Hospitalier Chum | Synthetic GHRH analogues of 29 amino acids or more |
| EP1558748A4 (en) * | 2002-11-01 | 2008-10-22 | Promega Corp | CELL SYSE COMPOSITIONS, USE METHOD, DEVICE AND KIT |
| EP1419786A1 (en) * | 2002-11-13 | 2004-05-19 | Bracco Imaging S.p.A. | Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof |
| WO2004047728A2 (en) * | 2002-11-26 | 2004-06-10 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| WO2004084837A2 (en) * | 2003-03-24 | 2004-10-07 | Mercia Pharma Llc | Methods and compositions for treating and preventing inflammatory conditions |
| JP5022028B2 (ja) | 2003-03-26 | 2012-09-12 | サイトス・バイオテクノロジー・アクチェンゲゼルシャフト | メラン−aペプチドアナログ−ウイルス様粒子コンジュゲート |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| CN100404070C (zh) * | 2003-07-10 | 2008-07-23 | 赛托斯生物技术公司 | 包装的病毒样颗粒 |
| WO2005035771A2 (en) * | 2003-10-10 | 2005-04-21 | Powderject Vaccines, Inc. | Nucleic acid constructs |
| US7923109B2 (en) * | 2004-01-05 | 2011-04-12 | Board Of Regents, The University Of Texas System | Inorganic nanowires |
| KR20060128924A (ko) * | 2004-01-20 | 2006-12-14 | 사이토스 바이오테크놀로지 아게 | 그레린-담체 접합체 |
| JP4914224B2 (ja) | 2004-02-10 | 2012-04-11 | バイオマリン ファーマシューティカル インコーポレイテッド | 酸性αグルコシダーゼおよびそのフラグメント |
| KR101013999B1 (ko) * | 2004-03-19 | 2011-02-14 | 재단법인서울대학교산학협력재단 | 표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트 |
| US20070248617A1 (en) * | 2004-06-02 | 2007-10-25 | Bachmann Martin F | Medical Uses of Carrier Conjugates of Non-Human Tnf -Peptides |
| EP1751186A2 (en) * | 2004-06-02 | 2007-02-14 | Cytos Biotechnology AG | Carrier conjugates of tnf-peptides |
| AU2005286475A1 (en) * | 2004-09-21 | 2006-03-30 | Cytos Biotechnology Ag | Virus-like particles comprising a fusion protein of the coat protein of AP205 and an antigenic polypeptide |
| WO2006037787A2 (en) * | 2004-10-05 | 2006-04-13 | Cytos Biotechnology Ag | Vlp-antigen conjugates and their uses as vaccines |
| WO2006045796A2 (en) | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| WO2006045849A1 (en) * | 2004-10-29 | 2006-05-04 | Cytos Biotechnology Ag | T-cadherin antigen arrays and uses thereof |
| AU2011253800B2 (en) * | 2004-11-05 | 2013-08-22 | Novartis Ag | Composition comprising VLP and amyloid-beta peptide |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| WO2006055638A2 (en) | 2004-11-17 | 2006-05-26 | Abgenix, Inc. | Fully human monoclonal antibodies to il-13 |
| US7767212B2 (en) | 2005-03-18 | 2010-08-03 | Cytos Biotechnology Ag | CAT allergen conjugates and uses thereof |
| EP1885847B1 (en) * | 2005-05-26 | 2011-07-06 | Cytos Biotechnology AG | Scalable fermentation process |
| EP1746165A1 (en) | 2005-07-21 | 2007-01-24 | Cytos Biotechnology AG | Scalable fermentation process |
| EP1736538A1 (en) | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Process for the preparative purification of virus-like-particles (VLPs) |
| AU2006298767B2 (en) | 2005-09-28 | 2013-01-10 | Cytos Biotechnology Ag | Interleukin-1 conjugates and uses thereof |
| KR20180058863A (ko) | 2005-11-30 | 2018-06-01 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| PT1954718E (pt) | 2005-11-30 | 2014-12-16 | Abbvie Inc | Anticorpos anti-globulómeros aβ, suas porções de ligação ao antigénio, correspondentes hibridomas, ácidos nucleicos, vectores, células hospedeiras, métodos de produção dos ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos para uso dos ditos anticorpos |
| US20070184068A1 (en) | 2005-12-14 | 2007-08-09 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| AT503690A1 (de) * | 2006-06-09 | 2007-12-15 | Biomay Ag | Hypoallergene moleküle |
| CN101466720B (zh) | 2006-06-12 | 2013-01-02 | 赛托斯生物技术公司 | 向rna噬菌体的病毒样颗粒内包装寡核苷酸的方法 |
| JP5564249B2 (ja) * | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
