NO20056093L - Metansulfonsyresalt av pyrazolpyrimidinforbindelse, krystall derav og fremgangsmate for fremstilling av den samme - Google Patents

Metansulfonsyresalt av pyrazolpyrimidinforbindelse, krystall derav og fremgangsmate for fremstilling av den samme

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Publication number
NO20056093L
NO20056093L NO20056093A NO20056093A NO20056093L NO 20056093 L NO20056093 L NO 20056093L NO 20056093 A NO20056093 A NO 20056093A NO 20056093 A NO20056093 A NO 20056093A NO 20056093 L NO20056093 L NO 20056093L
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NO
Norway
Prior art keywords
crystal
preparing
same
acid salt
methanesulfonic acid
Prior art date
Application number
NO20056093A
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English (en)
Other versions
NO332186B1 (no
Inventor
Tetsuji Saitoh
Tomoyuki Hasegawa
Toshiaki Matsui
Hiroshi Araki
Tetsuo Obitsu
Masaki Okamoto
Yuichi Gemba
Yutaka Mikami
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of NO20056093L publication Critical patent/NO20056093L/no
Publication of NO332186B1 publication Critical patent/NO332186B1/no

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

8-(3-pentylamino)-2-metyl-3-(2-klor-4-metoksyfenyl)-6,7-dihydro-5H-cyklopenta[d]pyrazolo[1,5-a]pyrimidinmetansulfonat, som er ny, og en fremgangsmåte for fremstilling av et mellomprodukt for forbindelsen. 8-(3-pentylamino)-2metyl-3-(2-klor-4-metoksyfenyl)-6,7-dihydro-5H-cyklopenta[d]pyrazolo[1,5-a]pyrimidinmetansulfonat er en forbindelse som har en svært utmerket termisk stabilitet. Den nye fremstillingsprosessen gjør det mulig å effektivt produsere en forbindelse representert ved den generelle formel (I): hvori Ar representerer en eventuelt substituert benzenring, osv.; og R1 representerer C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl osv., som er et mellomprodukt, i et høyt utbytte.
NO20056093A 2003-06-25 2005-12-21 Metansulfonsyresalt av pyrazolpyrimidinforbindelse, krystall derav, fremgangsmate for fremstilling av det samme, farmasoytisk preparat samt anvendelse derav NO332186B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003181908 2003-06-25
PCT/JP2004/009263 WO2004113344A1 (ja) 2003-06-25 2004-06-24 ピラゾロピリミジン化合物のメタンスルホン酸塩、その結晶およびその製造方法

Publications (2)

Publication Number Publication Date
NO20056093L true NO20056093L (no) 2006-03-24
NO332186B1 NO332186B1 (no) 2012-07-23

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NO20056093A NO332186B1 (no) 2003-06-25 2005-12-21 Metansulfonsyresalt av pyrazolpyrimidinforbindelse, krystall derav, fremgangsmate for fremstilling av det samme, farmasoytisk preparat samt anvendelse derav

Country Status (19)

Country Link
US (1) US7947697B1 (no)
EP (1) EP1637531B1 (no)
JP (1) JP4655276B2 (no)
KR (1) KR101082227B1 (no)
CN (1) CN100422186C (no)
AT (1) ATE478873T1 (no)
AU (1) AU2004249629B2 (no)
BR (1) BRPI0411923A (no)
CA (1) CA2529561C (no)
DE (1) DE602004028820D1 (no)
ES (1) ES2349393T3 (no)
IL (1) IL172697A (no)
MX (1) MXPA05013917A (no)
NO (1) NO332186B1 (no)
NZ (1) NZ544301A (no)
RU (1) RU2345995C2 (no)
TW (1) TWI356058B (no)
WO (1) WO2004113344A1 (no)
ZA (1) ZA200510450B (no)

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Publication number Priority date Publication date Assignee Title
WO2005061508A1 (ja) * 2003-12-22 2005-07-07 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分とする医薬
WO2005087775A1 (ja) * 2004-03-15 2005-09-22 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
CN112225732B (zh) * 2019-07-15 2024-01-09 四川科瑞德制药股份有限公司 一种盐酸哌罗匹隆水合物晶型及其制备方法

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ES2349393T3 (es) 2010-12-30
AU2004249629B2 (en) 2009-07-30
CA2529561C (en) 2012-05-29
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JPWO2004113344A1 (ja) 2006-07-27
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TWI356058B (en) 2012-01-11
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IL172697A0 (en) 2006-04-10
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EP1637531A4 (en) 2008-09-03
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CA2529561A1 (en) 2004-12-29
CN1842530A (zh) 2006-10-04
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