ATE498691T1 - Herstellung von monatin und monatinvorstufen - Google Patents
Herstellung von monatin und monatinvorstufenInfo
- Publication number
- ATE498691T1 ATE498691T1 AT04795689T AT04795689T ATE498691T1 AT E498691 T1 ATE498691 T1 AT E498691T1 AT 04795689 T AT04795689 T AT 04795689T AT 04795689 T AT04795689 T AT 04795689T AT E498691 T1 ATE498691 T1 AT E498691T1
- Authority
- AT
- Austria
- Prior art keywords
- monatin
- indole
- methods
- indol
- ylmethyl
- Prior art date
Links
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 title abstract 3
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 title abstract 3
- 239000002243 precursor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 5
- SLWQCDYJBNGHQV-UHFFFAOYSA-N 2-hydroxy-2-(1h-indol-3-ylmethyl)-4-oxopentanedioic acid Chemical compound C1=CC=C2C(CC(O)(CC(=O)C(=O)O)C(O)=O)=CNC2=C1 SLWQCDYJBNGHQV-UHFFFAOYSA-N 0.000 abstract 2
- RSTKLPZEZYGQPY-UHFFFAOYSA-N 3-(indol-3-yl)pyruvic acid Chemical compound C1=CC=C2C(CC(=O)C(=O)O)=CNC2=C1 RSTKLPZEZYGQPY-UHFFFAOYSA-N 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XGILAAMKEQUXLS-UHFFFAOYSA-N 3-(indol-3-yl)lactic acid Chemical compound C1=CC=C2C(CC(O)C(O)=O)=CNC2=C1 XGILAAMKEQUXLS-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51340603P | 2003-10-21 | 2003-10-21 | |
| PCT/US2004/034558 WO2005042756A2 (en) | 2003-10-21 | 2004-10-21 | Production of monatin and monatin precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE498691T1 true ATE498691T1 (de) | 2011-03-15 |
Family
ID=34549274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04795689T ATE498691T1 (de) | 2003-10-21 | 2004-10-21 | Herstellung von monatin und monatinvorstufen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8206955B2 (de) |
| EP (2) | EP1678313B1 (de) |
| JP (1) | JP4829117B2 (de) |
| KR (1) | KR101158592B1 (de) |
| CN (2) | CN1890377B (de) |
| AT (1) | ATE498691T1 (de) |
| AU (1) | AU2004286207B2 (de) |
| BR (1) | BRPI0415763A (de) |
| DE (1) | DE602004031444D1 (de) |
| RU (1) | RU2006117353A (de) |
| WO (1) | WO2005042756A2 (de) |
| ZA (1) | ZA200604080B (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4380029B2 (ja) * | 2000-07-05 | 2009-12-09 | 味の素株式会社 | 微生物を利用した物質の製造法 |
| US7297800B2 (en) * | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| US7572607B2 (en) * | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| DK1533376T3 (da) | 2002-08-26 | 2010-07-19 | Ajinomoto Kk | Nye aldolaser og fremgangsmåde til fremstilling af substitueret alfa-ketosyre |
| CN1723281B (zh) | 2002-12-09 | 2012-08-15 | 味之素株式会社 | 突变的d-氨基转移酶和使用它们生产旋光性谷氨酸衍生物的方法 |
| US20050112260A1 (en) * | 2003-08-01 | 2005-05-26 | Cargill, Inc. | Monatin tabletop sweetener compositions and methods of making same |
| US20050106305A1 (en) * | 2003-08-25 | 2005-05-19 | Cargill, Inc. | Beverage compositions comprising monatin and methods of making same |
| CN1890377B (zh) | 2003-10-21 | 2013-06-05 | 嘉吉有限公司 | 生产莫纳甜和莫纳甜前体 |
