BRPI0414343A - combinações que compreendem ligantes de alfa-2-delta e inibidores da reabsorção de serotonina/noradrenalina - Google Patents

combinações que compreendem ligantes de alfa-2-delta e inibidores da reabsorção de serotonina/noradrenalina

Info

Publication number
BRPI0414343A
BRPI0414343A BRPI0414343-4A BRPI0414343A BRPI0414343A BR PI0414343 A BRPI0414343 A BR PI0414343A BR PI0414343 A BRPI0414343 A BR PI0414343A BR PI0414343 A BRPI0414343 A BR PI0414343A
Authority
BR
Brazil
Prior art keywords
serotonin
alpha
combinations
norepinephrine reuptake
reuptake inhibitors
Prior art date
Application number
BRPI0414343-4A
Other languages
English (en)
Inventor
David J Dooley
Mark John Field
Richard Griffith Williams
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0414343A publication Critical patent/BRPI0414343A/pt

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Abstract

"COMBINAçõES QUE COMPREENDEM LIGANTES DE ALFA-2-DELTA E INIBIDORES DA REABSORçãO DE SEROTONINA/NORADRENALINA". A presente invenção refere-se a uma combinação, particularmente uma combinação sinérgica, de um ligante de alfa-2-delta e um inibidor da reabsorção dupla de serotonina/noradrenalina (DSNRI) ou um ou ambos entre um inibidor seletivo da reabsorção de serotonina (SSRI) e um inibidor seletivo da reabsorção de noradrenalina (SNRI), e seus sais farmaceuticamente aceitáveis, suas composições farmacêuticas e seu uso no tratamento de dor, particularmente dor neuropática.
BRPI0414343-4A 2003-09-12 2004-09-06 combinações que compreendem ligantes de alfa-2-delta e inibidores da reabsorção de serotonina/noradrenalina BRPI0414343A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50255603P 2003-09-12 2003-09-12
PCT/IB2004/002943 WO2005025675A1 (en) 2003-09-12 2004-09-06 Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors

Publications (1)

Publication Number Publication Date
BRPI0414343A true BRPI0414343A (pt) 2006-11-07

Family

ID=34312404

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414343-4A BRPI0414343A (pt) 2003-09-12 2004-09-06 combinações que compreendem ligantes de alfa-2-delta e inibidores da reabsorção de serotonina/noradrenalina

Country Status (21)

Country Link
US (4) US20050059715A1 (pt)
EP (2) EP2156863A3 (pt)
JP (2) JP2007505097A (pt)
KR (1) KR100828218B1 (pt)
CN (1) CN1849153A (pt)
AR (1) AR045634A1 (pt)
AT (1) ATE449633T1 (pt)
AU (2) AU2004271800A1 (pt)
BR (1) BRPI0414343A (pt)
CA (1) CA2537402C (pt)
CO (1) CO5660280A2 (pt)
DE (1) DE602004024317D1 (pt)
ES (1) ES2334673T3 (pt)
IL (1) IL173904A0 (pt)
MX (1) MXPA06002789A (pt)
NO (1) NO20061083L (pt)
NZ (1) NZ545494A (pt)
RU (1) RU2320369C2 (pt)
TW (1) TW200526249A (pt)
WO (1) WO2005025675A1 (pt)
ZA (1) ZA200602077B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934061B3 (en) 1996-07-24 2015-01-21 Warner-Lambert Company LLC Isobutylgaba and its derivatives for the treatment of pain
US7704527B2 (en) * 2002-10-25 2010-04-27 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
BRPI0511941A (pt) * 2004-06-09 2008-01-22 Pfizer uso de (s, s)-reboxetina ou reboxetina racêmica
WO2007088473A2 (en) * 2006-02-03 2007-08-09 Neurocure Ltd Treatment and prevention of depression with pain, depression secondary to pain, and of neuropathic pain
TW200914457A (en) * 2007-05-31 2009-04-01 Kyowa Hakko Kogyo Kk Pyrimidodiazepinone derivative
WO2009136375A1 (en) * 2008-05-08 2009-11-12 Pfizer Inc Treatment of interstitial cystitis
EP2123626A1 (en) * 2008-05-21 2009-11-25 Laboratorios del Dr. Esteve S.A. Co-crystals of duloxetine and co-crystal formers for the treatment of pain
EP2453910B1 (en) 2009-07-15 2016-08-31 Portola Pharmaceuticals, Inc. Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding
KR101786818B1 (ko) 2010-07-30 2017-10-18 도레이 카부시키가이샤 신경장애성 동통의 치료제 또는 예방제
US10576045B2 (en) 2011-02-16 2020-03-03 Nir Barak Low dosage combinations of fluoxetine and reboxetine for treating obesity
JP5926406B2 (ja) * 2013-01-18 2016-05-25 有限会社ケムフィズ 神経因性疾病の治療のための医薬
JP6491213B2 (ja) * 2013-12-18 2019-03-27 ノヴァッセイ エスエー 疼痛および他の障害の治療のためのガンマ−アミノ酪酸(gaba)類似体
WO2017067870A1 (en) 2015-10-22 2017-04-27 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Combination of trazodone and gabapentin for the treatment of pain
IT201900006602A1 (it) 2019-05-07 2020-11-07 Acraf Composizione farmaceutica per il trattamento del dolore neuropatico

