BRPI0313155B8 - composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto - Google Patents

composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto

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Publication number
BRPI0313155B8
BRPI0313155B8 BRPI0313155A BR0313155A BRPI0313155B8 BR PI0313155 B8 BRPI0313155 B8 BR PI0313155B8 BR PI0313155 A BRPI0313155 A BR PI0313155A BR 0313155 A BR0313155 A BR 0313155A BR PI0313155 B8 BRPI0313155 B8 BR PI0313155B8
Authority
BR
Brazil
Prior art keywords
combination
analog
administered
analogs
subject
Prior art date
Application number
BRPI0313155A
Other languages
English (en)
Other versions
BR0313155A (pt
BRPI0313155B1 (pt
Inventor
G Watumull David
Nadolski Geoff
Jackson Henry
M Hix Laura
Fournier Lockwood Samuel
O'malley Sean
Original Assignee
Cardax Pharmaceuticals Inc
Hawaii Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardax Pharmaceuticals Inc, Hawaii Biotech Inc filed Critical Cardax Pharmaceuticals Inc
Publication of BR0313155A publication Critical patent/BR0313155A/pt
Publication of BRPI0313155B1 publication Critical patent/BRPI0313155B1/pt
Publication of BRPI0313155B8 publication Critical patent/BRPI0313155B8/pt

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    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
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    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

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Abstract

composto químico, composição farmacêutica, método para sintetizar um composto químico, e, uso de um composto método para inibir e/ou melhorar a ocorrência de doenças associadas com espécies de oxigênio reativas espécies de nitrogênio reativas, radicais e/ou não radicais em um indivíduo, assim um indivíduo é administrado com um análogo estrutural de carotenóide, seja sozinho seja em combinação com outro análogo de carotenóide, ou formulação de co-antioxidante. o análogo ou combinação de análogos é administrado de modo que o risco do indivíduo de experimentar doenças associadas com espécies de oxigênio reativas, espécies de nitrogênio reativas, radicais e/ou não radicais pode ser assim reduzido. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de dano de isquemia-reperfusão. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora da doença do fígado. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de câncer. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de arritmia cardíaca e/ou morte cardíaca súbita. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de qualquer doença que envolva a produção de espécies de oxigênio reativas, espécies de nitrogênio reativas, radicais e/ou não radicais. em uma forma de realização, um análogo de astaxantina solúvel em água e/ou dispersível em água é particularmente eficaz. esta invenção ainda inclui composições farmacêuticas compreendendo análogos de carotenóides estruturais seja sozinhos seja em combinação.
BRPI0313155A 2002-07-29 2003-07-29 composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto BRPI0313155B8 (pt)

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US46797303P 2003-05-05 2003-05-05
US47283103P 2003-05-22 2003-05-22
US47374103P 2003-05-28 2003-05-28
US48530403P 2003-07-03 2003-07-03
PCT/US2003/023706 WO2004011423A2 (en) 2002-07-29 2003-07-29 Structural carotenoid analogs for the inhibition and amelioration of disease

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Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070160645A1 (en) * 2001-10-25 2007-07-12 Jakob Vinten-Johansen PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs
WO2003035142A2 (en) 2001-10-25 2003-05-01 Emory University Catheter for modified perfusion
US7759506B2 (en) * 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
CA2477245A1 (en) * 2002-02-25 2003-09-04 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US20050059659A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US20050026874A1 (en) * 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US7375133B2 (en) * 2002-07-29 2008-05-20 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US7320997B2 (en) * 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US7763649B2 (en) * 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
CN101845009B (zh) 2002-07-29 2012-10-03 卡达克斯药物公司 用于抑制和改善疾病的类胡萝卜素结构类似物
US20050049248A1 (en) * 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US20050059635A1 (en) * 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US20050004235A1 (en) * 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US7723327B2 (en) * 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US20050009788A1 (en) * 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling connexin 43 expression
US7345091B2 (en) * 2002-07-29 2008-03-18 Cardax Pharmaceuticals, Inc. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
WO2005069998A2 (en) * 2004-01-20 2005-08-04 Brigham Young University Technology Transfer Office Novel sirtuin activating compounds and methods for making the same
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
CA2564066A1 (en) * 2004-04-14 2005-11-03 Hawaii Biotech, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
WO2006039685A2 (en) * 2004-10-01 2006-04-13 Hawaii Biotech, Inc. Methods for synthesis of chiral intermediates of carotenoids, carotenoid analogs, and carotenoid derivatives
JP2007238441A (ja) * 2004-12-03 2007-09-20 Fuji Chem Ind Co Ltd アスタキサンチンを有効成分とする体脂肪減少用組成物
CA2592142A1 (en) * 2004-12-22 2006-06-29 Emory University Therapeutic adjuncts to enhance the organ protective effects of postconditioning
US20060270589A1 (en) * 2005-02-22 2006-11-30 Lockwood Samuel F Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of visual disabilities
EP2540696B1 (en) 2005-02-24 2020-01-01 Diffusion Pharmaceuticals LLC Trans carotenoids, formulation and uses
WO2006099015A2 (en) * 2005-03-09 2006-09-21 Cardax Pharmaceuticals, Inc. Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of proliferative disorders
CN103589650A (zh) 2005-03-18 2014-02-19 米克罗比亚公司 产油酵母和真菌中类胡萝卜素的产生
WO2006102576A1 (en) * 2005-03-23 2006-09-28 Cardax Pharmaceuticals, Inc. Water-dispersible carotenoids, including analogs and derivatives
CA2610502A1 (en) * 2005-03-29 2006-10-05 Cardax Pharmaceuticals, Inc. Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
JP2006016407A (ja) * 2005-06-15 2006-01-19 Yamaha Motor Co Ltd ホスホジエステラーゼ阻害剤
JP2006016408A (ja) * 2005-06-23 2006-01-19 Yamaha Motor Co Ltd 血中中性脂肪抑制剤
WO2007067957A1 (en) * 2005-12-07 2007-06-14 Cardax Pharmaceuticals, Inc. Structural carotenoid analogs or derivatives for the modulation of systemic and/or target organ redox status
JP2007153845A (ja) * 2005-12-07 2007-06-21 Yamaha Motor Co Ltd 脂肪蓄積抑制剤
US20070135521A1 (en) * 2005-12-14 2007-06-14 Yamaha Hatsudoki Kabushiki Kaisha Agent for Preventing Metabolic Syndrome
WO2007090095A2 (en) * 2006-01-27 2007-08-09 Cardax Pharmaceuticals, Inc. Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
WO2007147163A2 (en) * 2006-06-16 2007-12-21 Cardax Pharmaceuticals, Inc. Compositions comprising carotenoid analogs or derivatives and methods for synthesis
