BRPI0415836A - composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica - Google Patents

composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica

Info

Publication number
BRPI0415836A
BRPI0415836A BRPI0415836-9A BRPI0415836A BRPI0415836A BR PI0415836 A BRPI0415836 A BR PI0415836A BR PI0415836 A BRPI0415836 A BR PI0415836A BR PI0415836 A BRPI0415836 A BR PI0415836A
Authority
BR
Brazil
Prior art keywords
ameliorating
mammal
disorder
inflammatory
risk
Prior art date
Application number
BRPI0415836-9A
Other languages
English (en)
Inventor
Mark Jensen
Robert Larsen
Daniel Richard Sidler
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BRPI0415836A publication Critical patent/BRPI0415836A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO, MéTODOS PARA A MODULAçãO DA ATIVIDADE DE RECEPTOR DE QUIMOCINA EM UM MAMìFERO, E PARA O TRATAMENTO, A MELHORIA, O CONTROLE OU A REDUçãO DO RISCO DE UMA DOENçA OU DISTúRBIO INFLAMATóRIO E IMUNORREGULATóRIO, E DE ARTRITE REUMATóIDE, COMPOSIçãO FARMACêUTICA". A presente invenção proporciona uma sintese eficiente para a preparação de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6-naftiridin-6(5 H)-il!-carbonil}-ciclo-pentil)¢(3S,4S)-3-metóxi-tetra-hidro-2H-piran-4-il!- amina e seu sal de succinato. A presente invenção adicionalmente proporciona uma síntese eficiente para a preparação de intermediários (3R)-3-metóxi-tetra-hidro-4H-piran-4-ona; ácido (1S,4S)-4-(2,5-dimetil-1H-pirrol-1-il)-1-isopropil-ciclo-pent-2-eno-1-car boxílico; e 3-(trifluorometil)-5,6,7,8-tetra-hidro- 1,6-naftiridina; e para a preparação do precursor (3S,4S)-N-((1S,4S)-4-isopropil-4-{¢3-trifluorometil)-7,8-di-hidro-1,6-naft iridin-6(5H)il!-carbonil}-ciclo-pent-2-en-1-il)-3-metóxi-tetra-hidro-2H-pir an-4-amina. A invenção adicionalmente reside nas propriedades superiores do sal de succinato de ((1R,3S)-3-isopropil-3-{¢3-(trifluorometil)-7,8-di-hidro-1,6-naftiridin-6(5 H)-il!-carbonil}-ciclo-pentil)¢(3S,4S)-3-metóxi-tetra-hidro-2H-piran-4-il!- amina.
BRPI0415836-9A 2003-10-27 2004-10-25 composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica BRPI0415836A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51473503P 2003-10-27 2003-10-27
PCT/US2004/035069 WO2005044264A1 (en) 2003-10-27 2004-10-25 Ccr-2 antagonist salt

Publications (1)

Publication Number Publication Date
BRPI0415836A true BRPI0415836A (pt) 2007-01-02

Family

ID=34572774

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415836-9A BRPI0415836A (pt) 2003-10-27 2004-10-25 composto, métodos para a modulação da atividade de receptor de quimocina em um mamìfero, e para o tratamento, a melhoria, o controle ou a redução do risco de uma doença ou distúrbio inflamatório e imunorregulatório, e de artrite reumatóide, composição farmacêutica

Country Status (21)

Country Link
US (1) US7473696B2 (pt)
EP (1) EP1682135B1 (pt)
JP (1) JP4542550B2 (pt)
KR (1) KR20060101476A (pt)
CN (1) CN1870998B (pt)
AT (1) ATE517622T1 (pt)
AU (1) AU2004287416C1 (pt)
BR (1) BRPI0415836A (pt)
CA (1) CA2543201C (pt)
CO (1) CO5690606A2 (pt)
EC (1) ECSP066524A (pt)
IL (1) IL175009A0 (pt)
IS (1) IS8400A (pt)
MA (1) MA28104A1 (pt)
MX (1) MXPA06004647A (pt)
NO (1) NO20062377L (pt)
NZ (1) NZ546447A (pt)
RU (1) RU2317295C1 (pt)
UA (1) UA81365C2 (pt)
WO (1) WO2005044264A1 (pt)
ZA (1) ZA200602752B (pt)

