ATE498691T1 - Herstellung von monatin und monatinvorstufen - Google Patents
Herstellung von monatin und monatinvorstufenInfo
- Publication number
- ATE498691T1 ATE498691T1 AT04795689T AT04795689T ATE498691T1 AT E498691 T1 ATE498691 T1 AT E498691T1 AT 04795689 T AT04795689 T AT 04795689T AT 04795689 T AT04795689 T AT 04795689T AT E498691 T1 ATE498691 T1 AT E498691T1
- Authority
- AT
- Austria
- Prior art keywords
- monatin
- indole
- methods
- indol
- ylmethyl
- Prior art date
Links
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 title abstract 3
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 title abstract 3
- 239000002243 precursor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 5
- SLWQCDYJBNGHQV-UHFFFAOYSA-N 2-hydroxy-2-(1h-indol-3-ylmethyl)-4-oxopentanedioic acid Chemical compound C1=CC=C2C(CC(O)(CC(=O)C(=O)O)C(O)=O)=CNC2=C1 SLWQCDYJBNGHQV-UHFFFAOYSA-N 0.000 abstract 2
- RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XGILAAMKEQUXLS-UHFFFAOYSA-N 3-(indol-3-yl)lactic acid Chemical compound C1=CC=C2C(CC(O)C(O)=O)=CNC2=C1 XGILAAMKEQUXLS-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51340603P | 2003-10-21 | 2003-10-21 | |
| PCT/US2004/034558 WO2005042756A2 (en) | 2003-10-21 | 2004-10-21 | Production of monatin and monatin precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE498691T1 true ATE498691T1 (de) | 2011-03-15 |
Family
ID=34549274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04795689T ATE498691T1 (de) | 2003-10-21 | 2004-10-21 | Herstellung von monatin und monatinvorstufen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8206955B2 (de) |
| EP (2) | EP1678313B1 (de) |
| JP (1) | JP4829117B2 (de) |
| KR (1) | KR101158592B1 (de) |
| CN (2) | CN1890377B (de) |
| AT (1) | ATE498691T1 (de) |
| AU (1) | AU2004286207B2 (de) |
| BR (1) | BRPI0415763A (de) |
| DE (1) | DE602004031444D1 (de) |
| RU (1) | RU2006117353A (de) |
| WO (1) | WO2005042756A2 (de) |
| ZA (1) | ZA200604080B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4380029B2 (ja) * | 2000-07-05 | 2009-12-09 | 味の素株式会社 | 微生物を利用した物質の製造法 |
| US7297800B2 (en) * | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US7572607B2 (en) * | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| EP1533376B1 (de) | 2002-08-26 | 2010-04-07 | Ajinomoto Co., Inc. | Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäure |
| CA2507225C (en) | 2002-12-09 | 2012-02-07 | Ajinomoto Co., Inc. | Mutated d-aminotransferase and method for producing optically active glutamic acid derivatives using the same |
| WO2005014839A2 (en) * | 2003-08-01 | 2005-02-17 | Cargill, Incorporated | Monatin tabletop sweetener compositions and methods of making same |
| US20050106305A1 (en) * | 2003-08-25 | 2005-05-19 | Cargill, Inc. | Beverage compositions comprising monatin and methods of making same |
| AU2004286207B2 (en) | 2003-10-21 | 2011-02-24 | Cargill, Incorporated | Production of monatin and monatin precursors |
| WO2006113897A2 (en) * | 2005-04-20 | 2006-10-26 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US8158389B2 (en) | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| CN101365787B (zh) * | 2005-04-26 | 2014-03-05 | 嘉吉有限公司 | 用于生产莫纳甜的立体异构体和其前体的多肽和生物合成途径 |
| US8076108B2 (en) * | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| EP1885847B1 (de) * | 2005-05-26 | 2011-07-06 | Cytos Biotechnology AG | Skalierbares fermentationsverfahren |
| US8227228B2 (en) * | 2005-08-02 | 2012-07-24 | Kaneka Corporation | D-amino acid oxidase, and method for production of L-amino acid, 2-oxo acid, or cyclic imine |
| CN102690833B (zh) * | 2006-03-07 | 2015-09-09 | 巴斯夫酶有限责任公司 | 醛缩酶、编码它们的核酸及制备和使用它们的方法 |
