NO20062377L - CCR-2-antagonistsalt - Google Patents

CCR-2-antagonistsalt

Info

Publication number
NO20062377L
NO20062377L NO20062377A NO20062377A NO20062377L NO 20062377 L NO20062377 L NO 20062377L NO 20062377 A NO20062377 A NO 20062377A NO 20062377 A NO20062377 A NO 20062377A NO 20062377 L NO20062377 L NO 20062377L
Authority
NO
Norway
Prior art keywords
antagonistsalt
ccr
succinate salt
methoxytetrahydro
naphthyridin
Prior art date
Application number
NO20062377A
Other languages
English (en)
Inventor
Daniel Richard Sidler
Mark Jensen
Robert Lasen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20062377L publication Critical patent/NO20062377L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Foreliggende oppfinnelse tilveie-bringer en effektiv syntese for fremstilling av ((IR,3S)-3-isopropyl-3-{[3-(trifluormetyl)-7,8-dihydro-l,6-naftyridin-6(5H)-yl]karbonyl}syklo-pentyl) [(3S, 4S)-3-metoksytetrahydro-2H-pyran-4-yl]amin og dets sukkinat-salt. Foreliggende oppfinnelse tilveiebringer i tillegg en effektiv syntese for fremstilling av mellomproduktene (3R)-3-metoksytetrahydro-4H-pyran-4-on; (IS,4S)-4-(2,5-dimetyl-lH-pyrrol-1-yl)-1-isopropyl-syklopent-2-en-l-karboksylsyre; og 3-(trifluormetyl)-5,6,7,8-tetrahydro-1,6-naftyridin; og for fremstilling av forløperen (3S,4S)-N-((IS,4S)-4-isopropyl-4-{[3-(trifluormetyl)-7,8-dihydro-1,6-naftyridin-6(5H)-yl]karbonyl }syklopent-2-en-l-yl)-3-metoksy-tetrahydro-2H-pyran-4-amin. Oppfinnelsen ligger enn videre i tillegg i de glimrende egenskaper av sukkinat-saltet av ((IR,3S)-3-isopropyl-3-{[3-(trifluormetyl)-7,8-dihydro-l,6-naftyridin-6(5H)-yl]karbonyl}syklo-pentyl) [(3S, 4S)-3-metoksytetrahydro-2H-pyran-4-yl]amin.
NO20062377A 2003-10-27 2006-05-24 CCR-2-antagonistsalt NO20062377L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51473503P 2003-10-27 2003-10-27
PCT/US2004/035069 WO2005044264A1 (en) 2003-10-27 2004-10-25 Ccr-2 antagonist salt

Publications (1)

Publication Number Publication Date
NO20062377L true NO20062377L (no) 2006-05-24

Family

ID=34572774

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062377A NO20062377L (no) 2003-10-27 2006-05-24 CCR-2-antagonistsalt

Country Status (21)

Country Link
US (1) US7473696B2 (no)
EP (1) EP1682135B1 (no)
JP (1) JP4542550B2 (no)
KR (1) KR20060101476A (no)
CN (1) CN1870998B (no)
AT (1) ATE517622T1 (no)
AU (1) AU2004287416C1 (no)
BR (1) BRPI0415836A (no)
CA (1) CA2543201C (no)
CO (1) CO5690606A2 (no)
EC (1) ECSP066524A (no)
IL (1) IL175009A0 (no)
IS (1) IS8400A (no)
MA (1) MA28104A1 (no)
MX (1) MXPA06004647A (no)
NO (1) NO20062377L (no)
NZ (1) NZ546447A (no)
RU (1) RU2317295C1 (no)
UA (1) UA81365C2 (no)
WO (1) WO2005044264A1 (no)
ZA (1) ZA200602752B (no)

