BRPI0415015A - certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos - Google Patents

certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos

Info

Publication number
BRPI0415015A
BRPI0415015A BRPI0415015-5A BRPI0415015A BRPI0415015A BR PI0415015 A BRPI0415015 A BR PI0415015A BR PI0415015 A BRPI0415015 A BR PI0415015A BR PI0415015 A BRPI0415015 A BR PI0415015A
Authority
BR
Brazil
Prior art keywords
pharmaceuticals
certain substituted
substituted spirocyclic
spirocyclic lactams
lactams
Prior art date
Application number
BRPI0415015-5A
Other languages
English (en)
Inventor
Yves Auberson
Ralf Glatthar
Rhys Salter
Oliver Simic
Marina Tintelnot-Blomley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0415015A publication Critical patent/BRPI0415015A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"CERTAS LACTAMAS ESPIROCìCLICAS SUBSTITUìDAS E USO DESTAS COMO PRODUTOS FARMACêUTICOS". A presente invenção refere-se a novas 2-(6-oxo-1,7-diaza-espirol¢4,4!non-7-il)-propionamidas da fórmula onde R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, m e p são como definidos na especificação, para sua preparação, para seu uso como produtos farmacêuticos e para suas composições farmacêuticas que contêm estes.
BRPI0415015-5A 2003-10-03 2004-10-04 certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos BRPI0415015A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0323204.8A GB0323204D0 (en) 2003-10-03 2003-10-03 Organic compounds
PCT/EP2004/011054 WO2005035535A1 (en) 2003-10-03 2004-10-04 Certain substituted spirocyclic lactams and use thereof as pharmaceuticals

Publications (1)

Publication Number Publication Date
BRPI0415015A true BRPI0415015A (pt) 2006-11-07

Family

ID=29415468

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415015-5A BRPI0415015A (pt) 2003-10-03 2004-10-04 certas lactamas espirocìclicas substituìdas e uso destas como produtos farmacêuticos

Country Status (15)

Country Link
US (2) US20070015781A1 (pt)
EP (1) EP1670803B1 (pt)
JP (1) JP4549350B2 (pt)
CN (1) CN1863804B (pt)
AT (1) ATE388954T1 (pt)
AU (1) AU2004279553C1 (pt)
BR (1) BRPI0415015A (pt)
CA (1) CA2540249A1 (pt)
DE (1) DE602004012426T2 (pt)
ES (1) ES2300815T3 (pt)
GB (1) GB0323204D0 (pt)
MX (1) MXPA06003645A (pt)
PL (1) PL1670803T3 (pt)
PT (1) PT1670803E (pt)
WO (1) WO2005035535A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20040762A1 (es) * 2002-11-27 2004-11-06 Elan Pharm Inc Ureas substituidas y carbamatos utiles para el tratamiento de la enfermedad de alzheimer
CA2609562A1 (en) * 2005-06-14 2006-12-28 Schering Corporation Macrocyclic heterocyclic aspartyl protease inhibitors
CA2615656A1 (en) * 2005-07-18 2007-01-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
US7745484B2 (en) * 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
MX2011003015A (es) 2008-09-18 2011-11-18 Univ Northwestern Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos.
GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
SG11201505937SA (en) 2013-01-29 2015-09-29 Naurex Inc Spiro-lactam nmda receptor modulators and uses thereof
CN105308049A (zh) 2013-01-29 2016-02-03 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
CA2898861C (en) 2013-01-29 2021-07-20 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
JP6419087B2 (ja) 2013-01-29 2018-11-07 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
WO2014120784A1 (en) 2013-01-29 2014-08-07 Naurex, Inc. Spiro-lactam nmda receptor modulators and uses thereof
PE20190174A1 (es) 2016-05-19 2019-02-01 Aptinyx Inc Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
JP2019527235A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
CN109890825B (zh) 2016-08-01 2022-03-11 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
PE20190501A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores nmda espiro-lactam y metodos de uso de los mismos
CA3031534C (en) 2016-08-01 2023-10-17 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
EP3490992B1 (en) 2016-08-01 2023-03-22 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
PE20210455A1 (es) 2018-01-31 2021-03-08 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos
BR112021026380A2 (pt) * 2019-06-24 2022-05-10 Naurex Inc Formas sólidas de (s)-2-((2s,3r)-1-amino-3-hidróxi-1-oxobutan-2-il)-1-oxo-2,5-diazaespiro[3.4]octano-5-carboxilato de terc-butila e métodos de preparação das mesmas
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy
EP4608834A1 (en) * 2022-10-26 2025-09-03 Protego Biopharma, Inc. Spirocycle containing pyridine compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
ES2162503T3 (es) * 1998-06-12 2001-12-16 Hoffmann La Roche Derivados diaza-espiro(3,5)nonanos.
US6613764B1 (en) * 1999-01-06 2003-09-02 The United States Of America As Represented By The Department Of Health And Human Services Aspartic protease inhibitors
JP2004534017A (ja) * 2001-04-27 2004-11-11 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｂａｃｅのインヒビター
CA2590750A1 (en) * 2004-12-20 2006-06-29 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Myd88 homodimerization inhibitors

Also Published As

Publication number Publication date
PT1670803E (pt) 2008-04-23
JP2007509038A (ja) 2007-04-12
EP1670803B1 (en) 2008-03-12
ES2300815T3 (es) 2008-06-16
US7655686B2 (en) 2010-02-02
MXPA06003645A (es) 2006-06-05
ATE388954T1 (de) 2008-03-15
US20070015781A1 (en) 2007-01-18
CA2540249A1 (en) 2005-04-21
CN1863804A (zh) 2006-11-15
DE602004012426T2 (de) 2009-03-26
AU2004279553B2 (en) 2009-03-12
GB0323204D0 (en) 2003-11-05
AU2004279553A1 (en) 2005-04-21
CN1863804B (zh) 2010-05-26
WO2005035535A1 (en) 2005-04-21
DE602004012426D1 (de) 2008-04-24
JP4549350B2 (ja) 2010-09-22
HK1092472A1 (en) 2007-02-09
AU2004279553C1 (en) 2009-07-23
PL1670803T3 (pl) 2008-08-29
US20070265328A1 (en) 2007-11-15
EP1670803A1 (en) 2006-06-21

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07D 487/10; A61P 25/00

Ipc: C07D 487/10 (2011.01), A61P 25/00 (2011.01)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.