BRPI0415215A - aplicação de um polifenol para o tratamento de uma lesão cancerosa ou pré-cancerosa da pele - Google Patents

aplicação de um polifenol para o tratamento de uma lesão cancerosa ou pré-cancerosa da pele

Info

Publication number
BRPI0415215A
BRPI0415215A BRPI0415215-8A BRPI0415215A BRPI0415215A BR PI0415215 A BRPI0415215 A BR PI0415215A BR PI0415215 A BRPI0415215 A BR PI0415215A BR PI0415215 A BRPI0415215 A BR PI0415215A
Authority
BR
Brazil
Prior art keywords
polyphenol
treatment
application
cancerous
precancerous skin
Prior art date
Application number
BRPI0415215-8A
Other languages
English (en)
Inventor
Eggert Stockfleth
Original Assignee
Medigene Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34465119&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0415215(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medigene Ag filed Critical Medigene Ag
Publication of BRPI0415215A publication Critical patent/BRPI0415215A/pt
Publication of BRPI0415215B1 publication Critical patent/BRPI0415215B1/pt
Publication of BRPI0415215B8 publication Critical patent/BRPI0415215B8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"APLICAçãO DE UM POLIFENOL PARA O TRATAMENTO DE UMA LESãO CANCEROSA OU PRé-CANCEROSA DA PELE". A presente invenção refere-se a um método para tratar lesões cancerosas ou pré-cancerosas da pele por meio da administração de uma quantidade farmaceuticamente eficaz de um polifenol a um paciente bem como à produção de um medicamento para o mesmo.
BRPI0415215A 2003-10-09 2004-10-08 uso de polifenol na preparação de medicamento BRPI0415215B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51010103P 2003-10-09 2003-10-09
US60/510,101 2003-10-09
PCT/EP2004/011300 WO2005037300A1 (en) 2003-10-09 2004-10-08 The use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin

Publications (3)

Publication Number Publication Date
BRPI0415215A true BRPI0415215A (pt) 2006-12-05
BRPI0415215B1 BRPI0415215B1 (pt) 2021-02-23
BRPI0415215B8 BRPI0415215B8 (pt) 2021-05-25

Family

ID=34465119

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415215A BRPI0415215B8 (pt) 2003-10-09 2004-10-08 uso de polifenol na preparação de medicamento

Country Status (13)

