BRPI0411923A - sal de ácido metanossulfÈnico de composto pirazolopirimidina, cristal do mesmo e processo de produção do mesmo - Google Patents

sal de ácido metanossulfÈnico de composto pirazolopirimidina, cristal do mesmo e processo de produção do mesmo

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Publication number
BRPI0411923A
BRPI0411923A BRPI0411923-1A BRPI0411923A BRPI0411923A BR PI0411923 A BRPI0411923 A BR PI0411923A BR PI0411923 A BRPI0411923 A BR PI0411923A BR PI0411923 A BRPI0411923 A BR PI0411923A
Authority
BR
Brazil
Prior art keywords
crystal
production process
acid salt
methanesulfonic acid
pyrazolopyrimidine compound
Prior art date
Application number
BRPI0411923-1A
Other languages
English (en)
Inventor
Tomoyuki Hasegawa
Toshiaki Matsui
Hiroshi Araki
Tetsuji Saito
Tetsuo Obitsu
Masaki Okamoto
Yuichi Gemba
Yutaka Mikami
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of BRPI0411923A publication Critical patent/BRPI0411923A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Abstract

"SAL DE áCIDO METANOSSULFÈNICO DE COMPOSTO PIRAZOLOPIRIMIDINA, CRISTAL DO MESMO E PROCESSO DE PRODUçãO DO MESMO". Metanossulfonato de 8-(3-pentilamino)-2-metil-3(2-cloro-4-metoxifenil)-6,7-diidro-5Hciclope nta¢d!pirazol¢1,5-a!pirimidina, que se trata de um composto novo, e um processo para produção de um intermediário para o composto. Metanossulfonato de 8-(3-pentilamino)2-metil-3-(2-cloro-4-metoxifenil)-6,7-diidro-5Hciclope nta¢d!pirazol¢1,5-a!pirimidina se trata de um composto com excelente estabilidade térmica. O novo processo de produção permite que um composto representado pela fórmula geral (I): (I) onde Ar representa um anel benzeno opcionalmente substituído, etc. . , e R¬ 1¬ representa C~ 1-8~ alquila, C~ 2-8~ alquenila, C~ 2-8~ alquinila, etc., que é um intermediário, seja eficientemente produzido com alto rendimento.
BRPI0411923-1A 2003-06-25 2004-06-24 sal de ácido metanossulfÈnico de composto pirazolopirimidina, cristal do mesmo e processo de produção do mesmo BRPI0411923A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003181908 2003-06-25
PCT/JP2004/009263 WO2004113344A1 (ja) 2003-06-25 2004-06-24 ピラゾロピリミジン化合物のメタンスルホン酸塩、その結晶およびその製造方法

Publications (1)

Publication Number Publication Date
BRPI0411923A true BRPI0411923A (pt) 2006-08-15

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Application Number Title Priority Date Filing Date
BRPI0411923-1A BRPI0411923A (pt) 2003-06-25 2004-06-24 sal de ácido metanossulfÈnico de composto pirazolopirimidina, cristal do mesmo e processo de produção do mesmo

Country Status (19)

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US (1) US7947697B1 (pt)
EP (1) EP1637531B1 (pt)
JP (1) JP4655276B2 (pt)
KR (1) KR101082227B1 (pt)
CN (1) CN100422186C (pt)
AT (1) ATE478873T1 (pt)
AU (1) AU2004249629B2 (pt)
BR (1) BRPI0411923A (pt)
CA (1) CA2529561C (pt)
DE (1) DE602004028820D1 (pt)
ES (1) ES2349393T3 (pt)
IL (1) IL172697A (pt)
MX (1) MXPA05013917A (pt)
NO (1) NO332186B1 (pt)
NZ (1) NZ544301A (pt)
RU (1) RU2345995C2 (pt)
TW (1) TWI356058B (pt)
WO (1) WO2004113344A1 (pt)
ZA (1) ZA200510450B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005061508A1 (ja) * 2003-12-22 2005-07-07 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分とする医薬
WO2005087775A1 (ja) * 2004-03-15 2005-09-22 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
CN112225732B (zh) * 2019-07-15 2024-01-09 四川科瑞德制药股份有限公司 一种盐酸哌罗匹隆水合物晶型及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030768C (zh) * 1990-10-09 1996-01-24 大塚制药株式会社 嘧啶衍生物或其药用盐的制备方法
US5420128A (en) 1990-10-09 1995-05-30 Otsuka Pharmaceutical Co., Ltd. Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor
JPH05112571A (ja) 1990-10-19 1993-05-07 Otsuka Pharmaceut Co Ltd ピリミジン誘導体
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
AU707530B2 (en) 1995-09-28 1999-07-15 Otsuka Pharmaceutical Factory, Inc. Analgesic composition
US6194574B1 (en) 1998-06-09 2001-02-27 Neurogen Corporation Pyrido[2,3-b]indolizine derivatives and aza analogues thereof: CRF1 specific ligands
DK1129096T3 (da) 1998-11-12 2003-09-15 Neurocrine Biosciences Inc CRF-receptorantagonister og fremgangsmåder, der er relateret dertil
ES2180338T3 (es) 1998-11-12 2003-02-01 Neurocrine Biosciences Inc Antagonistas del receptor de crf y metodos relacionados.
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
ES2294047T3 (es) * 2000-12-28 2008-04-01 Ono Pharmaceutical Co., Ltd. Un compuesto de ciclopenta (d) pirazolo(1,5-a) pirimidina como antagonista del receptor de crf.

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CA2529561C (en) 2012-05-29
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ATE478873T1 (de) 2010-09-15
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IL172697A0 (en) 2006-04-10
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