BRPI0206809B8 - cepas de leveduras que produzem esteróides de modo autônomo e processo de produção de um esteroide - Google Patents

cepas de leveduras que produzem esteróides de modo autônomo e processo de produção de um esteroide

Info

Publication number
BRPI0206809B8
BRPI0206809B8 BRPI0206809A BRPI0206809B8 BR PI0206809 B8 BRPI0206809 B8 BR PI0206809B8 BR PI0206809 A BRPI0206809 A BR PI0206809A BR PI0206809 B8 BRPI0206809 B8 BR PI0206809B8
Authority
BR
Brazil
Prior art keywords
autonomously
yeast strains
production process
steroids
steroid production
Prior art date
Application number
Other languages
English (en)
Inventor
Dumas Bruno
Pompon Denis
Degryse Eric
Cauet Gilles
Winter Jacques
Spagnoli Roberto
Achstetter Tilman
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0206809A publication Critical patent/BR0206809A/pt
Publication of BRPI0206809B1 publication Critical patent/BRPI0206809B1/pt
Publication of BRPI0206809B8 publication Critical patent/BRPI0206809B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position
    • C12P33/18—Hydroxylating at 17 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15004—Steroid 11-beta-monooxygenase (1.14.15.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15006—Cholesterol monooxygenase (side-chain-cleaving) (1.14.15.6), i.e. cytochrome P450scc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99009—Steroid 17-alpha-monooxygenase (1.14.99.9), i.e. cytochrome-P450-steroid-17-alpha-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/9901—Steroid 21-monooxygenase (1.14.99.10), i.e. steroid cytochrome P450 21-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y118/00—Oxidoreductases acting on iron-sulfur proteins as donors (1.18)
    • C12Y118/01—Oxidoreductases acting on iron-sulfur proteins as donors (1.18) with NAD+ or NADP+ as acceptor (1.18.1)
    • C12Y118/01002—Ferredoxin-NADP+ reductase (1.18.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

cepas de leveduras que produzem esteróides de modo autônomo. a presente invenção refere-se a cepas de leveduras geneticamente modificadas e que produzem de maneira autônoma, a partir de uma fonte de carbono simples, esteróides. a invenção também refere-se a um processo de produção de esteróides a partir de tais cepas de levedura.
BRPI0206809 2001-01-31 2002-01-29 cepas de leveduras que produzem esteróides de modo autônomo e processo de produção de um esteroide BRPI0206809B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0101294A FR2820145B1 (fr) 2001-01-31 2001-01-31 Souche de levure produisant des steroides de facon autonome
PCT/FR2002/000348 WO2002061109A2 (fr) 2001-01-31 2002-01-29 Souches de levures produisant des steroides de facon autonome

Publications (3)

Publication Number Publication Date
BR0206809A BR0206809A (pt) 2004-02-03
BRPI0206809B1 BRPI0206809B1 (pt) 2020-04-22
BRPI0206809B8 true BRPI0206809B8 (pt) 2021-05-25

Family

ID=8859443

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0206809 BRPI0206809B8 (pt) 2001-01-31 2002-01-29 cepas de leveduras que produzem esteróides de modo autônomo e processo de produção de um esteroide

Country Status (20)

Country Link
US (2) US7670829B2 (pt)
EP (1) EP1385980B1 (pt)
JP (1) JP4620932B2 (pt)
KR (1) KR100882150B1 (pt)
AR (1) AR033857A1 (pt)
AT (1) ATE486134T1 (pt)
BR (1) BRPI0206809B8 (pt)
CA (1) CA2435096C (pt)
CY (1) CY1111099T1 (pt)
DE (1) DE60238114D1 (pt)
DK (1) DK1385980T3 (pt)
ES (1) ES2354603T3 (pt)
FR (1) FR2820145B1 (pt)
IL (2) IL157118A0 (pt)
MX (1) MXPA03006031A (pt)
NO (1) NO333769B1 (pt)
NZ (1) NZ526381A (pt)
PT (1) PT1385980E (pt)
WO (1) WO2002061109A2 (pt)
ZA (1) ZA200305772B (pt)

