BRPI0414791A - derivados de purina inibidores da replicação do hiv - Google Patents

derivados de purina inibidores da replicação do hiv

Info

Publication number
BRPI0414791A
BRPI0414791A BRPI0414791-0A BRPI0414791A BRPI0414791A BR PI0414791 A BRPI0414791 A BR PI0414791A BR PI0414791 A BRPI0414791 A BR PI0414791A BR PI0414791 A BRPI0414791 A BR PI0414791A
Authority
BR
Brazil
Prior art keywords
formula
radical
purine derivatives
hiv replication
compound
Prior art date
Application number
BRPI0414791-0A
Other languages
English (en)
Inventor
Paul Adriaan Jan Janssen
Marc Rene De Jonge
Lucien Maria Henricus Koymans
Frederik Frans Desire Daeyaert
Jan Heeres
Hendrik Maarten Vinkers
Ruben Gerardus George Leenders
Dirk Alfons Leo Vandenput
Paulus Joannes Lewi
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0414791A publication Critical patent/BRPI0414791A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADOS DE PURINA INIBIDORES DA REPLICAçãO DO HIV". A presente invenção diz respeito ao uso de um composto de fórmula (I) para a fabricação de um medicamento para a prevenção ou o tratamento de infecção por HIV em que o composto de fórmula (I) é um composto de fórmula (I), um N-óxido, um sal de adição farmaceuticamente aceitável, uma amina quaternária ou uma forma estereoquimicamente isomérica deste, em que A e B cada um representa um radical de fórmula (a) ou (b) e, em que -C-D- representa um radical bivalente de fórmula -N=CH-NR¬ 17¬-(c-1); ou -NR¬ 17¬-CH=N-(c-2); contanto que quando A representa um radical de fórmula (a) então B representa um radical de fórmula (b) e quando A representa um radical de fórmula (b) então B representa um radical de fórmula (a).
BRPI0414791-0A 2003-09-25 2004-09-21 derivados de purina inibidores da replicação do hiv BRPI0414791A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0350659 2003-09-25
PCT/EP2004/052262 WO2005028479A2 (en) 2003-09-25 2004-09-21 Hiv replication inhibiting purine derivatives

Publications (1)

Publication Number Publication Date
BRPI0414791A true BRPI0414791A (pt) 2006-11-21

Family

ID=34354400

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414791-0A BRPI0414791A (pt) 2003-09-25 2004-09-21 derivados de purina inibidores da replicação do hiv

Country Status (19)

Country Link
US (1) US8026245B2 (pt)
EP (1) EP1668011B1 (pt)
JP (1) JP5506751B2 (pt)
KR (1) KR20060121878A (pt)
CN (1) CN100475815C (pt)
AP (1) AP2006003517A0 (pt)
AT (1) ATE500254T1 (pt)
AU (1) AU2004274185B2 (pt)
BR (1) BRPI0414791A (pt)
CA (1) CA2535313C (pt)
DE (1) DE602004031641D1 (pt)
EA (1) EA009734B1 (pt)
ES (1) ES2361835T3 (pt)
IL (1) IL174467A0 (pt)
MX (1) MXPA06002069A (pt)
NO (1) NO20061788L (pt)
TW (1) TW200518758A (pt)
WO (1) WO2005028479A2 (pt)
ZA (1) ZA200602440B (pt)

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BRPI0515500A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados piridazina para inibição de estearoil-coa-desaturase
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BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
AU2006230447A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
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CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
BRPI0610876B8 (pt) 2005-06-08 2021-05-25 Rigel Pharmaceuticals Inc composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
ES2622493T3 (es) 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta de JAK
EP2132211A4 (en) * 2006-11-09 2011-12-07 Ardea Biosciences Inc 4-CYANPHENYLAMINO-SUBSTITUTED BICYCLIC AND HETEROCYCLIC COMPOUNDS AS AN HIV HEMMER
AU2008210455A1 (en) 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
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ES2389752T3 (es) 2007-12-14 2012-10-31 Ardea Biosciences, Inc. Inhibidores de la transcriptasa inversa
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
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CA2732765A1 (en) 2008-08-06 2010-02-11 Vertex Pharmaceuticals Incorporated Aminopyridine kinase inhibitors
CA2760705A1 (en) 2009-05-06 2010-11-11 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
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JP5769733B2 (ja) 2010-01-27 2015-08-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ ピラゾロピリジンキナーゼ阻害剤
CA2787079A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
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FR2962438B1 (fr) 2010-07-06 2012-08-17 Sanofi Aventis Derives d'indolizines, procedes de preparation et application en therapeutique
CN103570688B (zh) * 2012-07-19 2016-06-08 中国科学院上海药物研究所 2，5-二氨甲基吡嗪类化合物、其药物组合物、制备方法和用途
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Also Published As

Publication number Publication date
MXPA06002069A (es) 2006-05-19
JP2012006945A (ja) 2012-01-12
CA2535313C (en) 2012-07-17
ZA200602440B (en) 2007-09-26
AU2004274185B2 (en) 2009-12-10
DE602004031641D1 (de) 2011-04-14
JP5506751B2 (ja) 2014-05-28
NO20061788L (no) 2006-04-24
EA009734B1 (ru) 2008-02-28
ES2361835T3 (es) 2011-06-22
CN1856496A (zh) 2006-11-01
EP1668011A2 (en) 2006-06-14
CN100475815C (zh) 2009-04-08
US8026245B2 (en) 2011-09-27
KR20060121878A (ko) 2006-11-29
JP2007506707A (ja) 2007-03-22
AP2006003517A0 (en) 2006-02-28
US20060293330A1 (en) 2006-12-28
WO2005028479A3 (en) 2005-06-16
AU2004274185A1 (en) 2005-03-31
ATE500254T1 (de) 2011-03-15
EA200600648A1 (ru) 2006-08-25
WO2005028479A2 (en) 2005-03-31
EP1668011B1 (en) 2011-03-02
JP4825672B2 (ja) 2011-11-30
TW200518758A (en) 2005-06-16
CA2535313A1 (en) 2005-03-31
IL174467A0 (en) 2006-08-01

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Legal Events

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]