| JP2009543554A (ja) | 2006-07-14 | 2009-12-10 | サノフィ パスツール バイオロジクス カンパニー | ベクターウイルスタンパク質への外来免疫決定基の直接トランスポゾン媒介挿入による組換え型ウイルスワクチンの構築 |
| BRPI0603490B1 (pt) * | 2006-07-21 | 2018-04-24 | Universidade Federal De Minas Gerais | Vacina recombinante contra a leishmaniose visceral canina |
| CA2664791A1 (en) | 2006-09-29 | 2008-08-21 | Sanofi Pasteur Biologics Co. | Recombinant rhinovirus vectors |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US20100311767A1 (en) * | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| ES2337113B1 (es) | 2007-04-17 | 2011-01-24 | Centre De Recerca En Sanitat Animal (Cresa) | Empleo de la hemaglutinina del virus de la peste porcina africana como adyuvante. |
| EP2012122A1 (en) * | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
| ES2331271B1 (es) | 2007-06-29 | 2010-10-14 | Universidad Del Pais Vasco | Metodo para la internalizacion de bacterias no invasivas en celulas eucariotas. |
| DK2083856T3 (da) | 2007-08-15 | 2011-01-24 | Circassia Ltd | Peptider til desensibilisering mod allergener |
| TWI436775B (zh) | 2007-08-24 | 2014-05-11 | Oncotherapy Science Inc | 以抗原胜肽合併化療藥劑治療胰臟癌 |
| ES2327375B1 (es) | 2007-11-14 | 2010-08-05 | Universidad Del Pais Vasco | Empleo de microparticulas para su uso como vacunas y la liberacion de moleculas biologicamente activas. |
| WO2009067584A1 (en) * | 2007-11-20 | 2009-05-28 | Duke University | Methods and compositions for modulating drug-polymer architecture, pharmacokinetics and biodistribution |
| US20110223147A1 (en) | 2008-05-07 | 2011-09-15 | Zystor Therapeutics, Inc. | Lysosomal targeting peptides and uses thereof |
| WO2010042743A2 (en) * | 2008-10-08 | 2010-04-15 | Chimeros Inc. | Chimeric multiplexes, compositions, and methods for using same |
| WO2010060186A1 (en) | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| PE20110891A1 (es) | 2008-12-09 | 2011-12-23 | Pfizer Vaccines Llc | Vacuna de peptido ch3 de ige |
| WO2010122164A1 (en) | 2009-04-23 | 2010-10-28 | Cytos Biotechnology Ag | VIRUS-LIKE PARTICLES OF BACTERIOPHAGE φCB5 |
| CN102573915B (zh) * | 2009-04-30 | 2015-02-18 | 赛托斯生物技术公司 | 流感血凝素组合物及其用途 |
| US9119802B2 (en) | 2009-05-06 | 2015-09-01 | Cornell University | E. coli LpfA antigen for prevention and treatment of infectious diseases |
| TW201109029A (en) | 2009-06-11 | 2011-03-16 | Oncotherapy Science Inc | Vaccine therapy for choroidal neovascularization |
| US8993715B2 (en) * | 2009-07-06 | 2015-03-31 | Canon Kabushiki Kaisha | Labeled protein and method for obtaining the same |
| IN2012DN00446A (pt) | 2009-07-30 | 2015-05-15 | Pfizer Vaccines Llc | |
| PE20121544A1 (es) | 2009-09-03 | 2012-12-02 | Pfizer Vaccines Llc | Vacuna de pcsk9 |
| CN102497885A (zh) | 2009-09-10 | 2012-06-13 | 赛托斯生物技术公司 | 白介素-1β突变蛋白偶联物在糖尿病治疗中的用途 |
| WO2011033493A1 (en) | 2009-09-21 | 2011-03-24 | Conservatoire National des Arts et Métiers | Carrier conjugates of il-23-peptides and their induced antibodies |
| MX336196B (es) | 2010-04-15 | 2016-01-11 | Abbvie Inc | Proteinas de union a amiloide beta. |
| EP2575868A1 (en) | 2010-06-07 | 2013-04-10 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US20140004142A1 (en) | 2011-03-02 | 2014-01-02 | Pfizer Inc. | Pcsk9 vaccine |
| JP6294221B2 (ja) | 2011-03-31 | 2018-03-14 | アー・デー・ツェー・セラピューティクス・エス・アー | 腎臓関連抗原1に対する抗体およびその抗原結合性フラグメント |
| US20130028857A1 (en) | 2011-07-29 | 2013-01-31 | Selecta Biosciences, Inc. | Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents |
| JP6041896B2 (ja) | 2011-12-21 | 2016-12-14 | アプス, エルエルシー | 加水分解酵素に対して耐性があるカプシドを有するvlpを用いるプロセス |
| TR201908872T4 (tr) | 2012-01-09 | 2019-07-22 | Adc Therapeutics Sa | Üçlü negatif meme kanserini tedavi etmek için ajanlar. |
| AU2013207962B2 (en) * | 2012-01-12 | 2017-07-20 | Unm Rainforest Innovations | Immunogenic HPV L2-containing VLPs and related compositions and methods |
