NO20033242D0 - Gj¶rstammer av autonomiskproduserende steroider - Google Patents

Gj¶rstammer av autonomiskproduserende steroider

Info

Publication number
NO20033242D0
NO20033242D0 NO20033242A NO20033242A NO20033242D0 NO 20033242 D0 NO20033242 D0 NO 20033242D0 NO 20033242 A NO20033242 A NO 20033242A NO 20033242 A NO20033242 A NO 20033242A NO 20033242 D0 NO20033242 D0 NO 20033242D0
Authority
NO
Norway
Prior art keywords
strains
producing steroids
autonomously producing
autonomously
steroids
Prior art date
Application number
NO20033242A
Other languages
English (en)
Other versions
NO333769B1 (no
NO20033242L (no
Inventor
Roberto Spagnoli
Tilman Achstetter
Gilles Cauet
Eric Degryse
Bruno Dumas
Denis Pompon
Jacques Winter
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20033242D0 publication Critical patent/NO20033242D0/no
Publication of NO20033242L publication Critical patent/NO20033242L/no
Publication of NO333769B1 publication Critical patent/NO333769B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15004—Steroid 11-beta-monooxygenase (1.14.15.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position
    • C12P33/18—Hydroxylating at 17 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/15—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (1.14.15)
    • C12Y114/15006—Cholesterol monooxygenase (side-chain-cleaving) (1.14.15.6), i.e. cytochrome P450scc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99009—Steroid 17-alpha-monooxygenase (1.14.99.9), i.e. cytochrome-P450-steroid-17-alpha-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/9901—Steroid 21-monooxygenase (1.14.99.10), i.e. steroid cytochrome P450 21-hydroxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y118/00—Oxidoreductases acting on iron-sulfur proteins as donors (1.18)
    • C12Y118/01—Oxidoreductases acting on iron-sulfur proteins as donors (1.18) with NAD+ or NADP+ as acceptor (1.18.1)
    • C12Y118/01002—Ferredoxin-NADP+ reductase (1.18.1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20033242A 2001-01-31 2003-07-17 Genetisk modifisert gjaerstamme som autonomt produserer steroider, fremgangsmate for fremstilling samt farmasoytisk preparat. NO333769B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0101294A FR2820145B1 (fr) 2001-01-31 2001-01-31 Souche de levure produisant des steroides de facon autonome
PCT/FR2002/000348 WO2002061109A2 (fr) 2001-01-31 2002-01-29 Souches de levures produisant des steroides de facon autonome

Publications (3)

Publication Number Publication Date
NO20033242D0 true NO20033242D0 (no) 2003-07-17
NO20033242L NO20033242L (no) 2003-09-04
NO333769B1 NO333769B1 (no) 2013-09-16

Family

ID=8859443

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033242A NO333769B1 (no) 2001-01-31 2003-07-17 Genetisk modifisert gjaerstamme som autonomt produserer steroider, fremgangsmate for fremstilling samt farmasoytisk preparat.

Country Status (20)

Country Link
US (2) US7670829B2 (no)
EP (1) EP1385980B1 (no)
JP (1) JP4620932B2 (no)
KR (1) KR100882150B1 (no)
AR (1) AR033857A1 (no)
AT (1) ATE486134T1 (no)
BR (1) BRPI0206809B8 (no)
CA (1) CA2435096C (no)
CY (1) CY1111099T1 (no)
DE (1) DE60238114D1 (no)
DK (1) DK1385980T3 (no)
ES (1) ES2354603T3 (no)
FR (1) FR2820145B1 (no)
IL (2) IL157118A0 (no)
MX (1) MXPA03006031A (no)
NO (1) NO333769B1 (no)
NZ (1) NZ526381A (no)
PT (1) PT1385980E (no)
WO (1) WO2002061109A2 (no)
ZA (1) ZA200305772B (no)

Families Citing this family (27)