JP2010502572A (ja) * 2006-08-08 2010-01-28 ネステク ソシエテ アノニム カロテノイド異性体の安定で生物学的に利用可能な皮膚及び毛髪用組成物
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
ITMI20061874A1 (it) * 2006-09-29 2006-12-29 Rosario Ammirante Composizione per il trattamento degli stati patologici neurodegenerativi del sistema nervoso centrale ed in particolare nel morbo di parkinson
WO2008118862A1 (en) * 2007-03-23 2008-10-02 Cardax Pharmaceuticals, Inc. Carotenoid analogs and derivatives for the prevention of platelet aggregation
CN101687757A (zh) * 2007-04-13 2010-03-31 扩散药品有限公司 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用
KR20100083820A (ko) * 2007-10-31 2010-07-22 디퓨젼 파마슈티컬즈 엘엘씨 저분자 확산을 촉진시키는 신규한 치료요법
US20090297492A1 (en) * 2008-05-30 2009-12-03 Yamaha Hatsudoki Kabushiki Kaisha Method for Improving Cognitive Performance
WO2010120686A2 (en) * 2009-04-13 2010-10-21 Parsons J Kellogg Methods for the diagnosis and treatment of benign prostatic hyperplasia
EP2445339B1 (en) * 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
CA2773523A1 (en) * 2009-09-11 2011-03-17 Nestec S.A. Compositions and methods for enhancing cognitive and related functions in animals
US8541645B2 (en) * 2009-10-22 2013-09-24 University Of Calcutta Animal model for cigarette-smoke-induced atherosclerosis and related methods
AU2011262361A1 (en) 2010-06-02 2013-01-10 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
US20130129713A1 (en) * 2010-08-04 2013-05-23 Ieo - Istituto Europeo Di Oncologia S.R.L. Method of antigen loading for immunotherapy
CN102389407A (zh) * 2011-12-01 2012-03-28 滨州医学院 虾青素在制备治疗和预防肺纤维化的药品中的应用
GB201120772D0 (en) * 2011-12-02 2012-01-11 Ip Science Ltd Cocoa-based food products
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
CN110051672A (zh) * 2012-07-09 2019-07-26 诺格罗有限责任公司 使用膳食补充剂预防酒精反应
CN103073471B (zh) * 2013-01-30 2014-11-05 江苏省农业科学院 一种叶黄素二琥珀酸酯的超声辅助合成方法
US9482675B1 (en) * 2013-07-31 2016-11-01 University Of Kentucky Research Foundation Methods and systems for prognosis and diagnosis of brain damage
JP6183746B2 (ja) * 2013-11-13 2017-08-23 国立大学法人高知大学 遅延性アレルギー抑制剤
KR101963946B1 (ko) * 2014-05-20 2019-03-29 아스타 파마슈티칼즈 가부시키가이샤 카로테노이드 유도체, 그 약학상 허용되는 염 또는 그 약학상 허용되는 에스테르류 혹은 아미드류
WO2016063278A1 (en) * 2014-10-19 2016-04-28 Shenkar College Of Engineering And Design Astaxanthin based polymer and uses thereof
US10071141B2 (en) 2015-05-08 2018-09-11 Spectral Platforms, Inc. Albumin-based non-covalent complexes and methods of use thereof
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
US9572783B1 (en) * 2015-10-08 2017-02-21 Chuen Wei Lu Use of xanthophylls for the treatment of cancers
CN105646869B (zh) * 2016-01-04 2018-01-16 中国海洋大学 一种水溶性虾青素衍生物及其制备方法
CA3018550A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
CN106748946A (zh) * 2017-02-14 2017-05-31 烟台固特丽生物科技股份有限公司 一种含水溶性虾青素作物营养液的制备方法
MX2019011119A (es) 2017-03-20 2019-12-19 Spectral Platforms Inc Metodos espectroscopicos para detectar y caracterizar microorganismos.
JP7355394B2 (ja) * 2018-05-03 2023-10-03 エル．イー．エー．エフ． ホールディングス グループ エルエルシー カロテノイド組成物およびその使用
JP2021176821A (ja) * 2018-08-01 2021-11-11 アスタファーマシューティカルズ株式会社 新規カロテノイド関連誘導体、その塩又はエステル類若しくはアミド類
CN109678771A (zh) * 2018-12-28 2019-04-26 广州立达尔生物科技股份有限公司 一种叶黄素甘氨酸酯及其盐酸盐的制备方法
WO2021062237A1 (en) * 2019-09-27 2021-04-01 Cardax, Inc. Astaxanthin esters and methods of use thereof
FR3105790B1 (fr) * 2019-12-26 2022-01-14 Biophytis Composés chimiques ciblant l’œil et leur utilisation dans le traitement de maladies oculaires
CN111257466B (zh) * 2020-02-27 2022-04-01 南宁海关技术中心 一种红心鸭蛋中类胡萝卜素含量的测定方法
WO2022140580A1 (en) 2020-12-24 2022-06-30 Orn Almarsson Xanthophyll derivatives