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US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
WO2004050024A2 (en) 2002-11-27 2004-06-17 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
WO2004082616A2 (en) * 2003-03-18 2004-09-30 Merck & Co. Inc. Tetrahydropyranyl cyclopentyl heterocylic amide modulators of chemokine receptor activity
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2
CA2550596C (en) 2003-12-18 2011-03-15 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
CN1950085A (zh) 2004-05-11 2007-04-18 因赛特公司 作为趋化因子受体调节剂的3－(4－杂芳基环己基氨基)环戊烷羧酰胺
GB0413605D0 (en) * 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
AP2006003849A0 (en) 2004-06-28 2006-12-31 Incyte Corp 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
AU2005259983B2 (en) 2004-06-28 2011-07-28 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
MX2009005252A (es) 2006-11-17 2009-05-28 Abbott Lab Aminopirrolidinas como antagonistas del receptor de quimiocina.
US20090076065A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched mk-0812
US7741327B2 (en) 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
US8178689B2 (en) 2010-06-17 2012-05-15 Hoffman-La Roche Inc. Tricyclic compounds
WO2012125663A2 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
WO2013149376A1 (en) 2012-04-02 2013-10-10 Abbott Laboratories Chemokine receptor antagonists
EP2962691A4 (en) 2013-02-28 2016-08-31 Santen Pharmaceutical Co Ltd AGENT FOR THE PREVENTION OR TREATMENT OF DISEASES OF THE POSTERIOR PART OF THE IL CONTAINING A TETRAHYDROPYRANYLAMINOCYCLOPENTYLCARBONYLTETRAHYDROPYRIDOPYRIDINE DERIVATIVE AS ACTIVE INGREDIENT
RU2726206C2 (ru) 2015-05-21 2020-07-09 Кемосентрикс, Инк. Модуляторы ccr2
EP3687525B1 (en) 2017-09-25 2025-10-29 ChemoCentryx, Inc. Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN112105353B (zh) 2018-01-08 2024-04-19 凯莫森特里克斯股份有限公司 Ccr2拮抗剂治疗实体瘤的方法
CN112341350A (zh) * 2020-10-19 2021-02-09 江苏威奇达药业有限公司 酶法拆分γ-内酰胺后副产物的处理方法

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CN1608062A (zh) * 2001-12-12 2005-04-20 辉瑞产品公司 E－2－甲氧基－n－(3－{4－[3－甲基－4－(6－甲基－吡啶－3－基氧基) －苯氨基]－喹唑啉－6基}－烯丙基)－乙酰胺的盐，其制备和抗癌用途
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
JP3780291B2 (ja) * 2002-04-29 2006-05-31 メルク エンド カムパニー インコーポレーテッド テトラヒドロピラニルシクロペンチルテトラヒドロピリドピリジン系のケモカイン受容体活性調節剤
CA2483843A1 (en) * 2002-04-29 2003-11-13 Merck & Co. Inc. Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2

Also Published As

Publication number Publication date
WO2005044264A1 (en) 2005-05-19
NO20062377L (no) 2006-05-24
ATE517622T1 (de) 2011-08-15
NZ546447A (en) 2009-02-28
ECSP066524A (es) 2006-10-10
CN1870998A (zh) 2006-11-29
EP1682135A1 (en) 2006-07-26
JP2007509940A (ja) 2007-04-19
AU2004287416C1 (en) 2010-09-09
IS8400A (is) 2006-04-06
EP1682135B1 (en) 2011-07-27
AU2004287416A1 (en) 2005-05-19
MXPA06004647A (es) 2006-06-27
JP4542550B2 (ja) 2010-09-15
IL175009A0 (en) 2006-08-20
AU2004287416B2 (en) 2009-11-19
UA81365C2 (en) 2007-12-25
CO5690606A2 (es) 2006-10-31
CN1870998B (zh) 2010-10-20
CA2543201C (en) 2010-12-21
CA2543201A1 (en) 2005-05-19
EP1682135A4 (en) 2009-11-25
RU2317295C1 (ru) 2008-02-20
US7473696B2 (en) 2009-01-06
MA28104A1 (fr) 2006-08-01
KR20060101476A (ko) 2006-09-25
US20070135474A1 (en) 2007-06-14
ZA200602752B (en) 2007-08-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

Free format text: ALTERADO DE: MERCK AND CO., INC.

B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. A61K 31/4375; C07D 471/04; A61P 19/02

Ipc: A61K 31/4375 (2011.01), C07D 471/04 (2011.01), A61

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.