| WO2006113897A2 (en) * | 2005-04-20 | 2006-10-26 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US8158389B2 (en) | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US7582455B2 (en) * | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| JP5336182B2 (ja) * | 2005-04-26 | 2013-11-06 | カーギル，インコーポレイティド | モナティンの立体異性体及びそれらの前駆体の製造のためのポリペプチド及び生合成経路 |
| US8076108B2 (en) * | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| ATE515566T1 (de) * | 2005-05-26 | 2011-07-15 | Cytos Biotechnology Ag | Skalierbares fermentationsverfahren |
| WO2007015511A1 (ja) * | 2005-08-02 | 2007-02-08 | Kaneka Corporation | Ｄ－アミノ酸オキシダーゼ、およびｌ－アミノ酸、２－オキソ酸、又は環状イミンの製造方法。 |
| EP2112227B1 (de) * | 2006-03-07 | 2013-05-15 | Cargill, Incorporated | Aldolasen, Nukleinsäuren zu ihrer Kodierung sowie Verfahren zu ihrer Herstellung und Verwendung |
| EA029538B1 (ru) | 2006-03-07 | 2018-04-30 | Басф Энзаймс Ллк | Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида |
| US20090198072A1 (en) * | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| CN101490249A (zh) * | 2006-05-24 | 2009-07-22 | 嘉吉公司 | 提高平衡反应的产量的方法和系统 |
| CN101239941B (zh) * | 2007-02-08 | 2012-02-29 | 味之素株式会社 | 光学活性化合物的制造方法 |
| TWI568847B (zh) | 2007-03-16 | 2017-02-01 | 奇諾麥提卡公司 | 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法 |
| JP5219390B2 (ja) * | 2007-03-19 | 2013-06-26 | 学校法人立命館 | 微生物培養用培地及び微生物製剤 |
| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8367847B2 (en) | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| US9758810B2 (en) * | 2008-04-28 | 2017-09-12 | Synthetic Genomics, Inc. | Identification of centromere sequences and uses therefor |
| JP5275313B2 (ja) * | 2009-09-30 | 2013-08-28 | 三洋化成工業株式会社 | 有用物質分泌生産用細菌及び有用物質生産方法 |
| EP2501797A4 (de) | 2009-11-18 | 2013-04-17 | Myriant Corp | Technisierung von mikroben zur wirksamen herstellung von chemikalien |
| JP5796282B2 (ja) * | 2010-08-31 | 2015-10-21 | 東レ株式会社 | コリネ型細菌による化学品の製造方法 |
| US9023627B2 (en) | 2010-09-15 | 2015-05-05 | University Of Washington Through Its Center For Commercialization | Systems and methods for biotransformation of carbon dioxide into higher carbon compounds |
| EP2479272A4 (de) | 2010-10-14 | 2013-11-20 | Ajinomoto Kk | Verfahren zur herstellung von monatin |
| US8771997B2 (en) | 2011-04-20 | 2014-07-08 | Ajinomoto Co., Inc. | Method for producing monatin using an L-amino acid aminotransferase |
| WO2012147674A1 (ja) * | 2011-04-25 | 2012-11-01 | 味の素株式会社 | モナティンの製造方法 |
| EP2820121A1 (de) * | 2012-02-29 | 2015-01-07 | Danmarks Tekniske Universitet | Mikroorganismen zur herstellung von melatonin |
| CN102690762B (zh) * | 2012-06-25 | 2013-10-02 | 烟台恒源生物股份有限公司 | 游离细胞法生物转化l-天冬氨酸生产l-丙氨酸的方法 |
| JP6549558B2 (ja) * | 2014-03-28 | 2019-07-24 | 日本電気株式会社 | 売上登録装置、プログラム及び売上登録方法 |
| US20170298363A1 (en) * | 2014-09-18 | 2017-10-19 | Genomatica, Inc | Non-natural microbial organisms with improved energetic efficiency |
| JP6665740B2 (ja) * | 2016-09-13 | 2020-03-13 | 株式会社島津製作所 | ペプチド解析方法、ペプチド解析装置、及びペプチド解析用プログラム |
| EP3577220A2 (de) | 2017-02-06 | 2019-12-11 | Zymergen, Inc. | Manipulierte biosynthesewege zur herstellung von tyramin durch fermentation |
| US11518975B2 (en) * | 2018-04-30 | 2022-12-06 | Alliance For Sustainable Energy, Llc | Engineered microorganisms for the production of intermediates and final products |