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FR2812884B1 (fr) 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome
US20070160622A1 (en) * 2005-12-07 2007-07-12 Medivas, Llc Method for assembling a polymer-biologic delivery composition
FR2869914B1 (fr) 2004-05-06 2012-11-09 Aventis Pharma Sa Souches de levure produisant du cholesterol et leurs applications
GB0512707D0 (en) * 2005-06-22 2005-07-27 Delta Biotechnology Ltd Gene expression technique
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法
JP5178520B2 (ja) * 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
WO2007133616A2 (en) * 2006-05-09 2007-11-22 Medivas, Llc Biodegradable water soluble polymers
US20090029937A1 (en) * 2007-07-24 2009-01-29 Cornell University Biodegradable cationic polymer gene transfer compositions and methods of use
CN102186484A (zh) * 2008-08-13 2011-09-14 梅迪沃什有限公司 Aabb-聚(酯肽)可生物降解聚合物及其使用方法
WO2010079594A1 (ja) 2009-01-07 2010-07-15 三菱化学株式会社 ステロール側鎖切断酵素蛋白質およびその利用
FR2961218A1 (fr) 2010-06-10 2011-12-16 Sanofi Aventis Methode de detection de composes modulateurs du metabolisme du cholesterol
KR200458070Y1 (ko) * 2010-06-21 2012-01-19 주광진 양치 기능이 부가된 젖꼭지
WO2012095816A1 (en) 2011-01-14 2012-07-19 Sanofi Method for detecting the biological activity of alpha-synuclein
FR2976949B1 (fr) * 2011-06-21 2015-08-28 Sanofi Sa Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre
EP2723801B1 (en) 2011-06-23 2017-01-18 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
SG11201509965YA (en) * 2013-06-17 2016-01-28 Sanofi Sa Whole-cell system for cytochrome p450 monooxygenases biocatalysis
CN107106509B (zh) 2014-12-18 2021-11-30 帝斯曼知识产权资产管理有限公司 用于递送酸敏感药物的药物递送系统
EP3130680A1 (en) * 2015-08-11 2017-02-15 Universitat de Girona Method for the detection, follow up and/or classification of intestinal diseases
US11693017B2 (en) 2015-09-18 2023-07-04 President And Fellows Of Harvard College Small molecule biosensors
CN108866142B (zh) * 2017-05-10 2022-08-16 中国科学院分子植物科学卓越创新中心 细胞色素p450、烟酰胺腺嘌呤二核苷酸-细胞色素p450还原酶及其应用
CA3160955A1 (en) 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures
CN110903993A (zh) * 2019-12-20 2020-03-24 河北兰升生物科技有限公司 一种产生菜籽甾醇的酿酒酵母工程菌及其构建方法和应用
CN115521881A (zh) * 2021-06-24 2022-12-27 江苏瑞科生物技术股份有限公司 柯萨奇病毒16型重组病毒样颗粒表达系统、该表达系统制备的病毒样颗粒及手足口病疫苗
CN114456964B (zh) * 2022-03-15 2023-02-03 陕西海斯夫生物工程有限公司 一种高产豆甾醇的重组解脂亚罗酵母、其构建方法、用于产豆甾醇的发酵培养基及应用

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FR2799206A1 (fr) * 1999-10-05 2001-04-06 Transgene Sa Procede de production de steroides modifies par fermentation de levures
FR2812884B1 (fr) 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome

Also Published As

Publication number Publication date
MXPA03006031A (es) 2005-02-14
EP1385980B1 (fr) 2010-10-27
NO333769B1 (no) 2013-09-16
JP2004528827A (ja) 2004-09-24
KR20030082580A (ko) 2003-10-22
CA2435096A1 (en) 2002-08-08
US7670829B2 (en) 2010-03-02
BR0206809A (pt) 2004-02-03
US20100112634A1 (en) 2010-05-06
FR2820145B1 (fr) 2004-01-23
WO2002061109A2 (fr) 2002-08-08
FR2820145A1 (fr) 2002-08-02
IL157118A0 (en) 2004-02-08
AR033857A1 (es) 2004-01-07
ATE486134T1 (de) 2010-11-15
EP1385980A2 (fr) 2004-02-04
BRPI0206809B1 (pt) 2020-04-22
NO20033242L (no) 2003-09-04
CA2435096C (en) 2012-11-13
US7977065B2 (en) 2011-07-12
BRPI0206809B8 (pt) 2021-05-25
CY1111099T1 (el) 2015-06-11
DE60238114D1 (de) 2010-12-09
NZ526381A (en) 2005-07-29
US20040137556A1 (en) 2004-07-15
ZA200305772B (en) 2004-07-26
KR100882150B1 (ko) 2009-02-06
DK1385980T3 (da) 2011-02-21
JP4620932B2 (ja) 2011-01-26
ES2354603T3 (es) 2011-03-16
PT1385980E (pt) 2011-01-14
WO2002061109A3 (fr) 2003-11-27
IL157118A (en) 2010-11-30

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