BRPI0313155B8 - composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto - Google Patents

composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto

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Publication number
BRPI0313155B8
BRPI0313155B8 BRPI0313155A BR0313155A BRPI0313155B8 BR PI0313155 B8 BRPI0313155 B8 BR PI0313155B8 BR PI0313155 A BRPI0313155 A BR PI0313155A BR 0313155 A BR0313155 A BR 0313155A BR PI0313155 B8 BRPI0313155 B8 BR PI0313155B8
Authority
BR
Brazil
Prior art keywords
combination
analog
administered
analogs
subject
Prior art date
Application number
BRPI0313155A
Other languages
English (en)
Other versions
BRPI0313155B1 (pt
BR0313155A (pt
Inventor
G Watumull David
Nadolski Geoff
Jackson Henry
M Hix Laura
Fournier Lockwood Samuel
O'malley Sean
Original Assignee
Cardax Pharmaceuticals Inc
Hawaii Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardax Pharmaceuticals Inc, Hawaii Biotech Inc filed Critical Cardax Pharmaceuticals Inc
Publication of BR0313155A publication Critical patent/BR0313155A/pt
Publication of BRPI0313155B1 publication Critical patent/BRPI0313155B1/pt
Publication of BRPI0313155B8 publication Critical patent/BRPI0313155B8/pt

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    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
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    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

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Abstract

composto químico, composição farmacêutica, método para sintetizar um composto químico, e, uso de um composto método para inibir e/ou melhorar a ocorrência de doenças associadas com espécies de oxigênio reativas espécies de nitrogênio reativas, radicais e/ou não radicais em um indivíduo, assim um indivíduo é administrado com um análogo estrutural de carotenóide, seja sozinho seja em combinação com outro análogo de carotenóide, ou formulação de co-antioxidante. o análogo ou combinação de análogos é administrado de modo que o risco do indivíduo de experimentar doenças associadas com espécies de oxigênio reativas, espécies de nitrogênio reativas, radicais e/ou não radicais pode ser assim reduzido. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de dano de isquemia-reperfusão. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora da doença do fígado. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de câncer. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de arritmia cardíaca e/ou morte cardíaca súbita. o análogo ou combinação de análogos pode ser administrado a um indivíduo para a inibição e/ou melhora de qualquer doença que envolva a produção de espécies de oxigênio reativas, espécies de nitrogênio reativas, radicais e/ou não radicais. em uma forma de realização, um análogo de astaxantina solúvel em água e/ou dispersível em água é particularmente eficaz. esta invenção ainda inclui composições farmacêuticas compreendendo análogos de carotenóides estruturais seja sozinhos seja em combinação.
BRPI0313155A 2002-07-29 2003-07-29 composto químico derivado ou análogo de carotenóide, composição farmacêutica, e, uso do composto BRPI0313155B8 (pt)

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US39919402P 2002-07-29 2002-07-29
US46797303P 2003-05-05 2003-05-05
US47283103P 2003-05-22 2003-05-22
US47374103P 2003-05-28 2003-05-28
US48530403P 2003-07-03 2003-07-03
PCT/US2003/023706 WO2004011423A2 (en) 2002-07-29 2003-07-29 Structural carotenoid analogs for the inhibition and amelioration of disease

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US20050075337A1 (en) 2005-04-07
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US7317008B2 (en) 2008-01-08
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US20050037995A1 (en) 2005-02-17
US20050065097A1 (en) 2005-03-24
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AU2003256982A1 (en) 2004-02-16
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