ATE500254T1 - Die replikation von hiv hemmende purinderivate - Google Patents

Die replikation von hiv hemmende purinderivate

Info

Publication number: ATE500254T1
Authority: AT; Austria
Prior art keywords: hiv; replication; purine derivatives; derivatives inhibiting; inhibiting
Prior art date: 2003-09-25

Application number

AT04766834T

Other languages

English (en)

Inventor

Paulus Joannes Lewi

Jonge Marc Rene De

Lucien Maria H Koymans

Frederik F D Daeyaert

Jan Heeres

Hendrik Maarten Vinkers

Ruben Gerardus George Leenders

Dirk Alfons Leo Vandenput

Paul Janssen

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-25

Filing date

2004-09-21

Publication date

2011-03-15

2004-09-21 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE500254T1 publication Critical patent/ATE500254T1/de

Links

230000002401 inhibitory effect Effects 0.000 title 1
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
230000010076 replication Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT04766834T 2003-09-25 2004-09-21 Die replikation von hiv hemmende purinderivate ATE500254T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP0350659		2003-09-25
PCT/EP2004/052262 WO2005028479A2 (en)	2003-09-25	2004-09-21	Hiv replication inhibiting purine derivatives

Publications (1)

Publication Number	Publication Date
ATE500254T1 true ATE500254T1 (de)	2011-03-15

Family

ID=34354400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04766834T ATE500254T1 (de)	2003-09-25	2004-09-21	Die replikation von hiv hemmende purinderivate

Country Status (19)

