DK1454903T3 - Thiadiazolinderivater til behandling af cancer - Google Patents

Thiadiazolinderivater til behandling af cancer

Info

Publication number: DK1454903T3
Authority: DK; Denmark
Prior art keywords: substituted; unsubstituted; cancer; treatment; unsubstituted lower
Prior art date: 2001-12-11

Application number

DK02788786.8T

Other languages

English (en)

Inventor

Chikara Murakata

Kazuhiko Kato

Yoshihisa Ohta

Ryuichiro Nakai

Yoshinori Yamashita

Takeshi Takahashi

Tomohisa Nakano

Yoji Ino

Original Assignee

Kyowa Hakko Kirin Co Ltd

Fujifilm Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-11

Filing date

2002-12-11

Publication date

2010-11-22

2002-12-11 Application filed by Kyowa Hakko Kirin Co Ltd, Fujifilm Corp filed Critical Kyowa Hakko Kirin Co Ltd

2010-11-22 Application granted granted Critical

2010-11-22 Publication of DK1454903T3 publication Critical patent/DK1454903T3/da

Links

WEDKTMOIKOKBSH-UHFFFAOYSA-N 4,5-dihydrothiadiazole Chemical class C1CN=NS1 WEDKTMOIKOKBSH-UHFFFAOYSA-N 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)

DK02788786.8T 2001-12-11 2002-12-11 Thiadiazolinderivater til behandling af cancer DK1454903T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001377456		2001-12-11
JP2002237399		2002-08-16
PCT/JP2002/012961 WO2003051854A1 (fr)	2001-12-11	2002-12-11	Dérivé de thiadiazolines

Publications (1)

Publication Number	Publication Date
DK1454903T3 true DK1454903T3 (da)	2010-11-22

Family

ID=26624996

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02788786.8T DK1454903T3 (da)	2001-12-11	2002-12-11	Thiadiazolinderivater til behandling af cancer
DK07015426.5T DK1847534T3 (da)	2001-12-11	2002-12-11	Thiadiazolin-derivater til behandling af kræft

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK07015426.5T DK1847534T3 (da)	2001-12-11	2002-12-11	Thiadiazolin-derivater til behandling af kræft

Country Status (15)

Country	Link
US (4)	US7425636B2 (da)
EP (2)	EP1454903B9 (da)
JP (1)	JP4272994B2 (da)
KR (1)	KR100915287B1 (da)
CN (1)	CN100484928C (da)
AT (2)	ATE480527T1 (da)
AU (1)	AU2002354465B2 (da)
CA (1)	CA2469801C (da)
CY (2)	CY1112899T1 (da)
DE (1)	DE60237637D1 (da)
DK (2)	DK1454903T3 (da)
ES (1)	ES2350642T3 (da)
PT (2)	PT1847534E (da)
SI (2)	SI1454903T1 (da)
WO (1)	WO2003051854A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE480527T1 (de)	2001-12-11	2010-09-15	Kyowa Hakko Kirin Co Ltd	Thiadiazolinderivate zur krebsbehandlung
CA2522594C (en) *	2003-04-18	2012-01-24	Kyowa Hakko Kogyo Co., Ltd.	Mitotic kinesin inhibitor
US20070276017A1 (en) *	2003-06-10	2007-11-29	Chikara Murakata	Thiadiazoline Derivative
JPWO2004111023A1 (ja) *	2003-06-10	2006-07-27	協和醗酵工業株式会社	チアジアゾリン−１−オキシド誘導体
WO2005035512A1 (ja) *	2003-10-10	2005-04-21	Kyowa Hakko Kogyo Co., Ltd.	チアジアゾリン誘導体
WO2005061707A1 (ja) *	2003-12-24	2005-07-07	Kyowa Hakko Kogyo Co., Ltd.	癌細胞のEg5阻害剤に対する感受性を判定する方法
US7449486B2 (en)	2004-10-19	2008-11-11	Array Biopharma Inc.	Mitotic kinesin inhibitors and methods of use thereof
EP1870404A4 (en) *	2005-03-22	2010-07-14	Kyowa Hakko Kirin Co Ltd	MEANS FOR THE TREATMENT OF A HEMATOPOIETIC TUMOR
WO2006101102A1 (ja) *	2005-03-22	2006-09-28	Kyowa Hakko Kogyo Co., Ltd.	固形腫瘍治療剤
UA95907C2 (en)	2005-05-02	2011-09-26	Эррей Биофарма Инк.	Mitotic kinesin inhibitors and methods of use thereof
EP1908755A4 (en) *	2005-06-24	2009-06-24	Kyowa Hakko Kirin Co Ltd	THERAPEUTIC AGENT AGAINST RESTENOSIS
DE102005055354A1 (de) *	2005-11-21	2007-10-31	Merck Patent Gmbh	Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine
DE102006002065B4 (de) *	2006-01-16	2007-11-29	Infineon Technologies Austria Ag	Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand
EP2081918A2 (en) *	2006-10-03	2009-07-29	Array Biopharma, Inc.	Mitotic kinesin inhibitors and methods of use thereof
MX2010000468A (es)	2007-07-12	2010-04-09	Lilly Co Eli	Formulaciones estables de derivado de tiadiazol.
AR068888A1 (es)	2007-10-19	2009-12-16	Schering Corp	Derivados de 1, 3, 4 - tiadiazol, una composicion farmaceutica que los comprende y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por la inhibicion de la quinesina ksp.

