BRPI0412444A - fração de quil a com baixa toxidez e seu uso - Google Patents
fração de quil a com baixa toxidez e seu usoInfo
- Publication number
- BRPI0412444A BRPI0412444A BRPI0412444-8A BRPI0412444A BRPI0412444A BR PI0412444 A BRPI0412444 A BR PI0412444A BR PI0412444 A BRPI0412444 A BR PI0412444A BR PI0412444 A BRPI0412444 A BR PI0412444A
- Authority
- BR
- Brazil
- Prior art keywords
- adjuvant
- fraction
- derivatives
- lps
- synthetic
- Prior art date
Links
- 231100000053 low toxicity Toxicity 0.000 title 1
- 239000002671 adjuvant Substances 0.000 abstract 4
- 229930182490 saponin Natural products 0.000 abstract 4
- 150000007949 saponins Chemical class 0.000 abstract 4
- 235000017709 saponins Nutrition 0.000 abstract 4
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract 2
- 108010039939 Cell Wall Skeleton Proteins 0.000 abstract 1
- 108010028921 Lipopeptides Proteins 0.000 abstract 1
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 210000004520 cell wall skeleton Anatomy 0.000 abstract 1
- 210000003918 fraction a Anatomy 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 abstract 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
"FRAçãO DE QUIL A COM BAIXA TOXIDEZ E SEU USO". A invenção refere-se ao uso da fração A de Quil A em conjunto com pelo menos um outro adjuvante para a preparação de uma composição adjuvante, em que os componentes adjuvantes incluídos atuam sinergicamente para aumentar o nível de resposta imune e apresentam atividade imuno-moduladora sinérgica sobre os antígenos ou imunógenos co-administrados. O pelo menos outro adjuvante pode ser escolhido de saponinas, de ocorrência natural, moléculas de saponina sintéticas ou semi-sintéticas, por exemplo, saponinas e frações de saponina de Quil A, esqueleto de parede celular, polímeros em bloco, TDM, lipopeptídeos, LPS e derivados de LPS, lipídeo A de diferentes espécies de bactérias e derivados deste, por exemplo, monofosforil lipídeo A, variantes de CpG, CT e LT ou frações (derivados destes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0301998A SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Quil A fraction with low toxicity and use thereof |
| PCT/SE2004/001038 WO2005002620A1 (en) | 2003-07-07 | 2004-07-07 | Quil a fraction with low toxicity and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0412444A true BRPI0412444A (pt) | 2006-09-19 |
| BRPI0412444B1 BRPI0412444B1 (pt) | 2016-06-14 |
| BRPI0412444B8 BRPI0412444B8 (pt) | 2021-05-25 |
Family
ID=27731119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0412444A BRPI0412444B8 (pt) | 2003-07-07 | 2004-07-07 | fração de quil a com baixa toxidez e seu uso |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US8821881B2 (pt) |
| EP (1) | EP1648505B1 (pt) |
| JP (1) | JP4731475B2 (pt) |
| AT (1) | ATE442164T1 (pt) |
| AU (1) | AU2004254152B2 (pt) |
| BR (1) | BRPI0412444B8 (pt) |
| CA (1) | CA2529363C (pt) |
| DE (1) | DE602004023089D1 (pt) |
| DK (1) | DK1648505T3 (pt) |
| ES (1) | ES2331952T3 (pt) |
| NZ (1) | NZ544299A (pt) |
| PL (1) | PL1648505T3 (pt) |
| SE (1) | SE0301998D0 (pt) |
| WO (1) | WO2005002620A1 (pt) |
| ZA (1) | ZA200600151B (pt) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1104306E (pt) * | 1998-08-10 | 2006-05-31 | Antigenics Inc | Composicoes de cpg e adjuvantes de saponina e seus metodos |
| SE0202110D0 (sv) * | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| US8007806B2 (en) | 2005-01-20 | 2011-08-30 | Isconova Ab | Vaccine composition comprising a fibronectin binding protein or a fibronectin binding peptide |
| EP1764369A1 (de) * | 2005-09-16 | 2007-03-21 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
| CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| PT2054431E (pt) | 2006-06-09 | 2011-11-03 | Novartis Ag | Confórmeros de adesinas bacterianas |
| EP1902727A1 (de) * | 2006-09-22 | 2008-03-26 | Rhein Biotech Gesellschaft für neue biotechnologische Prozesse und Produkte mbH | Vakzine enthaltend trunkiertes HBV core protein plus Saponin-basierendes Adjuvants |
| WO2008031878A1 (en) * | 2006-09-15 | 2008-03-20 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | A composition for therapy and/or for prophylaxis of hbv-infections and hbv-mediated diseases |
| DK2094278T3 (en) * | 2006-11-20 | 2017-07-24 | Duecom | USE OF LIPID-CONTAINING PARTICLES INCLUDING QUILLAJA SAPONINS FOR CANCER TREATMENT |
| KR20100045437A (ko) | 2007-06-27 | 2010-05-03 | 노파르티스 아게 | 첨가물이 적은 인플루엔자 백신 |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