JP2024502909A (ja) * 2020-12-24 2024-01-23 アルマルソン、オーン キサントフィル誘導体
CN113788867B (zh) * 2021-06-30 2023-12-26 东北林业大学 一种叶黄素水溶性衍生物及其制备工艺
DE102022134274A1 (de) * 2022-12-21 2024-06-27 Endress+Hauser Conducta Gmbh+Co. Kg Sensorelement für einen optochemischen Sensor
WO2025096604A1 (en) * 2023-10-30 2025-05-08 Adjuvia Therapeutics Pharmaceutical composition and method of treating disease using a molecular complex assembled on astaxanthin core
CN118084755B (zh) * 2024-04-22 2024-08-02 潍坊富邦药业有限公司 一种高水溶性虾青素衍生物及制备方法
CN118108646B (zh) * 2024-04-22 2024-08-02 潍坊富邦药业有限公司 一种水溶性虾青素衍生物及其制备方法
CN118063368B (zh) * 2024-04-22 2024-08-02 潍坊富邦药业有限公司 一种水溶性虾青素衍生物及其合成方法

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH314001A (de) * 1952-12-18 1956-05-31 Hoffmann La Roche Verfahren zur Herstellung von Vitamin-A-Estern
CH420822A (de) * 1960-10-17 1966-09-15 Hoffmann La Roche Wasserdispergierbare Carotinoidzubereitung
US3354218A (en) 1963-05-10 1967-11-21 Hoffmann La Roche Process for preparing 4-(2, 6, 6-trimethyl-4-methoxy-1-cyclohexen-1-yl)-3-buten-2-one
FR2076448A5 (pt) 1970-01-15 1971-10-15 Rhone Poulenc Sa
US3788468A (en) * 1973-05-01 1974-01-29 Univ Virginia Process for increasing oxygen diffusivity
US3853993A (en) * 1973-05-01 1974-12-10 Univ Virginia Process for increasing oxygen diffusivity and method for treating atherosclerosis
US3989757A (en) 1973-08-29 1976-11-02 Hoffmann-La Roche Inc. Isomerizing cis-carotenoids to all-trans-carotenoids
CH609320A5 (pt) * 1974-06-20 1979-02-28 Hoffmann La Roche
US3965261A (en) 1975-04-29 1976-06-22 University Of Virginia Method for treating papillomas
US3975519A (en) 1975-06-09 1976-08-17 University Of Virginia Method for increasing the oxygen partial pressure in the bloodstream of mammals
US4070460A (en) 1975-11-10 1978-01-24 University Of Virginia Patents Foundation Method for treating cerebral edema
US4009270A (en) 1975-11-21 1977-02-22 The University Of Virginia Method for treating spinal cord injury
CH623304A5 (pt) * 1975-11-30 1981-05-29 Hoffmann La Roche
US4038144A (en) 1976-04-19 1977-07-26 The University Of Virginia Method of increasing fermentation yields
US4046880A (en) 1976-04-20 1977-09-06 The University Of Virginia Method of treating hypertension
JPS6053031B2 (ja) 1978-03-31 1985-11-22 武田薬品工業株式会社 スピロ化合物およびその製造方法
US4176179A (en) 1978-04-17 1979-11-27 The University Of Virginia Alumni Patents Foundation Method for treating arthritis
EP0005749B1 (de) * 1978-06-02 1983-03-30 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cyclohexenderivate, Verfahren zu deren Herstellung, sowie deren Verwendung
DE2964401D1 (en) * 1978-06-02 1983-02-03 Hoffmann La Roche Process for the preparation of cyclohexenyl derivatives, and intermediates produced in the synthesis
DE3048000A1 (de) 1980-12-19 1982-07-15 Basf Ag Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung
ATE22438T1 (de) * 1981-10-16 1986-10-15 Hoffmann La Roche Verfahren zur herstellung von cyclohexenderivaten, sowie ein neues ausgangsprodukt und neue zwischenprodukte in diesem verfahren.
DE3264086D1 (en) * 1982-02-09 1985-07-11 Hoffmann La Roche Process for the preparation of cyclohexen derivatives
EP0101597B1 (de) * 1982-08-20 1988-06-22 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Astaxanthin und Zwischenprodukten in der Astaxanthin-Synthese
US4491574A (en) 1983-03-02 1985-01-01 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Reduction of high dose aspirin toxicity by dietary vitamin A
DE3582439D1 (de) 1984-01-28 1991-05-16 Roshdy Ismail Mittel zur behandlung von herzerkrankungen.