| CN108841748B (zh) * | 2018-06-28 | 2021-10-08 | 新疆农业大学 | 中华根瘤固氮菌株系h6及其应用 |
| CN109402098B (zh) * | 2018-11-06 | 2021-09-17 | 王喆明 | 苏氨酸醛缩酶、突变体及其在制备取代苯丝氨酸衍生物中的应用 |
| KR102134418B1 (ko) * | 2019-06-17 | 2020-07-16 | 씨제이제일제당 주식회사 | L-타이로신을 생산하는 미생물 및 이를 이용한 l-타이로신 생산 방법 |
| CN113237834B (zh) * | 2021-07-08 | 2021-09-14 | 成都信息工程大学 | 基于光自旋霍尔效应的手性分子手性分辨装置及方法 |
| CN114540396A (zh) * | 2022-02-24 | 2022-05-27 | 天津大学 | 希瓦氏菌株中葡萄糖代谢通路的构建方法 |
| CN119506260B (zh) * | 2024-11-28 | 2025-07-25 | 杭州唯铂莱生物科技有限公司 | 一种色氨酸酶突变体及其在生产吲哚中的应用 |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3002889A (en) | 1960-06-20 | 1961-10-03 | Kyowa Hakko Kogyo Kk | Method of producing l-glutamic acid |
| US3128237A (en) | 1961-02-24 | 1964-04-07 | Ajinomoto Kk | Process for producing l-glutamic acid by bacterial fermentation |
| US3399114A (en) | 1964-08-22 | 1968-08-27 | Asahi Chemical Ind | Process for producing l-glutamic acid by using bacteria |
| US3751458A (en) | 1972-03-02 | 1973-08-07 | Miles Lab | Citroylformic acid and its production |
| JPS5119037B2 (de) | 1972-11-16 | 1976-06-14 | ||
| US4371614A (en) | 1980-08-22 | 1983-02-01 | Ajinomoto Co., Inc. | E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan |
| JPH0691827B2 (ja) | 1981-12-17 | 1994-11-16 | 協和醗酵工業株式会社 | 新規ベクタ−プラスミド |
| JPS60176593A (ja) | 1984-02-22 | 1985-09-10 | Kyowa Hakko Kogyo Co Ltd | Ｌ−トリプトフアンの製造法 |
| EP0232262A4 (de) | 1985-08-15 | 1989-09-19 | Stauffer Chemical Co | Tryptophan erzeugender mikroorganismus. |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| GB2205834B (en) | 1987-06-15 | 1990-10-31 | South African Inventions | 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indole compounds |
| US5300437A (en) | 1989-06-22 | 1994-04-05 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
| WO1989011212A2 (en) | 1989-08-30 | 1989-11-30 | Wm. Wrigley Jr. Company | Method of controlling release of cyclamate in chewing gum and gum produced thereby |
| DE69101791T2 (de) | 1990-01-19 | 1994-08-11 | Technology Finance Corp | Verfahren zur Herstellung von 3-(1-Amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indol. |
| US5173497A (en) | 1990-05-17 | 1992-12-22 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and related analogs |
| CA2116774C (en) | 1991-09-19 | 2003-11-11 | Paul J. Carter | Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies |
| US6264999B1 (en) | 1993-09-30 | 2001-07-24 | Wm. Wrigley Jr. Company | Chewing gum containing erythritol and method of making |
| JP3698742B2 (ja) | 1994-03-01 | 2005-09-21 | 協和醗酵工業株式会社 | 光学活性４−ヒドロキシ−２−ケトグルタル酸の製造法 |
| JP3709564B2 (ja) | 1994-08-30 | 2005-10-26 | 味の素株式会社 | Ｌ−バリン及びｌ−ロイシンの製造法 |
| US5985617A (en) | 1997-02-18 | 1999-11-16 | Liao; James C. | Microorganisms and methods for overproduction of DAHP by cloned PPS gene |
| EP0782621B1 (de) | 1994-09-16 | 2006-03-08 | THE TEXAS A&M UNIVERSITY SYSTEM | Mikroorganismen und Verfahren zur Überproduktion von DAHP mittels klonierten PPSGens |
| US5843782A (en) | 1995-02-09 | 1998-12-01 | Novaflora, Inc. | Micropropagation of rose plants |
