BRPI0311178B8 - regiões intergênicas como sítios de inserção no genoma do vírus vacínia ancara modificado (mva) - Google Patents

regiões intergênicas como sítios de inserção no genoma do vírus vacínia ancara modificado (mva)

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Publication number
BRPI0311178B8
BRPI0311178B8 BRPI0311178A BR0311178A BRPI0311178B8 BR PI0311178 B8 BRPI0311178 B8 BR PI0311178B8 BR PI0311178 A BRPI0311178 A BR PI0311178A BR 0311178 A BR0311178 A BR 0311178A BR PI0311178 B8 BRPI0311178 B8 BR PI0311178B8
Authority
BR
Brazil
Prior art keywords
mva
genome
insertion sites
modified vaccinia
intergenic regions
Prior art date
Application number
BRPI0311178A
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English (en)
Other versions
BRPI0311178B1 (pt
BR0311178A (pt
Inventor
Howley Paul
Leyrer Sonja
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Bavarian Nordic As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bavarian Nordic As filed Critical Bavarian Nordic As
Publication of BR0311178A publication Critical patent/BR0311178A/pt
Publication of BRPI0311178B1 publication Critical patent/BRPI0311178B1/pt
Publication of BRPI0311178B8 publication Critical patent/BRPI0311178B8/pt

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

regiões intergênicas como sítios de inserção no genoma do vírus vacínia ancara modificado (mva). a presente invenção refere-se a novos sítios de inserção úteis para a integração de seqüências exógenas no genoma do vírus vacínia ancara modificado (mva). a presente invenção fornece ainda vetores plasmideais para inserir o dna exógeno no genoma do mva. além disso, a presente invenção fornece mva recombinante que compreende uma seqüência exógena de dna inserida no novo dito sítio de inserção como medicina ou vacina.
BRPI0311178A 2002-05-16 2003-05-14 regiões intergênicas como sítios de inserção no genoma do vírus vacínia ancara modificado (mva) BRPI0311178B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200200753 2002-05-16
DKPA200200753 2002-05-16
DKPA200200752 2002-05-16
DKPA200200752 2002-05-16
PCT/EP2003/005045 WO2003097845A1 (en) 2002-05-16 2003-05-14 Intergenic regions as insertion sites in the genome of modified vaccinia virus ankara (mva)

Publications (3)

Publication Number Publication Date
BR0311178A BR0311178A (pt) 2005-03-29
BRPI0311178B1 BRPI0311178B1 (pt) 2020-11-17
BRPI0311178B8 true BRPI0311178B8 (pt) 2021-05-25

Family

ID=29551228

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0310051A BR0310051A (pt) 2002-05-16 2003-05-14 Poxvìrus recombinante expressando genes homólogos inseridos no genoma poxviral
BRPI0311178A BRPI0311178B8 (pt) 2002-05-16 2003-05-14 regiões intergênicas como sítios de inserção no genoma do vírus vacínia ancara modificado (mva)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0310051A BR0310051A (pt) 2002-05-16 2003-05-14 Poxvìrus recombinante expressando genes homólogos inseridos no genoma poxviral

Country Status (22)

Country Link
US (14) US7550147B2 (pt)
EP (3) EP1506301B1 (pt)
JP (4) JP4693092B2 (pt)
KR (4) KR101005630B1 (pt)
CN (6) CN101831411A (pt)
AT (1) ATE315660T1 (pt)
AU (4) AU2003236646B2 (pt)
BR (2) BR0310051A (pt)
CA (3) CA2812019A1 (pt)
DE (1) DE60303218T2 (pt)
DK (2) DK1506301T3 (pt)
EA (3) EA020230B1 (pt)
ES (1) ES2256776T3 (pt)
IL (4) IL164177A0 (pt)
MX (2) MXPA04011194A (pt)
NO (3) NO334273B1 (pt)
NZ (2) NZ536501A (pt)
PL (2) PL218318B1 (pt)
PT (1) PT1407033E (pt)
SI (1) SI1407033T1 (pt)
UA (1) UA82479C2 (pt)
WO (2) WO2003097845A1 (pt)

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