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| US8771709B2 (en) | 2010-09-20 | 2014-07-08 | Crucell Holland B.V. | Therapeutic vaccination against active Tuberculosis |
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| EP3566714A1 (en) | 2011-11-28 | 2019-11-13 | Janssen Vaccines & Prevention B.V. | Influenza virus vaccines and uses thereof |
| US8932607B2 (en) | 2012-03-12 | 2015-01-13 | Crucell Holland B.V. | Batches of recombinant adenovirus with altered terminal ends |
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Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS5839376B2 (ja) * | 1978-10-30 | 1983-08-30 | 富士通株式会社 | イオン注入法 |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| ATE71303T1 (de) | 1986-01-14 | 1992-01-15 | Nederlanden Staat | Verfahren zur herstellung immunologischer komplexe und diese enthaltende pharmazeutische zusammensetzung. |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| CA1331443C (en) | 1987-05-29 | 1994-08-16 | Charlotte A. Kensil | Saponin adjuvant |
| NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| NL9002314A (nl) | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
| US6231859B1 (en) | 1996-12-02 | 2001-05-15 | Aquila Biopharmaceuticals, Inc. | Saponin adjuvant compositions |
| AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| US6558670B1 (en) * | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
| SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
-
2003
- 2003-07-07 SE SE0301998A patent/SE0301998D0/xx unknown
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2004
- 2004-07-07 BR BRPI0412444A patent/BRPI0412444B8/pt active IP Right Grant
- 2004-07-07 EP EP04749076A patent/EP1648505B1/en not_active Expired - Lifetime
- 2004-07-07 ES ES04749076T patent/ES2331952T3/es not_active Expired - Lifetime
- 2004-07-07 WO PCT/SE2004/001038 patent/WO2005002620A1/en not_active Ceased
- 2004-07-07 JP JP2006518582A patent/JP4731475B2/ja not_active Expired - Lifetime
- 2004-07-07 AT AT04749076T patent/ATE442164T1/de not_active IP Right Cessation
- 2004-07-07 PL PL04749076T patent/PL1648505T3/pl unknown
- 2004-07-07 CA CA2529363A patent/CA2529363C/en not_active Expired - Lifetime
- 2004-07-07 DE DE602004023089T patent/DE602004023089D1/de not_active Expired - Lifetime
- 2004-07-07 US US10/562,866 patent/US8821881B2/en active Active
- 2004-07-07 NZ NZ544299A patent/NZ544299A/en not_active IP Right Cessation
- 2004-07-07 AU AU2004254152A patent/AU2004254152B2/en not_active Expired
- 2004-07-07 DK DK04749076T patent/DK1648505T3/da active
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2006
- 2006-01-06 ZA ZA200600151A patent/ZA200600151B/en unknown
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2014
- 2014-07-29 US US14/445,690 patent/US20140335049A1/en not_active Abandoned
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2015
- 2015-05-18 US US14/714,664 patent/US20150320858A1/en not_active Abandoned
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2016
- 2016-02-26 US US15/054,801 patent/US20160184427A1/en not_active Abandoned
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2018
- 2018-01-18 US US15/874,262 patent/US20180369368A1/en not_active Abandoned
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2019
- 2019-12-03 US US16/701,948 patent/US20200345840A1/en not_active Abandoned
-
2021
- 2021-09-17 US US17/477,739 patent/US20220241408A1/en not_active Abandoned
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2023
- 2023-10-04 US US18/376,666 patent/US12171828B2/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| US20150320858A1 (en) | 2015-11-12 |
| DK1648505T3 (da) | 2009-12-21 |
| PL1648505T3 (pl) | 2010-02-26 |
| ATE442164T1 (de) | 2009-09-15 |
| US20220241408A1 (en) | 2022-08-04 |
| US20160184427A1 (en) | 2016-06-30 |
| CA2529363A1 (en) | 2005-01-13 |
| JP4731475B2 (ja) | 2011-07-27 |
| BRPI0412444B1 (pt) | 2016-06-14 |
| US8821881B2 (en) | 2014-09-02 |
| AU2004254152A1 (en) | 2005-01-13 |
| US20200345840A1 (en) | 2020-11-05 |
| US12171828B2 (en) | 2024-12-24 |
| SE0301998D0 (sv) | 2003-07-07 |
| EP1648505A1 (en) | 2006-04-26 |
| ES2331952T3 (es) | 2010-01-21 |
| DE602004023089D1 (de) | 2009-10-22 |
| US20140335049A1 (en) | 2014-11-13 |
| WO2005002620A1 (en) | 2005-01-13 |
| AU2004254152B2 (en) | 2009-10-29 |
| JP2007527386A (ja) | 2007-09-27 |
| US20060239963A1 (en) | 2006-10-26 |
| EP1648505B1 (en) | 2009-09-09 |
| ZA200600151B (en) | 2007-01-31 |
| US20240024468A1 (en) | 2024-01-25 |
| NZ544299A (en) | 2009-03-31 |
| US20180369368A1 (en) | 2018-12-27 |
| CA2529363C (en) | 2013-04-02 |
| BRPI0412444B8 (pt) | 2021-05-25 |
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