DK1454903T3 - Thiadiazolinderivater til behandling af cancer - Google Patents

Thiadiazolinderivater til behandling af cancer

Info

Publication number: DK1454903T3
Authority: DK; Denmark
Prior art keywords: substituted; unsubstituted; cancer; treatment; unsubstituted lower
Prior art date: 2001-12-11

Application number

DK02788786.8T

Other languages

English (en)

Inventor

Chikara Murakata

Kazuhiko Kato

Yoshihisa Ohta

Ryuichiro Nakai

Yoshinori Yamashita

Takeshi Takahashi

Tomohisa Nakano

Yoji Ino

Original Assignee

Kyowa Hakko Kirin Co Ltd

Fujifilm Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-11

Filing date

2002-12-11

Publication date

2010-11-22

2002-12-11 Application filed by Kyowa Hakko Kirin Co Ltd, Fujifilm Corp filed Critical Kyowa Hakko Kirin Co Ltd

2010-11-22 Application granted granted Critical

2010-11-22 Publication of DK1454903T3 publication Critical patent/DK1454903T3/da

Links

WEDKTMOIKOKBSH-UHFFFAOYSA-N 4,5-dihydrothiadiazole Chemical class C1CN=NS1 WEDKTMOIKOKBSH-UHFFFAOYSA-N 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)

DK02788786.8T 2001-12-11 2002-12-11 Thiadiazolinderivater til behandling af cancer DK1454903T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2001377456		2001-12-11
JP2002237399		2002-08-16
PCT/JP2002/012961 WO2003051854A1 (fr)	2001-12-11	2002-12-11	Dérivé de thiadiazolines

Publications (1)

Publication Number	Publication Date
DK1454903T3 true DK1454903T3 (da)	2010-11-22

Family

ID=26624996

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK07015426.5T DK1847534T3 (da)	2001-12-11	2002-12-11	Thiadiazolin-derivater til behandling af kræft
DK02788786.8T DK1454903T3 (da)	2001-12-11	2002-12-11	Thiadiazolinderivater til behandling af cancer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK07015426.5T DK1847534T3 (da)	2001-12-11	2002-12-11	Thiadiazolin-derivater til behandling af kræft

Country Status (15)

Country	Link
US (4)	US7425636B2 (da)
EP (2)	EP1847534B9 (da)
JP (1)	JP4272994B2 (da)
KR (1)	KR100915287B1 (da)
CN (1)	CN100484928C (da)
AT (2)	ATE480527T1 (da)
AU (1)	AU2002354465B2 (da)
CA (1)	CA2469801C (da)
CY (2)	CY1112899T1 (da)
DE (1)	DE60237637D1 (da)
DK (2)	DK1847534T3 (da)
ES (1)	ES2350642T3 (da)
PT (2)	PT1454903E (da)
SI (2)	SI1454903T1 (da)
WO (1)	WO2003051854A1 (da)

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DK1847534T3 (da) *	2001-12-11	2011-08-29	Kyowa Hakko Kirin Co Ltd	Thiadiazolin-derivater til behandling af kræft
ATE537158T1 (de) *	2003-04-18	2011-12-15	Kyowa Hakko Kirin Co Ltd	M-stage-kinesin-inhibitor
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EP1671957A4 (en) *	2003-10-10	2007-03-14		THIADIAZOLINDERIVATE
JPWO2005061707A1 (ja) *	2003-12-24	2007-07-12	協和醗酵工業株式会社	癌細胞のＥｇ５阻害剤に対する感受性を判定する方法
US7449486B2 (en) *	2004-10-19	2008-11-11	Array Biopharma Inc.	Mitotic kinesin inhibitors and methods of use thereof
JP5060285B2 (ja) *	2005-03-22	2012-10-31	協和発酵キリン株式会社	固形腫瘍治療剤
AU2006225637A1 (en) *	2005-03-22	2006-09-28	Fuji Photo Film Co., Ltd.	Therapeutic agent for hematopoietic tumor
UA95907C2 (en)	2005-05-02	2011-09-26	Эррей Биофарма Инк.	Mitotic kinesin inhibitors and methods of use thereof
WO2006137490A1 (ja) *	2005-06-24	2006-12-28	Kyowa Hakko Kogyo Co., Ltd.	再狭窄治療剤
DE102005055354A1 (de) *	2005-11-21	2007-10-31	Merck Patent Gmbh	Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine
DE102006002065B4 (de) *	2006-01-16	2007-11-29	Infineon Technologies Austria Ag	Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand
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JP5455915B2 (ja) *	2007-10-19	2014-03-26	メルク・シャープ・アンド・ドーム・コーポレーション	Ｋｓｐキネシン活性を阻害するためのスピロ縮合した１，３，４−チアジアゾール誘導体

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DK1847534T3 (da)	2001-12-11	2011-08-29	Kyowa Hakko Kirin Co Ltd	Thiadiazolin-derivater til behandling af kræft
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ATE537158T1 (de)	2003-04-18	2011-12-15	Kyowa Hakko Kirin Co Ltd	M-stage-kinesin-inhibitor
AU2004247551A1 (en)	2003-06-10	2004-12-23	Fuji Photo Film Co., Ltd.	Thiadiazoline derivative
WO2004111023A1 (ja)	2003-06-10	2004-12-23	Kyowa Hakko Kogyo Co., Ltd.	チアジアゾリン－１－オキシド誘導体
EP1671957A4 (en)	2003-10-10	2007-03-14		THIADIAZOLINDERIVATE
US7449486B2 (en)	2004-10-19	2008-11-11	Array Biopharma Inc.	Mitotic kinesin inhibitors and methods of use thereof
JP5060285B2 (ja)	2005-03-22	2012-10-31	協和発酵キリン株式会社	固形腫瘍治療剤
AU2006225637A1 (en)	2005-03-22	2006-09-28	Fuji Photo Film Co., Ltd.	Therapeutic agent for hematopoietic tumor
WO2006137490A1 (ja)	2005-06-24	2006-12-28	Kyowa Hakko Kogyo Co., Ltd.	再狭窄治療剤

2002
- 2002-12-11 DK DK07015426.5T patent/DK1847534T3/da active
- 2002-12-11 DK DK02788786.8T patent/DK1454903T3/da active
- 2002-12-11 WO PCT/JP2002/012961 patent/WO2003051854A1/ja not_active Ceased
- 2002-12-11 KR KR1020047008915A patent/KR100915287B1/ko not_active Expired - Fee Related
- 2002-12-11 PT PT02788786T patent/PT1454903E/pt unknown
- 2002-12-11 DE DE60237637T patent/DE60237637D1/de not_active Expired - Lifetime
- 2002-12-11 CN CNB028279840A patent/CN100484928C/zh not_active Expired - Fee Related
- 2002-12-11 SI SI200230923T patent/SI1454903T1/sl unknown
- 2002-12-11 EP EP07015426A patent/EP1847534B9/en not_active Expired - Lifetime
- 2002-12-11 AT AT02788786T patent/ATE480527T1/de active
- 2002-12-11 US US10/497,531 patent/US7425636B2/en not_active Expired - Fee Related
- 2002-12-11 EP EP02788786A patent/EP1454903B9/en not_active Expired - Lifetime
- 2002-12-11 JP JP2003552739A patent/JP4272994B2/ja not_active Expired - Fee Related
- 2002-12-11 AT AT07015426T patent/ATE513821T1/de active
- 2002-12-11 ES ES02788786T patent/ES2350642T3/es not_active Expired - Lifetime
- 2002-12-11 AU AU2002354465A patent/AU2002354465B2/en not_active Ceased
- 2002-12-11 PT PT07015426T patent/PT1847534E/pt unknown
- 2002-12-11 SI SI200230956T patent/SI1847534T1/sl unknown
- 2002-12-11 CA CA2469801A patent/CA2469801C/en not_active Expired - Fee Related
2007
- 2007-05-11 US US11/798,214 patent/US20070213380A1/en not_active Abandoned
2008
- 2008-04-07 US US12/098,736 patent/US7759371B2/en not_active Expired - Fee Related
2010
- 2010-06-02 US US12/792,448 patent/US7902234B2/en not_active Expired - Fee Related
- 2010-11-04 CY CY20101100996T patent/CY1112899T1/el unknown
2011
- 2011-09-07 CY CY20111100863T patent/CY1111816T1/el unknown

Also Published As

Publication number	Publication date
CA2469801C (en)	2011-06-21
DK1847534T3 (da)	2011-08-29
EP1454903A4 (en)	2005-12-21
PT1454903E (pt)	2010-11-09
US20080207706A1 (en)	2008-08-28
US20100240716A1 (en)	2010-09-23
EP1847534B1 (en)	2011-06-22
CY1112899T1 (el)	2016-04-13
WO2003051854A1 (fr)	2003-06-26
JPWO2003051854A1 (ja)	2005-04-28
US7425636B2 (en)	2008-09-16
US20070213380A1 (en)	2007-09-13
SI1454903T1 (sl)	2010-12-31
KR20040072649A (ko)	2004-08-18
EP1454903B1 (en)	2010-09-08
SI1847534T1 (sl)	2011-10-28
CN100484928C (zh)	2009-05-06
EP1847534A3 (en)	2008-09-24
ATE513821T1 (de)	2011-07-15
CN1617864A (zh)	2005-05-18
EP1847534B9 (en)	2012-03-21
US7759371B2 (en)	2010-07-20
CA2469801A1 (en)	2003-06-26
DE60237637D1 (de)	2010-10-21
HK1107814A1 (en)	2008-04-18
ATE480527T1 (de)	2010-09-15
EP1847534A2 (en)	2007-10-24
KR100915287B1 (ko)	2009-09-03
ES2350642T3 (es)	2011-01-25
EP1454903A1 (en)	2004-09-08
CY1111816T1 (el)	2015-10-07
US7902234B2 (en)	2011-03-08
PT1847534E (pt)	2011-08-01
US20060074113A1 (en)	2006-04-06
EP1454903B9 (en)	2011-10-05
JP4272994B2 (ja)	2009-06-03
AU2002354465B2 (en)	2008-11-20
AU2002354465A1 (en)	2003-06-30

Publication	Publication Date	Title
CY1111816T1 (el)	2015-10-07	Παραγωγο θειαδιαζολινης για την θεραπεια του καρκινου
NO20012617L (no)	2001-09-14	Kinolin- og kinzolinderivater
EP1616866A4 (en)	2008-09-24	M-STAGE kinesin inhibitor
MXPA06001274A (es)	2006-04-11	Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio.
TR200201205T2 (tr)	2002-08-21	N-ikame edilmiş karbamoiloksialkil-azolyum türevleri.
NO20004485D0 (no)	2000-09-08	Sykloalkenderivater, deres fremstilling og anvendelse
TR200403436T2 (tr)	2005-03-21	Kristalin 1-metilkarbapenem türevleri.
EP1201668A4 (en)	2003-05-21	Staurosporine DERIVATIVES
ATE315550T1 (de)	2006-02-15	Fungizide phenylamidinderivative
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DE69623497D1 (de)	2002-10-10	1-methylcarbapenem-derivate
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