Country Link
US (3) US7910138B2 (pt)
EP (2) EP1684780B1 (pt)
AR (1) AR045865A1 (pt)
AU (1) AU2004281525B2 (pt)
BR (1) BRPI0415215B8 (pt)
CA (1) CA2541405C (pt)
ES (1) ES2391561T3 (pt)
IL (1) IL174434A0 (pt)
MX (1) MXPA06003404A (pt)
NZ (1) NZ546323A (pt)
RU (1) RU2366447C2 (pt)
WO (1) WO2005037300A1 (pt)
ZA (1) ZA200602544B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE417611T1 (de) * 2001-11-19 2009-01-15 Medigene Ag Arzneimittel zur behandlung von viralen haut- und tumorerkrankungen
US20050079235A1 (en) * 2003-10-09 2005-04-14 Eggert Stockfleth Use of a polyphenol for the treatment of actinic keratosis
AU2006222556B2 (en) * 2005-03-11 2011-09-29 Armaron Bio Pty Ltd Flavonoid compounds and uses thereof
RU2375089C1 (ru) * 2008-07-14 2009-12-10 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Способ кожесохраняющего, радикального лечения плоскоклеточного рака кожи без метастазов в региональные лимфатические узлы
RU2413484C1 (ru) * 2009-11-10 2011-03-10 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" Способ хирургического лечения доброкачественных новообразований век
RU2437672C1 (ru) * 2010-06-11 2011-12-27 Сергей Владимирович Енгашев Способ очистки экстракта зеленого чая, лекарственное средство на его основе и способ профилактики и лечения заболеваний кожи
RU2437671C1 (ru) * 2010-06-11 2011-12-27 Сергей Владимирович Енгашев Способ очистки экстракта зеленого чая, лекарственное средство на его основе и способ профилактики и лечения заболеваний кожи
CN110237447B (zh) 2013-09-27 2021-11-02 梅维昂医疗系统股份有限公司 粒子治疗系统
WO2015090853A1 (en) * 2013-12-20 2015-06-25 Unilever N.V. Sunless tanning
US10675487B2 (en) 2013-12-20 2020-06-09 Mevion Medical Systems, Inc. Energy degrader enabling high-speed energy switching
US9962560B2 (en) 2013-12-20 2018-05-08 Mevion Medical Systems, Inc. Collimator and energy degrader
US9661736B2 (en) 2014-02-20 2017-05-23 Mevion Medical Systems, Inc. Scanning system for a particle therapy system
US10786689B2 (en) 2015-11-10 2020-09-29 Mevion Medical Systems, Inc. Adaptive aperture
CN109803723B (zh) 2016-07-08 2021-05-14 迈胜医疗设备有限公司 一种粒子疗法系统
US11103730B2 (en) 2017-02-23 2021-08-31 Mevion Medical Systems, Inc. Automated treatment in particle therapy
JP6940676B2 (ja) 2017-06-30 2021-09-29 メビオン・メディカル・システムズ・インコーポレーテッド リニアモーターを使用して制御される構成可能コリメータ
WO2020185544A1 (en) 2019-03-08 2020-09-17 Mevion Medical Systems, Inc. Delivery of radiation by column and generating a treatment plan therefor
IT201900003843A1 (it) * 2019-03-15 2020-09-15 Lo Li Pharma Srl Trattamento di fibromi con vitamina D e un agente come l'epigallocatechina gallato (EGCG)
WO2025077883A1 (zh) * 2023-10-13 2025-04-17 恩康药业科技(广州)有限公司 治疗和/或预防皮肤癌或其癌前病变的化合物及方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002775A (en) 1973-07-09 1977-01-11 Kabara Jon J Fatty acids and derivatives of antimicrobial agents
JPS55105677A (en) 1979-02-07 1980-08-13 Norin Suisansyo Chiyagiyou Shikenjo Production of catechins
US4306568A (en) * 1979-12-04 1981-12-22 Torre Douglas P Method and apparatus for congelation cryometry in cryosurgery
EP0087161A3 (en) 1982-02-24 1984-04-04 Key Pharmaceuticals, Inc. Isopropylmyristate 4-alkyl-2,6-(bis-tert-butyl)-phenol medicament
JPS59219384A (ja) 1983-05-30 1984-12-10 Mitsui Norin Kk 天然抗酸化剤の製造方法
JPS6013780A (ja) 1983-07-05 1985-01-24 Mitsui Norin Kk 茶カテキン類の製造方法
JPS61238728A (ja) 1985-04-16 1986-10-24 Mitsui Norin Kk 茶葉抽出物と活性水酸化アルミニウムとの抗潰瘍性複合体
US4672810A (en) 1985-10-15 1987-06-16 Marlowe Christian P Hydraulic transmission device and method of using it
SE462894B (sv) 1985-10-28 1990-09-17 Biogram Ab Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
US4863970A (en) 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US5204089A (en) 1989-08-30 1993-04-20 Mitsui Norin Co., Ltd. Method of preventing the formation or aggrevation of dental plaque and method for reducing cariogenesis
JP2727471B2 (ja) 1989-09-14 1998-03-11 三井農林株式会社 インフルエンザウィルス感染予防剤
JP2888554B2 (ja) 1989-09-20 1999-05-10 三井農林株式会社 マイコプラズマ感染予防剤
US5318986A (en) 1989-10-19 1994-06-07 Mitsui Norin Co., Ltd. Method of inhibiting the activity of α-amylase
US5063787A (en) * 1989-11-22 1991-11-12 General Electric Company Venturi arrangement
US5358713A (en) 1990-02-23 1994-10-25 Mitsui Norin Co., Ltd. Method of preventing the transmission of infection caused by methicillin-resistant Staphylococcus aureus
JP3019996B2 (ja) 1990-03-01 2000-03-15 三井農林株式会社 白癬治療剤
JPH04253918A (ja) 1991-02-05 1992-09-09 Mitsui Norin Kk 血糖上昇抑制剤
US5303486A (en) * 1992-05-04 1994-04-19 Dell Gay D Quilting hoop
CA2136614C (en) 1992-06-08 2002-10-22 Petrus Johannes Meyer Nitrous oxide containing dermatological composition
US5306486A (en) 1993-03-01 1994-04-26 Elizabeth Arden Co., Division Of Conopco, Inc. Cosmetic sunscreen composition containing green tea and a sunscreen
JP3333584B2 (ja) 1993-04-19 2002-10-15 三井農林株式会社 歯質の耐酸性強化組成物
US5670154A (en) 1994-01-10 1997-09-23 Mitsui Norin Co., Ltd. Reducing tyrosinase activity
