BRPI0413484A - processo para preparação de n-arilmorfolinonas - Google Patents

processo para preparação de n-arilmorfolinonas

Info

Publication number
BRPI0413484A
BRPI0413484A BRPI0413484-2A BRPI0413484A BRPI0413484A BR PI0413484 A BRPI0413484 A BR PI0413484A BR PI0413484 A BRPI0413484 A BR PI0413484A BR PI0413484 A BRPI0413484 A BR PI0413484A
Authority
BR
Brazil
Prior art keywords
arylmorpholinones
preparation
preparing
morpholinones
precursors
Prior art date
Application number
BRPI0413484-2A
Other languages
English (en)
Inventor
Dieter Dorsch
Bertram Cezanne
Werner Mederski
Christos Tsaklakidis
Hanns Wurziger
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0413484A publication Critical patent/BRPI0413484A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE N-ARIL-MORFOLINONAS". A presente invenção refere-se a um processo para preparação de compostos da fórmula (1) onde X possui o significado indicado na Reivindicação 1 da Patente e precursores do mesmo.
BRPI0413484-2A 2003-08-11 2004-07-16 processo para preparação de n-arilmorfolinonas BRPI0413484A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10336716A DE10336716A1 (de) 2003-08-11 2003-08-11 Verfahren zur Herstellung von N-Aryl-morpholinonen
PCT/EP2004/007938 WO2005016899A1 (de) 2003-08-11 2004-07-16 Verfahren zur herstellung von n-aryl-morpholinonen

Publications (1)

Publication Number Publication Date
BRPI0413484A true BRPI0413484A (pt) 2006-10-17

Family

ID=34177411

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413484-2A BRPI0413484A (pt) 2003-08-11 2004-07-16 processo para preparação de n-arilmorfolinonas

Country Status (19)

Country Link
US (2) US7687624B2 (pt)
EP (1) EP1654240B1 (pt)
JP (1) JP4668903B2 (pt)
KR (1) KR101119940B1 (pt)
CN (1) CN100537549C (pt)
AR (1) AR045244A1 (pt)
AT (1) ATE344252T1 (pt)
AU (1) AU2004265056B2 (pt)
BR (1) BRPI0413484A (pt)
CA (1) CA2535412C (pt)
DE (2) DE10336716A1 (pt)
DK (1) DK1654240T3 (pt)
ES (1) ES2275233T3 (pt)
MX (1) MXPA06001567A (pt)
PL (1) PL1654240T3 (pt)
PT (1) PT1654240E (pt)
RU (1) RU2343149C2 (pt)
WO (1) WO2005016899A1 (pt)
ZA (1) ZA200602068B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104211654B (zh) * 2013-08-13 2017-03-29 联化科技（台州）有限公司 一种利伐沙班中间体的制备方法以及中间体
CN103804221B (zh) * 2014-02-25 2016-09-14 湖北迅达药业股份有限公司 一种4-(4-氨基苯基)-3-吗啉酮的制备方法及其中间体
CN103804222A (zh) * 2014-02-25 2014-05-21 湖北迅达药业股份有限公司 一种4-（4-氨基苯基）-3-吗啉酮的合成方法及其中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3074939A (en) * 1961-06-26 1963-01-22 American Home Prod 10-(2-morpholinoethoxyacetyl) pheno-thiazine and its preparation
CH512247A (de) * 1968-05-02 1971-09-15 Bracco Ind Chimica Spa Neue Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
DE19743435A1 (de) * 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10102322A1 (de) 2001-01-19 2002-07-25 Merck Patent Gmbh Phenylderivate
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone

Also Published As

Publication number Publication date
CN100537549C (zh) 2009-09-09
KR20060066086A (ko) 2006-06-15
EP1654240A1 (de) 2006-05-10
ES2275233T3 (es) 2007-06-01
CN1832933A (zh) 2006-09-13
AU2004265056A1 (en) 2005-02-24
PT1654240E (pt) 2007-02-28
US7687624B2 (en) 2010-03-30
ZA200602068B (en) 2007-05-30
AU2004265056B2 (en) 2011-03-17
US20100210864A1 (en) 2010-08-19
AR045244A1 (es) 2005-10-19
KR101119940B1 (ko) 2012-03-19
PL1654240T3 (pl) 2007-02-28
RU2343149C2 (ru) 2009-01-10
JP2007501818A (ja) 2007-02-01
JP4668903B2 (ja) 2011-04-13
EP1654240B1 (de) 2006-11-02
CA2535412A1 (en) 2005-02-24
WO2005016899A1 (de) 2005-02-24
DE10336716A1 (de) 2005-03-10
CA2535412C (en) 2012-08-28
HK1095145A1 (en) 2007-04-27
DE502004001923D1 (de) 2006-12-14
DK1654240T3 (da) 2007-03-26
RU2006107291A (ru) 2007-09-20
US20060217550A1 (en) 2006-09-28
MXPA06001567A (es) 2006-05-15
ATE344252T1 (de) 2006-11-15

Similar Documents

Publication Publication Date Title
BRPI0500393A (pt) Processo para a sìntese e forma cristalina de agomelatina e composições farmacêuticas contendo-a
BR0215493A (pt) Processo para preparação de ésteres escopìnicos
BR0316375A (pt) Diazinopirimidinas
SE0104140D0 (sv) Novel Compounds
BRPI0607455A2 (pt) composto, processo para a preparação do mesmo, uso de um composto, e composição farmacêutica
BRPI0415613A (pt) novos compostos de diazaspiroalcanos e seu uso no tratamento de doenças mediadas por ccr8
BR9916633A (pt) Benzopiranos e benzoxepinas, composições farmacêuticas compreendendo-as e processo de preparação
EA200900023A1 (ru) Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли
ATE372767T1 (de) Dpp-iv-hemmer
BR9909844A (pt) Processo para sintetizar um composto, e, composto.
BRPI0413245A (pt) compostos heteroarila de 6 membros para o tratamento de distúrbio neurodegenerativos
BRPI0416287A (pt) compostos, processo para a manufatura dos mesmos, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que são moduladas por inibidores de accß e sua utilização
BRPI0512335A (pt) compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades e sua utilização
BRPI0806400A8 (pt) composto, composição farmacêutica, produtos, usos de pelo menos um composto, método in vitro, kit, ligantes e processo de preparação de um composto
BR0311984A (pt) Difenilazetidinonas substituìdas cationicamente, processo para a sua preparação, medicamentos contendo estes compostos e sua aplicação
CY1112960T1 (el) Παραγωγα ουριας, μεθοδοι για την παρασκευη τους και χρησεις αυτων
BRPI0502382A (pt) processo para a preparação de artigos moldados de poliuretano
BR0315574A (pt) Forma amorfa de esomeprazol, composição farmacêutica contendo o mesmo e processo para sua preparação
BR0212535A (pt) Compostos e composições como inibidores de catepsina
BRPI0410635A (pt) isÈmeros enriquecidos e opticamente puros de ligantes de quelação e agentes de contraste
BRPI0415203A (pt) pentanóis reestruturados, um processo para sua produção e seu uso como agentes antiinflamatórios
BR0110357A (pt) Sais bicìclicos e n-aciclados de aminas imidazo - 3 e imidazo -5
BRPI0406824A (pt) Indolonaoxazoldinonas antiibacterianas, intermediários para seu preparo e composições farmacêuticas que as contêm
BR0205062A (pt) Spandex e processo para produzir spandex
BRPI0409069A (pt) compostos quìmicos

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2264 DE 27/05/2014.