| CA2643416C (en) | 2006-03-07 | 2016-07-26 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
| JP2009538145A (ja) * | 2006-05-24 | 2009-11-05 | カーギル・インコーポレイテッド | 平衡反応の収量を増加させるための方法およびシステム |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| CN101239941B (zh) * | 2007-02-08 | 2012-02-29 | 味之素株式会社 | 光学活性化合物的制造方法 |
| JP5551448B2 (ja) | 2007-03-16 | 2014-07-16 | ジェノマティカ・インコーポレイテッド | １，４−ブタンジオールおよびその前駆体の生合成のための組成物および方法 |
| JP5219390B2 (ja) * | 2007-03-19 | 2013-06-26 | 学校法人立命館 | 微生物培養用培地及び微生物製剤 |
| US8003361B2 (en) | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US8367847B2 (en) * | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US9758810B2 (en) * | 2008-04-28 | 2017-09-12 | Synthetic Genomics, Inc. | Identification of centromere sequences and uses therefor |
| JP5275313B2 (ja) * | 2009-09-30 | 2013-08-28 | 三洋化成工業株式会社 | 有用物質分泌生産用細菌及び有用物質生産方法 |
| EP2501797A4 (de) | 2009-11-18 | 2013-04-17 | Myriant Corp | Technisierung von mikroben zur wirksamen herstellung von chemikalien |
| JP5796282B2 (ja) * | 2010-08-31 | 2015-10-21 | 東レ株式会社 | コリネ型細菌による化学品の製造方法 |
| WO2012037413A2 (en) | 2010-09-15 | 2012-03-22 | University Of Washington Through Its Center For Commercialization | Systems and methods for biotransformation of carbon dioxide into higher carbon compounds |
| EP2479272A4 (de) | 2010-10-14 | 2013-11-20 | Ajinomoto Kk | Verfahren zur herstellung von monatin |
| US8771997B2 (en) | 2011-04-20 | 2014-07-08 | Ajinomoto Co., Inc. | Method for producing monatin using an L-amino acid aminotransferase |
| WO2012147674A1 (ja) * | 2011-04-25 | 2012-11-01 | 味の素株式会社 | モナティンの製造方法 |
| WO2013127915A1 (en) * | 2012-02-29 | 2013-09-06 | Danmarks Tekniske Universitet | Microorganisms for the production of melatonin |
| CN102690762B (zh) * | 2012-06-25 | 2013-10-02 | 烟台恒源生物股份有限公司 | 游离细胞法生物转化l-天冬氨酸生产l-丙氨酸的方法 |
| WO2015147333A1 (ja) * | 2014-03-28 | 2015-10-01 | 日本電気株式会社 | 売上登録装置、プログラム及び売上登録方法 |
| DK3194604T3 (da) * | 2014-09-18 | 2020-05-25 | Genomatica Inc | Ikke-naturlig mikrobielle organismer med forbedret energisk effektivitet |
| JP6665740B2 (ja) * | 2016-09-13 | 2020-03-13 | 株式会社島津製作所 | ペプチド解析方法、ペプチド解析装置、及びペプチド解析用プログラム |
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| US11518975B2 (en) * | 2018-04-30 | 2022-12-06 | Alliance For Sustainable Energy, Llc | Engineered microorganisms for the production of intermediates and final products |
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| CN113481188B (zh) * | 2018-11-06 | 2023-03-24 | 王喆明 | 苏氨酸醛缩酶的突变体及其在制备取代苯丝氨酸衍生物中的应用 |
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| CN113237834B (zh) * | 2021-07-08 | 2021-09-14 | 成都信息工程大学 | 基于光自旋霍尔效应的手性分子手性分辨装置及方法 |
| CN114540396A (zh) * | 2022-02-24 | 2022-05-27 | 天津大学 | 希瓦氏菌株中葡萄糖代谢通路的构建方法 |
| CN119506260B (zh) * | 2024-11-28 | 2025-07-25 | 杭州唯铂莱生物科技有限公司 | 一种色氨酸酶突变体及其在生产吲哚中的应用 |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3002889A (en) * | 1960-06-20 | 1961-10-03 | Kyowa Hakko Kogyo Kk | Method of producing l-glutamic acid |
| US3128237A (en) * | 1961-02-24 | 1964-04-07 | Ajinomoto Kk | Process for producing l-glutamic acid by bacterial fermentation |
| US3399114A (en) | 1964-08-22 | 1968-08-27 | Asahi Chemical Ind | Process for producing l-glutamic acid by using bacteria |
| US3751458A (en) * | 1972-03-02 | 1973-08-07 | Miles Lab | Citroylformic acid and its production |
| JPS5119037B2 (de) | 1972-11-16 | 1976-06-14 | ||
| US4371614A (en) | 1980-08-22 | 1983-02-01 | Ajinomoto Co., Inc. | E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan |
| JPH0691827B2 (ja) | 1981-12-17 | 1994-11-16 | 協和醗酵工業株式会社 | 新規ベクタ−プラスミド |
| JPS60176593A (ja) | 1984-02-22 | 1985-09-10 | Kyowa Hakko Kogyo Co Ltd | Ｌ−トリプトフアンの製造法 |