US5346488A (en) 1985-04-08 1994-09-13 The General Hospital Corporation Laser-induced ablation of atherosclerotic plaque
US4851339A (en) * 1986-04-01 1989-07-25 Hills Christopher B Extraction of anti-mutagenic pigments from algae and vegetables
DK171297B1 (da) * 1987-03-27 1996-08-26 Hoffmann La Roche Fremgangsmåde til fremstilling af cyclohexenderivater som mellemprodukter til fremstilling af zeaxanthin samt cyclohexenderivater
US5057494A (en) 1988-08-03 1991-10-15 Ethicon, Inc. Method for preventing tissue damage after an ischemic episode
WO1990010440A1 (en) 1989-03-08 1990-09-20 President And Fellows Of Harvard College Composition and method for inducing tumor regression
ATE96312T1 (de) 1989-07-25 1993-11-15 Hoffmann La Roche Verfahren zur herstellung von carotinoidpraeparaten.
US5278189A (en) 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
JPH06501695A (ja) 1990-10-01 1994-02-24 ブリガム・アンド・ウイメンズ・ホスピタル 主要血管事象を抑制するためのベータ−カロテン及びビタミンｅ療法
US6132790A (en) 1991-09-06 2000-10-17 Betatene Limited Carotenoid composition
WO1993013660A1 (en) 1992-01-06 1993-07-22 Health Maintenance Programs, Inc. Pharmaceutically active antioxydant containing composition and the method of its use to prevent and treat restenosis following angioplasty
US5221668A (en) 1992-02-26 1993-06-22 Abbott Laboratories Nutritional product for trauma and surgery patients
IL104736A0 (en) 1992-03-27 1993-06-10 Zeagen Inc Method for producing beta-carotene using a fungal mated culture
US5328845A (en) 1992-03-27 1994-07-12 Universal Foods Corporation Fungal negative microorganism capable of producing high levels of beta-carotene
EP0565989B1 (de) 1992-04-14 1997-06-25 F. Hoffmann-La Roche Ag Präparate von fettlöslichen Substanzen
US5310764A (en) 1992-05-08 1994-05-10 Steven Baranowitz Treatment of age related macular degeneration with beta-carotene
WO1993024454A1 (en) 1992-06-04 1993-12-09 Betatene Limited High cis beta-carotene composition
GB9219524D0 (en) 1992-09-15 1992-10-28 Smithkline Beecham Plc Novel composition
US5310554A (en) 1992-10-27 1994-05-10 Natural Carotene Corporation High purity beta-carotene
DE19609538A1 (de) 1996-03-11 1997-09-18 Basf Ag Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung
ES2149264T3 (es) 1993-03-22 2000-11-01 Cognis Australia Pty Ltd Agente terapeutico para el tratamiento de melanomas.
ES2178651T3 (es) 1993-03-22 2003-01-01 Cognis Australia Pty Ltd Compuestos carotenoides terapeuticos deispersables en agua.
DE69424719T2 (de) * 1993-06-24 2000-11-02 F. Hoffmann-La Roche Ag, Basel Pigmentierung mit Carotinoiden
GB2301775B (en) 1995-06-07 1999-08-04 Howard Foundation Treatment of age-related macular degeneration with carotenoids
US6218436B1 (en) 1993-06-28 2001-04-17 The Howard Foundation Pharmaceutically active carotenoids
DE4322277A1 (de) 1993-07-05 1995-01-12 Basf Ag Verbessertes Verfahren zur Herstellung von Astaxanthin, neue Zwischenprodukte hierfür sowie ein Verfahren zu deren Herstellung
FR2707184B1 (fr) 1993-07-08 1995-08-11 Rhone Poulenc Nutrition Animal Procédé de préparation de sphérules contenant un principe actif alimentaire ou pharmaceutique.
US5607839A (en) 1993-07-22 1997-03-04 Nippon Oil Company, Ltd. Bacteria belonging to new genus process for production of carotenoids using same
JP3249867B2 (ja) * 1993-10-21 2002-01-21 株式会社クラレ アスタキサンチンの製造方法
CH685189A5 (de) * 1993-11-19 1995-04-28 Marigen Sa Ultramikroemulsionen aus spontan dispergierbaren Konzentraten mit antitumoral wirksamen Xanthophyll-Estern.