Country	Link
US (1)	US8026245B2 (de)
EP (1)	EP1668011B1 (de)
JP (1)	JP5506751B2 (de)
KR (1)	KR20060121878A (de)
CN (1)	CN100475815C (de)
AP (1)	AP2006003517A0 (de)
AT (1)	ATE500254T1 (de)
AU (1)	AU2004274185B2 (de)
BR (1)	BRPI0414791A (de)
CA (1)	CA2535313C (de)
DE (1)	DE602004031641D1 (de)
EA (1)	EA009734B1 (de)
ES (1)	ES2361835T3 (de)
IL (1)	IL174467A0 (de)
MX (1)	MXPA06002069A (de)
NO (1)	NO20061788L (de)
TW (1)	TW200518758A (de)
WO (1)	WO2005028479A2 (de)
ZA (1)	ZA200602440B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
HRP20050089B1 (hr)	2002-07-29	2015-06-19	Rigel Pharmaceuticals	Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
JP4886511B2 (ja)	2003-07-30	2012-02-29	ライジェルファーマシューティカルズ，インコーポレイテッド	２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
AU2005218655A1 (en) *	2004-03-02	2005-09-15	Neurogen Corporation	Aryl substituted purine analogues
KR101241716B1 (ko)	2004-08-25	2013-03-08	아디아 바이오사이언스즈 인크.	ＨＩＶ 역 전사 효소의 억제제로서 Ｓ-트리아졸릴 α-메르캅토아세트아닐리드
WO2007050087A1 (en)	2004-08-25	2007-05-03	Ardea Biosciences, Inc.	N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
WO2006034341A2 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
US8071603B2 (en)	2004-09-20	2011-12-06	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
MX2007003327A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
CA2580855A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AR051026A1 (es)	2004-09-20	2006-12-13	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
BRPI0515482A (pt)	2004-09-20	2008-07-22	Xenon Pharmaceuticals Inc	derivados heterocìclicos e seus usos como agentes terapêuticos
TW200626138A (en)	2004-09-20	2006-08-01	Xenon Pharmaceuticals Inc	Heterocyclic derivatives and their use as therapeutic agents
BRPI0609509A2 (pt)	2005-03-30	2010-04-13	Conforma Therapeutics Corp	composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável
EP1877411B9 (de) *	2005-05-05	2012-08-29	Ardea Biosciences, Inc.	Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv
EP1881987B1 (de) *	2005-05-16	2016-10-19	Prometic Pharma Smt Limited	Purinderivate und ihre verwendung zur behandlung von autoimmunerkrankungen
US8541457B2 (en)	2005-06-03	2013-09-24	Xenon Pharmaceuticals Inc.	Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
AU2006254840B2 (en)	2005-06-08	2012-08-02	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the JAK pathway
US20070203161A1 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
ES2622493T3 (es)	2006-02-24	2017-07-06	Rigel Pharmaceuticals, Inc.	Composiciones y métodos para la inhibición de la ruta de JAK
EP2132211A4 (de) *	2006-11-09	2011-12-07	Ardea Biosciences Inc	4-cyanphenylamino-substituierte bizyklische und heterozyklische verbindungen als hiv-hemmer
JP2010518014A (ja)	2007-01-31	2010-05-27	バーテックスファーマシューティカルズインコーポレイテッド	キナーゼ阻害剤として有用な２−アミノピリジン誘導体
DK2217577T3 (da)	2007-11-27	2014-10-20	Ardea Biosciences Inc	Hidtil ukendte forbindelser og præparater og fremgangsmåder til anvendelse deraf
ES2389752T3 (es)	2007-12-14	2012-10-31	Ardea Biosciences, Inc.	Inhibidores de la transcriptasa inversa
JP5631310B2 (ja)	2008-07-23	2014-11-26	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	三環式ピラゾロピリジンキナーゼ阻害剤
EP2318407B1 (de)	2008-07-23	2013-01-02	Vertex Pharmaceuticals Incorporated	Pyrazolpyridine als kinaseinhibitoren
US8569337B2 (en)	2008-07-23	2013-10-29	Vertex Pharmaceuticals Incorporated	Tri-cyclic pyrazolopyridine kinase inhibitors
CA2732765A1 (en)	2008-08-06	2010-02-11	Vertex Pharmaceuticals Incorporated	Aminopyridine kinase inhibitors
WO2010129668A1 (en)	2009-05-06	2010-11-11	Vertex Pharmaceuticals Incorporated	Pyrazolopyridines
KR101447789B1 (ko)	2009-11-12	2014-10-06	에프. 호프만-라 로슈 아게	Ｎ-7 치환된 퓨린 및 피라졸로피리미딘 화합물, 조성물 및 사용 방법
US9067932B2 (en)	2010-01-27	2015-06-30	Vertex Pharmaceuticals Incorporated	Pyrazolopyridine kinase inhibitors
MX2012008643A (es)	2010-01-27	2013-02-26	Vertex Pharma	Inhibidores de cinasas de pirazolopiridinas.
CN102869663A (zh)	2010-01-27	2013-01-09	沃泰克斯药物股份有限公司	吡唑并吡嗪激酶抑制剂
EP2536696A1 (de)	2010-02-18	2012-12-26	Concert Pharmaceuticals Inc.	Pyrimidinderivate
FR2962438B1 (fr)	2010-07-06	2012-08-17	Sanofi Aventis	Derives d'indolizines, procedes de preparation et application en therapeutique
FR2962437B1 (fr)	2010-07-06	2012-08-17	Sanofi Aventis	Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique
CN103570688B (zh) *	2012-07-19	2016-06-08	中国科学院上海药物研究所	2，5-二氨甲基吡嗪类化合物、其药物组合物、制备方法和用途
EP3099672A4 (de)	2014-01-31	2017-09-20	ONO Pharmaceutical Co., Ltd.	Kondensierte imidazolverbindungen
BR112017012917A2 (pt)	2014-12-18	2018-03-13	Nissan Chemical Industries, Ltd.	?composto de cetona ou oxima ou sal do mesmo; produto químico agrícola e herbicida obtido do mesmo?
AU2017345736B2 (en)	2016-10-21	2022-04-07	Takeda Pharmaceutical Company Limited	TYK2 inhibitors and uses thereof
EP3870568B1 (de) *	2018-10-25	2023-06-28	Minakem	Verfahren zur herstellung von rilpivirine
CN110526873B (zh) *	2019-08-15	2022-09-16	复旦大学	氰乙烯基取代的苯并二芳基嘧啶类化合物及其制备方法和用途
CN114805369B (zh) *	2022-05-30	2023-05-16	自贡市第四人民医院(自贡市急救中心)	一种2，6-二取代嘌呤类化合物及制备方法及应用
KR20250101955A (ko) *	2023-12-27	2025-07-04	주식회사 에이조스바이오	신규 퓨린계 화합물 및 이의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3459731A (en) *	1966-12-16	1969-08-05	Corn Products Co	Cyclodextrin polyethers and their production
EP0862463A1 (de)	1995-11-23	1998-09-09	Janssen Pharmaceutica N.V.	Feste mischungen von cyclodextrinen, hergestellt durch schmelzextrusionsverfahren
US5866702A (en) *	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
NZ506679A (en)	1998-03-27	2002-11-26	Janssen Pharmaceutica Nv	HIV inhibiting pyrimidine derivatives
SK287269B6 (sk)	1998-11-10	2010-05-07	Janssen Pharmaceutica N. V.	Derivát pyrimidínu, jeho použitie, spôsob jeho prípravy a farmaceutická kompozícia, kombinácia a produkt s jeho obsahom
US6414147B1 (en) *	1998-12-23	2002-07-02	Neurogen Corporation	2-amino-9-alkylpurines: GABA brain receptor ligands
CZ27399A3 (cs) *	1999-01-26	2000-08-16	Ústav Experimentální Botaniky Av Čr	Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
GB9918035D0 (en)	1999-07-30	1999-09-29	Novartis Ag	Organic compounds
US20030187261A1 (en)	2000-01-07	2003-10-02	Libor Havlicek	Purine derivatives, process for their preparation and use thereof
JO3429B1 (ar) *	2001-08-13	2019-10-20	Janssen Pharmaceutica Nv	مشتقات برميدينات مثبطة فيروس الايدز
US6897307B2 (en) *	2002-03-28	2005-05-24	Novartis Ag	Process for preparing 2,6-diaminopurine derivatives
US20050124637A1 (en) *	2003-08-15	2005-06-09	Irm Llc	Compounds and compositions as inhibitors of receptor tyrosine kinase activity
EP1877411B9 (de) *	2005-05-05	2012-08-29	Ardea Biosciences, Inc.	Diaryl-purin, azapurine und deazapurine als nichtnukleoside reverse-transkriptase-inhibitoren zur behandlung von hiv