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3454554A (en) 1960-10-14 1969-07-08 Colgate Palmolive Co Aminoalkyliminodibenzyl compounds
BE674185A (pt) 1961-10-10
US3198834A (en) 1964-07-27 1965-08-03 Snc Science Union Et Compagnie Optical isomers of trifluoromethylated phenethylamines
NL129434C (pt) 1966-03-12
GB1177525A (en) 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest
BE759838A (fr) 1969-12-04 1971-06-03 Wellcome Found Cetones a activite biologique
US3885046A (en) 1969-12-04 1975-05-20 Burroughs Wellcome Co Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4194009A (en) 1974-01-10 1980-03-18 Eli Lilly And Company Aryloxyphenylpropylamines for obtaining a psychotropic effect
US4018895A (en) 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
US4626549A (en) 1974-01-10 1986-12-02 Eli Lilly And Company Treatment of obesity with aryloxyphenylpropylamines
US4314081A (en) 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
NL7503310A (nl) 1975-03-20 1976-09-22 Philips Nv Verbindingen met antidepressieve werking.
US4062843A (en) 1976-12-29 1977-12-13 G. D. Searle & Co. 23-Hydroxy-3-oxo-24-norchola-4,17(20)-dien-21-oic acid γ-lactone and intermediates thereto
IL56369A (en) 1978-01-20 1984-05-31 Erba Farmitalia Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
US4536518A (en) 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
DK149624C (da) 1983-03-07 1987-02-02 Ferrosan As Fremgangsmaade til fremstilling af (+)-trans-3-((4-methoxyphenoxy)-methyl)-1-methyl-4-phenylpiperidin eller et farmaceutisk acceptabelt salt heraf ud fra en blanding af enantiomererne
US4761501A (en) 1983-10-26 1988-08-02 American Home Products Corporation Substituted phenylacetamides
US4611078A (en) 1983-10-26 1986-09-09 American Home Products Corporation Substituted phenylacetonitriles
GB8419683D0 (en) 1984-08-02 1984-09-05 Erba Farmitalia 3-substituted derivatives of 1-amino-2-hydroxy-propane
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
DK0641330T3 (da) 1992-05-20 2001-12-03 Univ Northwestern Gaba- og L-glutaminsyreanaloger til antikrampeanfaldsbehandling
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
DE69712877T2 (de) 1996-02-07 2002-11-14 Warner-Lambert Co., Morris Plains Zyklischaminosäure als pharmazeutische mittel
DK0888286T3 (da) 1996-03-14 2002-02-18 Warner Lambert Co Nye substituerede cykliske aminosyrer som farmaceutiske midler
EA001214B1 (ru) 1996-03-14 2000-12-25 Варнер-Ламберт Компани Новые мостиковые циклические аминокислоты как фармацевтически применимые вещества
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
EP0934061B3 (en) * 1996-07-24 2015-01-21 Warner-Lambert Company LLC Isobutylgaba and its derivatives for the treatment of pain
NZ334898A (en) 1996-10-23 2000-09-29 Warner Lambert Co Substituted gamma aminobutyric acids as pharamceutical agents
WO1998046601A1 (en) * 1997-04-11 1998-10-22 Eli Lilly And Company Composition for treating pain
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US5942530A (en) * 1997-08-28 1999-08-24 Eli Lilly And Company Method for treating pain
ATE323067T1 (de) 1997-10-27 2006-04-15 Warner Lambert Co Zyklische aminosäuren und deren derivate als arzneimittel
CN1279667A (zh) 1997-12-16 2001-01-10 沃尼尔·朗伯公司 4(3)取代-4(3)-氨基甲基-(硫代)吡喃(噻喃)或-哌啶衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途
NZ503963A (en) 1997-12-16 2002-09-27 Warner Lambert Co 1-substituted-1-aminomethyl-cycloalkane derivatives, or gabapentin analogues, preparation and use in the treatment of neurological disorders
WO1999031074A2 (en) 1997-12-16 1999-06-24 Warner-Lambert Company ((cyclo)alkyl substituted)-.gamma.-aminobutyric acid derivatives (=gaba analogues), their preparation and their use in the treatment of neurological disorders
CA2309354A1 (en) * 1998-01-23 1999-07-29 Leslie Magnus-Miller Gabapentin and its derivatives for the treatment of muscular and skeletal pain
DE69911603T2 (de) * 1998-06-22 2004-07-29 Neurosearch A/S Synthese von 5- oder 8-bromoisoquinolin derivaten