US6428816B1 (en) 1994-04-08 2002-08-06 Cognis Australia Pty., Ltd. Carotenoid agent for inhibiting the conversion of epithelial cells to tumors
JPH07300421A (ja) 1994-04-28 1995-11-14 Itano Reitou Kk 抗炎症剤
SE9401738D0 (sv) 1994-05-19 1994-05-19 Ewos Ab Bioactive feed
JPH0873312A (ja) * 1994-09-02 1996-03-19 Noevir Co Ltd 皮膚外用剤
SE503336C2 (sv) 1994-09-19 1996-05-28 Asta Carotene Ab Medel och sätt för att öka produktionen av/hos fjäderfän
US5527533A (en) 1994-10-27 1996-06-18 Board Of Trustees Of The University Of Illinois Method of retarding and ameliorating central nervous system and eye damage
DK0718284T3 (da) 1994-12-21 2000-01-31 Hoffmann La Roche Carotenoidketoner og -estere
US5643943A (en) 1994-12-23 1997-07-01 Alcon Laboratories, Inc. Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
US5589468A (en) 1995-01-13 1996-12-31 Clintec Nutrition Co. Method for providing nutrition to elderly patients
JPH10513444A (ja) 1995-02-03 1998-12-22 ビーエーエスエフ アクチェンゲゼルシャフト 皮膚疾患の治療のための医薬品の製造のためのカロチノイドの使用
US5532009A (en) * 1995-06-07 1996-07-02 The Procter & Gamble Company Fat substitutes containing water soluble beta-carotene
JPH08337592A (ja) * 1995-06-13 1996-12-24 Kaiyo Bio Technol Kenkyusho:Kk 新規カロテノイド
JPH0984591A (ja) * 1995-09-26 1997-03-31 Kaiyo Bio Technol Kenkyusho:Kk カロテノイド硫酸エステルおよびその製造方法
US6060511A (en) 1995-10-05 2000-05-09 Gainer; John L. Trans-sodium crocetinate, methods of making and methods of use thereof
WO1997014705A1 (fr) 1995-10-17 1997-04-24 Showa Denko K.K. Phosphates de tocopherol tres purs, procedes de preparation, techniques d'analyse et produits cosmetiques correspondants
JPH09124470A (ja) 1995-10-26 1997-05-13 Suntory Ltd 抗ストレス組成物
US5854015A (en) 1995-10-31 1998-12-29 Applied Food Biotechnology, Inc. Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion
US5827539A (en) 1995-12-28 1998-10-27 Amway Corporation Dry carotenoid-oil powder and process for making same
US5837224A (en) 1996-01-19 1998-11-17 The Regents Of The University Of Michigan Method of inhibiting photoaging of skin
US6232060B1 (en) 1996-01-19 2001-05-15 Galileo Laboratories, Inc. Assay system for anti-stress agents
JPH09202730A (ja) * 1996-01-24 1997-08-05 Nippon Mektron Ltd 発ガン抑制作用剤
US5801159A (en) 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress
DE19609477A1 (de) 1996-03-11 1997-09-18 Basf Ag Stabile wäßrige Solubilisate von Carotinoiden und Vitamine
DE19609476A1 (de) 1996-03-11 1997-09-18 Basf Ag Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen
SE506191C2 (sv) 1996-03-27 1997-11-17 Astacarotene Ab Medel och sätt för att öka produktionen av/hos däggdjur
DK0807431T3 (da) 1996-05-14 2004-07-26 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af carotenoidpræparater
DE19637517A1 (de) 1996-09-13 1998-03-19 Basf Ag Herstellung von pulverförmigen, kaltwasserdispergierbaren Carotinoid-Zubereitungen und die Verwendung der neuen Carotinoid-Zubereitungen
DE19649062A1 (de) 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen
JPH10155459A (ja) 1996-11-27 1998-06-16 Suntory Ltd アスタキサンチン含有飲食物
AU7888498A (en) * 1996-12-25 1998-07-31 Designer Foods Association Ltd. Carcinogenesis inhibitors
SE522246C2 (sv) 1997-02-27 2004-01-27 Astacarotene Ab Oralt preparat för profylaktisk och terapeutisk behandling av Helicobacter Sp. infektion
ES2239801T3 (es) 1997-04-02 2005-10-01 The Brigham And Women's Hospital, Inc. Uso de un agente para disminuir el riesgo de enfermedad cardiovascular.