2004
- 2004-09-21 EA EA200600648A patent/EA009734B1/ru not_active IP Right Cessation
- 2004-09-21 BR BRPI0414791-0A patent/BRPI0414791A/pt not_active Application Discontinuation
- 2004-09-21 EP EP04766834A patent/EP1668011B1/de not_active Expired - Lifetime
- 2004-09-21 DE DE602004031641T patent/DE602004031641D1/de not_active Expired - Lifetime
- 2004-09-21 CN CNB2004800278401A patent/CN100475815C/zh not_active Expired - Fee Related
- 2004-09-21 CA CA2535313A patent/CA2535313C/en not_active Expired - Fee Related
- 2004-09-21 KR KR1020067005328A patent/KR20060121878A/ko not_active Withdrawn
- 2004-09-21 AP AP2006003517A patent/AP2006003517A0/xx unknown
- 2004-09-21 ES ES04766834T patent/ES2361835T3/es not_active Expired - Lifetime
- 2004-09-21 US US10/573,364 patent/US8026245B2/en not_active Expired - Fee Related
- 2004-09-21 MX MXPA06002069A patent/MXPA06002069A/es active IP Right Grant
- 2004-09-21 AU AU2004274185A patent/AU2004274185B2/en not_active Ceased
- 2004-09-21 WO PCT/EP2004/052262 patent/WO2005028479A2/en not_active Ceased
- 2004-09-21 AT AT04766834T patent/ATE500254T1/de not_active IP Right Cessation
- 2004-09-24 TW TW093128936A patent/TW200518758A/zh unknown
2006
- 2006-03-21 IL IL174467A patent/IL174467A0/en active IP Right Grant
- 2006-03-24 ZA ZA200602440A patent/ZA200602440B/en unknown
- 2006-04-24 NO NO20061788A patent/NO20061788L/no not_active Application Discontinuation
2011
- 2011-08-01 JP JP2011168572A patent/JP5506751B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN100475815C (zh)	2009-04-08
EA200600648A1 (ru)	2006-08-25
CA2535313C (en)	2012-07-17
KR20060121878A (ko)	2006-11-29
NO20061788L (no)	2006-04-24
WO2005028479A3 (en)	2005-06-16
JP4825672B2 (ja)	2011-11-30
AP2006003517A0 (en)	2006-02-28
CN1856496A (zh)	2006-11-01
IL174467A0 (en)	2006-08-01
EP1668011B1 (de)	2011-03-02
TW200518758A (en)	2005-06-16
AU2004274185B2 (en)	2009-12-10
ES2361835T3 (es)	2011-06-22
MXPA06002069A (es)	2006-05-19
BRPI0414791A (pt)	2006-11-21
JP2007506707A (ja)	2007-03-22
US20060293330A1 (en)	2006-12-28
JP2012006945A (ja)	2012-01-12
DE602004031641D1 (de)	2011-04-14
EA009734B1 (ru)	2008-02-28
JP5506751B2 (ja)	2014-05-28
EP1668011A2 (de)	2006-06-14
WO2005028479A2 (en)	2005-03-31
US8026245B2 (en)	2011-09-27
AU2004274185A1 (en)	2005-03-31
CA2535313A1 (en)	2005-03-31
ZA200602440B (en)	2007-09-26

