UA86041C2 - Сульфоксімінзаміщені піримідини як інгібітори cdk та/або vegf, їх одержання та застосування як лікарських засобів - Google Patents

Сульфоксімінзаміщені піримідини як інгібітори cdk та/або vegf, їх одержання та застосування як лікарських засобів

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Publication number
UA86041C2
UA86041C2 UAA200605171A UAA200605171A UA86041C2 UA 86041 C2 UA86041 C2 UA 86041C2 UA A200605171 A UAA200605171 A UA A200605171A UA A200605171 A UAA200605171 A UA A200605171A UA 86041 C2 UA86041 C2 UA 86041C2
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UA
Ukraine
Prior art keywords
drugs
sulfoximine
cdk
production
substituted pyrimidines
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Application number
UAA200605171A
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English (en)
Russian (ru)
Inventor
Ульріх Люкінг
Мартін Крюгер
Рольф Яутелат
Герхард Зімайстер
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Шерінг Акцієнгезелльшафт
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Publication of UA86041C2 publication Critical patent/UA86041C2/uk

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

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Abstract

Даний винахід стосується похідних піримідину загальної формули І EMBED ISISServer (І), в якій Q, R1, R2, R3, R4, R5, X і m мають значення такі, які вказано в описі, як інгібіторів циклінзалежних кіназ і тирозинкіназ рецептора VEGF, їх одержання, а також їх застосування як лікарських засобів для лікування різних захворювань.
UAA200605171A 2003-10-16 2004-10-12 Сульфоксімінзаміщені піримідини як інгібітори cdk та/або vegf, їх одержання та застосування як лікарських засобів UA86041C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349423A DE10349423A1 (de) 2003-10-16 2003-10-16 Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
PCT/EP2004/011661 WO2005037800A1 (de) 2003-10-16 2004-10-12 Sulfoximinsubstituierte pyrimidine als cdk- und/oder vegf-inhibitoren, deren herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
UA86041C2 true UA86041C2 (uk) 2009-03-25

Family

ID=34442222

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200605171A UA86041C2 (uk) 2003-10-16 2004-10-12 Сульфоксімінзаміщені піримідини як інгібітори cdk та/або vegf, їх одержання та застосування як лікарських засобів

Country Status (35)

Country Link
US (2) US8507510B2 (uk)
EP (1) EP1673352B1 (uk)
JP (1) JP4700006B2 (uk)
KR (1) KR101117387B1 (uk)
CN (1) CN1867553B (uk)
AR (1) AR046119A1 (uk)
AT (1) ATE427939T1 (uk)
AU (1) AU2004281960B2 (uk)
BR (1) BRPI0415421A (uk)
CA (1) CA2542492C (uk)
CR (1) CR8363A (uk)
CY (1) CY1110058T1 (uk)
DE (2) DE10349423A1 (uk)
DK (1) DK1673352T3 (uk)
EC (1) ECSP066568A (uk)
ES (1) ES2324475T3 (uk)
GT (1) GT200400206A (uk)
HR (1) HRP20090348T1 (uk)
IL (1) IL174952A (uk)
JO (1) JO2534B1 (uk)
ME (1) ME00158B (uk)
MX (1) MXPA06004091A (uk)
MY (1) MY140291A (uk)
NO (1) NO337290B1 (uk)
NZ (1) NZ546510A (uk)
PE (1) PE20050907A1 (uk)
PL (1) PL1673352T3 (uk)
PT (1) PT1673352E (uk)
RS (1) RS51657B (uk)
RU (1) RU2410378C2 (uk)
SI (1) SI1673352T1 (uk)
TW (1) TWI347844B (uk)
UA (1) UA86041C2 (uk)
WO (1) WO2005037800A1 (uk)
ZA (1) ZA200603885B (uk)

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