| US6358714B1 (en) | 1995-04-03 | 2002-03-19 | The Nutrasweet Company | Materials and methods for the production of D-phenylalanine |
| GB2304718B (en) | 1995-09-05 | 2000-01-19 | Degussa | The production of tryptophan by the bacterium escherichia coli |
| US5728555A (en) | 1996-09-30 | 1998-03-17 | Monsanto Company | Preparation of d-amino acids by direct fermentative means |
| CA2234412C (en) | 1997-06-09 | 2008-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Method for producing optically active compound |
| US20030077765A1 (en) | 1997-07-09 | 2003-04-24 | Ajinomoto Co. Inc. | Temperature-sensitive dtsR gene |
| DE19818541C2 (de) | 1998-04-24 | 2003-04-10 | Forschungszentrum Juelich Gmbh | Mikrobielle Herstellung von Substanzen aus dem aromatischen Stoffwechsel / III |
| US5994559A (en) | 1998-08-06 | 1999-11-30 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Synthesis of monatin-A high intensity natural sweetener |
| ATE311199T1 (de) | 1999-05-07 | 2005-12-15 | Genentech Inc | Behandlung von autoimmunkrankheiten mit antagonisten die oberflächenmarker von b zellen binden |
| JP2002060382A (ja) | 2000-08-22 | 2002-02-26 | Ajinomoto Co Inc | モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体 |
| WO2002085293A2 (en) * | 2001-04-20 | 2002-10-31 | Cargill, Incorporated | Production of alpha-lipoic acid |
| DE10129711B4 (de) | 2001-06-22 | 2007-08-23 | Forschungszentrum Jülich GmbH | Verfahren zur fermentativen Herstellung von Pyruvat |
| US6489217B1 (en) | 2001-07-03 | 2002-12-03 | Maxim Integrated Products, Inc. | Method of forming an integrated circuit on a low loss substrate |
| JP2003171365A (ja) | 2001-11-30 | 2003-06-20 | Ajinomoto Co Inc | モナティン類及びその製造中間体の製造方法並びに新規中間体 |
| JP4991091B2 (ja) | 2001-11-30 | 2012-08-01 | 味の素株式会社 | モナティンの非天然型立体異性体塩の結晶及びその使用 |
| JP4196832B2 (ja) | 2001-12-27 | 2008-12-17 | 味の素株式会社 | グルタミン酸化合物及びそれらの製造中間体の製造方法並びにそのための新規中間体 |
| WO2003056026A1 (en) * | 2001-12-27 | 2003-07-10 | Ajinomoto Co., Inc. | Process for production of glutamic acid derivatives |
| US7297800B2 (en) | 2001-12-27 | 2007-11-20 | Ajinomoto Co., Inc. | Process of producing glutamate derivatives |
| JPWO2003074690A1 (ja) | 2002-03-01 | 2005-06-30 | 協和醗酵工業株式会社 | 低基質特異性アミノ酸ラセマーゼおよびラセミ体のアミノ酸の製造法 |
| JP2003292484A (ja) | 2002-04-01 | 2003-10-15 | Ajinomoto Co Inc | γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法 |
| US7572607B2 (en) | 2002-04-23 | 2009-08-11 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| US8372989B2 (en) | 2002-04-23 | 2013-02-12 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin and its precursors |
| CA2483126C (en) | 2002-04-23 | 2014-05-20 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of monatin |
| DK1533376T3 (da) | 2002-08-26 | 2010-07-19 | Ajinomoto Kk | Nye aldolaser og fremgangsmåde til fremstilling af substitueret alfa-ketosyre |
| CN1723281B (zh) | 2002-12-09 | 2012-08-15 | 味之素株式会社 | 突变的d-氨基转移酶和使用它们生产旋光性谷氨酸衍生物的方法 |
| AU2003301508A1 (en) | 2003-01-09 | 2004-08-23 | Ajinomoto Co., Inc. | Processes for producing glutamic acid derivative and pyroglutamic acid derivative and novel intermediate for production |
| JP4239600B2 (ja) | 2003-01-24 | 2009-03-18 | 味の素株式会社 | ２ｒ−モナティンの製造方法 |
