ATE490318T1 - Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken - Google Patents

Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken

Info

Publication number
ATE490318T1
ATE490318T1 AT06818144T AT06818144T ATE490318T1 AT E490318 T1 ATE490318 T1 AT E490318T1 AT 06818144 T AT06818144 T AT 06818144T AT 06818144 T AT06818144 T AT 06818144T AT E490318 T1 ATE490318 T1 AT E490318T1
Authority
AT
Austria
Prior art keywords
mediating
enzyme
coding methods
large libraries
efficient synthesis
Prior art date
Application number
AT06818144T
Other languages
English (en)
Inventor
Thomas Franch
Mikkel Dybro Lundorf
Soren Jakobsen
Eva Kampmann Olsen
Anne Lee Andersen
Anette Holtmann
Anders Holm Hansen
Anders Malling Syrensen
Anne Goldbech
Leon Daen De
Ditte Kievsmose Kaldor
Frank Abilgaard Slyk
Birgitte Nystrup Husemoen
Johannes Dolberg
Kim Birkebek Jensen
Lene Petersen
Mads Nyrregaard-Madsen
Michael Anders Godskesen
Sanne Schroder Glad
Soren Neve
Thomas Thisted
Tine Titilola Akinleminu Kronborg
Christian Sams
Jakob Felding
Per-Ola Freskgaard
Alex Haahr Gouliaev
Henrik Pedersen
Original Assignee
Nuevolution As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution As filed Critical Nuevolution As
Application granted granted Critical
Publication of ATE490318T1 publication Critical patent/ATE490318T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06818144T 2005-12-01 2006-12-01 Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken ATE490318T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200501704 2005-12-01
US74149005P 2005-12-02 2005-12-02
PCT/DK2006/000685 WO2007062664A2 (en) 2005-12-01 2006-12-01 Enzymatic encoding methods for efficient synthesis of large libraries

Publications (1)

Publication Number Publication Date
ATE490318T1 true ATE490318T1 (de) 2010-12-15

Family

ID=38001974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06818144T ATE490318T1 (de) 2005-12-01 2006-12-01 Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken

Country Status (12)