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MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
US20060030582A1 (en) * 2002-04-29 2006-02-09 Demartino Julie Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
MXPA05005660A (es) 2002-11-27 2005-10-18 Incyte Corp Derivados de 3-aminopirrolidina como moduladores de receptores de quimocina.
US7393844B2 (en) * 2003-03-18 2008-07-01 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2
BRPI0417605B8 (pt) 2003-12-18 2021-05-25 Incyte Corp “n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende”.
JP2007537264A (ja) 2004-05-11 2007-12-20 インサイト コーポレイション ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド
GB0413605D0 (en) * 2004-06-17 2004-07-21 Addex Pharmaceuticals Sa Novel compounds
WO2006004741A2 (en) 2004-06-28 2006-01-12 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
JP4116670B2 (ja) 2004-06-28 2008-07-09 インサイト コーポレイション ケモカイン受容体の調節剤としての３−アミノシクロペンタンカルボキサミド
CA2669917A1 (en) 2006-11-17 2008-05-22 Dawn M. George Aminopyrrolidines as chemokine receptor antagonists
US20090076065A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched mk-0812
US7741327B2 (en) 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
US8178689B2 (en) 2010-06-17 2012-05-15 Hoffman-La Roche Inc. Tricyclic compounds
WO2012125663A2 (en) * 2011-03-17 2012-09-20 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
WO2013149376A1 (en) 2012-04-02 2013-10-10 Abbott Laboratories Chemokine receptor antagonists
EP2962691A4 (en) * 2013-02-28 2016-08-31 Santen Pharmaceutical Co Ltd AGENT FOR THE PREVENTION OR TREATMENT OF DISEASES OF THE POSTERIOR PART OF THE IL CONTAINING A TETRAHYDROPYRANYLAMINOCYCLOPENTYLCARBONYLTETRAHYDROPYRIDOPYRIDINE DERIVATIVE AS ACTIVE INGREDIENT
ES2904252T3 (es) 2015-05-21 2022-04-04 Chemocentryx Inc Moduladores de CCR2
CN118267479A (zh) 2017-09-25 2024-07-02 凯莫森特里克斯股份有限公司 使用趋化因子受体2(ccr2)拮抗剂和pd-1/pd-l1抑制剂的联合治疗
IL275898B2 (en) 2018-01-08 2025-05-01 Chemocentryx Inc Methods for treating solid tumors with CCR2 antagonists
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
CN112341350A (zh) * 2020-10-19 2021-02-09 江苏威奇达药业有限公司 酶法拆分γ-内酰胺后副产物的处理方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO108347B1 (ro) * 1989-10-30 1994-04-28 Bellon Labor Sa Roger DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA
GB9417249D0 (en) * 1994-08-26 1994-10-19 Wellcome Found A novel salt
JPH09291034A (ja) * 1996-02-27 1997-11-11 Yoshitomi Pharmaceut Ind Ltd 縮合ピリジン化合物およびその医薬としての用途
RU2174123C2 (ru) * 1996-10-28 2001-09-27 Новартис Аг Производные 8-арил-1,7-нафтиридина и фармацевтическая композиция, обладающая противовоспалительной активностью
US6312689B1 (en) * 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
FR2787790A3 (fr) * 1998-12-23 2000-06-30 Sanofi Sa Procede de preparation du (r)-(+)-3-{1°2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl!-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates
AU5473400A (en) 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
EP1318811B1 (en) * 2000-08-17 2006-08-30 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
CZ20031315A3 (cs) * 2000-11-28 2004-04-14 Pfizer Products Inc. Soli isothiazolkarboxamidu a jejich použití jako prostředků proti hyperproliferaci
EP1461040B1 (en) * 2001-11-29 2006-03-15 Pfizer Products Inc. Succinic acid salts of 5,8,14-triazatetracyclo[10.3.1.0 2,11 .0 4,9 ]-hexadeca-2(11),3,5,7,9,-pentaene and pharmaceutical compositions thereof
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JP4459807B2 (ja) * 2002-04-29 2010-04-28 メルク エンド カムパニー インコーポレーテッド テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤
EP1501507B1 (en) * 2002-04-29 2008-05-28 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2

Also Published As

Publication number Publication date
ZA200602752B (en) 2007-08-29
US7473696B2 (en) 2009-01-06
JP4542550B2 (ja) 2010-09-15
EP1682135A1 (en) 2006-07-26
MA28104A1 (fr) 2006-08-01
JP2007509940A (ja) 2007-04-19
CN1870998A (zh) 2006-11-29
KR20060101476A (ko) 2006-09-25
BRPI0415836A (pt) 2007-01-02
AU2004287416A1 (en) 2005-05-19
ATE517622T1 (de) 2011-08-15
AU2004287416C1 (en) 2010-09-09
IL175009A0 (en) 2006-08-20
CA2543201A1 (en) 2005-05-19
ECSP066524A (es) 2006-10-10
RU2317295C1 (ru) 2008-02-20
CA2543201C (en) 2010-12-21
UA81365C2 (en) 2007-12-25
CN1870998B (zh) 2010-10-20
WO2005044264A1 (en) 2005-05-19
MXPA06004647A (es) 2006-06-27
NZ546447A (en) 2009-02-28
EP1682135A4 (en) 2009-11-25
US20070135474A1 (en) 2007-06-14
IS8400A (is) 2006-04-06
CO5690606A2 (es) 2006-10-31
EP1682135B1 (en) 2011-07-27
AU2004287416B2 (en) 2009-11-19

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Legal Events

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