NO20061788L - HIV-replikasjonshemmede purinderivater - Google Patents
HIV-replikasjonshemmede purinderivaterInfo
- Publication number
- NO20061788L NO20061788L NO20061788A NO20061788A NO20061788L NO 20061788 L NO20061788 L NO 20061788L NO 20061788 A NO20061788 A NO 20061788A NO 20061788 A NO20061788 A NO 20061788A NO 20061788 L NO20061788 L NO 20061788L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- radical
- hiv replication
- purine derivatives
- compound
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0350659 | 2003-09-25 | ||
| PCT/EP2004/052262 WO2005028479A2 (en) | 2003-09-25 | 2004-09-21 | Hiv replication inhibiting purine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20061788L true NO20061788L (no) | 2006-04-24 |
Family
ID=34354400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20061788A NO20061788L (no) | 2003-09-25 | 2006-04-24 | HIV-replikasjonshemmede purinderivater |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8026245B2 (pt) |
| EP (1) | EP1668011B1 (pt) |
| JP (1) | JP5506751B2 (pt) |
| KR (1) | KR20060121878A (pt) |
| CN (1) | CN100475815C (pt) |
| AP (1) | AP2006003517A0 (pt) |
| AT (1) | ATE500254T1 (pt) |
| AU (1) | AU2004274185B2 (pt) |
| BR (1) | BRPI0414791A (pt) |
| CA (1) | CA2535313C (pt) |
| DE (1) | DE602004031641D1 (pt) |
| EA (1) | EA009734B1 (pt) |
| ES (1) | ES2361835T3 (pt) |
| IL (1) | IL174467A0 (pt) |
| MX (1) | MXPA06002069A (pt) |
| NO (1) | NO20061788L (pt) |
| TW (1) | TW200518758A (pt) |
| WO (1) | WO2005028479A2 (pt) |
| ZA (1) | ZA200602440B (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| HRP20050089B1 (hr) | 2002-07-29 | 2015-06-19 | Rigel Pharmaceuticals | Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti |
| WO2005012294A1 (en) | 2003-07-30 | 2005-02-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
| EP1720877A4 (en) * | 2004-03-02 | 2009-11-04 | Neurogen Corp | ANALOGUES OF PURINS ARYL SUBSTITUTION |
| DK2135608T3 (da) | 2004-08-25 | 2012-01-23 | Ardea Biosciences Inc | S-triazolyl-alfa-mercaptoacetanilider som inhibitorer for HIV-revers transkriptase |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| BRPI0515500A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| AU2006230447A1 (en) | 2005-03-30 | 2006-10-05 | Conforma Therapeutics Corporation | Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors |
| AU2006244195B2 (en) | 2005-05-05 | 2012-03-15 | Ardea Biosciences, Inc. | Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV |
| WO2006136005A1 (en) * | 2005-05-16 | 2006-12-28 | Prometic Biosciences Inc. | Purine derivatives and their use for treatment of autoimmune diseases |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| BRPI0610876B8 (pt) | 2005-06-08 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel |
| US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| ES2622493T3 (es) | 2006-02-24 | 2017-07-06 | Rigel Pharmaceuticals, Inc. | Composiciones y métodos para la inhibición de la ruta de JAK |
| EP2132211A4 (en) * | 2006-11-09 | 2011-12-07 | Ardea Biosciences Inc | 4-CYANPHENYLAMINO-SUBSTITUTED BICYCLIC AND HETEROCYCLIC COMPOUNDS AS AN HIV HEMMER |
| AU2008210455A1 (en) | 2007-01-31 | 2008-08-07 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as kinase inhibitors |
| ME01294B (me) | 2007-11-27 | 2013-06-20 | Ardea Biosciences Inc | Nova jedinjenja i kompozicije i metode upotrebe |
| ES2389752T3 (es) | 2007-12-14 | 2012-10-31 | Ardea Biosciences, Inc. | Inhibidores de la transcriptasa inversa |
| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| ES2402087T3 (es) | 2008-07-23 | 2013-04-26 | Vertex Pharmaceuticals Incorporated | Inhibidores de la pirazolopiridina quinasa |
| AU2009274023A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| CA2732765A1 (en) | 2008-08-06 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Aminopyridine kinase inhibitors |
| CA2760705A1 (en) | 2009-05-06 | 2010-11-11 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines |
| EP2499143B1 (en) | 2009-11-12 | 2016-03-16 | F.Hoffmann-La Roche Ag | N7-substituted purine and pyrazolopyrimidine compounds, compositions and methods of use |
| JP5769733B2 (ja) | 2010-01-27 | 2015-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ピラゾロピリジンキナーゼ阻害剤 |
| CA2787079A1 (en) | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| EP2582702A1 (en) | 2010-01-27 | 2013-04-24 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
| WO2011103457A1 (en) | 2010-02-18 | 2011-08-25 | Concert Pharmaceuticals Inc. | Pyrimidine derivatives |
| FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
| FR2962438B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'indolizines, procedes de preparation et application en therapeutique |
