BRPI0415763A - produção de monatina e precursores de monatina - Google Patents

produção de monatina e precursores de monatina

Info

Publication number
BRPI0415763A
BRPI0415763A BRPI0415763-0A BRPI0415763A BRPI0415763A BR PI0415763 A BRPI0415763 A BR PI0415763A BR PI0415763 A BRPI0415763 A BR PI0415763A BR PI0415763 A BRPI0415763 A BR PI0415763A
Authority
BR
Brazil
Prior art keywords
monatin
indole
methods
precursors
production
Prior art date
Application number
BRPI0415763-0A
Other languages
English (en)
Inventor
Sara C Mcfarlan
Paula M Hicks
Mary Jo Zidwick
Fernando A Sanchez-Riera
Douglas C Cameron
Mervyn L De Souza
Jack Rosazza
Steven J Gort
Timothy W Abraham
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Publication of BRPI0415763A publication Critical patent/BRPI0415763A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PRODUçãO DE MONATINA E PRECURSORES DE MONATINA". São proporcionados métodos e composições que podem ser usados para produzir monatina ou sal da mesma a partir de glicose, triptofano, ácido indol-3-láctico, indol-3-piruvato, e ácido 2-hidróxi 2-(indol-3- ilmetil)-4-ceto glutárico. Também são descritos métodos para produzir os intermediários de indol-3-piruvato e ácido 2-hidróxi 2-(indol-3-ilmetil)-4-ceto glutárico. As composições proporcionadas incluem moléculas de ácidos nucléicos, polipeptídeos, estruturas químicas, e células. Os métodos incluem processos in vitro e in vivo, e os métodos in vivo incluem reação química.
BRPI0415763-0A 2003-10-21 2004-10-21 produção de monatina e precursores de monatina BRPI0415763A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51340603P 2003-10-21 2003-10-21
PCT/US2004/034558 WO2005042756A2 (en) 2003-10-21 2004-10-21 Production of monatin and monatin precursors

Publications (1)

Publication Number Publication Date
BRPI0415763A true BRPI0415763A (pt) 2006-12-26

Family

ID=34549274

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415763-0A BRPI0415763A (pt) 2003-10-21 2004-10-21 produção de monatina e precursores de monatina

Country Status (12)