| ES2428405B1 (es) | 2012-03-29 | 2014-06-02 | Universidad De Valladolid | Vehiculización de moléculas antigénicas en polímeros recombinantes similares a elastina |
| US20160000901A1 (en) * | 2013-03-05 | 2016-01-07 | Shifa Biomedical | Compositions and Methods for the Production of Virus-Like Particles |
| US10392611B2 (en) | 2013-05-30 | 2019-08-27 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| US10364451B2 (en) | 2013-05-30 | 2019-07-30 | Duke University | Polymer conjugates having reduced antigenicity and methods of using the same |
| MX394708B (es) | 2013-06-19 | 2025-03-24 | Rnaissance Ag Llc | Composiciones y metodos que usan capsides resistentes a hidrolasas. |
| WO2015017280A1 (en) | 2013-07-28 | 2015-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations that induce a th2 immune response |
| US9017698B2 (en) * | 2013-09-25 | 2015-04-28 | Sequoia Sciences, Inc. | Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections |
| WO2015101666A1 (en) | 2014-01-03 | 2015-07-09 | Fundación Biofísica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
| US10279019B2 (en) | 2014-02-11 | 2019-05-07 | Stc.Unm | PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same |
| US10648014B2 (en) * | 2014-05-05 | 2020-05-12 | Purdue Research Foundation | Degradation resistant peptide based biosensors |
| JP2017525370A (ja) * | 2014-08-21 | 2017-09-07 | ザ ジェネラル ホスピタル コーポレイション | 腫瘍壊死因子スーパーファミリーおよびtnf様リガンドムテインならびに腫瘍壊死因子スーパーファミリーおよびtnf様リガンドムテインを調製および使用する方法 |
| US10385115B2 (en) | 2015-03-26 | 2019-08-20 | Duke University | Fibronectin type III domain-based fusion proteins |
| NZ735720A (en) * | 2015-04-14 | 2024-07-05 | Academia Sinica | Anti-vegfr2 human antibody for anti-angiogenic and targeted cancer therapy |
| CA2994279A1 (en) | 2015-08-04 | 2017-02-09 | Duke University | Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same |
| WO2017042212A1 (en) | 2015-09-08 | 2017-03-16 | Universität Zürich | Treatment of insect bite hypersensitivity |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| WO2017123652A1 (en) | 2016-01-11 | 2017-07-20 | Verndari, Inc. | Microneedle compositions and methods of using same |
| WO2017179025A1 (en) | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
| FR3051192B1 (fr) | 2016-05-13 | 2020-12-25 | Univ De Lorraine | Methode de purification de proteines recombinantes par affinite basee sur l'activite lectinique du domaine crd d'une galectine |
| WO2017210476A1 (en) | 2016-06-01 | 2017-12-07 | Duke University | Nonfouling biosensors |
| WO2018017442A1 (en) | 2016-07-18 | 2018-01-25 | President And Fellows Of Harvard College | Methods and compositions relating to covalently circularized nanodiscs |
| WO2018053201A1 (en) | 2016-09-14 | 2018-03-22 | Duke University | Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs |
| JP2020500150A (ja) | 2016-09-23 | 2020-01-09 | デューク ユニバーシティ | 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド |
| US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| AU2018220515B2 (en) * | 2017-02-17 | 2022-06-30 | DayLife LLC | Universal antivenom |
| US11207390B2 (en) | 2017-03-07 | 2021-12-28 | Universität Zürich | Treatment of pruritus in horses |
| WO2018191557A1 (en) * | 2017-04-14 | 2018-10-18 | The Regents Of The University Of California | Human resistin compositions and methods of treating tlr4-mediated disease and infection |
| WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| US11680083B2 (en) | 2017-06-30 | 2023-06-20 | Duke University | Order and disorder as a design principle for stimuli-responsive biopolymer networks |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング,インコーポレイテッド | Tim-3とそのリガンドとの相互作用の遮断によるがん治療 |
| CN107703294B (zh) * | 2017-10-12 | 2019-06-04 | 华派生物工程集团有限公司 | 一种用于检测鸡血清中cLHRH抗体效价的ELISA方法 |