| CN103570688B (zh) * | 2012-07-19 | 2016-06-08 | 中国科学院上海药物研究所 | 2，5-二氨甲基吡嗪类化合物、其药物组合物、制备方法和用途 |
| WO2015115673A1 (en) | 2014-01-31 | 2015-08-06 | Ono Pharmaceutical Co., Ltd. | Fused imidazole compounds |
| EP3235799B1 (en) | 2014-12-18 | 2022-02-23 | Nissan Chemical Corporation | Oxime compound and herbicide |
| EP3528816A4 (en) * | 2016-10-21 | 2020-04-08 | Nimbus Lakshmi, Inc. | TYK2 INHIBITORS AND USES THEREOF |
| US20210380540A1 (en) * | 2018-10-25 | 2021-12-09 | Minakem | Process for the preparation of rilpivirine |
| CN110526873B (zh) * | 2019-08-15 | 2022-09-16 | 复旦大学 | 氰乙烯基取代的苯并二芳基嘧啶类化合物及其制备方法和用途 |
| CN114805369B (zh) * | 2022-05-30 | 2023-05-16 | 自贡市第四人民医院(自贡市急救中心) | 一种2，6-二取代嘌呤类化合物及制备方法及应用 |
| KR20250101955A (ko) * | 2023-12-27 | 2025-07-04 | 주식회사 에이조스바이오 | 신규 퓨린계 화합물 및 이의 용도 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| BR9611562A (pt) | 1995-11-23 | 1999-03-02 | Janssen Pharmaceutica Nv | Misturas sólidas de ciclodextrinas preparadas via extrusão sob fusão |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| EA002973B1 (ru) | 1998-03-27 | 2002-12-26 | Янссен Фармацевтика Н.В. | Производные пиримидина в качестве ингибиторов репликации вируса иммунодефицита человека |
| SK287270B6 (sk) | 1998-11-10 | 2010-05-07 | Janssen Pharmaceutica N. V. | Derivát pyrimidínu |
| WO2000037471A1 (en) * | 1998-12-23 | 2000-06-29 | Neurogen Corporation | 2-amino-9-alkylpurines: gaba brain receptor ligands |
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| GB9918035D0 (en) * | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
| IL150594A0 (en) | 2000-01-07 | 2003-02-12 | Ustav Ex Botan Adademie Ved Ce | Purine derivatives, process for their preparation and use |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| US6897307B2 (en) * | 2002-03-28 | 2005-05-24 | Novartis Ag | Process for preparing 2,6-diaminopurine derivatives |
| MXPA06001758A (es) * | 2003-08-15 | 2006-08-11 | Irm Llc | Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk. |
| AU2006244195B2 (en) * | 2005-05-05 | 2012-03-15 | Ardea Biosciences, Inc. | Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV |
-
2004
- 2004-09-21 CN CNB2004800278401A patent/CN100475815C/zh not_active Expired - Fee Related
- 2004-09-21 BR BRPI0414791-0A patent/BRPI0414791A/pt not_active Application Discontinuation
- 2004-09-21 MX MXPA06002069A patent/MXPA06002069A/es active IP Right Grant
- 2004-09-21 WO PCT/EP2004/052262 patent/WO2005028479A2/en not_active Ceased
- 2004-09-21 US US10/573,364 patent/US8026245B2/en not_active Expired - Fee Related
- 2004-09-21 AT AT04766834T patent/ATE500254T1/de not_active IP Right Cessation
- 2004-09-21 AU AU2004274185A patent/AU2004274185B2/en not_active Ceased
- 2004-09-21 AP AP2006003517A patent/AP2006003517A0/xx unknown
- 2004-09-21 KR KR1020067005328A patent/KR20060121878A/ko not_active Withdrawn
- 2004-09-21 EP EP04766834A patent/EP1668011B1/en not_active Expired - Lifetime
- 2004-09-21 DE DE602004031641T patent/DE602004031641D1/de not_active Expired - Lifetime
- 2004-09-21 ES ES04766834T patent/ES2361835T3/es not_active Expired - Lifetime
- 2004-09-21 EA EA200600648A patent/EA009734B1/ru not_active IP Right Cessation
- 2004-09-21 CA CA2535313A patent/CA2535313C/en not_active Expired - Fee Related
- 2004-09-24 TW TW093128936A patent/TW200518758A/zh unknown
-
2006
- 2006-03-21 IL IL174467A patent/IL174467A0/en active IP Right Grant
- 2006-03-24 ZA ZA200602440A patent/ZA200602440B/en unknown
- 2006-04-24 NO NO20061788A patent/NO20061788L/no not_active Application Discontinuation
-
2011
- 2011-08-01 JP JP2011168572A patent/JP5506751B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06002069A (es) | 2006-05-19 |
| JP2012006945A (ja) | 2012-01-12 |
| CA2535313C (en) | 2012-07-17 |
| ZA200602440B (en) | 2007-09-26 |
| AU2004274185B2 (en) | 2009-12-10 |
| DE602004031641D1 (de) | 2011-04-14 |
| JP5506751B2 (ja) | 2014-05-28 |
| EA009734B1 (ru) | 2008-02-28 |
| ES2361835T3 (es) | 2011-06-22 |
| CN1856496A (zh) | 2006-11-01 |
| EP1668011A2 (en) | 2006-06-14 |
| CN100475815C (zh) | 2009-04-08 |
| US8026245B2 (en) | 2011-09-27 |
| KR20060121878A (ko) | 2006-11-29 |
| JP2007506707A (ja) | 2007-03-22 |
| AP2006003517A0 (en) | 2006-02-28 |
| US20060293330A1 (en) | 2006-12-28 |
| WO2005028479A3 (en) | 2005-06-16 |
| AU2004274185A1 (en) | 2005-03-31 |
| ATE500254T1 (de) | 2011-03-15 |
| EA200600648A1 (ru) | 2006-08-25 |
| WO2005028479A2 (en) | 2005-03-31 |
| EP1668011B1 (en) | 2011-03-02 |
| JP4825672B2 (ja) | 2011-11-30 |
| TW200518758A (en) | 2005-06-16 |
| CA2535313A1 (en) | 2005-03-31 |
| BRPI0414791A (pt) | 2006-11-21 |
| IL174467A0 (en) | 2006-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |