BRPI0410235A - inibição de pde4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento - Google Patents

inibição de pde4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento

Info

Publication number
BRPI0410235A
BRPI0410235A BRPI0410235-5A BRPI0410235A BRPI0410235A BR PI0410235 A BRPI0410235 A BR PI0410235A BR PI0410235 A BRPI0410235 A BR PI0410235A BR PI0410235 A BRPI0410235 A BR PI0410235A
Authority
BR
Brazil
Prior art keywords
patient
treatment
treating
patient suffering
pde4
Prior art date
Application number
BRPI0410235-5A
Other languages
English (en)
Inventor
Ashok Tehim
Allen Hopper
Ruiping Liu
Erik Kuester
Robert F Dunn
Thomas E Renau
Original Assignee
Memory Pharm Corp
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharm Corp, Hoffmann La Roche filed Critical Memory Pharm Corp
Publication of BRPI0410235A publication Critical patent/BRPI0410235A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Abstract

"INIBIçãO DE PDE4, COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO PARA EFETUAR A INIBIçãO DA ENZIMA PDE4, INCREMENTAR A COGNIçãO E/OU TRATAR A PSICOSE EM UM PACIENTE, MéTODO PARA O TRATAMENTO DE UM PACIENTE QUE TEM UMA DOENçA QUE ENVOLVE NìVEIS DE CAMP DIMINUìDOS, MéTODO PARA O TRATAMENTO DE UM PACIENTE QUE SOFRE DE UMA DOENçA ALéRGICA OU INFLAMATóRIA E MéTODO PARA O TRATAMENTO DE UM PACIENTE QUE SOFRE DE NEURODEGENERAçãO RESULTANTE DE UMA DOENçA OU DE UM FERIMENTO". A inibição de PDE4 seletiva é obtida pelos compostos de 4-(fenila substituída)-2-pirrolidinona. Os compostos exibem uma inibição de PDE4 melhorada em comparação com os compostos tais como rolipram e mostram seletividade no que diz respeito à inibição de outras classes de PDEs. Os compostos da presente invenção são da fórmula I: na qual R¬ 1¬, R¬ 2¬ e R¬ 3¬ são tal como aqui definido.
BRPI0410235-5A 2003-04-16 2004-04-16 inibição de pde4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento BRPI0410235A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46305403P 2003-04-16 2003-04-16
PCT/US2004/011765 WO2004094375A2 (en) 2003-04-16 2004-04-16 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0410235A true BRPI0410235A (pt) 2006-05-09

Family

ID=33310747

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410235-5A BRPI0410235A (pt) 2003-04-16 2004-04-16 inibição de pde4, composto, composição farmacêutica, método para efetuar a inibição da enzima pde4, incrementar a cognição e/ou tratar a psicose em um paciente, método para o tratamento de um paciente que tem uma doença que envolve nìveis de camp diminuìdos, método para o tratamento de um paciente que sofre de uma doença alérgica ou inflamatória e método para o tratamento de um paciente que sofre de neurodegeneração resultante de uma doença ou de um ferimento

Country Status (11)

Country Link
US (1) US7696198B2 (pt)
EP (1) EP1613590A2 (pt)
JP (1) JP2006523710A (pt)
KR (1) KR20060039392A (pt)
CN (1) CN1805929A (pt)
AU (1) AU2004232958A1 (pt)
BR (1) BRPI0410235A (pt)
CA (1) CA2522631A1 (pt)
RU (1) RU2005135330A (pt)
SG (1) SG169900A1 (pt)
WO (1) WO2004094375A2 (pt)

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US7696198B2 (en) 2010-04-13
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CA2522631A1 (en) 2004-11-04
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