| WO2019147954A1 (en) | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| WO2019173438A1 (en) | 2018-03-06 | 2019-09-12 | Stc. Unm | Compositions and methods for reducing serum triglycerides |
| KR102529094B1 (ko) | 2018-04-05 | 2023-05-08 | 엘지전자 주식회사 | 냉장고 |
| CN112105733B (zh) | 2018-04-19 | 2024-10-29 | 查美特制药公司 | 合成rig-i样受体激动剂 |
| US12257308B2 (en) | 2018-04-30 | 2025-03-25 | Duke University | Stimuli-responsive PEG-like polymer-based drug delivery platform |
| CN112203682A (zh) | 2018-05-28 | 2021-01-08 | 埃瓦克斯有限公司 | 荨麻疹的治疗 |
| US11649275B2 (en) | 2018-08-02 | 2023-05-16 | Duke University | Dual agonist fusion proteins |
| CN120058944A (zh) | 2019-01-30 | 2025-05-30 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| US11203614B2 (en) * | 2019-03-25 | 2021-12-21 | Immunwork Inc. | Composite polypeptide having a metal binding motif and molecular construct comprising the same |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| US12161710B2 (en) | 2019-07-24 | 2024-12-10 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| CN115279905B (zh) | 2019-10-23 | 2026-03-17 | 里珍纳龙药品有限公司 | 合成rig-i样受体激动剂 |
| WO2021083766A1 (en) | 2019-10-29 | 2021-05-06 | Evax Ag | Treatment of pruritus in horses |
| US20230063876A1 (en) * | 2020-03-02 | 2023-03-02 | Unm Rainforest Innovations | Virus-Like Particle Vaccines for Opioid Drugs |
| CA3179246A1 (en) * | 2020-05-19 | 2021-11-25 | Yves Durocher | Use of resistin as a trimerization partner for expression of trimeric proteins |
| WO2021236809A2 (en) | 2020-05-19 | 2021-11-25 | Othair Prothena Limited | Multi-epitope vaccine for the treatment of alzheimer's disease |
| JP2023528797A (ja) | 2020-05-26 | 2023-07-06 | トゥルーバインディング,インコーポレイテッド | ガレクチン-3を遮断することにより炎症性疾患を処置する方法 |
| JP2023529925A (ja) | 2020-06-12 | 2023-07-12 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ナノ粒子ワクチンを使用する細菌免疫化 |
| CA3192383A1 (en) * | 2020-09-17 | 2022-03-24 | Robin Barbour | .beta.-amyloid vaccine for the treatment of alzheimer's disease |
| US12121574B2 (en) | 2021-09-28 | 2024-10-22 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| WO2023111826A1 (en) | 2021-12-14 | 2023-06-22 | Glaxosmithkline Biologicals Sa | Bacterial immunization using qbeta hairpin nanoparticle constructs |
| JP2025504364A (ja) * | 2022-01-08 | 2025-02-12 | カロジェン コーポレイション | 慢性b型肝炎感染症を処置または防止するための複数抗原治療ワクチン |
| CN118647399A (zh) | 2022-01-19 | 2024-09-13 | 伯尔尼大学 | 病毒样颗粒和微晶酪氨酸的组合物 |
| EP4580668A2 (en) | 2022-08-30 | 2025-07-09 | Saiba Animal Health Ag | Veterinary compositions of modified virus-like particles of cmv and ngf antigens |
| EP4581044A1 (en) | 2022-08-31 | 2025-07-09 | Unm Rainforest Innovations | Compositions targeting apoptosis-associated speck-like protein with caspase activation and recruitment domain (asc) and methods of use |
| WO2025172892A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified proteins and methods |
| WO2025172894A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified nanoparticle subunits and use thereof |
| WO2025186188A1 (en) | 2024-03-04 | 2025-09-12 | Boehringer Ingelheim Vetmedica Gmbh | Active vaccination for the treatment of ngf-related disorders |
| TW202544252A (zh) | 2024-03-06 | 2025-11-16 | 美商禮藍美國股份有限公司 | 經修飾的CMV類病毒粒子及貓IL-1β突變蛋白抗原之獸醫組成物 |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US522013A (en) * | 1894-06-26 | Wardrobe-bedstead | ||
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| JPS61250560A (ja) * | 1985-04-30 | 1986-11-07 | Toshiba Corp | 免疫分析方法 |
| US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| DE3750176T2 (de) | 1986-09-22 | 1994-10-13 | Emory University, Atlanta, Ga. | Impfstoff und verfahren zur herstellung. |
| US5223482A (en) | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
| US5220013A (en) | 1986-11-17 | 1993-06-15 | Scios Nova Inc. | DNA sequence useful for the detection of Alzheimer's disease |