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE243930C (da)
US4246225A (en) *	1978-05-25	1981-01-20	Owens-Illinois, Inc.	Method for forming tubular plastic articles
US4338449A (en) *	1981-06-15	1982-07-06	Eli Lilly And Company	Herbicidal thiadiazolines
US4346225A (en) *	1981-06-15	1982-08-24	Eli Lilly And Company	Herbicidal 2-methylamino thiadiazolines
US4699913A (en)	1985-06-28	1987-10-13	Ciba-Geigy Corporation	Substituted 4,5-dihydro-1,3,4-thiadiazoles useful as insecticides
ATE72431T1 (de)	1985-08-31	1992-02-15	Fisons Plc	5-gliedrige heterocyclische angiotensinumwandlungsenzym-inhibitoren.
DD243930A1 (de)	1985-12-04	1987-03-18	Akad Wissenschaften Ddr	Verfahren zur herstellung von neuen 5,5-disubstituierten 4-carbamoyl-4,5-dihydro-1,3,4-thiadiazol-2-yl-harnstoffen
AU4288293A (en) *	1992-04-27	1993-11-29	E.I. Du Pont De Nemours And Company	Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines
JP2798005B2 (ja)	1994-05-19	1998-09-17	三菱化学株式会社	平滑筋細胞増殖に起因する疾患の治療・予防剤
ATE157871T1 (de)	1994-05-19	1997-09-15	Mitsubishi Chem Corp	Arzneimittel zur therapeutischen und prophylaktischen behandlung von krankheiten, die durch hyperplasie der glatten muskelzellen bedingt sind
US5814647A (en) *	1997-03-04	1998-09-29	Board Of Regents, The University Of Texas System	Use of troglitazone and related compounds for the treatment of the climacteric symptoms
US6235762B1 (en) *	1998-11-23	2001-05-22	American Cyanamid Company	2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents
JP2000159756A (ja)	1998-11-23	2000-06-13	American Cyanamid Co	２―アリ―ル―δ２―１，３，４―（オキサおよびチア）ジアゾリン殺虫および殺ダニ剤
HUP0105092A3 (en)	1999-01-13	2003-12-29	Warner Lambert Co	1-heterocycle substituted diarylamines and medicaments containing them
JP2000204077A (ja)	1999-01-13	2000-07-25	Warner Lambert Co	ジアリ―ルアミン
JP2000229959A (ja) *	1999-02-04	2000-08-22	Sumitomo Pharmaceut Co Ltd	Ｓｔａｔ６活性化阻害剤
US6545004B1 (en) *	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
US6617115B1 (en) *	1999-10-27	2003-09-09	Cytokinetics, Inc.	Methods of screening for modulators of cell proliferation
ATE327224T1 (de)	1999-10-27	2006-06-15	Cytokinetics Inc	Chinazolinone benutzende verfahren und zusammenstellungen
WO2001056994A1 (en) *	2000-02-04	2001-08-09	Biogen, Inc.	Integrin antagonists
US6310716B1 (en)	2000-08-18	2001-10-30	Corning Incorporated	Amplifier system with a discrete Raman fiber amplifier module
WO2002056880A1 (en)	2001-01-19	2002-07-25	Cytokinetics, Inc.	Triphenylmethane kinesin inhibitors
WO2002057244A1 (en)	2001-01-19	2002-07-25	Cytokinetics, Inc.	Phenothiazine kinesin inhibitors
US20040087548A1 (en)	2001-02-27	2004-05-06	Salvati Mark E.	Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6809102B2 (en) *	2001-03-29	2004-10-26	Bristol-Myers Squibb Company	Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
IL158083A0 (en) *	2001-03-29	2004-03-28	Bristol Myers Squibb Co	A PHARMACEUTICAL COMPOSITION CONTAINING AN Eg5 PROTEIN INHIBITOR
US6900214B2 (en)	2001-03-29	2005-05-31	Bristol-Myers Squibb Company	Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
CA2465491A1 (en)	2001-11-07	2003-05-15	Merck & Co., Inc.	Mitotic kinesin inhibitors
ATE480527T1 (de) *	2001-12-11	2010-09-15	Kyowa Hakko Kirin Co Ltd	Thiadiazolinderivate zur krebsbehandlung
US6561831B1 (en)	2001-12-27	2003-05-13	Hon Hai Precision Ind. Co., Ltd.	Housing of socket connector and conductive terminal thereof
EP1492487B1 (en) *	2002-03-08	2009-11-11	Merck & Co., Inc.	Mitotic kinesin inhibitors
WO2004039774A2 (en)	2002-05-23	2004-05-13	Merck & Co., Inc.	Mitotic kinesin inhibitors
CA2522594C (en)	2003-04-18	2012-01-24	Kyowa Hakko Kogyo Co., Ltd.	Mitotic kinesin inhibitor
US20070276017A1 (en)	2003-06-10	2007-11-29	Chikara Murakata	Thiadiazoline Derivative
JPWO2004111023A1 (ja)	2003-06-10	2006-07-27	協和醗酵工業株式会社	チアジアゾリン−１−オキシド誘導体
WO2005035512A1 (ja)	2003-10-10	2005-04-21	Kyowa Hakko Kogyo Co., Ltd.	チアジアゾリン誘導体
US7449486B2 (en)	2004-10-19	2008-11-11	Array Biopharma Inc.	Mitotic kinesin inhibitors and methods of use thereof
EP1870404A4 (en)	2005-03-22	2010-07-14	Kyowa Hakko Kirin Co Ltd	MEANS FOR THE TREATMENT OF A HEMATOPOIETIC TUMOR
WO2006101102A1 (ja)	2005-03-22	2006-09-28	Kyowa Hakko Kogyo Co., Ltd.	固形腫瘍治療剤
EP1908755A4 (en)	2005-06-24	2009-06-24	Kyowa Hakko Kirin Co Ltd	THERAPEUTIC AGENT AGAINST RESTENOSIS

2002
- 2002-12-11 AT AT02788786T patent/ATE480527T1/de active
- 2002-12-11 KR KR1020047008915A patent/KR100915287B1/ko not_active Expired - Fee Related
- 2002-12-11 SI SI200230923T patent/SI1454903T1/sl unknown
- 2002-12-11 US US10/497,531 patent/US7425636B2/en not_active Expired - Fee Related
- 2002-12-11 ES ES02788786T patent/ES2350642T3/es not_active Expired - Lifetime
- 2002-12-11 EP EP02788786A patent/EP1454903B9/en not_active Expired - Lifetime
- 2002-12-11 DK DK02788786.8T patent/DK1454903T3/da active
- 2002-12-11 SI SI200230956T patent/SI1847534T1/sl unknown
- 2002-12-11 CN CNB028279840A patent/CN100484928C/zh not_active Expired - Fee Related
- 2002-12-11 EP EP07015426A patent/EP1847534B9/en not_active Expired - Lifetime
- 2002-12-11 DK DK07015426.5T patent/DK1847534T3/da active
- 2002-12-11 CA CA2469801A patent/CA2469801C/en not_active Expired - Fee Related
- 2002-12-11 WO PCT/JP2002/012961 patent/WO2003051854A1/ja not_active Ceased
- 2002-12-11 PT PT07015426T patent/PT1847534E/pt unknown
- 2002-12-11 DE DE60237637T patent/DE60237637D1/de not_active Expired - Lifetime
- 2002-12-11 AU AU2002354465A patent/AU2002354465B2/en not_active Ceased
- 2002-12-11 AT AT07015426T patent/ATE513821T1/de active
- 2002-12-11 JP JP2003552739A patent/JP4272994B2/ja not_active Expired - Fee Related
- 2002-12-11 PT PT02788786T patent/PT1454903E/pt unknown
2007
- 2007-05-11 US US11/798,214 patent/US20070213380A1/en not_active Abandoned
2008
- 2008-04-07 US US12/098,736 patent/US7759371B2/en not_active Expired - Fee Related
2010
- 2010-06-02 US US12/792,448 patent/US7902234B2/en not_active Expired - Fee Related
- 2010-11-04 CY CY20101100996T patent/CY1112899T1/el unknown
2011
- 2011-09-07 CY CY20111100863T patent/CY1111816T1/el unknown

