BRPI0406694A - Polipeptìdios terapêutico, seus homólogos, seus fragmentos, que são usados nas modulações da agregação plaquetária - Google Patents

Polipeptìdios terapêutico, seus homólogos, seus fragmentos, que são usados nas modulações da agregação plaquetária

Info

Publication number
BRPI0406694A
BRPI0406694A BR0406694-4A BRPI0406694A BRPI0406694A BR PI0406694 A BRPI0406694 A BR PI0406694A BR PI0406694 A BRPI0406694 A BR PI0406694A BR PI0406694 A BRPI0406694 A BR PI0406694A
Authority
BR
Brazil
Prior art keywords
polypeptides
platelet aggregation
vwf
domain
modulations
Prior art date
Application number
BR0406694-4A
Other languages
English (en)
Inventor
Karen Silence
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/BE2003/000189 external-priority patent/WO2005044858A1/en
Priority claimed from PCT/BE2003/000190 external-priority patent/WO2004041867A2/en
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of BRPI0406694A publication Critical patent/BRPI0406694A/pt
Publication of BRPI0406694B1 publication Critical patent/BRPI0406694B1/pt
Publication of BRPI0406694B8 publication Critical patent/BRPI0406694B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166—Streptokinase
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
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Abstract

"POLIPEPTìDIOSTERAPEUTICO, SEUS HOMóLOGOS, SEUS FRAGMENTOS, QUE SãO USADOS NAS MODULAçõES DA AGREGAçãO PLAQUETáRIA". A presente invenção se relaciona aos polipeptídios que compreendem pelo menos um anticorpo de domínio único é direcionado contra vWF, o domínio vWF A1, o domínio A1 do vWF ativado, o domínio do vWF A3, gplb e/ou colágeno, homólogos dos ditos polipeptídios, e/ou partes funcionais dos ditos polipeptídios, para o tratamento patológico que requer uma modulação da agregação plaquetária e que supera os problemas da técnica anterior. Um aspecto adicional da invenção é fornecer um método para produzir os ditos polipeptídios, método para revestir dispositivos com tais polipeptídios usados nos procedimentos médicos (por exemplo, PCTA, inserção de endoprótese expansível), métodos e kits para selecionar agentes que modulam agregação plaquetária e kits para diagnosticar doenças relacionadas agregação plaquetária.
BRPI0406694A 2003-01-10 2004-01-09 polipeptídios terapêutico, seus homólogos, seus fragmentos, que são usados nas modulações da agregação plaquetária BRPI0406694B8 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
EP03447005 2003-01-10
EPPCT/EP03/06581 2003-06-23
EPPCT/EP2003/007313 2003-07-08
PCT/BE2003/000192 WO2004041862A2 (en) 2002-11-08 2003-11-07 Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
PCT/BE2003/000194 WO2004041863A2 (en) 2002-11-08 2003-11-07 Single domain antibodies directed against interferon- gamma and uses therefor
PCT/BE2003/000189 WO2005044858A1 (en) 2003-11-07 2003-11-07 Camelidae single domain antibodies vhh directed against epidermal growth factor receptor and uses therefor
PCT/BE2003/000190 WO2004041867A2 (en) 2002-11-08 2003-11-07 Camelidae antibodies against imminoglobulin e and use thereof for the treatment of allergic disorders
PCT/BE2003/000193 WO2004041865A2 (en) 2002-11-08 2003-11-07 Stabilized single domain antibodies
BEPCT/BE03/00206 2003-12-01
BEPCT/BE03/00191 2003-12-02
PCT/BE2004/000002 WO2004062551A2 (en) 2003-01-10 2004-01-09 RECOMBINANT VHH SINGLE DOMAIN ANTIBODY FROM CAMELIDAE AGAINST VON WILLEBRAND FACTOR (vWF) OR AGAINST COLLAGEN

Publications (3)

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BRPI0406694A true BRPI0406694A (pt) 2005-12-20
BRPI0406694B1 BRPI0406694B1 (pt) 2017-03-07
BRPI0406694B8 BRPI0406694B8 (pt) 2021-05-25

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