| EP0332640A1 (en) | 1986-11-17 | 1989-09-20 | California Biotechnology, Inc. | Recombinant alzheimer's amyloid protein |
| US5187153A (en) | 1986-11-17 | 1993-02-16 | Scios Nova Inc. | Methods of treatment using Alzheimer's amyloid polypeptide derivatives |
| US5143726A (en) | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| GB8903313D0 (en) | 1989-02-14 | 1989-04-05 | Wellcome Found | Conjugates |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| GB8913737D0 (en) * | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
| DE69018926T2 (de) | 1989-09-04 | 1995-08-24 | Wellcome Found | Vakzine gegen Bordetella. |
| US6174916B1 (en) | 1990-04-27 | 2001-01-16 | Milkhaus Laboratory, Ltd. | Methods for treating herpes virus infections |
| US5753624A (en) | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
| WO1991016819A1 (en) | 1990-04-27 | 1991-11-14 | Molecular Rx., Inc. | Method and composition for treatment of central nervous systems disease states associated with abnormal amyloid beta protein |
| US5178882A (en) | 1990-06-22 | 1993-01-12 | The Regents Of The University Of California | Viral decoy vaccine |
| US5334394A (en) | 1990-06-22 | 1994-08-02 | The Regents Of The University Of California | Human immunodeficiency virus decoy |
| SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| FR2670800B1 (fr) | 1990-12-19 | 1994-05-20 | Gaches Chimie Sa | Procede de traitement de peaux ou cuirs, agents de tannage et procede de fabrication. |
| EP0563091A1 (en) | 1990-12-20 | 1993-10-06 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccines based on hepatitis b surface antigen |
| GB9114003D0 (en) * | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| ZA934199B (en) | 1992-06-18 | 1994-01-10 | Akzo Nv | Carrier system against gnrh |
| GB9213601D0 (en) * | 1992-06-26 | 1992-08-12 | Mastico Robert A | Protein based delivery system |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| US6004763A (en) | 1992-09-11 | 1999-12-21 | Institut Pasteur | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses |
| GB2271826B (en) | 1992-10-26 | 1996-06-05 | British Gas Plc | Apparatus for bending plastic tube |
| JPH08505625A (ja) | 1993-01-11 | 1996-06-18 | ダナ−ファーバー キャンサー インスティチュート | 細胞毒性tリンパ球応答の誘導 |
| WO1994017813A1 (en) | 1993-02-08 | 1994-08-18 | Paravax, Inc. | Defective sindbis virus vectors that express toxoplasma gondii p30 antigens |
| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US5602301A (en) * | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
| US5652223A (en) * | 1994-03-14 | 1997-07-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | DNA encoding CAI resistance proteins and uses thereof |
| US6727230B1 (en) * | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| EP0760676B1 (en) | 1994-05-25 | 2001-07-11 | McMICHAEL, John | Materials and methods for treatment of plaquing diseases |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) * | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AT402898B (de) | 1994-08-08 | 1997-09-25 | Int Centre Genetic Eng & Bio | Molekulares präsentiersystem |
| US5589154A (en) * | 1994-11-22 | 1996-12-31 | Rutgers, The State University Of New Jersey | Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease |
| US5935821A (en) | 1995-01-17 | 1999-08-10 | Board Of Trustees Of The University Of Kentucky | Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
| US5854215A (en) | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals Incorporated | Modulators of β-amyloid peptide aggregation |
| JPH11514333A (ja) | 1995-03-14 | 1999-12-07 | プレーシス ファーマスーティカルズ インコーポレイテッド | アミロイドの凝集の調節剤 |
| US5817626A (en) | 1995-03-14 | 1998-10-06 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation |
| US6303567B1 (en) | 1995-03-14 | 2001-10-16 | Praecis Pharmaceuticals, Inc . | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| EP0817854A2 (en) | 1995-03-31 | 1998-01-14 | Wolf, Hans, Prof. Dr. | Antigen presentation system based on retrovirus-like particles |
| US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| US5835821A (en) * | 1995-09-28 | 1998-11-10 | Canon Kabushiki Kaisha | Image forming apparatus |
| US5985242A (en) | 1995-10-27 | 1999-11-16 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| US6277826B1 (en) | 1996-08-27 | 2001-08-21 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
| CN1174998C (zh) | 1996-03-01 | 2004-11-10 | 诺瓦提斯公司 | 用于预防和治疗过敏的肽免疫原 |
| AU4089397A (en) | 1996-08-26 | 1998-03-19 | Hybridon, Inc. | Improved reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| US6084668A (en) | 1997-07-10 | 2000-07-04 | American Air Liquide Inc. | In-line cell for absorption spectroscopy |
| DE69832706T2 (de) | 1997-08-05 | 2006-08-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Immunschützendes influenzaantigen und dessen verwendung zur impfung |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US6054312A (en) | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| US6703015B1 (en) | 1999-09-03 | 2004-03-09 | Ramot At Tel-Aviv University Ltd. | Filamentous bacteriophage displaying an β-amyloid epitope |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| DE69831971T2 (de) | 1997-12-03 | 2006-07-06 | Neuralab Ltd., Flatts | Unterdrückung von veränderungen in zusammenhang mit beta-amyloid bei alzheimer |
| NZ506245A (en) | 1998-02-12 | 2003-08-29 | Immune Complex Corp | Strategically modified hepatitis b core proteins and their derivatives |
| NZ507195A (en) | 1998-03-27 | 2003-07-25 | Cytos Biotechnology Ag | Inducible alphaviral gene expression system |
| US5990085A (en) | 1998-05-04 | 1999-11-23 | Michigan State University | Inhibin-HBc fusion protein |
| TWI227241B (en) | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
| US6927278B1 (en) * | 1998-09-01 | 2005-08-09 | Trustees Of The University Of Pennsylvania | Peptide scaffolds for transfer of molecules into eukaryotic cells |
| AU770802B2 (en) | 1998-10-21 | 2004-03-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Virus-like particles for the induction of autoantibodies |
| US6548651B1 (en) * | 1998-11-11 | 2003-04-15 | Pantheco A/S | Modified peptide nucleic acid (PNA) molecules |
| US6380364B1 (en) | 1998-11-23 | 2002-04-30 | Loyola University Of Chicago | Chimeric biotin-binding papillomavirus protein |
| CN1193791C (zh) * | 1998-11-30 | 2005-03-23 | 希托斯生物技术股份公司 | 抗原的有序分子呈递,制备及使用的方法 |
| AU770225B2 (en) | 1998-12-04 | 2004-02-19 | Biogen Idec Ma Inc. | HBV core antigen particles with multiple immunogenic components attached via peptide ligands |
| WO2000050461A1 (en) | 1999-02-25 | 2000-08-31 | Smithkline Beecham Biologicals S.A. | Epitopes or mimotopes derived from the c-epsilon-3 or c-epsilon-4 domains of ige, antagonists thereof, and their therapeutic uses |
| US6613742B1 (en) | 1999-04-07 | 2003-09-02 | Thomas Jefferson University | Chemokine-derived synthetic peptides |
| US20020052311A1 (en) * | 1999-09-03 | 2002-05-02 | Beka Solomon | Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders |
| US6919075B1 (en) * | 1999-09-03 | 2005-07-19 | Ramot At Tel Aviv University Ltd. | Bacteriophage displaying aβ epitopes and method of use |
| KR100879810B1 (ko) | 2000-02-21 | 2009-01-22 | 하. 룬드벡 아크티에셀스카브 | 아밀로이드의 하향-조절을 위한 신규한 방법 |
| EE200200444A (et) | 2000-02-21 | 2003-12-15 | Pharmexa A/S | Meetod autoloogse beeta-amüloidvaigu in vivo mahasurumiseks, amüloidogeense polüpeptiidi analoog, seda kodeeriv nukleiinhappefragment ning kasutamineimmunogeense kompositsiooni valmistamiseks |