| WO1987001130A1 (en) | 1985-08-15 | 1987-02-26 | Stauffer Chemical Company | Tryptophan producing microorganism |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB2205834B (en) * | 1987-06-15 | 1990-10-31 | South African Inventions | 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indole compounds |
| US5300437A (en) * | 1989-06-22 | 1994-04-05 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
| WO1989011212A2 (en) | 1989-08-30 | 1989-11-30 | Wm. Wrigley Jr. Company | Method of controlling release of cyclamate in chewing gum and gum produced thereby |
| DE69101791T2 (de) * | 1990-01-19 | 1994-08-11 | Technology Finance Corp | Verfahren zur Herstellung von 3-(1-Amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indol. |
| US5173497A (en) | 1990-05-17 | 1992-12-22 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and related analogs |
| EP0604580A1 (de) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | Expression in E.Coli von Antikörperfragmenten mit mindestens einem cystein in freier -SH Form. Anwendung in der Herstellung bifunktioneller Antikörper. |
| US6264999B1 (en) * | 1993-09-30 | 2001-07-24 | Wm. Wrigley Jr. Company | Chewing gum containing erythritol and method of making |
| JP3698742B2 (ja) | 1994-03-01 | 2005-09-21 | 協和醗酵工業株式会社 | 光学活性４−ヒドロキシ−２−ケトグルタル酸の製造法 |
| JP3709564B2 (ja) | 1994-08-30 | 2005-10-26 | 味の素株式会社 | Ｌ−バリン及びｌ−ロイシンの製造法 |
| US5985617A (en) * | 1997-02-18 | 1999-11-16 | Liao; James C. | Microorganisms and methods for overproduction of DAHP by cloned PPS gene |
| WO1996008567A1 (en) | 1994-09-16 | 1996-03-21 | Texas A & M University System | Microorganisms and methods for overproduction of dahp by cloned pps gene |
| US5843782A (en) | 1995-02-09 | 1998-12-01 | Novaflora, Inc. | Micropropagation of rose plants |
| US6358714B1 (en) | 1995-04-03 | 2002-03-19 | The Nutrasweet Company | Materials and methods for the production of D-phenylalanine |
| GB2304718B (en) * | 1995-09-05 | 2000-01-19 | Degussa | The production of tryptophan by the bacterium escherichia coli |
| US5728555A (en) * | 1996-09-30 | 1998-03-17 | Monsanto Company | Preparation of d-amino acids by direct fermentative means |
| CA2234412C (en) * | 1997-06-09 | 2008-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Method for producing optically active compound |
| US20030077765A1 (en) | 1997-07-09 | 2003-04-24 | Ajinomoto Co. Inc. | Temperature-sensitive dtsR gene |
| DE19818541C2 (de) | 1998-04-24 | 2003-04-10 | Forschungszentrum Juelich Gmbh | Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III |
| US5994559A (en) * | 1998-08-06 | 1999-11-30 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Synthesis of monatin-A high intensity natural sweetener |
| HK1043312B (en) | 1999-05-07 | 2006-07-28 | Genentech, Inc. | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| JP2002060382A (ja) | 2000-08-22 | 2002-02-26 | Ajinomoto Co Inc | モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体 |
| EP1390470A4 (de) * | 2001-04-20 | 2004-08-18 | Cargill Inc | Herstellung von alpha-liponsäure |
| DE10129711B4 (de) | 2001-06-22 | 2007-08-23 | Forschungszentrum Jülich GmbH | Verfahren zur fermentativen Herstellung von Pyruvat |
| US6489217B1 (en) | 2001-07-03 | 2002-12-03 | Maxim Integrated Products, Inc. | Method of forming an integrated circuit on a low loss substrate |
| AU2002349604A1 (en) | 2001-11-30 | 2003-06-10 | Ajinomoto Co., Inc. | Crystals of non-natural stereoisomer salts of monatin and utilization thereof |
| JP2003171365A (ja) | 2001-11-30 | 2003-06-20 | Ajinomoto Co Inc | モナティン類及びその製造中間体の製造方法並びに新規中間体 |
| EP1466890B1 (de) * | 2001-12-27 | 2012-04-04 | Ajinomoto Co., Inc. | "verfahren zur herstellung von glutaminsäureverbindungen und zwischenprodukten davon, und in den verfahren verwendete neue zwischenprodukte" |