Legal Events

Date	Code	Title	Description
2011-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE500254T1 (de)	2011-03-15	Die replikation von hiv hemmende purinderivate
ATE506353T1 (de)	2011-05-15	Die hiv-replikation inhibierende indan- substituierte pyrimidine
CY2012013I1 (el)	2015-08-05	Παραγωγα πυριμιδινης που αναστελλουν τον hiv
NO20054143D0 (no)	2005-09-06	Pyrimidinderivater for forhindringen av HIV-infeksjon
IS8275A (is)	2006-01-31	Píperasín afleiður til meðhöndlunar á HIV sýkingum
NL1024643A1 (nl)	2004-05-03	Purineverbindingen en gebruik daarvan.
EP1495141A4 (de)	2006-03-22	Hiv-therapeutikum
LTPA2013018I1 (lt)	2022-09-12	4-oksochinolino junginiai ir jų, kaip živ inregrazės inhibitorių, panaudojimas
ATE335755T1 (de)	2006-09-15	Antivirale nukleosidderivate
AR028423A1 (es)	2003-05-07	Inhibidores de la replicacion del hiv
IS7872A (is)	2005-05-30	Pýrrólópýrimidín afleiður
EP1587535A4 (de)	2010-02-24	N-cyclohexylaminocarbonyl-benzolsulfonamid-derivate
ATE340782T1 (de)	2006-10-15	Piperidinbenzolsulfonamidderivate
ATE352550T1 (de)	2007-02-15	Chinazolinderivate
DK1682493T3 (da)	2009-04-20	Amidoacetonitrilderivater
EP1500371A4 (de)	2011-07-27	Ultraschallgerät
DE602004013746D1 (de)	2008-06-26	Imidazol-4-yl-ethynyl-pyridin-derivate
ATE473981T1 (de)	2010-07-15	Antivirale diazaindol-dicarbonyl- piperazinylmittel
BR0312136B1 (pt)	2012-09-04	artigo ornamental.
EP1484367A4 (de)	2005-12-28	Wässriger einbrennlack
DE602004029209D1 (de)	2010-10-28	Bearbeitungszentrum
ATE449064T1 (de)	2009-12-15	Amidoacetonitrilderivate
ATE535775T1 (de)	2011-12-15	Präzisionsdendrometer
DK1603910T3 (da)	2009-11-23	Substituerede 2-(diazabicykloalkyl)-pyrimidon-derivater
CL2004000960A1 (es)	2005-03-18	3-aminobutenos, utiles como intermediarios en la sintesis de los inhibidores de las proteasas de vih.