Country Link
US (1) US8206955B2 (pt)
EP (2) EP2302067B1 (pt)
JP (1) JP4829117B2 (pt)
KR (1) KR101158592B1 (pt)
CN (2) CN103555782B (pt)
AT (1) ATE498691T1 (pt)
AU (1) AU2004286207B2 (pt)
BR (1) BRPI0415763A (pt)
DE (1) DE602004031444D1 (pt)
RU (1) RU2006117353A (pt)
WO (1) WO2005042756A2 (pt)
ZA (1) ZA200604080B (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4380029B2 (ja) * 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
CN1678742B (zh) 2002-08-26 2013-07-17 味之素株式会社 新型醛缩酶和取代α-酮酸的制备方法
EP1580268B1 (en) * 2002-12-09 2013-10-02 Ajinomoto Co., Inc. Mutant d-aminotransferase and process for producing optically active glutamic acid derivative using the same
US20050112260A1 (en) * 2003-08-01 2005-05-26 Cargill, Inc. Monatin tabletop sweetener compositions and methods of making same
KR101191542B1 (ko) * 2003-08-25 2012-10-15 카아길, 인코포레이팃드 모나틴을 포함하는 음료 조성물 및 이의 제조 방법
US8206955B2 (en) 2003-10-21 2012-06-26 Cargill, Incorporated Production of monatin and monatin precursors
CN101223444B (zh) * 2005-04-20 2013-04-24 嘉吉有限公司 在体内分泌莫纳甜的方法
US8158389B2 (en) * 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP3168299A3 (en) * 2005-04-26 2017-07-05 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP1885847B1 (en) * 2005-05-26 2011-07-06 Cytos Biotechnology AG Scalable fermentation process
EP1918375B1 (en) * 2005-08-02 2015-03-11 Kaneka Corporation D-amino acid oxidase, and method for production of l-amino acid, 2-oxo acid or cyclic imine
CA2645225A1 (en) 2006-03-07 2007-09-13 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them
MX2008011477A (es) 2006-03-07 2008-09-23 Cargill Inc Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas.
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
AU2007267618B2 (en) * 2006-05-24 2013-07-18 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
CN101239941B (zh) * 2007-02-08 2012-02-29 味之素株式会社 光学活性化合物的制造方法
PL2137315T3 (pl) 2007-03-16 2015-02-27 Genomatica Inc Kompozycje i sposoby do biosyntezy 1,4-butanodiolu i jego prekursorów
JP5219390B2 (ja) * 2007-03-19 2013-06-26 学校法人立命館 微生物培養用培地及び微生物製剤
US8076107B2 (en) * 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8367847B2 (en) 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
WO2009134814A2 (en) * 2008-04-28 2009-11-05 Synthetic Genomics, Inc. Identification of centromere sequences and uses therefor
JP5275313B2 (ja) * 2009-09-30 2013-08-28 三洋化成工業株式会社 有用物質分泌生産用細菌及び有用物質生産方法
KR20120099258A (ko) 2009-11-18 2012-09-07 미리안트 코포레이션 화합물들의 효과적인 생산을 위한 미생물 엔지니어링
JP5796282B2 (ja) * 2010-08-31 2015-10-21 東レ株式会社 コリネ型細菌による化学品の製造方法
WO2012037413A2 (en) 2010-09-15 2012-03-22 University Of Washington Through Its Center For Commercialization Systems and methods for biotransformation of carbon dioxide into higher carbon compounds
KR20120068872A (ko) 2010-10-14 2012-06-27 아지노모토 가부시키가이샤 모나틴의 제조 방법
US8771997B2 (en) 2011-04-20 2014-07-08 Ajinomoto Co., Inc. Method for producing monatin using an L-amino acid aminotransferase
WO2012147674A1 (ja) * 2011-04-25 2012-11-01 味の素株式会社 モナティンの製造方法
US20150024440A1 (en) * 2012-02-29 2015-01-22 Danmarks Tekniske Universitet Microorganisms for the production of melatonin
CN102690762B (zh) * 2012-06-25 2013-10-02 烟台恒源生物股份有限公司 游离细胞法生物转化l-天冬氨酸生产l-丙氨酸的方法
US20170185985A1 (en) * 2014-03-28 2017-06-29 Nec Corporation Sales registration apparatus, program, and sales registration method
CN107208118A (zh) * 2014-09-18 2017-09-26 基因组股份公司 具有提高的能源效率的非天然微生物
JP6665740B2 (ja) * 2016-09-13 2020-03-13 株式会社島津製作所 ペプチド解析方法、ペプチド解析装置、及びペプチド解析用プログラム
KR20190120238A (ko) 2017-02-06 2019-10-23 지머젠 인코포레이티드 발효에 의한 티라민의 제조를 위해 조작된 생합성 경로
US11518975B2 (en) * 2018-04-30 2022-12-06 Alliance For Sustainable Energy, Llc Engineered microorganisms for the production of intermediates and final products
CN108841748B (zh) * 2018-06-28 2021-10-08 新疆农业大学 中华根瘤固氮菌株系h6及其应用
CN113481188B (zh) * 2018-11-06 2023-03-24 王喆明 苏氨酸醛缩酶的突变体及其在制备取代苯丝氨酸衍生物中的应用
KR102134418B1 (ko) * 2019-06-17 2020-07-16 씨제이제일제당 주식회사 L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법
CN113237834B (zh) * 2021-07-08 2021-09-14 成都信息工程大学 基于光自旋霍尔效应的手性分子手性分辨装置及方法
CN114540396A (zh) * 2022-02-24 2022-05-27 天津大学 希瓦氏菌株中葡萄糖代谢通路的构建方法
CN119506260B (zh) * 2024-11-28 2025-07-25 杭州唯铂莱生物科技有限公司 一种色氨酸酶突变体及其在生产吲哚中的应用

