BRPI0415434A - compostos e métodos para tratar e prevenir arritmias cardìacas induzidas por exercìcios - Google Patents

compostos e métodos para tratar e prevenir arritmias cardìacas induzidas por exercìcios

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Publication number
BRPI0415434A
BRPI0415434A BRPI0415434-7A BRPI0415434A BRPI0415434A BR PI0415434 A BRPI0415434 A BR PI0415434A BR PI0415434 A BRPI0415434 A BR PI0415434A BR PI0415434 A BRPI0415434 A BR PI0415434A
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BR
Brazil
Prior art keywords
methods
preventing
induced
exercise
treating
Prior art date
Application number
BRPI0415434-7A
Other languages
English (en)
Inventor
Andrew Robert Marks
Donald W Landry
Shi Xian Deng
Zhen Zhuang Cheng
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Univ Columbia
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Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of BRPI0415434A publication Critical patent/BRPI0415434A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/325—Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/326—Arrhythmias, e.g. ventricular fibrillation, tachycardia, atrioventricular block, torsade de pointes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"COMPOSTOS E MéTODOS PARA TRATAR E PREVENIR ARRITMIAS CARDìACAS INDUZIDAS POR EXERCìCIOS". A presente invenção refere-se a um método para limitar ou prevenir uma diminuição no nível de FKBP12.6 ligado a RyR2 em um indivíduo, um método para tratar ou prevenir a arritmia cardíaca induzida por exercícios em um indivíduo, e um método para prevenir a morte cardíaca súbita induzida por exercícios em um indivíduo. Também são oferecidos os usos de JTV-519 nesses métodos. A presente invenção refere-se ainda métodos para identificar agentes para uso na prevenção de morte cardiaca súbita induzida por exercícios, bem como agentes identificados por tais métodos. Também são fornecidos métodos para prevenir a morte cardíaca súbita induzida por exercícios pela administração desses compostos. Além disso, a presente invenção fornece métodos para sintetizar JTV-519, JTV-519 radiomarcado, e intermediários e derivados de 1,4-benzotiazepina.
BRPI0415434-7A 2003-10-07 2004-10-04 compostos e métodos para tratar e prevenir arritmias cardìacas induzidas por exercìcios BRPI0415434A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/680,988 US20040229781A1 (en) 2000-05-10 2003-10-07 Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
PCT/US2004/032550 WO2005037195A2 (en) 2003-10-07 2004-10-04 Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias

Publications (1)

Publication Number Publication Date
BRPI0415434A true BRPI0415434A (pt) 2006-12-05

Family

ID=34465444

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415434-7A BRPI0415434A (pt) 2003-10-07 2004-10-04 compostos e métodos para tratar e prevenir arritmias cardìacas induzidas por exercìcios

Country Status (14)

Country Link
US (1) US20040229781A1 (pt)
EP (1) EP1684735A4 (pt)
JP (1) JP2007507536A (pt)
KR (1) KR20060110290A (pt)
CN (1) CN100502845C (pt)
AU (1) AU2004281672A1 (pt)
BR (1) BRPI0415434A (pt)
CA (1) CA2541847A1 (pt)
EA (1) EA011357B1 (pt)
MA (1) MA28146A1 (pt)
NO (1) NO20062063L (pt)
SG (1) SG147414A1 (pt)
WO (1) WO2005037195A2 (pt)
ZA (1) ZA200603593B (pt)

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US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
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AU2004281672A1 (en) 2005-04-28
CN100502845C (zh) 2009-06-24
JP2007507536A (ja) 2007-03-29
US20040229781A1 (en) 2004-11-18
SG147414A1 (en) 2008-11-28
WO2005037195A3 (en) 2005-12-01
NO20062063L (no) 2006-07-07
EP1684735A2 (en) 2006-08-02
CN1886122A (zh) 2006-12-27
KR20060110290A (ko) 2006-10-24
EA200600740A1 (ru) 2006-10-27
MA28146A1 (fr) 2006-09-01
ZA200603593B (en) 2010-10-27
EA011357B1 (ru) 2009-02-27
CA2541847A1 (en) 2005-04-28
EP1684735A4 (en) 2009-01-07

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