US5858700A (en) 1997-04-03 1999-01-12 Kemin Foods, Lc Process for the isolation and purification of lycopene crystals
JP2002513411A (ja) * 1997-04-04 2002-05-08 ヘンケル コーポレーション 高いバイオアベイラビリティを有するルテインエステル
US5811446A (en) 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US5876782A (en) 1997-05-14 1999-03-02 Kemin Industries, Inc. Method for the conversion of xanthophylls in plant material
JPH10327865A (ja) * 1997-05-29 1998-12-15 Kirin Brewery Co Ltd カロテノイド配糖体およびその製造法
SE512531C2 (sv) 1997-09-04 2000-03-27 Astacarotene Ab Användning av åtminstone en typ av xantofyller för framställning av ett läkemedel för profylaktisk och/eller terapeutisk förbättring av muskelfunktionsdurationen hos däggdjur och/eller behandling av muskelstörningar eller - sjukdomar hos däggdjur
US6008417A (en) 1997-10-20 1999-12-28 Roche Vitamins Inc. Process for making metabolites of lycopene
US5959138A (en) * 1997-11-25 1999-09-28 Industrial Organica S.A. De C.V. Short chain diesters and process for making the same
SE511237C2 (sv) 1997-12-16 1999-08-30 Astacarotene Ab Användning av åtminstone en typ av xantofyller för framställning av ett humant eller verinärmedicinskt läkemedel för profylaktisk behandling av mastit hos däggdjursmammor
DE19802134A1 (de) * 1998-01-21 1999-07-22 Basf Ag Verwendung von Carotinoid-Aggregaten als Färbemittel
US6020003A (en) 1998-02-23 2000-02-01 Basf Corporation Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin
US6051587A (en) 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6043259A (en) 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
NL1010351C2 (nl) * 1998-10-19 2001-01-08 Werklust & Beheer B V Esters van caroteno´den voor gebruik in de preventie en behandeling van oogaandoeningen.
JP2000143688A (ja) 1998-11-02 2000-05-26 Kuraray Co Ltd ゼアキサンチンモノ−β−グルコシドの製造方法
US6075058A (en) 1998-12-12 2000-06-13 Tufts University Compositions for increased bioavailability of carotenoids
US6399105B1 (en) 1999-01-20 2002-06-04 Peter Donald Collin Sea cucumber carotenoid lipid fraction products and methods of use
US6426362B1 (en) 1999-10-08 2002-07-30 Galileo Laboratories, Inc. Formulations of tocopherols and methods of making and using them
JP4491090B2 (ja) * 1999-10-08 2010-06-30 ヒガシマル醤油株式会社 アポトーシス誘導剤
EP1238068A1 (en) 1999-12-08 2002-09-11 California Institute Of Technology Directed evolution of biosynthetic and biodegration pathways
US6344214B1 (en) 1999-12-13 2002-02-05 Cyanotech Corporation Method for retarding and ameliorating fever blisters and canker sores
US6258855B1 (en) 2000-02-08 2001-07-10 Cyanotech Corporation Method of retarding and ameliorating carpal tunnel syndrome
WO2001076588A1 (en) 2000-04-06 2001-10-18 Coastside Research Method to inhibit lipoxygenase and cancer cell proliferation
US20030104090A1 (en) 2000-05-05 2003-06-05 Levy Pedro E. Supplements containing annatto extracts and carotenoids and methods for using the same
US6579544B1 (en) 2000-05-31 2003-06-17 Nutriex, L.L.C. Method for supplementing the diet
US20020110604A1 (en) 2000-08-11 2002-08-15 Ashni Naturaceuticals, Inc. Composition exhibiting synergistic antioxidant activity
AU2002239748A1 (en) 2000-12-15 2002-06-24 Galileo Laboratories, Inc. Use of tocopherol, metabolites or derivatives thereof or flavonoid metabolites or derivatives thereof in the manufacture of a medicament for the treatment of tissue ischemia
JP2004515508A (ja) 2000-12-16 2004-05-27 アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 化合物の健康促進組成物
IL141039A (en) 2001-01-23 2006-10-31 Lycored Natural Prod Ind Ltd The composition for the prevention of atherosclerosis containing carotenoids and use for the preparation of drugs to inhibit LDL oxidation
AU2002258077B2 (en) * 2001-02-23 2007-03-15 Richard H. Binnington Novel carotenoid esters