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002889A (en) * 1960-06-20 1961-10-03 Kyowa Hakko Kogyo Kk Method of producing l-glutamic acid
US3128237A (en) 1961-02-24 1964-04-07 Ajinomoto Kk Process for producing l-glutamic acid by bacterial fermentation
US3399114A (en) * 1964-08-22 1968-08-27 Asahi Chemical Ind Process for producing l-glutamic acid by using bacteria
US3751458A (en) 1972-03-02 1973-08-07 Miles Lab Citroylformic acid and its production
JPS5119037B2 (pt) 1972-11-16 1976-06-14
US4371614A (en) 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
JPH0691827B2 (ja) 1981-12-17 1994-11-16 協和醗酵工業株式会社 新規ベクタ−プラスミド
JPS60176593A (ja) 1984-02-22 1985-09-10 Kyowa Hakko Kogyo Co Ltd Ｌ−トリプトフアンの製造法
WO1987001130A1 (en) 1985-08-15 1987-02-26 Stauffer Chemical Company Tryptophan producing microorganism
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
GB2205834B (en) 1987-06-15 1990-10-31 South African Inventions 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indole compounds
US5300437A (en) 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
WO1989011212A2 (en) 1989-08-30 1989-11-30 Wm. Wrigley Jr. Company Method of controlling release of cyclamate in chewing gum and gum produced thereby
GB2240105B (en) 1990-01-19 1993-06-09 Technology Finance Corp Process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole
US5173497A (en) 1990-05-17 1992-12-22 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and related analogs
WO1993006217A1 (en) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
US6264999B1 (en) 1993-09-30 2001-07-24 Wm. Wrigley Jr. Company Chewing gum containing erythritol and method of making
JP3698742B2 (ja) 1994-03-01 2005-09-21 協和醗酵工業株式会社 光学活性４−ヒドロキシ−２−ケトグルタル酸の製造法
US5888783A (en) 1994-08-30 1999-03-30 Ajinomoto Co., Inc. Methods for producing L-valine and L-leucine
MX9702011A (es) 1994-09-16 1998-04-30 Texas A & M Univ Sys Mocrioorganismos y metodos para la sobreproduccion de dahp mediante el gen pps clonado.
US5985617A (en) 1997-02-18 1999-11-16 Liao; James C. Microorganisms and methods for overproduction of DAHP by cloned PPS gene
US5843782A (en) 1995-02-09 1998-12-01 Novaflora, Inc. Micropropagation of rose plants
US6358714B1 (en) 1995-04-03 2002-03-19 The Nutrasweet Company Materials and methods for the production of D-phenylalanine
GB2304718B (en) 1995-09-05 2000-01-19 Degussa The production of tryptophan by the bacterium escherichia coli
US5728555A (en) 1996-09-30 1998-03-17 Monsanto Company Preparation of d-amino acids by direct fermentative means
CA2633357A1 (en) 1997-06-09 1998-12-09 Kyowa Hakko Kogyo Co., Ltd. Method for producing optically active compound
US20030077765A1 (en) 1997-07-09 2003-04-24 Ajinomoto Co. Inc. Temperature-sensitive dtsR gene
DE19818541C2 (de) 1998-04-24 2003-04-10 Forschungszentrum Juelich Gmbh Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III
US5994559A (en) 1998-08-06 1999-11-30 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Synthesis of monatin-A high intensity natural sweetener
EP1637160A3 (en) 1999-05-07 2006-05-03 Genentech, Inc. Treatment of autoimmune diseases with antagonists which bind to B cell surface markers
JP2002060382A (ja) 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
EP1390470A4 (en) * 2001-04-20 2004-08-18 Cargill Inc PRODUCTION OF ALPHA-LIPOIC ACID
DE10129711B4 (de) 2001-06-22 2007-08-23 Forschungszentrum Jülich GmbH Verfahren zur fermentativen Herstellung von Pyruvat
US6489217B1 (en) 2001-07-03 2002-12-03 Maxim Integrated Products, Inc. Method of forming an integrated circuit on a low loss substrate
JP2003171365A (ja) 2001-11-30 2003-06-20 Ajinomoto Co Inc モナティン類及びその製造中間体の製造方法並びに新規中間体
EP1449832A4 (en) 2001-11-30 2005-02-02 Ajinomoto Kk CRYSTALS OF NON-NATURAL STEREO-ISOMERAL SALTS OF MONATIN AND THEIR USE
US7297800B2 (en) 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
KR100673283B1 (ko) * 2001-12-27 2007-01-24 아지노모토 가부시키가이샤 글루탐산 유도체의 제조방법
CN101450907B (zh) 2001-12-27 2013-07-17 味之素株式会社 制备谷氨酸化合物中间体的制造方法与为此所用的新型中间体
US7247466B2 (en) 2002-03-01 2007-07-24 Kyowa Hakko Kogyo Co., Ltd. Amino acid racemase having low substrate specificity and process for producing racemic amino acid
JP2003292484A (ja) 2002-04-01 2003-10-15 Ajinomoto Co Inc γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
ES2356132T3 (es) 2002-04-23 2011-04-05 Cargill, Incorporated Polipéptidos y rutas biosintéticas.
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
CN1678742B (zh) 2002-08-26 2013-07-17 味之素株式会社 新型醛缩酶和取代α-酮酸的制备方法