Country Link
US (4) US9574189B2 (de)
EP (5) EP1957644B1 (de)
AT (1) ATE490318T1 (de)
DE (1) DE602006018648D1 (de)
DK (5) DK3305900T3 (de)
ES (2) ES2897529T3 (de)
HK (1) HK1245329A1 (de)
HU (1) HUE056836T2 (de)
LT (4) LT3305900T (de)
PT (2) PT3018206T (de)
SI (4) SI2341140T1 (de)
WO (1) WO2007062664A2 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (de) * 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
IL163822A0 (en) 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
AU2003266932B2 (en) 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
PT1558744E (pt) 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
CN101801521B (zh) 2007-05-14 2015-06-17 纽约州立大学研究基金会 生物膜中细菌细胞内的生理学分散响应诱导
US20100298324A1 (en) * 2007-12-19 2010-11-25 Smith Kline Beecham Corporation Prolyl Hydroxylase Inhibitors
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
CN102272117B (zh) 2008-11-14 2015-06-17 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
EP2387567B1 (de) 2009-01-14 2014-06-11 The Salk Institute for Biological Studies Gegen amyloidkrankheiten schützende verbindungen
EP3653763A1 (de) 2009-02-13 2020-05-20 X-Chem, Inc. Verfahren zur erstellung und durchsuchung von dna-codierten bibliotheken
ES2713873T3 (es) 2010-04-16 2019-05-24 Nuevolution As Complejos bifuncionales y métodos para hacer y utilizar tales complejos
US20130217585A1 (en) * 2010-08-25 2013-08-22 The Trustees Of The University Of Columbia In The City Of New York Quantitative Total Definition of Biologically Active Sequence Elements
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
WO2012178023A1 (en) 2011-06-23 2012-12-27 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
DK2748357T3 (en) * 2011-09-07 2018-07-16 X Chem Inc Methods for labeling DNA-encoded libraries
CA2879018A1 (en) 2012-07-13 2014-01-16 X-Chem, Inc. Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
US10174310B2 (en) * 2012-08-08 2019-01-08 Roche Sequencing Solutions, Inc. Increasing dynamic range for identifying multiple epitopes in cells
RU2519546C1 (ru) * 2013-01-16 2014-06-10 Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а
WO2014152715A1 (en) * 2013-03-15 2014-09-25 University Of Rochester Use of inhibitors of binding between a par-1 receptor and its ligands for the treatment of glioma
US11331643B2 (en) 2013-04-02 2022-05-17 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US11384377B2 (en) 2013-04-02 2022-07-12 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
JP6262848B2 (ja) 2013-05-21 2018-01-17 成都先導薬物開発有限公司 薬物標的の捕獲方法
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
CA2961493C (en) 2014-09-15 2023-10-03 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
EP3218479A1 (de) 2014-11-11 2017-09-20 Nanocore ApS Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften
US10900065B2 (en) 2014-11-14 2021-01-26 University Of Washington Methods and kits for labeling cellular molecules
CN119574873A (zh) * 2016-05-02 2025-03-07 Encodia公司 采用核酸编码的大分子分析
JP7283727B2 (ja) 2016-06-16 2023-05-30 ヘイスタック サイエンシィズ コーポレーション コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド
ES2870639T3 (es) 2016-10-24 2021-10-27 Geneinfosec Inc Ocultación de información presente en los ácidos nucleicos
US20180214476A1 (en) * 2017-02-01 2018-08-02 North Carolina State University Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation
WO2018162724A1 (en) * 2017-03-09 2018-09-13 Mab Discovery Gmbh Antibodies specifically binding to human il-1r7
US20200149034A1 (en) 2017-03-17 2020-05-14 Hitgen Ltd. Methods and Compositions for Synthesis of Encoded Libraries
US20180274001A1 (en) * 2017-03-21 2018-09-27 Molecular Assemblies, Inc. Nucleic acid synthesis using dna polymerase theta