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FR2812884B1 (fr) 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome
FR2869914B1 (fr) 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications
GB0512707D0 (en) * 2005-06-22 2005-07-27 Delta Biotechnology Ltd Gene expression technique
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
WO2007038246A2 (en) * 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
EP1962894A4 (en) * 2005-12-07 2012-11-14 Medivas Llc METHOD OF COMPOSING A POLYMERIC COMPOSITION FOR DELIVERING A BIOLOGICAL AGENT
EP2021141A4 (en) * 2006-05-09 2013-07-03 Medivas Llc BIODEGRADABLE WATER SOLUBLE POLYMERS
US20090029937A1 (en) * 2007-07-24 2009-01-29 Cornell University Biodegradable cationic polymer gene transfer compositions and methods of use
EP2323671A4 (en) * 2008-08-13 2012-09-26 Medivas Llc BIODEGRADABLE AABB POLY (DEPSIPEPTIDE) POLYMERS AND METHOD FOR THEIR USE
EP2386634A4 (en) 2009-01-07 2012-07-18 Mitsubishi Chem Corp STEROL SIDE CHAINS COLUMNY ENZYM PREBONE AND USE THEREOF
FR2961218A1 (fr) 2010-06-10 2011-12-16 Sanofi Aventis Methode de detection de composes modulateurs du metabolisme du cholesterol
KR200458070Y1 (ko) * 2010-06-21 2012-01-19 주광진 양치 기능이 부가된 젖꼭지
WO2012095816A1 (en) 2011-01-14 2012-07-19 Sanofi Method for detecting the biological activity of alpha-synuclein
FR2976949B1 (fr) * 2011-06-21 2015-08-28 Sanofi Sa Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre
ES2558357T3 (es) 2011-06-23 2016-02-03 Dsm Ip Assets B.V. Micro- o nanopartículas que comprenden un copolímero de poliesteramida biodegradable para uso en el suministro de agentes bioactivos
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
KR20160019451A (ko) * 2013-06-17 2016-02-19 사노피 시토크롬 p450 모노옥시게나제 생체촉매작용을 위한 전세포 시스템
CA2969171C (en) 2014-12-18 2023-12-12 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
EP3130680A1 (en) * 2015-08-11 2017-02-15 Universitat de Girona Method for the detection, follow up and/or classification of intestinal diseases
WO2017048316A1 (en) * 2015-09-18 2017-03-23 President And Fellows Of Harvard College Small molecule biosensors
CN108866142B (zh) * 2017-05-10 2022-08-16 中国科学院分子植物科学卓越创新中心 细胞色素p450、烟酰胺腺嘌呤二核苷酸-细胞色素p450还原酶及其应用
EP4058504A1 (en) 2019-11-12 2022-09-21 DSM IP Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures
CN110903993A (zh) * 2019-12-20 2020-03-24 河北兰升生物科技有限公司 一种产生菜籽甾醇的酿酒酵母工程菌及其构建方法和应用
CN115521921A (zh) * 2021-06-24 2022-12-27 江苏瑞科生物技术股份有限公司 柯萨奇病毒6型重组病毒样颗粒的表达系统、该表达系统制备的病毒样颗粒及手足口病疫苗
CN114456964B (zh) * 2022-03-15 2023-02-03 陕西海斯夫生物工程有限公司 一种高产豆甾醇的重组解脂亚罗酵母、其构建方法、用于产豆甾醇的发酵培养基及应用
CN116716266A (zh) * 2023-07-13 2023-09-08 上海交通大学 一种甾体羟化酶的突变体、重组酵母菌株、底物及应用

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FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome

Also Published As

Publication number Publication date
US20040137556A1 (en) 2004-07-15
US7977065B2 (en) 2011-07-12
KR20030082580A (ko) 2003-10-22
IL157118A0 (en) 2004-02-08
US7670829B2 (en) 2010-03-02
NO20033242D0 (no) 2003-07-17
KR100882150B1 (ko) 2009-02-06
NO333769B1 (no) 2013-09-16
DE60238114D1 (de) 2010-12-09
BR0206809A (pt) 2004-02-03
MXPA03006031A (es) 2005-02-14
DK1385980T3 (da) 2011-02-21
CA2435096A1 (en) 2002-08-08
JP2004528827A (ja) 2004-09-24
JP4620932B2 (ja) 2011-01-26
NO20033242L (no) 2003-09-04
US20100112634A1 (en) 2010-05-06
ES2354603T3 (es) 2011-03-16
FR2820145A1 (fr) 2002-08-02
BRPI0206809B1 (pt) 2020-04-22
WO2002061109A3 (fr) 2003-11-27
CY1111099T1 (el) 2015-06-11
PT1385980E (pt) 2011-01-14
AR033857A1 (es) 2004-01-07
ZA200305772B (en) 2004-07-26
ATE486134T1 (de) 2010-11-15
EP1385980A2 (fr) 2004-02-04
CA2435096C (en) 2012-11-13
EP1385980B1 (fr) 2010-10-27
FR2820145B1 (fr) 2004-01-23
NZ526381A (en) 2005-07-29
WO2002061109A2 (fr) 2002-08-08
IL157118A (en) 2010-11-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C12P 33/00 (2006.01), C12P 33/08 (2006.01), C12P 3

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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