| US7297800B2 (en) * | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| ATE497013T1 (de) * | 2001-12-27 | 2011-02-15 | Ajinomoto Kk | Verfahren zur herstellung von glutaminsäurederivaten |
| EP1489166A4 (de) * | 2002-03-01 | 2006-04-05 | Kyowa Hakko Kogyo Kk | Aminosäure-racemase mit niedriger substratspezifität und verfahren zur herstellung von racemischer aminosäure |
| JP2003292484A (ja) * | 2002-04-01 | 2003-10-15 | Ajinomoto Co Inc | γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法 |
| CN100516043C (zh) * | 2002-04-23 | 2009-07-22 | 嘉吉有限公司 | 多肽和生物合成途径 |
| US7572607B2 (en) | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US8372989B2 (en) * | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| EP1533376B1 (de) * | 2002-08-26 | 2010-04-07 | Ajinomoto Co., Inc. | Neue aldolasen und verfahren zur herstellung von substituierter alpha-ketosäure |
| CA2507225C (en) * | 2002-12-09 | 2012-02-07 | Ajinomoto Co., Inc. | Mutated d-aminotransferase and method for producing optically active glutamic acid derivatives using the same |
| ATE522497T1 (de) * | 2003-01-09 | 2011-09-15 | Ajinomoto Kk | Verfahren zur herstellung eines glutaminsäurederivats, ein pyroglutaminsäurederivat und ein neues zwischenprodukt für die herstellung |
| JP4239600B2 (ja) | 2003-01-24 | 2009-03-18 | 味の素株式会社 | ２ｒ−モナティンの製造方法 |
| WO2004085624A2 (en) | 2003-03-24 | 2004-10-07 | Diversa Corporation | Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification |
| JP2004331644A (ja) | 2003-04-14 | 2004-11-25 | Kanazawa Univ Tlo Inc | モナチン類の製造法 |
| JP2004331650A (ja) | 2003-04-14 | 2004-11-25 | Kanazawa Univ Tlo Inc | モナチン類の製造法 |
| WO2005001105A1 (ja) | 2003-06-26 | 2005-01-06 | Ajinomoto Co., Inc. | モナティンの製造方法 |
| WO2005014839A2 (en) | 2003-08-01 | 2005-02-17 | Cargill, Incorporated | Monatin tabletop sweetener compositions and methods of making same |
| MXPA06001663A (es) * | 2003-08-14 | 2006-07-03 | Cargill Inc | Composiciones de goma de mascar que comprenden monatina y metodos para hacer las mismas. |
| US20050106305A1 (en) * | 2003-08-25 | 2005-05-19 | Cargill, Inc. | Beverage compositions comprising monatin and methods of making same |
| AU2004286207B2 (en) | 2003-10-21 | 2011-02-24 | Cargill, Incorporated | Production of monatin and monatin precursors |
| JP4500977B2 (ja) * | 2003-11-05 | 2010-07-14 | 味の素株式会社 | 新規アミノ酸誘導体及び甘味剤 |
| JP5113978B2 (ja) * | 2003-11-21 | 2013-01-09 | 味の素株式会社 | グルタミン酸誘導体の有機アミン塩及びその利用 |
| CA2557274C (en) * | 2004-02-27 | 2012-12-04 | Ajinomoto Co., Inc. | Method for producing monatin |
| JP4604524B2 (ja) * | 2004-03-16 | 2011-01-05 | 味の素株式会社 | 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法 |
| JP4604537B2 (ja) * | 2004-03-31 | 2011-01-05 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US7935377B2 (en) * | 2004-06-04 | 2011-05-03 | Ajinomoto Co., Inc. | Crystals of free (2R, 4R)-monatin and use thereof |
| CA2506247C (en) * | 2004-06-07 | 2012-02-21 | Ajinomoto Co., Inc. | Novel aldolase, and method for producing optically active ihog and monatin |
| KR101216575B1 (ko) * | 2004-07-14 | 2012-12-31 | 아지노모토 가부시키가이샤 | (2ｒ,4ｒ)-모나틴 칼륨 염 결정 및 이를 함유하는 감미료조성물 |
| JP2007284349A (ja) * | 2004-07-27 | 2007-11-01 | Ajinomoto Co Inc | モナティンまたはその塩の製造方法 |
| RU2007116971A (ru) * | 2004-10-05 | 2008-11-27 | Адзиномото Ко., Инк. (Jp) | Способ получения производного аминокислоты из гидроксииминокислоты |
| KR101205568B1 (ko) * | 2004-10-15 | 2012-11-27 | 아지노모토 가부시키가이샤 | 감미료 조성물 |