| WO2004085624A2 (en) | 2003-03-24 | 2004-10-07 | Diversa Corporation | Transaminases, deaminases and aminomutases and compositions and methods for enzymatic detoxification |
| JP2004331644A (ja) | 2003-04-14 | 2004-11-25 | Kanazawa Univ Tlo Inc | モナチン類の製造法 |
| JP2004331650A (ja) | 2003-04-14 | 2004-11-25 | Kanazawa Univ Tlo Inc | モナチン類の製造法 |
| JP4760375B2 (ja) | 2003-06-26 | 2011-08-31 | 味の素株式会社 | Ｉｈｏｇの回収方法およびモナティンの製造方法 |
| US20050112260A1 (en) | 2003-08-01 | 2005-05-26 | Cargill, Inc. | Monatin tabletop sweetener compositions and methods of making same |
| ATE360370T1 (de) * | 2003-08-14 | 2007-05-15 | Cargill Inc | Monatinhaltige kaugummizusammensetzungen und verfahren zu ihrer herstellung |
| US20050106305A1 (en) | 2003-08-25 | 2005-05-19 | Cargill, Inc. | Beverage compositions comprising monatin and methods of making same |
| CN1890377B (zh) | 2003-10-21 | 2013-06-05 | 嘉吉有限公司 | 生产莫纳甜和莫纳甜前体 |
| JP4500977B2 (ja) | 2003-11-05 | 2010-07-14 | 味の素株式会社 | 新規アミノ酸誘導体及び甘味剤 |
| JP5113978B2 (ja) | 2003-11-21 | 2013-01-09 | 味の素株式会社 | グルタミン酸誘導体の有機アミン塩及びその利用 |
| WO2005082850A1 (ja) | 2004-02-27 | 2005-09-09 | Ajinomoto Co., Inc. | モナティンの製造方法 |
| JP4604524B2 (ja) | 2004-03-16 | 2011-01-05 | 味の素株式会社 | 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法 |
| JP4604537B2 (ja) | 2004-03-31 | 2011-01-05 | 味の素株式会社 | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US7935377B2 (en) | 2004-06-04 | 2011-05-03 | Ajinomoto Co., Inc. | Crystals of free (2R, 4R)-monatin and use thereof |
| CA2506247C (en) | 2004-06-07 | 2012-02-21 | Ajinomoto Co., Inc. | Novel aldolase, and method for producing optically active ihog and monatin |
| KR101216575B1 (ko) | 2004-07-14 | 2012-12-31 | 아지노모토 가부시키가이샤 | (2ｒ,4ｒ)-모나틴 칼륨 염 결정 및 이를 함유하는 감미료조성물 |
| JP2007284349A (ja) | 2004-07-27 | 2007-11-01 | Ajinomoto Co Inc | モナティンまたはその塩の製造方法 |
| KR20070062542A (ko) | 2004-10-05 | 2007-06-15 | 아지노모토 가부시키가이샤 | 하이드록시이미노산으로부터 아미노산 유도체의 제조방법 |
| RU2392834C2 (ru) | 2004-10-15 | 2010-06-27 | Адзиномото Ко., Инк. | Композиция подсластителя |
| US8158389B2 (en) | 2005-04-20 | 2012-04-17 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| WO2006113897A2 (en) | 2005-04-20 | 2006-10-26 | Cargill, Incorporated | Products and methods for in vivo secretion of monatin |
| US8076108B2 (en) | 2005-04-26 | 2011-12-13 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| US7582455B2 (en) | 2005-04-26 | 2009-09-01 | Cargill, Incorporated | Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors |
| EP2112227B1 (de) | 2006-03-07 | 2013-05-15 | Cargill, Incorporated | Aldolasen, Nukleinsäuren zu ihrer Kodierung sowie Verfahren zu ihrer Herstellung und Verwendung |
| CN101490249A (zh) | 2006-05-24 | 2009-07-22 | 嘉吉公司 | 提高平衡反应的产量的方法和系统 |
| US20090198072A1 (en) | 2006-05-24 | 2009-08-06 | Cargill, Incorporated | Methods and systems for increasing production of equilibrium reactions |
| US8003361B2 (en) * | 2007-10-01 | 2011-08-23 | Cargill Incorporated | Production of monatin enantiomers |
| US8367847B2 (en) | 2007-10-01 | 2013-02-05 | Cargill, Incorporated | Production of monatin enantiomers |
