BRPI0413309B8 - método para a preparação de uma vacina conjugada de polissacarídeo-proteína - Google Patents

método para a preparação de uma vacina conjugada de polissacarídeo-proteína

Info

Publication number
BRPI0413309B8
BRPI0413309B8 BRPI0413309A BRPI0413309A BRPI0413309B8 BR PI0413309 B8 BRPI0413309 B8 BR PI0413309B8 BR PI0413309 A BRPI0413309 A BR PI0413309A BR PI0413309 A BRPI0413309 A BR PI0413309A BR PI0413309 B8 BRPI0413309 B8 BR PI0413309B8
Authority
BR
Brazil
Prior art keywords
polysaccharide
protein conjugate
preparing
conjugate vaccine
reagent
Prior art date
Application number
BRPI0413309A
Other languages
English (en)
Inventor
E Frasch Carl
Robert Lee Che-Hung
Original Assignee
The Government Of The Us Secretary Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The Us Secretary Department Of Health And Human Services filed Critical The Government Of The Us Secretary Department Of Health And Human Services
Publication of BRPI0413309A publication Critical patent/BRPI0413309A/pt
Publication of BRPI0413309B1 publication Critical patent/BRPI0413309B1/pt
Publication of BRPI0413309B8 publication Critical patent/BRPI0413309B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

vacinas conjugadas de polissacarida-proteína são providos métodos para a síntese e a fabricação de vacinas conjugadas de polissacarida-proteína em alto rendimento. os métodos envolvem a reação de um grupo hidrazida sobre um reagente com um grupo éster aldeído ou cianato sobre o outro reagente. a reação se processa rapidamente com uma alta eficiência de conjugação, tal que um processo simplificado de purificação pode ser empregado para separar o produto conjugado da não conjugada proteína e polissacarida e outros subprodutos de molécula pequena.
BRPI0413309A 2003-08-06 2004-08-06 método para a preparação de uma vacina conjugada de polissacarídeo-proteína BRPI0413309B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49338903P 2003-08-06 2003-08-06
US60/493,389 2003-08-06
PCT/US2004/025477 WO2005014037A2 (en) 2003-08-06 2004-08-06 Polysaccharide-protein conjugate vaccines

Publications (3)

Publication Number Publication Date
BRPI0413309A BRPI0413309A (pt) 2006-10-10
BRPI0413309B1 BRPI0413309B1 (pt) 2019-10-01
BRPI0413309B8 true BRPI0413309B8 (pt) 2021-05-25

Family

ID=34135243

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0413323A BRPI0413323B8 (pt) 2003-08-06 2004-08-06 método para a preparação de uma vacina meningocócica conjugada ao toxóide tetânico em volumes comerciais
BRPI0413309A BRPI0413309B8 (pt) 2003-08-06 2004-08-06 método para a preparação de uma vacina conjugada de polissacarídeo-proteína

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0413323A BRPI0413323B8 (pt) 2003-08-06 2004-08-06 método para a preparação de uma vacina meningocócica conjugada ao toxóide tetânico em volumes comerciais

Country Status (8)

Country Link
US (1) US9173931B2 (pt)
EP (4) EP1651262A2 (pt)
CN (4) CN102151331B (pt)
AU (2) AU2004263135B2 (pt)
BR (2) BRPI0413323B8 (pt)
CA (4) CA2948114C (pt)
WO (2) WO2005014037A2 (pt)
ZA (2) ZA200601689B (pt)

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GB0500787D0 (en) 2005-01-14 2005-02-23 Chiron Srl Integration of meningococcal conjugate vaccination
NZ550533A (en) * 2004-04-30 2010-02-26 Novartis Vaccines & Diagnostic Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin
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GB0502095D0 (en) 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
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Also Published As

Publication number Publication date
ZA200601688B (en) 2007-05-30
CA2534870C (en) 2014-05-06
CA2948114C (en) 2019-02-26
EP1651262A2 (en) 2006-05-03
CN100423774C (zh) 2008-10-08
EP1651261A2 (en) 2006-05-03
HK1195512A1 (zh) 2014-11-14
WO2005037320A3 (en) 2006-01-05
WO2005014037A3 (en) 2006-01-26
EP2366403B1 (en) 2014-10-08
WO2005014037A2 (en) 2005-02-17
CA2844154A1 (en) 2005-02-17
WO2005037320A2 (en) 2005-04-28
BRPI0413309B1 (pt) 2019-10-01
AU2004281630A1 (en) 2005-04-28
CA2844154C (en) 2016-12-20
BRPI0413323B8 (pt) 2021-05-25
EP2366404B1 (en) 2014-11-19
ZA200601689B (en) 2007-12-27
EP2366404A2 (en) 2011-09-21
US20070110762A1 (en) 2007-05-17
AU2004263135A1 (en) 2005-02-17
CA2534870A1 (en) 2005-02-17
EP2366403A3 (en) 2012-03-14
AU2004263135B2 (en) 2010-11-25
CN1863554A (zh) 2006-11-15
BRPI0413323B1 (pt) 2019-09-10
CN103623405A (zh) 2014-03-12
CA2948114A1 (en) 2005-02-17
CN103623405B (zh) 2016-06-15
CA2535043A1 (en) 2005-04-28
EP2366403A2 (en) 2011-09-21
EP2366404A3 (en) 2012-03-14
CN102151331A (zh) 2011-08-17
US9173931B2 (en) 2015-11-03
BRPI0413323A (pt) 2006-10-10
CN1863553A (zh) 2006-11-15
EP1651261B1 (en) 2014-10-08
CN102151331B (zh) 2013-10-30
CN1863553B (zh) 2011-05-04
BRPI0413309A (pt) 2006-10-10

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