EP3619340A4 (de) 2017-05-02 2021-01-20 Haystack Sciences Corporation Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon
US12220416B2 (en) * 2017-07-20 2025-02-11 Rush University Medical Center Methylene-tetrahydrofolate reductase isoform-based biomarker and method of use thereof
CN111295444B (zh) * 2017-09-25 2024-08-09 哈斯达克科学公司 用于寡核苷酸指导的组合化学的多项式编码
SG11202003923PA (en) * 2017-10-31 2020-05-28 Encodia Inc Methods and kits using nucleic acid encoding and/or label
US11513126B2 (en) * 2017-10-31 2022-11-29 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
WO2019089846A1 (en) * 2017-10-31 2019-05-09 Encodia, Inc. Methods and compositions for polypeptide analysis
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN108753861B (zh) * 2018-06-08 2022-02-01 福建省微生物研究所 一种毒三素链霉菌发酵产利普司他汀的培养基及方法
CN112513269A (zh) 2018-07-12 2021-03-16 德克萨斯大学系统董事会 通过寡核苷酸进行分子邻域检测
EP3861009A4 (de) 2018-10-05 2023-01-11 Board of Regents, The University of Texas System Erfassung und freisetzung von n-terminalem festphasenpeptid
WO2020163789A1 (en) * 2019-02-08 2020-08-13 The Trustees Of Columbia University In The City Of New York Single cell/exosome/vesicle protein profiling
US20220145362A1 (en) * 2019-03-14 2022-05-12 Haystack Sciences Corporation Methods and systems for processing or analyzing oligonucleotide encoded molecules
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
EP3958727A4 (de) 2019-04-23 2023-05-03 Encodia, Inc. Verfahren zur räumlichen analyse von proteinen und zugehörige kits
CN114072499B (zh) 2019-04-30 2024-08-06 Encodia公司 用于制备分析物的方法和相关试剂盒
US11926820B2 (en) * 2019-09-13 2024-03-12 Google Llc Methods and compositions for protein and peptide sequencing
US11834664B2 (en) 2019-09-13 2023-12-05 Google Llc Methods and compositions for protein and peptide sequencing
US11834756B2 (en) 2019-09-13 2023-12-05 Google Llc Methods and compositions for protein and peptide sequencing
GB2604481A (en) 2019-10-10 2022-09-07 1859 Inc Methods and systems for microfluidic screening
CN112779606A (zh) * 2019-11-06 2021-05-11 成都先导药物开发股份有限公司 一种On-DNA曼尼希反应的方法
EP4073263A4 (de) 2020-01-07 2023-11-08 Encodia, Inc. Verfahren zur stabilen komplexbildung und entsprechende kits
CN113105554B (zh) * 2020-01-13 2022-07-26 广东泰禾医药科技有限公司 一种抗肿瘤融合蛋白及其制法和应用
CN111269870A (zh) * 2020-03-06 2020-06-12 南京工业大学 一种高产胞苷酸的重组大肠杆菌及其应用
WO2022094148A1 (en) 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
CN113444730A (zh) * 2021-03-17 2021-09-28 昆明市延安医院 一种原发性肝细胞klotho基因转导干细胞筛选构建方法
CN113416713A (zh) * 2021-05-11 2021-09-21 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种重组腺病毒的构建及其应用
WO2022266658A1 (en) * 2021-06-17 2022-12-22 Insitro, Inc. Methods of preparing bivalent molecules
DE102021210272A1 (de) * 2021-09-16 2023-03-16 Continental Reifen Deutschland Gmbh Klebstoffzusammensetzung, Verfahren zum dauerhaften Verbinden einer ersten vulkanisierten Kautschukkomponente mit einer zweiten vulkanisierten Kautschukkomponente und Verbund umfassend eine erste vulkanisierte Kautschukkomponente und eine zweite vulkanisierte Kautschukkomponente
CN113755527B (zh) * 2021-10-21 2022-04-26 广东源心再生医学有限公司 一种同时表达plaur和gpld1基因的质粒载体及其构建方法
US12474346B2 (en) 2021-11-05 2025-11-18 Encodia, Inc. Methods and kits for multicycle encoding assay
EP4206674B1 (de) 2021-12-28 2025-10-22 Encodia, Inc. Serotypisierungs- und antikörperprofilierungsassays mit hohem durchsatz
CA3261351A1 (en) 2022-07-12 2024-01-18 Abrus Bio, Inc. DETERMINATION OF PROTEIN INFORMATION BY RECODED AMINO ACID POLYMERS INTO DNA POLYMERS
EP4573372A2 (de) 2022-08-19 2025-06-25 Abrus Bio, Inc. Bestimmung von proteininformationen durch umkodierung von aminosäurepolymeren in dna-polymeren