| US8076107B2 (en) | 2007-10-01 | 2011-12-13 | Cargill, Incorporated | Production of monatin stereoisomers |
| BRPI0822219A2 (pt) | 2008-01-03 | 2014-11-04 | Cargill Inc | Ácidos nucléicos de aminotransferase e oxidoreductase e polipeptídeos e métodos de uso. |
| WO2011002469A1 (en) | 2009-07-02 | 2011-01-06 | Cargill, Incorporated | Isomerases and epimerases and methods of using |
| CN102318313B (zh) | 2009-02-16 | 2015-04-01 | 瑞典爱立信有限公司 | 不加密的网络操作解决方案 |
| AU2010224131A1 (en) | 2009-03-12 | 2011-09-22 | Cargill, Incorporated | Compositions comprising monatin and calcium |
| CN102481007A (zh) | 2009-05-28 | 2012-05-30 | 嘉吉公司 | 储存稳定的莫纳汀增甜饮料 |
| WO2011082351A1 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | A polymer and methods of preparing and using a polymer |
| WO2011082363A1 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Membrane separation and purification of monatin |
| WO2011082365A2 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Improved bioreactor performance in the production of monatin |
| WO2011082353A1 (en) | 2009-12-30 | 2011-07-07 | Cargill, Incorporated | Separation and purification of monatin |
-
2004
- 2004-10-21 CN CN2004800348419A patent/CN1890377B/zh not_active Expired - Fee Related
- 2004-10-21 WO PCT/US2004/034558 patent/WO2005042756A2/en not_active Ceased
- 2004-10-21 AT AT04795689T patent/ATE498691T1/de not_active IP Right Cessation
- 2004-10-21 EP EP04795689A patent/EP1678313B1/de not_active Expired - Lifetime
- 2004-10-21 RU RU2006117353/13A patent/RU2006117353A/ru not_active Application Discontinuation
- 2004-10-21 AU AU2004286207A patent/AU2004286207B2/en not_active Ceased
- 2004-10-21 EP EP10009952.2A patent/EP2302067B1/de not_active Expired - Lifetime
- 2004-10-21 JP JP2006536714A patent/JP4829117B2/ja not_active Expired - Fee Related
- 2004-10-21 DE DE602004031444T patent/DE602004031444D1/de not_active Expired - Lifetime
- 2004-10-21 KR KR1020067009839A patent/KR101158592B1/ko not_active Expired - Fee Related
- 2004-10-21 US US10/969,245 patent/US8206955B2/en not_active Expired - Fee Related
- 2004-10-21 BR BRPI0415763-0A patent/BRPI0415763A/pt not_active Application Discontinuation
- 2004-10-21 CN CN201310188490.8A patent/CN103555782B/zh not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2007508840A (ja) | 2007-04-12 |
| BRPI0415763A (pt) | 2006-12-26 |
| CN103555782B (zh) | 2017-04-12 |
| CN1890377A (zh) | 2007-01-03 |
| EP2302067A1 (de) | 2011-03-30 |
| KR20060125761A (ko) | 2006-12-06 |
| DE602004031444D1 (de) | 2011-03-31 |
| AU2004286207A1 (en) | 2005-05-12 |
| US20050221455A1 (en) | 2005-10-06 |
| KR101158592B1 (ko) | 2012-06-22 |
| WO2005042756A2 (en) | 2005-05-12 |
| CN1890377B (zh) | 2013-06-05 |
| EP2302067B1 (de) | 2014-03-05 |
| WO2005042756A3 (en) | 2005-11-24 |
| EP1678313A2 (de) | 2006-07-12 |
| AU2004286207B2 (en) | 2011-02-24 |
| ZA200604080B (en) | 2007-11-28 |
| US8206955B2 (en) | 2012-06-26 |
| CN103555782A (zh) | 2014-02-05 |
| JP4829117B2 (ja) | 2011-12-07 |
| RU2006117353A (ru) | 2007-12-27 |
| EP1678313B1 (de) | 2011-02-16 |
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