FR2718022B1 (fr) 1994-04-01 1996-04-26 Roussel Uclaf Compositions cosmétiques ou dermatologiques et leur préparation.
IL115156A (en) 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
JP2718653B2 (ja) 1995-01-31 1998-02-25 日本配合飼料株式会社 新規卵および卵質改良方法
IT1275905B1 (it) 1995-03-14 1997-10-24 Indena Spa Frazioni polifenoliche di te', loro uso e formulazioni che le contengono
GB2300578B (en) 1995-05-11 1998-01-14 Matsushita Seiko Kk Gargling cup,antiviral mask,antiviral filter,antifungal,antibacterial,and antiviral filter air cleaner and air-cleaner-humidifier
US5888527A (en) 1995-05-11 1999-03-30 Matsushita Seiko Co., Ltd. Gargling cup, antiviral mask, antiviral filter, antifungal, antibacterial, and antiviral filter air cleaner and air-cleaner humidifier
JPH09132532A (ja) 1995-09-06 1997-05-20 Mitsui Norin Kk 抗生物質の抗菌力増強方法
US6127393A (en) 1995-12-29 2000-10-03 Novactyl, Inc. Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method
US5804567A (en) 1996-07-18 1998-09-08 Cancer Institute (Hospital), Chinese Academy Of Medical Sciences Method of increasing the effectiveness of anti-metabolites
US6337320B1 (en) * 1996-10-11 2002-01-08 Thione International, Inc. Reparatives for ultraviolet radiation skin damage
ATE442844T1 (de) 1996-11-14 2009-10-15 Lipomedica Ehf Topische zusammensetzungen enthaltend als therapeutisch aktiven wirkstoff ein monoglycerid zur behandlung von schleimhautinfektionen
US5968973A (en) 1996-11-18 1999-10-19 Cancer Institute (Hospital), Chinese Academy Of Medical Sciences Method for treating hyperplasia
JP3213557B2 (ja) 1996-11-18 2001-10-02 三井農林株式会社 茶カテキンを有効成分として含有する尖圭コンジローマ治療剤
US6197808B1 (en) * 1996-11-18 2001-03-06 Cancer Instititute (Hospital), Chinese Academy Of Medical Sciences Methods for treating hyperplasia
AU6436998A (en) * 1997-02-20 1998-09-09 Yale University Therapeutic uses for antioxidants
JP3202938B2 (ja) 1997-03-18 2001-08-27 三井農林株式会社 チューインガム及びその製造法
US5910308A (en) 1997-03-19 1999-06-08 Sante International Inc. Herbal extract composition containing gynostemma pentaphyllum, crataegus pinnatifida and camellia sinensis
US6372234B1 (en) 1997-05-27 2002-04-16 Sembiosys Genetics Inc. Products for topical applications comprising oil bodies
AU1289899A (en) 1997-10-31 1999-05-24 Arch Development Corporation Methods and compositions for regulation of 5-alpha reductase activity
US6696484B2 (en) 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
US20020006447A1 (en) 1998-04-21 2002-01-17 Mitsui Norin Co., Ltd. Anti-chlamydia agent
KR100417703B1 (ko) 1998-04-21 2004-02-11 미쓰이 노린 가부시키가이샤 항클라미디아제
DE19827624A1 (de) 1998-06-20 1999-12-23 Beiersdorf Ag Verwendung von einem mit einem Gehalt an Catecinen oder einem Gehalt an Extrakt von grünem Tee in kosmetischen Zubereitungen zur Bräunung der Haut
SE9803929D0 (sv) 1998-11-18 1998-11-18 Medivir Ab Antiviral formulation
KR100319973B1 (ko) 1998-12-05 2002-04-22 이인수 녹차카테킨을 유효성분으로 하는 자궁경부 상피내종양 예방 또는 치료제 조성물
US6210679B1 (en) * 1999-01-07 2001-04-03 Hauser, Inc. Method for isolation of caffeine-free catechins from green tea
DE19962369A1 (de) 1999-12-23 2001-06-28 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Catechinen oder einem Gehalt an Extrakt von grünem Tee und einem weiteren Gehalt an Ascorbinsäure
US6248341B1 (en) 2000-01-14 2001-06-19 Color Access, Inc. Method of treating topical angiogenesis-related disorders
US20020031535A1 (en) * 2000-09-11 2002-03-14 Sheffield Felix H. Topical formulation to treat skin disorders
US6538023B1 (en) * 2000-09-15 2003-03-25 Tsuyoshi Ohnishi Therapeutic uses of green tea polyphenols for sickle cell disease
US6713506B2 (en) * 2000-10-11 2004-03-30 University Of South Florida Tea polyphenol esters and analogs thereof for cancer prevention and treatment
ATE417611T1 (de) 2001-11-19 2009-01-15 Medigene Ag Arzneimittel zur behandlung von viralen haut- und tumorerkrankungen
US20030143165A1 (en) * 2002-01-25 2003-07-31 Allan Evans NSAID-containing topical formulations that demonstrate chemopreventive activity
US20030166583A1 (en) * 2002-02-22 2003-09-04 Oliver Yoa-Pu Hu Dermal cytochrome P450 1A inhibitors and enhancers
US6723750B2 (en) * 2002-03-15 2004-04-20 Allergan, Inc. Photodynamic therapy for pre-melanomas
BRPI0204130B8 (pt) 2002-09-18 2021-05-25 Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp composição gel à base de extrato de pothomorphe umbellata, seus usos e método cosmético não-terapêutico.
US20040191842A1 (en) 2002-12-10 2004-09-30 Medical College Of Georgia Research Institute, Inc. Chemopreventive and therapeutic aspects of polyphenolic compositions and assays
US6817511B2 (en) * 2002-12-16 2004-11-16 Dana Corporation Method for joining axle components
WO2004080293A2 (en) 2003-03-13 2004-09-23 3M Innovative Properties Company Methods for diagnosing skin lesions
US20050079235A1 (en) 2003-10-09 2005-04-14 Eggert Stockfleth Use of a polyphenol for the treatment of actinic keratosis