| WO2001085208A2 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| US7018638B2 (en) * | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| US7097837B2 (en) | 2001-02-19 | 2006-08-29 | Pharmexa A/S | Synthetic vaccine agents |
| MY144532A (en) | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| DE60234375D1 (de) * | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| US7115266B2 (en) * | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| CA2462857C (en) * | 2001-10-05 | 2012-01-24 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| ES2320638T3 (es) * | 2001-11-07 | 2009-05-27 | Cytos Biotechnology Ag | Disposicion ordenada de antigenos il-5, il-13 o eotasina, para el tratamiento de enfermedades alergicas con un componente eosinofilico. |
| KR20050044314A (ko) * | 2001-11-07 | 2005-05-12 | 사이토스 바이오테크놀로지 아게 | 뼈 질환 치료용 항원 어레이 |
| US20050163776A1 (en) | 2002-03-20 | 2005-07-28 | Raven Neil D.H. | Treatment of tse infection |
| DE10228059B4 (de) * | 2002-06-19 | 2005-12-29 | Eberhard-Karls-Universität Tübingen | Verwendung von amphiphilen Nucleosid-Phosphonoameisensäure-Derivaten zur Behandlung von viralen Infektionskrankheiten |
| AU2003246690B2 (en) * | 2002-07-17 | 2010-03-11 | Cytos Biotechnology Ag | Molecular antigen arrays using a virus like particle derived from the AP205 coat protein |
| NZ537003A (en) * | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| US20040076645A1 (en) * | 2002-07-19 | 2004-04-22 | Bachmann Martin F. | Ghrelin-carrier conjugates |
| EP1524994B1 (en) * | 2002-07-19 | 2011-04-27 | Cytos Biotechnology AG | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| JP5022028B2 (ja) * | 2003-03-26 | 2012-09-12 | サイトス・バイオテクノロジー・アクチェンゲゼルシャフト | メラン−aペプチドアナログ−ウイルス様粒子コンジュゲート |
| US7537767B2 (en) * | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| US6946769B2 (en) * | 2003-05-08 | 2005-09-20 | Asmo Co., Ltd. | Insulator and manufacturing method thereof, and stator for electric rotating machine |
| WO2005009928A2 (en) | 2003-07-24 | 2005-02-03 | The Queen's Medical Center | Preparation and use of alkylating agents |
| AU2005286475A1 (en) * | 2004-09-21 | 2006-03-30 | Cytos Biotechnology Ag | Virus-like particles comprising a fusion protein of the coat protein of AP205 and an antigenic polypeptide |
| WO2006037787A2 (en) * | 2004-10-05 | 2006-04-13 | Cytos Biotechnology Ag | Vlp-antigen conjugates and their uses as vaccines |
| WO2006045796A2 (en) * | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| KR20070089186A (ko) * | 2004-12-13 | 2007-08-30 | 사이토스 바이오테크놀로지 아게 | Il-15 항원 어레이 및 그 용도 |
| US7767212B2 (en) * | 2005-03-18 | 2010-08-03 | Cytos Biotechnology Ag | CAT allergen conjugates and uses thereof |
| EP1982729A1 (en) * | 2007-04-20 | 2008-10-22 | Cytos Biotechnology AG | Vaccination Regimen for B-Cell Vaccines |
-
2002
- 2002-01-18 US US10/050,898 patent/US7320793B2/en not_active Expired - Fee Related
- 2002-01-18 US US10/050,902 patent/US7264810B2/en not_active Expired - Lifetime
- 2002-01-21 RU RU2003125363/13A patent/RU2295973C2/ru not_active IP Right Cessation
- 2002-01-21 WO PCT/IB2002/000168 patent/WO2002056907A2/en not_active Ceased
- 2002-01-21 WO PCT/IB2002/000166 patent/WO2002056905A2/en not_active Ceased
- 2002-01-21 DE DE60230963T patent/DE60230963D1/de not_active Expired - Lifetime
- 2002-01-21 AU AU2002226603A patent/AU2002226603B2/en not_active Ceased
- 2002-01-21 EP EP09150831A patent/EP2055312A1/en not_active Withdrawn
- 2002-01-21 CN CNB02803869XA patent/CN1301133C/zh not_active Expired - Fee Related
- 2002-01-21 DK DK02716207T patent/DK1353691T3/da active
- 2002-01-21 EP EP02710211.0A patent/EP1370290B1/en not_active Expired - Lifetime
- 2002-01-21 EP EP02716207A patent/EP1353691B1/en not_active Expired - Lifetime
- 2002-01-21 BR BR0206566-5A patent/BR0206566A/pt not_active Application Discontinuation
- 2002-01-21 JP JP2002557414A patent/JP4489349B2/ja not_active Expired - Fee Related