Family Cites Families (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719667A (en) 1970-08-24 1973-03-06 Lilly Co Eli Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters
US3840556A (en) 1971-05-28 1974-10-08 Lilly Co Eli Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby
JPS60222842A (ja) 1984-04-19 1985-11-07 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤およびその製造方法
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US6040166A (en) * 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4822731A (en) 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
EP0260032B1 (de) 1986-09-08 1994-01-26 Ajinomoto Co., Inc. Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
JPH04504651A (ja) 1988-11-18 1992-08-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 自然に存在しないアミノ酸をタンパク質に部位特異的に導入する方法
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
DK0494955T3 (da) 1989-10-05 1998-10-26 Optein Inc Cellefri syntese og isolering af hidtil ukendte gener og polypeptider
US5646265A (en) 1990-01-11 1997-07-08 Isis Pharmceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
AU8498091A (en) 1990-08-02 1992-03-02 Regents Of The University Of Colorado, The Systematic polypeptide evolution by reverse translation
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
US6037120A (en) 1995-10-12 2000-03-14 Benner; Steven Albert Recognition of oligonucleotides containing non-standard base pairs
US5432272A (en) * 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
WO1993003172A1 (en) 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5770358A (en) 1991-09-18 1998-06-23 Affymax Technologies N.V. Tagged synthetic oligomer libraries
US6197556B1 (en) * 1991-12-20 2001-03-06 The University Of Chicago Nucleic acid amplification using modular branched primers
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
DE69333087T2 (de) 1992-10-01 2004-05-06 The Trustees Of Columbia University In The City Of New York Komplexe kombinatorische chemische banken, die mit markierungen versehen sind
US6503759B1 (en) * 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5684169A (en) * 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
CA2151473A1 (en) 1992-12-11 1994-06-23 Ronald N . Zuckermann Synthesis of encoded polymers
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
DE69433010T2 (de) 1993-04-12 2004-06-09 Northwestern University, Evanston Verfahren zur darstellung von oligonukleotiden
US5840485A (en) * 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
ES2289194T3 (es) * 1993-05-27 2008-02-01 Aventis Pharmaceuticals Inc. Bibliotecas en fase solida codificadas, segregadas topologicamente.
US5473060A (en) * 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
EP0706531A4 (de) * 1993-07-02 1998-11-25 Lynx Therapeutics Inc Synthese verzweigter nukleinsäuren
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
DK96093D0 (da) 1993-08-25 1993-08-25 Symbicom Ab Improvements in molecular modelling and drug design
CN1525171A (zh) * 1993-10-01 2004-09-01 ŦԼ�и��ױ��Ǵ�ѧ���� 用标示物编码的多元组合化学库
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
NZ276860A (en) 1993-11-02 1997-09-22 Affymax Tech Nv Apparatus and its use for synthesising diverse molecular products on substrates
AU692212B2 (en) * 1993-12-17 1998-06-04 Roger S. Cubicciotti Nucleotide-directed assembly of bimolecular and multimolecular drugs and devices
EP0739486A4 (de) * 1994-01-13 1998-09-09 Univ Columbia Synthetische rezeptoren, bibliotheken und ihre verwendung
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5449613A (en) 1994-03-01 1995-09-12 The University Of Iowa Research Foundation Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent
US6936477B2 (en) * 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5643722A (en) * 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5663046A (en) 1994-06-22 1997-09-02 Pharmacopeia, Inc. Synthesis of combinatorial libraries
CA2193228A1 (en) 1994-06-23 1996-01-04 Christopher Holmes Photolabile compounds and methods for their use
WO1996003418A1 (en) 1994-07-26 1996-02-08 The Scripps Research Institute Soluble combinatorial libraries
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6045671A (en) 1994-10-18 2000-04-04 Symyx Technologies, Inc. Systems and methods for the combinatorial synthesis of novel materials
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
WO1996024847A1 (en) 1995-02-10 1996-08-15 Smithkline Beecham Corporation A process for identifiying pharmaceutically active agents using an epitope-tagged library
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
WO1996035669A1 (de) 1995-05-09 1996-11-14 Basf Aktiengesellschaft (het)aryloxy-, -thio-, aminocrotonate, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von tierischen schädlin gen und schadpilzen