Also Published As

Publication number Publication date
US20110166219A1 (en) 2011-07-07
CA2541405C (en) 2014-07-29
EP2292226A2 (en) 2011-03-09
EP1684780B1 (en) 2012-07-25
US9060998B2 (en) 2015-06-23
ES2391561T3 (es) 2012-11-27
EP1684780A1 (en) 2006-08-02
NZ546323A (en) 2009-04-30
AU2004281525B2 (en) 2010-01-28
IL174434A0 (en) 2006-08-01
US20070059387A1 (en) 2007-03-15
AU2004281525A1 (en) 2005-04-28
US8455022B2 (en) 2013-06-04
BRPI0415215B1 (pt) 2021-02-23
RU2366447C2 (ru) 2009-09-10
WO2005037300A1 (en) 2005-04-28
US7910138B2 (en) 2011-03-22
CA2541405A1 (en) 2005-04-28
MXPA06003404A (es) 2006-06-27
AR045865A1 (es) 2005-11-16
BRPI0415215B8 (pt) 2021-05-25
US20130245113A1 (en) 2013-09-19
RU2006115603A (ru) 2007-11-27
EP2292226A3 (en) 2011-08-10
ZA200602544B (en) 2007-06-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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Ipc: A61K 31/353 (2006.01), A61K 31/7048 (2006.01), A61

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