- 2002-01-21 AT AT02716207T patent/ATE421332T1/de not_active IP Right Cessation
- 2002-01-21 CA CA2433862A patent/CA2433862C/en not_active Expired - Fee Related
- 2002-01-21 EP EP10012605A patent/EP2364727A3/en not_active Withdrawn
- 2002-01-21 BR BRPI0206565A patent/BRPI0206565A8/pt active Search and Examination
- 2002-01-21 RU RU2006141850/10A patent/RU2438701C2/ru not_active IP Right Cessation
- 2002-01-21 ES ES02716207T patent/ES2321382T3/es not_active Expired - Lifetime
- 2002-01-21 CA CA2433316A patent/CA2433316C/en not_active Expired - Lifetime
- 2002-01-21 JP JP2002557412A patent/JP2004522735A/ja not_active Withdrawn
- 2002-01-21 CN CNB028038673A patent/CN1301132C/zh not_active Expired - Fee Related
-
2006
- 2006-11-03 US US11/592,127 patent/US20070048287A1/en not_active Abandoned
-
2008
- 2008-01-18 US US12/010,107 patent/US20080274131A1/en not_active Abandoned
- 2008-10-24 JP JP2008274671A patent/JP5175160B2/ja not_active Expired - Fee Related
-
2010
- 2010-12-23 US US12/978,365 patent/US20110305723A1/en not_active Abandoned
-
2011
- 2011-04-28 US US13/096,970 patent/US20120114674A1/en not_active Abandoned
-
2012
- 2012-08-13 JP JP2012179555A patent/JP2013028608A/ja not_active Withdrawn
- 2012-12-07 US US13/708,259 patent/US20130315949A1/en not_active Abandoned
-
2013
- 2013-05-30 US US13/906,139 patent/US20150202281A1/en not_active Abandoned
-
2014
- 2014-11-14 US US14/541,248 patent/US20160008453A1/en not_active Abandoned
-
2015
- 2015-05-07 JP JP2015094858A patent/JP2015205881A/ja not_active Withdrawn
-
2017
- 2017-01-17 US US15/407,920 patent/US20180036399A1/en not_active Abandoned
- 2017-04-20 JP JP2017083363A patent/JP2017171666A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0206565A8 (pt) | Composições e seus usos, e processo de produção de um arranjo de antígeno ordenado e repetitivo, de ocorrência não-natural | |
| BR0312792A (pt) | Composições de vacinas contendo séries antigênicas de amilóide beta1-6 | |
| BR0213950A (pt) | Arranjos de antìgenos para o tratamento de doenças eosinofólicas alérgicas | |
| ATE441429T1 (de) | Ghrelin-träger-konjugate | |
| DK1441764T3 (da) | Antigen-Arrays der omfatter RANKL til behandling af knoglesygdom | |
| BR0312935A (pt) | Partìcula semelhante a vìrus, muteìna, vetores para produzir a referida partìcula e proteìna recombinante, composição, processo para produção de fileira ordena e repetitva de antìgeno, molécula de ácido nucléico, célula hospedeira, método para produção da referida partìcula e uso da composição de vacina | |
| CY1110585T1 (el) | ΣΥΣΚΕΥΑΣΙΑ (ΠΑΚΕΤΑΡΙΣΜΑ) ΑΝΟΣΟΔΙΕΓΕΡΤIΚΩΝ CpG ΕΝΤΟΣ ΟΜΟΙΑΖΟΝΤΩΝ ΜΕ ΙΟ ΣΩΜΑΤΙΩΝ: ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΚΑΙ ΧΡΗΣΗ | |
| WO2006063974A3 (en) | Il-15 antigen arrays and uses thereof | |
| BR0113155A (pt) | Métodos para produção de uma vacina para hepatite b e de um antìgeno de superfìcie para hepatite b e para tratamento e/ou profilaxia de infeções pelo vìrus da hepatite b, composição de vacina, uso de um antìgeno de superfìcie para hepatite b, antìgeno imunogênico de hepatite b e vacina | |
| WO2003059386A3 (en) | Prion protein carrier-conjugates | |
| MXPA04003901A (es) | Disposiciones de antigenos para el tratamiento de enfermedades eosinofilicas alergicas. | |
| MXPA04003900A (es) | Disposiciones de antigenos para el tratamiento de enfermedades oseas. | |
| WO2001030989A3 (en) | Method for creating divergent populations of nucleic acid molecules and proteins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: NOVARTIS PHARMA AG (CH) |
|
| B25A | Requested transfer of rights approved |
Owner name: NOVARTIS AG (CH) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 17A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2497 DE 13-11-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |