ATE478873T1 - Methansulfonsäuresalz einer pyrazolopyrimidinverbindung, kristall davon und verfahren zu deren herstellung - Google Patents

Methansulfonsäuresalz einer pyrazolopyrimidinverbindung, kristall davon und verfahren zu deren herstellung

Info

Publication number: ATE478873T1
Authority: AT; Austria
Prior art keywords: crystal; production; acid salt; methanesulphonic acid; compound
Prior art date: 2003-06-25

Application number

AT04746732T

Other languages

English (en)

Inventor

T Hasegawa

T Matsui

H Araki

T Saito

T Obitsu

Masaki Okamoto

Y Gemba

Y Mikami

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-25

Filing date

2004-06-24

Publication date

2010-09-15

2004-06-24 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

2010-09-15 Application granted granted Critical

2010-09-15 Publication of ATE478873T1 publication Critical patent/ATE478873T1/de

Links

238000000034 method Methods 0.000 title abstract 4
239000013078 crystal Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title 1
-1 PYRAZOLOPYRIMIDINE COMPOUND Chemical class 0.000 title 1
PBBUMRSJZFHLJA-UHFFFAOYSA-N CS(O)(=O)=O.CC1=NN2C(NC(CC)CC)=C3CCCC3=NC2=C1C1=CC=C(OC)C=C1Cl Chemical compound CS(O)(=O)=O.CC1=NN2C(NC(CC)CC)=C3CCCC3=NC2=C1C1=CC=C(OC)C=C1Cl PBBUMRSJZFHLJA-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hematology (AREA)
Addiction (AREA)
Dermatology (AREA)
Otolaryngology (AREA)
Psychology (AREA)
Reproductive Health (AREA)
Anesthesiology (AREA)
Vascular Medicine (AREA)

AT04746732T 2003-06-25 2004-06-24 Methansulfonsäuresalz einer pyrazolopyrimidinverbindung, kristall davon und verfahren zu deren herstellung ATE478873T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003181908		2003-06-25
PCT/JP2004/009263 WO2004113344A1 (ja)	2003-06-25	2004-06-24	ピラゾロピリミジン化合物のメタンスルホン酸塩、その結晶およびその製造方法

Publications (1)

Publication Number	Publication Date
ATE478873T1 true ATE478873T1 (de)	2010-09-15

Family

ID=33535237

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04746732T ATE478873T1 (de)	2003-06-25	2004-06-24	Methansulfonsäuresalz einer pyrazolopyrimidinverbindung, kristall davon und verfahren zu deren herstellung

Country Status (19)

Country	Link
US (1)	US7947697B1 (de)
EP (1)	EP1637531B1 (de)
JP (1)	JP4655276B2 (de)
KR (1)	KR101082227B1 (de)
CN (1)	CN100422186C (de)
AT (1)	ATE478873T1 (de)
AU (1)	AU2004249629B2 (de)
BR (1)	BRPI0411923A (de)
CA (1)	CA2529561C (de)
DE (1)	DE602004028820D1 (de)
ES (1)	ES2349393T3 (de)
IL (1)	IL172697A (de)
MX (1)	MXPA05013917A (de)
NO (1)	NO332186B1 (de)
NZ (1)	NZ544301A (de)
RU (1)	RU2345995C2 (de)
TW (1)	TWI356058B (de)
WO (1)	WO2004113344A1 (de)
ZA (1)	ZA200510450B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005061508A1 (ja) *	2003-12-22	2005-07-07	Ono Pharmaceutical Co., Ltd.	三環式複素環化合物およびその化合物を有効成分とする医薬
WO2005087775A1 (ja) *	2004-03-15	2005-09-22	Ono Pharmaceutical Co., Ltd.	三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
CN112225732B (zh) *	2019-07-15	2024-01-09	四川科瑞德制药股份有限公司	一种盐酸哌罗匹隆水合物晶型及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1030768C (zh) *	1990-10-09	1996-01-24	大塚制药株式会社	嘧啶衍生物或其药用盐的制备方法
US5420128A (en)	1990-10-09	1995-05-30	Otsuka Pharmaceutical Co., Ltd.	Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor
JPH05112571A (ja)	1990-10-19	1993-05-07	Otsuka Pharmaceut Co Ltd	ピリミジン誘導体
TW444018B (en) *	1992-12-17	2001-07-01	Pfizer	Pyrazolopyrimidines
AU707530B2 (en)	1995-09-28	1999-07-15	Otsuka Pharmaceutical Factory, Inc.	Analgesic composition
US6194574B1 (en)	1998-06-09	2001-02-27	Neurogen Corporation	Pyrido[2,3-b]indolizine derivatives and aza analogues thereof: CRF1 specific ligands
DK1129096T3 (da)	1998-11-12	2003-09-15	Neurocrine Biosciences Inc	CRF-receptorantagonister og fremgangsmåder, der er relateret dertil
ES2180338T3 (es)	1998-11-12	2003-02-01	Neurocrine Biosciences Inc	Antagonistas del receptor de crf y metodos relacionados.
US6531475B1 (en)	1998-11-12	2003-03-11	Neurocrine Biosciences, Inc.	CRF receptor antagonists and methods relating thereto
ES2294047T3 (es) *	2000-12-28	2008-04-01	Ono Pharmaceutical Co., Ltd.	Un compuesto de ciclopenta (d) pirazolo(1,5-a) pirimidina como antagonista del receptor de crf.

2004
- 2004-06-24 AT AT04746732T patent/ATE478873T1/de not_active IP Right Cessation
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Also Published As

Publication number	Publication date
AU2004249629A1 (en)	2004-12-29
CN100422186C (zh)	2008-10-01
NO332186B1 (no)	2012-07-23
IL172697A (en)	2013-05-30
BRPI0411923A (pt)	2006-08-15
WO2004113344A1 (ja)	2004-12-29
ES2349393T3 (es)	2010-12-30
AU2004249629B2 (en)	2009-07-30
CA2529561C (en)	2012-05-29
EP1637531A1 (de)	2006-03-22
JPWO2004113344A1 (ja)	2006-07-27
TWI356058B (en)	2012-01-11
RU2345995C2 (ru)	2009-02-10
DE602004028820D1 (de)	2010-10-07
IL172697A0 (en)	2006-04-10
MXPA05013917A (es)	2006-03-09
KR20060026060A (ko)	2006-03-22
NZ544301A (en)	2008-08-29
TW200504064A (en)	2005-02-01
US7947697B1 (en)	2011-05-24
NO20056093L (no)	2006-03-24
EP1637531A4 (de)	2008-09-03
KR101082227B1 (ko)	2011-11-09
RU2006101986A (ru)	2006-07-27
CA2529561A1 (en)	2004-12-29
CN1842530A (zh)	2006-10-04
ZA200510450B (en)	2006-12-27
EP1637531B1 (de)	2010-08-25
JP4655276B2 (ja)	2011-03-23

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2011-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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