US5679519A (en) * 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US6210900B1 (en) * 1995-05-23 2001-04-03 Smithkline Beecham Corporation Method of encoding a series of combinatorial libraries and developing structure activity relationships
US5830658A (en) 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5824471A (en) * 1995-06-05 1998-10-20 Brigham And Women's Hospital Detection of mismatches by cleavage of nucleic acid heteroduplexes
HUP9900910A2 (hu) 1995-06-07 1999-07-28 Lynx Therapeutics, Inc. Oligonukleotid jelzések osztályozáshoz és azonosításhoz
US5958792A (en) 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
US5795976A (en) * 1995-08-08 1998-08-18 The Board Of Trustees Of The Leland Stanford Junior University Detection of nucleic acid heteroduplex molecules by denaturing high-performance liquid chromatography and methods for comparative sequencing
US5723320A (en) * 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
US6495314B1 (en) 1995-09-29 2002-12-17 The Scripps Research Institute Process for characterizing proteins
DE19646372C1 (de) 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
WO1997019039A1 (en) 1995-11-17 1997-05-29 Novartis Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
CA2249419A1 (en) 1996-03-22 1997-09-25 Ontogen Corporation Methods for spatially-dispersed positionally-encoded combinatorial library synthesis
US6294325B1 (en) 1996-07-05 2001-09-25 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of thermostable multi genes and proteins and uses thereof
US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
US6355490B1 (en) 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis
DE19642751A1 (de) 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
US5954874A (en) 1996-10-17 1999-09-21 Hunter; Charles Eric Growth of bulk single crystals of aluminum nitride from a melt
EP1477561B1 (de) 1996-10-17 2008-12-10 Mitsubishi Chemical Corporation Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
ATE529509T1 (de) 1997-01-21 2011-11-15 Gen Hospital Corp Selektion von proteinen unter verwendung von rna- protein-fusionen
US6127533A (en) 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
US5739314A (en) 1997-04-25 1998-04-14 Hybridon, Inc. Method for synthesizing 2'-O-substituted pyrimidine nucleosides
US6620587B1 (en) 1997-05-28 2003-09-16 Discerna Limited Ribosome complexes as selection particles for in vitro display and evolution of proteins
US6969584B2 (en) 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
AU8147798A (en) 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6348322B1 (en) 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
US20030004122A1 (en) 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
WO1999042605A1 (en) 1998-02-21 1999-08-26 Schwabacher Alan W One dimensional chemical compound arrays and methods for assaying them
US6316616B1 (en) 1998-04-02 2001-11-13 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
AU3463699A (en) 1998-04-03 1999-10-25 Phylos, Inc. Addressable protein arrays
EP1073730A1 (de) 1998-04-17 2001-02-07 Whitehead For Biomedical Research Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden
WO1999060007A2 (en) 1998-05-15 1999-11-25 Isis Innovation Limited Libraries of oligomers labelled with different tags
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US5948648A (en) * 1998-05-29 1999-09-07 Khan; Shaheer H. Nucleotide compounds including a rigid linker
US6096875A (en) * 1998-05-29 2000-08-01 The Perlein-Elmer Corporation Nucleotide compounds including a rigid linker
EP1086064A2 (de) 1998-06-10 2001-03-28 Glycodesign Inc. Gerichtete kombinatorische verbindungsbibliothek und hochdurchsatz assays für deren screening
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
AU6502599A (en) 1998-10-05 2000-04-26 Lynx Therapeutics, Inc. Enzymatic synthesis of oligonucleotide tags
EP1119530A2 (de) 1998-10-09 2001-08-01 Pharmacopeia, Inc. Auswahl von codes für die codierung von kombinatorischen bibliotheken
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
CA2346989A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
AU6188699A (en) 1998-10-28 2000-05-15 Novozymes A/S Method for generating a gene library
US5942609A (en) 1998-11-12 1999-08-24 The Porkin-Elmer Corporation Ligation assembly and detection of polynucleotides on solid-support
ATE354675T1 (de) 1998-12-02 2007-03-15 Adnexus Therapeutics Inc Dna-protein fusionen sowie anwendungen derselben
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
AU2225000A (en) 1999-01-08 2000-07-24 Ceres, Inc. Sequence-determined dna fragments and corresponding polypeptides encoded thereby
AU2951599A (en) 1999-04-08 2000-11-14 Pavel Sergeev Synthesis of biologically active compounds in cells
CA2374390A1 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
CA2376623C (en) 1999-06-25 2011-04-19 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP1196637B1 (de) 1999-07-27 2007-04-25 Adnexus Therapeutics, Inc. Peptidakzeptor ligationsverfahren
GB9920194D0 (en) 1999-08-27 1999-10-27 Advanced Biotech Ltd A heat-stable thermostable DNA polymerase for use in nucleic acid amplification
DE60002821T2 (de) 1999-08-27 2004-05-06 Japan Science And Technology Corp., Kawaguchi Reversibel photokuppelnde nukleinsäure und phosphoramidit
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US20020048760A1 (en) * 1999-12-10 2002-04-25 Hyseq, Inc. Use of mismatch cleavage to detect complementary probes
DE60118527D1 (de) 2000-01-24 2006-05-18 Compound Therapeutics Inc Sensible und multiplexe diagnostische tests zur proteinanalyse
WO2001057523A1 (en) 2000-02-03 2001-08-09 Nanoscale Combinatorial Synthesis, Inc. Structure identification methods using mass measurements
US20020127598A1 (en) 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
US6368801B1 (en) * 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
HK1054410B (en) 2000-05-19 2008-03-07 Richard B. Williams In vitro evolution of nucleic acids and encoded polypeptide
US7244560B2 (en) 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
ATE360207T1 (de) * 2000-06-05 2007-05-15 Novartis Vaccines & Diagnostic Mikroarrays für durchführen von proteomanalyse
US20020115068A1 (en) 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
JP2004502705A (ja) 2000-07-03 2004-01-29 メルク　エンド　カムパニー　インコーポレーテッド コンビナトリアルライブラリーにおけるコード化方法
US6811977B2 (en) 2000-07-27 2004-11-02 California Institute Of Technology Rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping
US20020072887A1 (en) * 2000-08-18 2002-06-13 Sandor Szalma Interaction fingerprint annotations from protein structure models
WO2002020639A1 (en) 2000-09-08 2002-03-14 Isotag Technology, Inc. Monomeric dye inkjet printing ink formulations for invisible marking/identification
WO2002034948A2 (en) 2000-10-25 2002-05-02 City Of Hope Candidate region mismatch scanning for genotyping and mutation detection
JP2002315577A (ja) 2000-11-14 2002-10-29 Gencom Co 核酸ライブラリーの作製方法
AU2002257076A1 (en) 2001-03-19 2002-10-03 President And Fellows Of Harvard College Nucleic acid shuffling
IL158000A0 (en) 2001-03-19 2004-03-28 Harvard College Evolving new molecular function
WO2002083951A1 (en) 2001-04-10 2002-10-24 Northeastern University Multiplexed ligand/protein binding assays with pna labels
WO2002090581A2 (en) 2001-05-03 2002-11-14 Genevision Inc. A molecular tag code for monitoring a product and process using same
WO2004059289A2 (en) 2001-05-22 2004-07-15 Epicentre Technologies Target-dependent transcription using deletion mutants of n4 rna polymerase
AU2002312389A1 (en) 2001-06-05 2002-12-16 Irm Llc Functional proteomic profiling
EP2305808B1 (de) 2001-06-20 2016-03-02 Nuevolution A/S Matrizenabhängige Moleküle und Verfahren zur Verwendung derartiger Moleküle
EP1401850A1 (de) * 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
DE10145226A1 (de) 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
WO2003038558A2 (en) 2001-10-30 2003-05-08 Nanomics Biosystems Pty, Ltd. Device and methods for directed synthesis of chemical libraries
WO2003062417A1 (fr) 2002-01-22 2003-07-31 Mitsubishi Chemical Corporation Produit de ligation arn-adn, et utilisation correspondante
WO2003078445A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c=c double bond upon reaction
DE60231436D1 (de) 2002-03-08 2009-04-16 Eidgenoess Tech Hochschule Kodierte, selbst-assemblierende chemische bibliotheken (esachel)
WO2003078627A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
WO2003078446A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
EP1490384A2 (de) * 2002-03-15 2004-12-29 Nuevolution A/S Ein baublock zur c-c bindungsbildung
IL163822A0 (en) * 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
US7255991B2 (en) 2002-03-22 2007-08-14 Emory University Template-drive processes for synthesizing polymers and components related to such processes
ES2566761T3 (es) 2002-05-30 2016-04-15 The Scripps Research Institute Ligación de azidas y acetilenos catalizada por cobre
GB0213816D0 (en) 2002-06-14 2002-07-24 Univ Aston Method of producing DNA and protein libraries
EP1520040A2 (de) 2002-06-20 2005-04-06 Nuevolution A/S Mikroarrays zur darstellung von kodierten molekülen
EP1578777B1 (de) 2002-07-15 2008-11-26 The Trustees of Princeton University Iap-bindende verbindungen
AU2003242516A1 (en) 2002-07-23 2004-02-09 Nuevolution A/S Gene shuffling by template switching
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
WO2004016767A2 (en) 2002-08-19 2004-02-26 The President And Fellows Of Harvard College Evolving new molecular function
US20040197845A1 (en) 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
AU2003260291A1 (en) 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
WO2004029223A2 (en) * 2002-09-30 2004-04-08 Parallele Bioscience, Inc. Polynucleotide synthesis and labeling by kinetic sampling ligation
