BRPI0514857A - composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central - Google Patents

composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central

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Publication number
BRPI0514857A
BRPI0514857A BRPI0514857-0A BRPI0514857A BRPI0514857A BR PI0514857 A BRPI0514857 A BR PI0514857A BR PI0514857 A BRPI0514857 A BR PI0514857A BR PI0514857 A BRPI0514857 A BR PI0514857A
Authority
BR
Brazil
Prior art keywords
inhibit
cell
treat
mark
block
Prior art date
Application number
BRPI0514857-0A
Other languages
English (en)
Inventor
George W Muller
Hon-Wah Man
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of BRPI0514857A publication Critical patent/BRPI0514857A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07—ORGANIC CHEMISTRY
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

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  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

COMPOSTO OU UM SAL, SOLVATO OU HIDRATO FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA, E, MéTODOS PARA INIBIR A ANGIOGêNESE, PARA INIBIR OU REDUZIR A POLIMERIZAçãO DA TUBULINA OU A ESTABILIDADE DA TUBULINA EM UMA CéLULA, PARA INIBIR A ATIVIDADE DE PDE4 EM UMA CéLULA, PARA INIBIR ATIVIDADE DO FATOR-ALFA DE NECROSE DE TUMOR (TNF-ALFA) EM UMA CéLULA, PARA TRATAR OU MELHORAR UM DISTúRBIO INFLAMATóRIO, PARA TRATAR OU MELHORAR CáNCER, PARA INIBIR A PROLIFERAçãO DE CéLULA CANCEROSA, PARA MARCAR, BLOQUEAR OU DESTRUIR A FUNçãO DE VASCULATURA TUMORAL, PARA MARCAR, BLOQUEAR OU DESTRUIR O ENDOTéLIO DE VASOS DE TUMOR, PARA MARCAR, BLOQUEAR OU DESTRUIR A FUNçãO DE VASCULATURA TUMORAL E INIBIR A ANGIOGêNESE EM UM TUMOR E PARA TRATAR OU MELHORAR UM DISTúRBIO DO SISTEMA NERVOSO CENTRAL A presente invenção diz respeito a compostos heterocíclicos substituídos e composições que compreendem um composto heterocíclico substituído. A presente invenção também diz respeito a métodos para prevenir ou tratar várias doenças e distúrbios pela administração a um paciente em necessidade deste um ou mais compostos heterocíclicos substituídos. Em particular, a invenção diz respeito a métodos para prevenir ou tratar câncer ou um distúrbio inflamatório pela administração a um paciente em necessidade deste um ou mais compostos heterocíclicos substituídos. A presente invenção diz respeito ainda a artigos of fabricação e kits que compreendem um ou mais compostos heterocíclicos substituídos.
BRPI0514857-0A 2004-09-03 2005-08-31 composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central BRPI0514857A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60740804P 2004-09-03 2004-09-03
PCT/US2005/031317 WO2006028963A2 (en) 2004-09-03 2005-08-31 Substituted heterocyclic compounds and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0514857A true BRPI0514857A (pt) 2008-05-06

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BRPI0514857-0A BRPI0514857A (pt) 2004-09-03 2005-08-31 composto ou um sal, solvato ou hidrato farmaceuticamente aceitável do mesmo, composição farmacêutica, e, métodos para inibir a angiogênese, para inibir ou reduzir a polimerização da tubulina ou a estabilidade da tubulina em uma célula, para inibir a atividade de pde4 em uma célula, para inibir atividade do fator-alfa de necrose de tumor (tnf-alfa) em uma célula, para tratar ou melhorar um distúrbio inflamatório, para tratar ou melhorar cáncer, para inibir a proliferação de célula cancerosa, para marcar, bloquear ou destruir a função de vasculatura tumoral, para marcar, bloquear ou destruir o endotélio de vasos tumor, para marcar, bloquear ou destruir a função de vasculatura tumoral e inibir a angiogênese em um tumor e para tratar ou melhorar um distúrbio do sistema nervoso central

Country Status (12)

Country Link
US (2) US7468446B2 (pt)
EP (1) EP1794139A2 (pt)
JP (1) JP2008512378A (pt)
KR (1) KR20070050987A (pt)
CN (1) CN101052630A (pt)
AR (1) AR050557A1 (pt)
AU (1) AU2005282727A1 (pt)
BR (1) BRPI0514857A (pt)
CA (1) CA2578789A1 (pt)
IL (1) IL181677A0 (pt)
WO (1) WO2006028963A2 (pt)
ZA (1) ZA200702380B (pt)

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WO2006028963A2 (en) * 2004-09-03 2006-03-16 Celgene Corporation Substituted heterocyclic compounds and uses thereof
JP2009539774A (ja) * 2006-06-03 2009-11-19 サイリーン ファーマシューティカルズ インコーポレーティッド 薬物の投与方法
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GEP20125574B (en) * 2008-01-11 2012-07-10 Glenmark Pharmaceuticals Sa Fused pyrimidine derivatives as trpv3 modulators
US8119647B2 (en) * 2008-04-23 2012-02-21 Glenmark Pharmaceuticals S.A. Fused pyrimidineone compounds as TRPV3 modulators
CA2790407A1 (en) * 2010-03-11 2011-09-15 Oxigene, Inc. Ophthalmic formulations
DE202011108135U1 (de) 2011-11-11 2012-02-06 Metso Paper, Inc. Vorrichtung zur Entlüftung eines auf eine Faserbahn aufzutragenden Beschichtungsmedium
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
SMT202100509T1 (it) * 2013-04-17 2021-11-12 Sage Therapeutics Inc Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
CN105764904B (zh) 2013-09-12 2020-02-11 詹森生物制药有限公司 氮杂-吡啶酮化合物及其用途
WO2016145103A1 (en) 2015-03-11 2016-09-15 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
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US20060052596A1 (en) 2006-03-09
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