BRPI0409888A - derivados de pirazol como inibidores de fosfodiesterase 4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento - Google Patents

derivados de pirazol como inibidores de fosfodiesterase 4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento

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Publication number
BRPI0409888A
BRPI0409888A BRPI0409888-9A BRPI0409888A BRPI0409888A BR PI0409888 A BRPI0409888 A BR PI0409888A BR PI0409888 A BRPI0409888 A BR PI0409888A BR PI0409888 A BRPI0409888 A BR PI0409888A
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BR
Brazil
Prior art keywords
patient
treating
patient suffering
phosphodiesterase
allergic
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Application number
BRPI0409888-9A
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English (en)
Inventor
Allen Hopper
Erik Kuester
Robert Dunn
Richard Conticello
Original Assignee
Memory Pharm Corp
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Publication date
Application filed by Memory Pharm Corp filed Critical Memory Pharm Corp
Publication of BRPI0409888A publication Critical patent/BRPI0409888A/pt

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Abstract

"DERIVADOS DE PIRAZOL COMO INIBIDORES DE FOSFODIESTERASE 4, COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO PARA EFETUAR A INIBIçãO DA ENZIMA PDE4, INCREMENTAR A COGNIçãO E/OU TRATAR A PSICOSE EM UM PACIENTE, MéTODO PARA O TRATAMENTO DE UM PACIENTE QUE TEM UMA DOENçA QUE ENVOLVE NìVEIS DE CAMP DIMINUìDOS, MéTODO PARA O TRATAMENTO DE UM PACIENTE QUE SOFRE DE UMA DOENçA ALéRGICA OU INFLAMATóRIA E MéTODO PARA O TRATAMENTO DE UM PACIENTE QUE SOFRE DE NEURODEGENERAçãO RESULTANTE DE UMA DOENçA OU DE UM FERIMENTO". A inibição seletiva de PDE4 é obtida por compostos de aril e heteroaril pirazol. Os compostos exibem uma inibição de PDE4 maior em relação a compostos tais como rolipram e exibem seletividade com respeito à inibição de outras classes de PDEs.
BRPI0409888-9A 2003-04-18 2004-04-16 derivados de pirazol como inibidores de fosfodiesterase 4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento BRPI0409888A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46372503P 2003-04-18 2003-04-18
PCT/US2004/011899 WO2004094411A1 (en) 2003-04-18 2004-04-16 Pyrazole derivatives as phosphodiesterase 4 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0409888A true BRPI0409888A (pt) 2006-05-23

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BRPI0409888-9A BRPI0409888A (pt) 2003-04-18 2004-04-16 derivados de pirazol como inibidores de fosfodiesterase 4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento

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US (3) US7226930B2 (pt)
EP (1) EP1631568A1 (pt)
JP (1) JP2006523719A (pt)
KR (1) KR20060005375A (pt)
CN (1) CN1809559B (pt)
AU (1) AU2004232973A1 (pt)
BR (1) BRPI0409888A (pt)
CA (1) CA2522687A1 (pt)
MX (1) MXPA05011200A (pt)
RU (1) RU2379292C2 (pt)
SG (1) SG168409A1 (pt)
WO (1) WO2004094411A1 (pt)

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KR20060005375A (ko) 2006-01-17
WO2004094411A1 (en) 2004-11-04
RU2379292C2 (ru) 2010-01-20
SG168409A1 (en) 2011-02-28
RU2005135562A (ru) 2006-07-10
US7495017B2 (en) 2009-02-24
CN1809559B (zh) 2010-06-02
US7226930B2 (en) 2007-06-05
CA2522687A1 (en) 2004-11-04
US20090221661A1 (en) 2009-09-03
AU2004232973A1 (en) 2004-11-04
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