Also Published As

Publication number	Publication date
US20100240716A1 (en)	2010-09-23
EP1847534B9 (en)	2012-03-21
EP1454903B9 (en)	2011-10-05
DK1847534T3 (da)	2011-08-29
KR20040072649A (ko)	2004-08-18
EP1847534B1 (en)	2011-06-22
US7902234B2 (en)	2011-03-08
EP1847534A3 (en)	2008-09-24
PT1847534E (pt)	2011-08-01
ES2350642T3 (es)	2011-01-25
JPWO2003051854A1 (ja)	2005-04-28
US20060074113A1 (en)	2006-04-06
SI1454903T1 (sl)	2010-12-31
CN100484928C (zh)	2009-05-06
US7759371B2 (en)	2010-07-20
US20070213380A1 (en)	2007-09-13
PT1454903E (pt)	2010-11-09
CN1617864A (zh)	2005-05-18
HK1107814A1 (en)	2008-04-18
EP1454903A4 (en)	2005-12-21
EP1454903B1 (en)	2010-09-08
JP4272994B2 (ja)	2009-06-03
ATE480527T1 (de)	2010-09-15
SI1847534T1 (sl)	2011-10-28
CA2469801A1 (en)	2003-06-26
WO2003051854A1 (fr)	2003-06-26
US20080207706A1 (en)	2008-08-28
AU2002354465B2 (en)	2008-11-20
CY1112899T1 (el)	2016-04-13
CY1111816T1 (el)	2015-10-07
CA2469801C (en)	2011-06-21
AU2002354465A1 (en)	2003-06-30
KR100915287B1 (ko)	2009-09-03
ATE513821T1 (de)	2011-07-15
US7425636B2 (en)	2008-09-16
EP1847534A2 (en)	2007-10-24
DE60237637D1 (de)	2010-10-21
EP1454903A1 (en)	2004-09-08

Publication	Publication Date	Title
CY1111816T1 (el)	2015-10-07	Παραγωγο θειαδιαζολινης για την θεραπεια του καρκινου
NO20012617L (no)	2001-09-14	Kinolin- og kinzolinderivater
EP1616866A4 (en)	2008-09-24	M-STAGE kinesin inhibitor
TR200201205T2 (tr)	2002-08-21	N-ikame edilmiş karbamoiloksialkil-azolyum türevleri.
NO20004485L (no)	2000-09-08	Sykloalkenderivater, deres fremstilling og anvendelse
TR200403436T2 (tr)	2005-03-21	Kristalin 1-metilkarbapenem türevleri.
EP1201668A4 (en)	2003-05-21	Staurosporine DERIVATIVES
ATE315550T1 (de)	2006-02-15	Fungizide phenylamidinderivative
NO20025035D0 (no)	2002-10-18	Oksadiazolderivater som har anticancer-effekter
EP1671957A4 (en)	2007-03-14	THIADIAZOLINDERIVATE
DE69623497D1 (de)	2002-10-10	1-methylcarbapenem-derivate
ATE283840T1 (de)	2004-12-15	Chondrogonese promotoren und indolin-2-on derivate
ATE320417T1 (de)	2006-04-15	Naphthimidobenzamid-derivate
DK1433480T3 (da)	2011-04-11	Lægemiddel indeholdende pyrimidin-derivat
EP1431293A4 (en)	2004-12-22	WATER-SOLUBLE PHENYLPYRIDAZINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
ATE552003T1 (de)	2012-04-15	Chinoxalinderivate
ATE262522T1 (de)	2004-04-15	Benzimidazolverbindungen
MX9704976A (es)	1998-01-31	Derivados de 1,2,3-benzotiadiazol.