BRPI0410002A - derivados de tiadiazina e sua utilização como modeladores positivos dos receptores ampa - Google Patents

derivados de tiadiazina e sua utilização como modeladores positivos dos receptores ampa

Info

Publication number
BRPI0410002A
BRPI0410002A BRPI0410002-6A BRPI0410002A BRPI0410002A BR PI0410002 A BRPI0410002 A BR PI0410002A BR PI0410002 A BRPI0410002 A BR PI0410002A BR PI0410002 A BRPI0410002 A BR PI0410002A
Authority
BR
Brazil
Prior art keywords
branched
group
alkyl
hydrogen atom
alkyl group
Prior art date
Application number
BRPI0410002-6A
Other languages
English (en)
Inventor
Emmanuel Graindorge
Pierre Francotte
Stephane Boverie
Pascal De Tullio
Bernard Pirotte
Pierre Lestage
Laurence Danober
Pierre Renard
Daniel Henri Caignard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0410002A publication Critical patent/BRPI0410002A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"DERIVADOS DE TIADIAZINA E SUA UTILIZAçãO COMO MODELADORES POSITIVOS DOS RECEPTORES AMPA". A presente invenção refere-se a compostos de fórmula (I), na qual A representa um grupamento tienila, furila, pirrolila, oxatiol, tiazol, isotiazol, oxazol ou imidazol, -<sym> ç representa uma ligação simples ou uma ligação dupla, R~ 1~ representa um átomo de hidrogênio, um grupamento alquila (C~ 1~-C~ 6~), linear ou ramificado, eventualmente substituído por um ou vários átomos de halogênio, ou um grupamento alcóxi (C~ 1~-C~ 6~) alquila (C~ 1~-C~ 6~), R~2~ representa um átomo de hidrogênio ou um grupamento alquila (C~ 1~-C~ 6~), linear ou ramificado, eventualmente substituído por um ou vários átomos de halogênio, R~ 3~ representa um átomo de hidrogênio ou um grupamento escolhido dentre alquila (C~ 1~-C~ 6~), linear ou ramificado, CONHR<39> ou SO~ 2~NHR<39> nos quais R<39> representa um grupamento alquila (C~ 1~-C~ 6~), linear ou ramificado, seus enantiómeros, diastereoisómeros, assim como seus sais de adição a um ácido ou a uma base farmaceuticamente aceitável. Medicamentos.
BRPI0410002-6A 2003-05-05 2004-05-04 derivados de tiadiazina e sua utilização como modeladores positivos dos receptores ampa BRPI0410002A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0305448A FR2854634B1 (fr) 2003-05-05 2003-05-05 Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2004/001070 WO2004099217A1 (fr) 2003-05-05 2004-05-04 Derives de thiadiazine et leur utilisation comme modulateurs positifs des recepteurs ampa

Publications (1)

Publication Number Publication Date
BRPI0410002A true BRPI0410002A (pt) 2006-04-25

Family

ID=33306157

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410002-6A BRPI0410002A (pt) 2003-05-05 2004-05-04 derivados de tiadiazina e sua utilização como modeladores positivos dos receptores ampa

Country Status (20)

Country Link
US (1) US7476668B2 (pt)
EP (1) EP1620441A1 (pt)
JP (1) JP4461139B2 (pt)
KR (1) KR100741235B1 (pt)
CN (1) CN100363368C (pt)
AR (1) AR044245A1 (pt)
AU (1) AU2004236005B2 (pt)
BR (1) BRPI0410002A (pt)
CA (1) CA2524377C (pt)
EA (1) EA009240B1 (pt)
FR (1) FR2854634B1 (pt)
GE (1) GEP20084318B (pt)
MA (1) MA27732A1 (pt)
MX (1) MXPA05011823A (pt)
MY (1) MY136694A (pt)
NO (1) NO20055695L (pt)
NZ (1) NZ543214A (pt)
UA (1) UA80046C2 (pt)
WO (1) WO2004099217A1 (pt)
ZA (1) ZA200508660B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510835A (ja) 2004-08-25 2008-04-10 エッセンシャリス，インク． カリウムａｔｐチャンネル開放因子の製剤処方、及びその使用
WO2007081521A2 (en) 2006-01-05 2007-07-19 Essentialis, Inc. Salts of potassium atp channel openers and uses thereof
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2012020848A1 (en) * 2010-08-10 2012-02-16 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP5901365B2 (ja) * 2012-03-12 2016-04-06 株式会社トクヤマ イミダート化合物の製造方法
EP3311842A1 (en) 2013-06-13 2018-04-25 VeroScience LLC Compositions and methods for treating metabolic disorders
PL3321252T3 (pl) 2015-07-06 2021-04-06 Public University Corporation Yokohama City University Nowy związek, który specyficznie wiąże się z receptorem AMPA
EP3436021B1 (en) 2016-03-29 2026-07-29 RespireRx Pharmaceuticals, Inc. Compositions comprising low impact ampakines for treating attention deficit disorders
JP6241974B1 (ja) 2017-01-11 2017-12-06 公立大学法人横浜市立大学 霊長類生体の脳内ａｍｐａ受容体のイメージング方法、プログラム、及びスクリーニング方法
US10680583B1 (en) * 2019-02-26 2020-06-09 Xilinx, Inc. Control circuit for and method of controlling an operation of an integrated circuit device
TWI873185B (zh) 2019-09-16 2025-02-21 日商武田藥品工業股份有限公司 唑稠合之嗒-3(2h)-酮衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3733409A (en) * 1969-05-20 1973-05-15 Schering Corp Method of treating hypertension using thieno (1,2,4) thiadiazines
AU4345297A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor
AU757693B2 (en) * 1997-07-16 2003-03-06 Novo Nordisk A/S Fused 1,2,4-thiadiazine derivatives, their preparation and use
RU2214405C2 (ru) * 1998-02-18 2003-10-20 НьюроСёрч А/С Новые соединения и их применение в качестве положительных модуляторов амра-рецепторов
FR2801587B1 (fr) * 1999-11-30 2002-01-11 Adir Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
MY136694A (en) 2008-11-28
FR2854634A1 (fr) 2004-11-12
CA2524377C (fr) 2010-08-24
JP4461139B2 (ja) 2010-05-12
US7476668B2 (en) 2009-01-13
AU2004236005A1 (en) 2004-11-18
AR044245A1 (es) 2005-09-07
EP1620441A1 (fr) 2006-02-01
UA80046C2 (en) 2007-08-10
GEP20084318B (en) 2008-03-10
MA27732A1 (fr) 2006-01-02
KR100741235B1 (ko) 2007-07-19
EA009240B1 (ru) 2007-12-28
JP2006525292A (ja) 2006-11-09
US20070004709A1 (en) 2007-01-04
ZA200508660B (en) 2007-01-31
CN100363368C (zh) 2008-01-23
AU2004236005B2 (en) 2010-01-21
NZ543214A (en) 2009-02-28
HK1088327A1 (en) 2006-11-03
MXPA05011823A (es) 2006-05-25
NO20055695L (no) 2005-12-01
EA200501696A1 (ru) 2006-06-30
FR2854634B1 (fr) 2005-07-08
KR20060006830A (ko) 2006-01-19
CA2524377A1 (fr) 2004-11-18
WO2004099217A1 (fr) 2004-11-18
CN1798750A (zh) 2006-07-05

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 513/04; A61K 31/549; A61P 25/18

Ipc: C07D 513/04 (2011.01), A61K 31/549 (2011.01), A61P

B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2258 DE 15/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.