AU2003291677A1 (en) 2002-10-30 2004-05-25 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
PT1558744E (pt) * 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
EP1576188B1 (de) * 2002-11-21 2008-10-15 Epicentre Technologies Verfahren zur verwendung von riboprimern zur strangverdrängungsreplikation von zielsequenzen
US20040197804A1 (en) 2002-12-03 2004-10-07 Keefe Anthony D. Method for in vitro selection of 2'-substituted nucleic acids
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
AU2004209001B2 (en) 2003-01-29 2007-10-11 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
EP1597395A2 (de) * 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
EP1597394A2 (de) * 2003-02-21 2005-11-23 Nuevolution A/S Eine methode zur erlangung struktureller information über ein kodiertes molekül
JP4054871B2 (ja) 2003-02-24 2008-03-05 独立行政法人産業技術総合研究所 耐熱性ｄｎａリガーゼ
DK1608748T3 (da) 2003-03-20 2009-06-29 Nuevolution As Ligeringskodning af små molekyler
WO2004099441A2 (en) 2003-05-09 2004-11-18 Hyscite Discovery As Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
WO2005008240A2 (en) * 2003-07-03 2005-01-27 Biogen Idec Ma Inc. STRUCTURAL INTERACTION FINGERPRINT (SIFt)
EP1533385A1 (de) 2003-09-05 2005-05-25 Nuevolution A/S Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen
DE602004023960D1 (de) * 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7972994B2 (en) * 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1694693A2 (de) * 2003-12-17 2006-08-30 Praecis Pharmaceuticals Inc. Verfahren zur synthese codierter bibliotheken
EP1723255B1 (de) 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
US20050208503A1 (en) * 2004-03-16 2005-09-22 Handy Yowanto Chemical ligation of nucleic acids
ATE447020T1 (de) * 2004-03-22 2009-11-15 Nuevolution As Ligationscodierung unter verwendung von oligonukleotidbausteinen
GB2413796B (en) 2004-03-25 2006-03-29 Global Genomics Ab Methods and means for nucleic acid sequencing
WO2005116213A2 (en) 2004-04-15 2005-12-08 President And Fellows Of Harvard College Directed evolution of proteins
AU2005300886B2 (en) * 2004-11-08 2009-11-12 Vipergen Aps Structural nucleic acid guided chemical synthesis
WO2006053571A2 (en) 2004-11-22 2006-05-26 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
DK1836201T4 (da) 2004-12-20 2013-11-11 Genentech Inc Pyrrolidininhibitorer af IAP.
JP4969459B2 (ja) 2005-01-21 2012-07-04 プレジデント アンド フェロウズ オブ ハーバード カレッジ 核酸鋳型合成において使用される遊離反応体
US7968289B2 (en) 2005-05-03 2011-06-28 Ensemble Therapeutics Corporation Turn over probes and use thereof for nucleic acid detection
BRPI0611474A2 (pt) 2005-05-26 2010-09-14 Ensemble Discovery Corp biodetecção por quìmica modelada com ácido nucléico
WO2006130669A2 (en) 2005-05-31 2006-12-07 Ensemble Discovery Corporation Anchor-assisted fragment selection and directed assembly
EP1888746B1 (de) 2005-06-07 2010-03-17 President And Fellows Of Harvard College Geordnete mehrschrittsynthese mittels nukleinsäurevermittelter chemie
US20090203530A1 (en) 2005-06-07 2009-08-13 Liu David R Polymer evolution via templated synthesis
PL1910538T3 (pl) 2005-06-09 2011-12-30 Praecis Pharm Inc Sposób syntezy kodowanych bibliotek
ATE462005T1 (de) 2005-06-17 2010-04-15 Harvard College Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
US20090035824A1 (en) * 2005-06-17 2009-02-05 Liu David R Nucleic acid-templated chemistry in organic solvents
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
WO2007016488A2 (en) 2005-07-29 2007-02-08 Ensemble Discovery Corporation Analysis of encoded chemical libraries
WO2007053358A2 (en) 2005-10-28 2007-05-10 Praecis Pharmaceuticals, Inc. Methods for identifying compounds of interest using encoded libraries
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
WO2007124758A1 (en) 2006-05-03 2007-11-08 Vipergen Aps A method for preparing compounds by nucleic acid directed synthesis
US20100143499A1 (en) 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
EP2064348B1 (de) 2006-09-18 2012-02-08 Ensemble Therapeutics Corporation Profilierung einer rezeptorfamilie
JP2010504983A (ja) 2006-09-28 2010-02-18 アンサンブル ディスカバリー コーポレイション 核酸を鋳型とする化学による生物学的検出のための組成物および方法
US8383370B2 (en) 2007-01-30 2013-02-26 The Rockefeller University Modified RNA ligase for efficient 3′ modification of RNA
GB0712245D0 (en) * 2007-06-25 2007-08-01 Cythera Technologies Ltd Combinatorial libraries and related methods
WO2009018003A2 (en) 2007-07-27 2009-02-05 Ensemble Discovery Corporation Detection assays and use thereof
WO2009077173A2 (en) 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
TW201011006A (en) 2008-06-16 2010-03-16 Nuevolution As IAP binding compounds
ES2713873T3 (es) 2010-04-16 2019-05-24 Nuevolution As Complejos bifuncionales y métodos para hacer y utilizar tales complejos
US10597650B2 (en) * 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity

