BRPI0409002A - pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos - Google Patents

pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos

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Publication number
BRPI0409002A
BRPI0409002A BRPI0409002-0A BRPI0409002A BRPI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A
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Brazil
Prior art keywords
psychosis
treatment
receptor antagonists
neurological disorders
substituted pyrazoles
Prior art date
Application number
BRPI0409002-0A
Other languages
English (en)
Inventor
Kai Schiemann
Oliver Schadt
Christoph Van Amsterdam
Gerd Bartoszyk
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0409002A publication Critical patent/BRPI0409002A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Psychiatry (AREA)
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  • Obesity (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
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Abstract

"PIRAZóIS 1,3,4-SUBSTITUìDOS PARA USO COMO ANTAGONISTAS RECEPTORES 5H-T NO TRATAMENTO DE PSICOSES E DISTúRBIOS NEUROLóGICOS". A presente invenção refere-se a compostos de fórmula (I) e sais e solvatos dos mesmos, em que X, R¬ 1¬, R¬ 2¬, R¬ 5¬ e Q possuem os significados indicados na reivindicação 1, que são adequados como ligantes de receptores de 5HT; bem como como compostos intermediários de fórmula (IA).
BRPI0409002-0A 2003-04-05 2004-03-08 pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos BRPI0409002A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2003115573 DE10315573A1 (de) 2003-04-05 2003-04-05 Substituierte Pyrazole
PCT/EP2004/002354 WO2004089910A1 (de) 2003-04-05 2004-03-08 1,3,4-substituierte pyrazole als 5-ht rezeptor-antagonisten zur behandlung von psychosen und neurologischen störungen

Publications (1)

Publication Number Publication Date
BRPI0409002A true BRPI0409002A (pt) 2006-03-28

Family

ID=32981074

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409002-0A BRPI0409002A (pt) 2003-04-05 2004-03-08 pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos

Country Status (16)

Country Link
US (1) US7566709B2 (pt)
EP (1) EP1611107B1 (pt)
JP (1) JP4740116B2 (pt)
KR (1) KR20050119194A (pt)
CN (1) CN1768043A (pt)
AR (1) AR043838A1 (pt)
AT (1) ATE478052T1 (pt)
AU (1) AU2004228121B2 (pt)
BR (1) BRPI0409002A (pt)
CA (1) CA2521202A1 (pt)
DE (2) DE10315573A1 (pt)
ES (1) ES2349922T3 (pt)
MX (1) MXPA05010646A (pt)
RU (1) RU2005133990A (pt)
WO (1) WO2004089910A1 (pt)
ZA (1) ZA200508951B (pt)

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DE10315572A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
DE10315569A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazolverbindungen
DE10315571A1 (de) * 2003-04-05 2004-10-14 Merck Patent Gmbh Pyrazolverbindungen
CA2581623A1 (en) 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyridine compounds, process for their preparation and compositions containing them
EP1848428A4 (en) * 2005-02-18 2012-04-18 Neurogen Corp THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGS
CN101248049B (zh) * 2005-06-27 2013-08-28 埃克塞利希斯专利有限责任公司 咪唑类lxr调节剂
WO2007002563A1 (en) * 2005-06-27 2007-01-04 Exelixis, Inc. Imidazole based lxr modulators
CA2617413A1 (en) 2005-08-02 2007-02-08 Lexicon Pharmaceuticals, Inc. 2-aminoaryl pyridines as protein kinases inhibitors
JP2008169191A (ja) * 2006-02-20 2008-07-24 Eisai R & D Management Co Ltd 運動ニューロン疾患治療剤
WO2008073825A1 (en) 2006-12-08 2008-06-19 Exelixis, Inc. Lxr and fxr modulators
US8524909B2 (en) * 2010-02-02 2013-09-03 Hoffmann-La Roche Inc. Tetrahydro-pyran derivatives
TW201321367A (zh) * 2011-10-25 2013-06-01 Du Pont 經１，３－二芳基取代之雜環殺蟲劑
CN104302637A (zh) 2012-05-16 2015-01-21 纳幕尔杜邦公司 1,3-二芳基取代的杂环杀虫剂
GB201312800D0 (en) 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
WO2015022293A2 (en) * 2013-08-12 2015-02-19 Basf Se 1,3-(het)aryl-substituted pyrazole compounds
TW201601632A (zh) 2013-11-20 2016-01-16 杜邦股份有限公司 １－芳基－３－烷基吡唑殺蟲劑
MD3762368T2 (ro) 2018-03-08 2022-07-31 Incyte Corp Compuși diol aminopirazină ca inhibitori ai PI3K-Y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

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Also Published As

Publication number Publication date
ATE478052T1 (de) 2010-09-15
AU2004228121A1 (en) 2004-10-21
EP1611107A1 (de) 2006-01-04
ES2349922T3 (es) 2011-01-13
DE10315573A1 (de) 2004-10-14
DE502004011551D1 (de) 2010-09-30
AR043838A1 (es) 2005-08-17
AU2004228121B2 (en) 2010-11-04
CA2521202A1 (en) 2004-10-21
US20070105871A1 (en) 2007-05-10
KR20050119194A (ko) 2005-12-20
EP1611107B1 (de) 2010-08-18
JP2006522036A (ja) 2006-09-28
RU2005133990A (ru) 2006-03-20
ZA200508951B (en) 2007-03-28
JP4740116B2 (ja) 2011-08-03
CN1768043A (zh) 2006-05-03
MXPA05010646A (es) 2005-12-12
WO2004089910A1 (de) 2004-10-21
US7566709B2 (en) 2009-07-28

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