EP1580268B1 (en) 2002-12-09 2013-10-02 Ajinomoto Co., Inc. Mutant d-aminotransferase and process for producing optically active glutamic acid derivative using the same
RU2342360C2 (ru) 2003-01-09 2008-12-27 Адзиномото Ко., Инк. Способ получения производного глутаминовой кислоты и производного пироглутаминовой кислоты и новое промежуточное соединение для получения этих производных
JP4239600B2 (ja) 2003-01-24 2009-03-18 味の素株式会社 ２ｒ−モナティンの製造方法
WO2004085624A2 (en) 2003-03-24 2004-10-07 Diversa Corporation Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification
JP2004331650A (ja) 2003-04-14 2004-11-25 Kanazawa Univ Tlo Inc モナチン類の製造法
JP2004331644A (ja) 2003-04-14 2004-11-25 Kanazawa Univ Tlo Inc モナチン類の製造法
WO2005001105A1 (ja) 2003-06-26 2005-01-06 Ajinomoto Co., Inc. モナティンの製造方法
US20050112260A1 (en) 2003-08-01 2005-05-26 Cargill, Inc. Monatin tabletop sweetener compositions and methods of making same
ATE360370T1 (de) 2003-08-14 2007-05-15 Cargill Inc Monatinhaltige kaugummizusammensetzungen und verfahren zu ihrer herstellung
KR101191542B1 (ko) * 2003-08-25 2012-10-15 카아길, 인코포레이팃드 모나틴을 포함하는 음료 조성물 및 이의 제조 방법
US8206955B2 (en) 2003-10-21 2012-06-26 Cargill, Incorporated Production of monatin and monatin precursors
JP4500977B2 (ja) 2003-11-05 2010-07-14 味の素株式会社 新規アミノ酸誘導体及び甘味剤
JP5113978B2 (ja) 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
CN1922140B (zh) 2004-02-27 2010-06-16 味之素株式会社 生产莽那亭的方法
JP4604524B2 (ja) 2004-03-16 2011-01-05 味の素株式会社 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法
JP4604537B2 (ja) 2004-03-31 2011-01-05 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
US7935377B2 (en) 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
CA2506247C (en) 2004-06-07 2012-02-21 Ajinomoto Co., Inc. Novel aldolase, and method for producing optically active ihog and monatin
KR101216575B1 (ko) 2004-07-14 2012-12-31 아지노모토 가부시키가이샤 (2ｒ,4ｒ)-모나틴 칼륨 염 결정 및 이를 함유하는 감미료조성물
JP2007284349A (ja) 2004-07-27 2007-11-01 Ajinomoto Co Inc モナティンまたはその塩の製造方法
CA2583426A1 (en) 2004-10-05 2006-04-13 Ajinomoto Co., Inc. Process for producing amino acid derivative from hydroxyimino acid
RU2392834C2 (ru) 2004-10-15 2010-06-27 Адзиномото Ко., Инк. Композиция подсластителя
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
CN101223444B (zh) 2005-04-20 2013-04-24 嘉吉有限公司 在体内分泌莫纳甜的方法
US7582455B2 (en) 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
MX2008011477A (es) 2006-03-07 2008-09-23 Cargill Inc Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas.
AU2007267618B2 (en) 2006-05-24 2013-07-18 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US20090198072A1 (en) 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US8076107B2 (en) 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8003361B2 (en) 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
US8367847B2 (en) 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
BRPI0822219A2 (pt) 2008-01-03 2014-11-04 Cargill Inc Ácidos nucléicos de aminotransferase e oxidoreductase e polipeptídeos e métodos de uso.
WO2011002469A1 (en) 2009-07-02 2011-01-06 Cargill, Incorporated Isomerases and epimerases and methods of using
WO2010091966A2 (en) 2009-02-16 2010-08-19 Telefonaktiebolaget L M Ericsson (Publ) Un-ciphered network operation solution
JP2012520079A (ja) 2009-03-12 2012-09-06 カーギル・インコーポレイテッド モナチンおよびカルシウムを含む組成物
CN102481007A (zh) 2009-05-28 2012-05-30 嘉吉公司 储存稳定的莫纳汀增甜饮料
WO2011082353A1 (en) 2009-12-30 2011-07-07 Cargill, Incorporated Separation and purification of monatin
WO2011082365A2 (en) 2009-12-30 2011-07-07 Cargill, Incorporated Improved bioreactor performance in the production of monatin
WO2011082363A1 (en) 2009-12-30 2011-07-07 Cargill, Incorporated Membrane separation and purification of monatin
EP2519406A4 (en) 2009-12-30 2014-03-26 Cargill Inc POLYMER AND METHODS FOR PREPARING AND USING POLYMER

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CN1890377A (zh) 2007-01-03
EP2302067B1 (en) 2014-03-05
EP1678313A2 (en) 2006-07-12
JP4829117B2 (ja) 2011-12-07
EP2302067A1 (en) 2011-03-30
AU2004286207A1 (en) 2005-05-12
KR20060125761A (ko) 2006-12-06
CN103555782B (zh) 2017-04-12
RU2006117353A (ru) 2007-12-27
US20050221455A1 (en) 2005-10-06
JP2007508840A (ja) 2007-04-12
ATE498691T1 (de) 2011-03-15
AU2004286207B2 (en) 2011-02-24
EP1678313B1 (en) 2011-02-16
WO2005042756A3 (en) 2005-11-24
KR101158592B1 (ko) 2012-06-22
ZA200604080B (en) 2007-11-28
WO2005042756A2 (en) 2005-05-12
US8206955B2 (en) 2012-06-26
DE602004031444D1 (de) 2011-03-31
CN103555782A (zh) 2014-02-05
CN1890377B (zh) 2013-06-05

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