YU56301A (sh) 1999-02-23 2004-05-12 Pfizer Products Inc. Inhibitori resorpcije monoamina za tretiranje poremećaja cns
JP3547360B2 (ja) 1999-03-30 2004-07-28 株式会社東芝 フィールドエミッション型表示装置及びその駆動方法
WO2000061234A1 (en) * 1999-04-09 2000-10-19 Warner-Lambert Company Combinations of gaba analogs and tricyclic compounds to treat depression
CZ300834B6 (cs) 1999-06-10 2009-08-19 Warner-Lambert Company Llc Mono- a disubstituované kyseliny 3-propyl-gamma-aminomáselné
US20020022662A1 (en) * 1999-06-15 2002-02-21 American Home Products Corporation Enantiomers of O-desmethyl venlafaxine
ATE305788T1 (de) * 1999-07-01 2005-10-15 Pharmacia & Upjohn Co Llc (s,s)-reboxetin zur behandlung von inkontinenz
HN2000000224A (es) 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
GB2362646A (en) 2000-05-26 2001-11-28 Warner Lambert Co Cyclic amino acid derivatives useful as pharmaceutical agents
GB2365425A (en) 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
NZ525143A (en) 2000-09-14 2005-12-23 Gruenenthal Chemie Beta-thio-amino acids
PE20021046A1 (es) 2000-09-30 2002-12-14 Gruenenthal Chemie Sulfonilguanidina que tiene afinidad al punto de fijacion de gabapentina
DE10048715A1 (de) 2000-09-30 2004-05-19 Grünenthal GmbH Verwendung von Aminosäure zur Behandlung von Schmerz
WO2002028881A1 (en) 2000-10-06 2002-04-11 Xenoport, Inc. Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
GB2367869B (en) 2000-10-14 2004-10-06 Trw Ltd Rear-axle demand for use with front push-through in electrohydraulic (EHB) braking systems
GB2368579A (en) 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
AU2002239257A1 (en) 2000-11-17 2002-06-03 Xenoport, Inc. Amino acid conjugates providing for sustained systemic concentrations of gaba analogues
US6500972B2 (en) * 2001-01-03 2002-12-31 Chinese Petroleim Corp. Synthesis of TMBQ with transition metal-containing molecular sieve as catalysts
US6500955B1 (en) * 2001-02-02 2002-12-31 National Institute Of Pharmaceutical Education And Research One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
CA2444053C (en) 2001-04-19 2008-06-17 Warner-Lambert Company Llc Fused bicyclic or tricyclic amino acids
AU783516B2 (en) * 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
ES2265040T3 (es) * 2001-05-25 2007-02-01 Warner-Lambert Company Llc Composicion farmaceutica liquida.
AU2002310409C1 (en) 2001-06-11 2008-04-17 Xenoport, Inc. Orally administered dosage forms of GABA analog prodrugs having reduced toxicity
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
CA2473536A1 (en) * 2002-01-16 2003-07-31 Endo Pharmaceuticals, Inc. Pharmaceutical composition and method for treating disorders of the central nervous system
JP4428053B2 (ja) * 2002-02-05 2010-03-10 味の素株式会社 ガバペンチン若しくはプレガバリンおよびn型カルシウムチャンネル拮抗剤を含有する医薬組成物
RU2286151C2 (ru) * 2002-02-22 2006-10-27 Уорнер-Ламберт Компани Ллс Комбинации альфа-2-дельта-лиганда с селективным ингибитором циклооксигеназы-2
PT1572173E (pt) * 2002-12-13 2010-05-10 Warner Lambert Co Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior

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AR045634A1 (es) 2005-11-02
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US20050059715A1 (en) 2005-03-17
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CA2537402C (en) 2009-05-05
CA2537402A1 (en) 2005-03-24
EP1663398A1 (en) 2006-06-07
ZA200602077B (en) 2007-06-27
IL173904A0 (en) 2006-07-05
EP2156863A3 (en) 2011-01-12
ATE449633T1 (de) 2009-12-15
WO2005025675A1 (en) 2005-03-24
US20100081718A1 (en) 2010-04-01
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US20120329781A1 (en) 2012-12-27
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DE602004024317D1 (de) 2010-01-07
RU2006107552A (ru) 2007-09-20
NZ545494A (en) 2009-10-30
EP1663398B1 (en) 2009-11-25
CN1849153A (zh) 2006-10-18
KR20060082861A (ko) 2006-07-19
JP2012144545A (ja) 2012-08-02
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