Also Published As

Publication number Publication date
EP3305900B1 (de) 2021-07-21
EP2336315A3 (de) 2012-02-22
SI2341140T1 (sl) 2017-12-29
ES2901551T3 (es) 2022-03-22
EP1957644B1 (de) 2010-12-01
DK1957644T3 (da) 2011-03-28
LT2341140T (lt) 2017-11-10
HUE056836T2 (hu) 2022-03-28
DK2336315T3 (da) 2017-11-06
US10287576B2 (en) 2019-05-14
EP2336315B1 (de) 2017-07-19
EP2341140A1 (de) 2011-07-06
SI3018206T1 (sl) 2022-02-28
DE602006018648D1 (de) 2011-01-13
EP3305900A1 (de) 2018-04-11
SI3305900T1 (sl) 2022-02-28
EP3018206A1 (de) 2016-05-11
WO2007062664A3 (en) 2007-08-02
LT3018206T (lt) 2021-12-10
LT3305900T (lt) 2021-11-10
EP2341140B1 (de) 2017-07-19
HK1245329A1 (en) 2018-08-24
DK3018206T3 (da) 2021-11-15
US11702652B2 (en) 2023-07-18
US9574189B2 (en) 2017-02-21
SI2336315T1 (sl) 2017-12-29
EP3018206B1 (de) 2021-08-11
DK3305900T3 (da) 2021-10-25
EP2336315A2 (de) 2011-06-22
EP1957644A2 (de) 2008-08-20
US20090264300A1 (en) 2009-10-22
PT3018206T (pt) 2021-11-15
LT2336315T (lt) 2017-11-10
ES2897529T3 (es) 2022-03-01
US20190330618A1 (en) 2019-10-31
PT3305900T (pt) 2021-10-27
US20200216836A1 (en) 2020-07-09
WO2007062664A2 (en) 2007-06-07
US20170247688A1 (en) 2017-08-31
DK2341140T3 (da) 2017-11-06

Similar Documents

Publication Publication Date Title
ATE490318T1 (de) Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken
DK3299463T3 (da) Enzymatisk kodning
Summerer et al. DNA‐Templated Synthesis: More Versatile than Expected
ATE358185T1 (de) Mutationsanalyse mittels pcr und massenspektrometrie
ATE420170T1 (de) Matrizengerichtete split-and-mix-synthese von bibliotheken kleiner moleküle
WO2007041342A3 (en) Labeled nucleotide analogs and uses therefor
ATE462005T1 (de) Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
ATE483020T1 (de) Enzymatische herstellung von nukleinsäuremolekülen
WO2004001042A3 (en) Microarrays displaying encoded molecules
WO2006079061A3 (en) Free reactant use in nucleic acid-templated synthesis
DE602005009693D1 (de) 2"-nitrobenzyl-modifizierte ribonukleotide
WO2005064018A3 (en) Microwave mediated synthesis of nucleic acid probes
DE69902799D1 (de) Von kreisförmiger Matrize abhängige Kettenreaktion
DE602005004834D1 (de) Ein verbessertes Verfahren für die Synthese von Methylphenidaten und Zwischenprodukten
Henry DNA synthesized from TNA template

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1957644

Country of ref document: EP