BRPI0514380A - amidas de ácido 5- e 6-amnoalquil indol-2-carboxìlico 3-substituìdo e análogos relacionados como inibidores de caseìna quinase i - Google Patents

amidas de ácido 5- e 6-amnoalquil indol-2-carboxìlico 3-substituìdo e análogos relacionados como inibidores de caseìna quinase i

Info

Publication number
BRPI0514380A
BRPI0514380A BRPI0514380-2A BRPI0514380A BRPI0514380A BR PI0514380 A BRPI0514380 A BR PI0514380A BR PI0514380 A BRPI0514380 A BR PI0514380A BR PI0514380 A BRPI0514380 A BR PI0514380A
Authority
BR
Brazil
Prior art keywords
formula
kinase inhibitors
amnoalkyl
carboxylic acid
acid amides
Prior art date
Application number
BRPI0514380-2A
Other languages
English (en)
Inventor
William Arthur Metz
Fa-Xiang Ding
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BRPI0514380A publication Critical patent/BRPI0514380A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

AMIDAS DE áCIDO 5-E 6-AMNOALQUIL INDOL-2-CARBOXìLICO 3-SUBSTITUìDO E ANáLOGOS RELACIONADOS COMO INIBIDORES DE CASEìNA QUINASE A presente invenção refere-se e reivindica compostos de fórmula (1) e fórmula (II) como inibidores da caseína quinase Ie humana, e métodos de uso dos ditos compostos de fórmula (1) e fórmula (II) para o tratamento de doenças e transtornos do sistema nervoso central, incluindo transtornos do humor e transtornos do sono. Também se apresentam e reivindicam composições farmacêuticas compreendendo compostos de fórmula (I) ou fórmula (II).
BRPI0514380-2A 2004-08-19 2005-08-16 amidas de ácido 5- e 6-amnoalquil indol-2-carboxìlico 3-substituìdo e análogos relacionados como inibidores de caseìna quinase i BRPI0514380A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60338004P 2004-08-19 2004-08-19
PCT/US2005/029053 WO2006023467A1 (en) 2004-08-19 2005-08-16 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE Iϵ

Publications (1)

Publication Number Publication Date
BRPI0514380A true BRPI0514380A (pt) 2008-06-10

Family

ID=35311279

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514380-2A BRPI0514380A (pt) 2004-08-19 2005-08-16 amidas de ácido 5- e 6-amnoalquil indol-2-carboxìlico 3-substituìdo e análogos relacionados como inibidores de caseìna quinase i

Country Status (26)

Country Link
US (2) US7629376B2 (pt)
EP (1) EP1794122B1 (pt)
JP (1) JP4843608B2 (pt)
KR (2) KR20070043012A (pt)
CN (1) CN101006055B (pt)
AR (1) AR050919A1 (pt)
AT (1) ATE508112T1 (pt)
AU (1) AU2005277523B2 (pt)
BR (1) BRPI0514380A (pt)
CA (1) CA2577667C (pt)
DE (1) DE602005027858D1 (pt)
GT (1) GT200500214A (pt)
IL (1) IL181156A (pt)
JO (1) JO2724B1 (pt)
MA (1) MA28863B1 (pt)
MX (1) MX2007001382A (pt)
NO (1) NO20071466L (pt)
NZ (1) NZ552800A (pt)
PA (1) PA8642901A1 (pt)
PE (1) PE20060498A1 (pt)
RU (1) RU2369599C2 (pt)
SV (1) SV2006002192A (pt)
TW (1) TWI357897B (pt)
UY (1) UY29078A1 (pt)
WO (1) WO2006023467A1 (pt)
ZA (1) ZA200700651B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092660A1 (ja) * 2009-02-12 2010-08-19 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
EP2419101A2 (en) * 2009-04-17 2012-02-22 Cylene Pharmaceuticals, Inc. Method of treating disorders associated with protein kinase ck2 activity
KR102155559B1 (ko) 2012-06-27 2020-09-15 4에스체 악티엔게젤샤프트 암, 자가면역성 염증 및 중추신경계 장애를 치료하기 위한 비플루오로디옥살란-아미노-벤즈이미다졸 키나제 억제제
CN111757879A (zh) 2018-01-29 2020-10-09 卡地拉健康护理有限公司 用作抗菌剂的杂环化合物
WO2022006377A2 (en) * 2020-07-02 2022-01-06 Mbq Pharma Heterocyclic inhibitors of rho gtpases for the treatment of disease
US12209078B2 (en) 2021-10-06 2025-01-28 Mbq Pharma Crystalline forms of carbazole inhibitors of RhoGTPase for the treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
ATE322016T1 (de) * 1999-06-08 2006-04-15 Aventis Pharma Inc Screeningsverfahren zur änderung zirkadiane- rhythmus-eiweisse
AU5919001A (en) * 2000-04-28 2001-11-12 Acadia Pharm Inc Muscarinic agonists
ATE482938T1 (de) * 2002-08-09 2010-10-15 Merck Sharp & Dohme Tyrosinkinaseinhibitoren
PT1747220E (pt) * 2003-12-11 2009-07-08 Aventis Pharma Inc 1h-pirrolo[3,2-b, 3,2-c e 2,3-c]piridina-2-carboxamidas e análogos relacionados como inibidores da caseína-cinase i epsilon

Also Published As

Publication number Publication date
EP1794122B1 (en) 2011-05-04
IL181156A0 (en) 2007-07-04
TWI357897B (en) 2012-02-11
JO2724B1 (en) 2013-09-15
CN101006055B (zh) 2011-06-22
TW200621711A (en) 2006-07-01
US20090082340A1 (en) 2009-03-26
RU2369599C2 (ru) 2009-10-10
SV2006002192A (es) 2006-06-28
AR050919A1 (es) 2006-12-06
US7923466B2 (en) 2011-04-12
NZ552800A (en) 2010-11-26
AU2005277523B2 (en) 2011-09-29
UY29078A1 (es) 2006-03-31
GT200500214A (es) 2006-03-27
ATE508112T1 (de) 2011-05-15
MX2007001382A (es) 2007-04-19
WO2006023467A1 (en) 2006-03-02
KR20070043012A (ko) 2007-04-24
ZA200700651B (en) 2008-09-25
IL181156A (en) 2011-09-27
KR20130038409A (ko) 2013-04-17
JP2008510017A (ja) 2008-04-03
CN101006055A (zh) 2007-07-25
PE20060498A1 (es) 2006-07-10
MA28863B1 (fr) 2007-09-03
NO20071466L (no) 2007-04-19
CA2577667A1 (en) 2006-03-02
US7629376B2 (en) 2009-12-08
EP1794122A1 (en) 2007-06-13
JP4843608B2 (ja) 2011-12-21
RU2007109783A (ru) 2008-09-27
AU2005277523A1 (en) 2006-03-02
DE602005027858D1 (de) 2011-06-16
PA8642901A1 (es) 2006-05-16
HK1105196A1 (en) 2008-02-06
CA2577667C (en) 2011-01-04
US20080027124A1 (en) 2008-01-31

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: AVENTIS PHARMACEUTICALS, INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2320 DE 23-06-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.