US6984523B2 (en) 2001-08-02 2006-01-10 E.I. Du Pont De Nemours And Company Carotenoid ketolase gene
GB0119052D0 (en) 2001-08-03 2001-09-26 Mars Uk Ltd Foodstuff
JP4420675B2 (ja) * 2002-02-06 2010-02-24 ディーエスエム アイピー アセッツ ビー．ブイ． アスタキサンチンエステル
US7105634B2 (en) 2002-02-11 2006-09-12 E. I. Du Pont De Nemours And Company Genetic constructs encoding carotenoid biosynthetic enzymes
US7514107B2 (en) 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
IL164089A0 (en) * 2002-04-30 2005-12-18 Suntory Ltd Astaxanthin medium-chain fatty acidester, production method of the same, and composition comprising the same
GB0211136D0 (en) 2002-05-15 2002-06-26 Univ London Treatment and prevention of tissue damage
US20050049248A1 (en) 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
US7763649B2 (en) 2002-07-29 2010-07-27 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for controlling connexin 43 expression
US20050009788A1 (en) 2002-07-29 2005-01-13 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling connexin 43 expression
US20050143475A1 (en) 2002-07-29 2005-06-30 Lockwood Samuel F. Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury
CN101845009B (zh) 2002-07-29 2012-10-03 卡达克斯药物公司 用于抑制和改善疾病的类胡萝卜素结构类似物
US20050059659A1 (en) 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid analogs or derivatives for controlling C-reactive protein levels
US20050059635A1 (en) 2002-07-29 2005-03-17 Lockwood Samuel Fournier Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
US7521584B2 (en) 2002-07-29 2009-04-21 Cardax Pharmaceuticals, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of disease
US7320997B2 (en) 2002-07-29 2008-01-22 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease
US20050004235A1 (en) 2002-07-29 2005-01-06 Lockwood Samuel Fournier Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease
US7345091B2 (en) 2002-07-29 2008-03-18 Cardax Pharmaceuticals, Inc. Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US20050026874A1 (en) 2002-07-29 2005-02-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease
US20050148517A1 (en) 2002-07-29 2005-07-07 Lockwood Samuel F. Carotenoid ether analogs or derivatives for controlling connexin 43 expression
US7375133B2 (en) 2002-07-29 2008-05-20 Cardax Pharmaceuticals, Inc. Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
US7723327B2 (en) 2002-07-29 2010-05-25 Cardax Pharmaceuticals, Inc. Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease
US20060058269A1 (en) * 2004-04-14 2006-03-16 Lockwood Samuel F Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
CA2564066A1 (en) 2004-04-14 2005-11-03 Hawaii Biotech, Inc. Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation
WO2006039685A2 (en) * 2004-10-01 2006-04-13 Hawaii Biotech, Inc. Methods for synthesis of chiral intermediates of carotenoids, carotenoid analogs, and carotenoid derivatives

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US20050037995A1 (en) 2005-02-17
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BR0313155A (pt) 2005-07-12
CN101845009B (zh) 2012-10-03
US20050075337A1 (en) 2005-04-07
MXPA05001202A (es) 2005-11-23
US20040162329A1 (en) 2004-08-19
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AU2003256982A1 (en) 2004-02-16
US20050065097A1 (en) 2005-03-24
US7145025B2 (en) 2006-12-05
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US7317008B2 (en) 2008-01-08
CA2495167C (en) 2018-08-21
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CA2495167A1 (en) 2004-02-05
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JP4601549B2 (ja) 2010-12-22
BRPI0313155B1 (pt) 2018-11-06
CN101845009A (zh) 2010-09-29
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US20060229446A1 (en) 2006-10-12
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