| US8158389B2 (en) * | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| WO2006113897A2 (en) | 2005-04-20 | 2006-10-26 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US8076108B2 (en) * | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| CA2643416C (en) * | 2006-03-07 | 2016-07-26 | Cargill, Incorporated | Aldolases, nucleic acids encoding them and methods for making and using them |
| JP2009538145A (ja) * | 2006-05-24 | 2009-11-05 | カーギル・インコーポレイテッド | 平衡反応の収量を増加させるための方法およびシステム |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| US8367847B2 (en) * | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) * | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| WO2011002469A1 (en) * | 2009-07-02 | 2011-01-06 | Cargill, Incorporated | Isomerases and epimerases and methods of using |
| CA2726928A1 (en) * | 2008-01-03 | 2009-07-16 | Cargill, Incorporated | Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using |
| MX2011008278A (es) | 2009-02-16 | 2011-09-08 | Ericsson Telefon Ab L M | Solucion de operacion de red no cifrada. |
| AU2010224131A1 (en) * | 2009-03-12 | 2011-09-22 | Cargill, Incorporated | Compositions comprising monatin and calcium |
| EP2434910B1 (de) | 2009-05-28 | 2015-10-21 | Cargill, Incorporated | Lagerstabiles mit monatin gesüsstes getränk |
| WO2011082353A1 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Separation and purification of monatin |
| US20120322906A1 (en) | 2009-12-30 | 2012-12-20 | Cargill, Incorporated | Polymer and methods of preparing and using a polymer |
| WO2011082365A2 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Improved bioreactor performance in the production of monatin |
| WO2011082363A1 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Membrane separation and purification of monatin |
-
2004
- 2004-10-21 AU AU2004286207A patent/AU2004286207B2/en not_active Ceased
- 2004-10-21 KR KR1020067009839A patent/KR101158592B1/ko not_active Expired - Fee Related
- 2004-10-21 WO PCT/US2004/034558 patent/WO2005042756A2/en not_active Ceased
- 2004-10-21 JP JP2006536714A patent/JP4829117B2/ja not_active Expired - Fee Related
- 2004-10-21 RU RU2006117353/13A patent/RU2006117353A/ru not_active Application Discontinuation
- 2004-10-21 EP EP04795689A patent/EP1678313B1/de not_active Expired - Lifetime
- 2004-10-21 EP EP10009952.2A patent/EP2302067B1/de not_active Expired - Lifetime
- 2004-10-21 CN CN2004800348419A patent/CN1890377B/zh not_active Expired - Fee Related
- 2004-10-21 AT AT04795689T patent/ATE498691T1/de not_active IP Right Cessation
- 2004-10-21 CN CN201310188490.8A patent/CN103555782B/zh not_active Expired - Fee Related
- 2004-10-21 BR BRPI0415763-0A patent/BRPI0415763A/pt not_active Application Discontinuation
- 2004-10-21 US US10/969,245 patent/US8206955B2/en not_active Expired - Fee Related
- 2004-10-21 DE DE602004031444T patent/DE602004031444D1/de not_active Expired - Lifetime
-
2006
- 2006-05-19 ZA ZA200604080A patent/ZA200604080B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1890377A (zh) | 2007-01-03 |
| JP4829117B2 (ja) | 2011-12-07 |
| AU2004286207A1 (en) | 2005-05-12 |
| WO2005042756A2 (en) | 2005-05-12 |
| JP2007508840A (ja) | 2007-04-12 |
| RU2006117353A (ru) | 2007-12-27 |
| BRPI0415763A (pt) | 2006-12-26 |
| KR101158592B1 (ko) | 2012-06-22 |
| CN1890377B (zh) | 2013-06-05 |
| KR20060125761A (ko) | 2006-12-06 |
| CN103555782A (zh) | 2014-02-05 |
| EP1678313B1 (de) | 2011-02-16 |
| WO2005042756A3 (en) | 2005-11-24 |
| US8206955B2 (en) | 2012-06-26 |
| AU2004286207B2 (en) | 2011-02-24 |
| EP1678313A2 (de) | 2006-07-12 |
| EP2302067A1 (de) | 2011-03-30 |
| EP2302067B1 (de) | 2014-03-05 |
| US20050221455A1 (en) | 2005-10-06 |
| DE602004031444D1 (de) | 2011-03-31 |
| ZA200604080B (en) | 2007-11-28 |
| CN103555782B (zh) | 2017-04-12 |
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