BRPI0415860A - pirimidinas como inibidores de fosfoinositìdeo 3-quinases (pi3k) - Google Patents

pirimidinas como inibidores de fosfoinositìdeo 3-quinases (pi3k)

Info

Publication number
BRPI0415860A
BRPI0415860A BRPI0415860-1A BRPI0415860A BRPI0415860A BR PI0415860 A BRPI0415860 A BR PI0415860A BR PI0415860 A BRPI0415860 A BR PI0415860A BR PI0415860 A BRPI0415860 A BR PI0415860A
Authority
BR
Brazil
Prior art keywords
pyrimidines
pi3k
inhibitors
phosphoinositide
kinases
Prior art date
Application number
BRPI0415860-1A
Other languages
English (en)
Inventor
Michael Kevin Connolly
Rocco Dean Gogliotti
Mark Stephen Plummer
Melean Visnick
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BRPI0415860A publication Critical patent/BRPI0415860A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PIRIMIDINAS COMO INIBIDORES DE FOSFOINOSITìDEO 3QUINASES (PI3K)". A presente invenção proporciona pirimidinas de Fórmula (I) : em que R¬ 4¬, R¬ 6¬ e Y têm qualquer um dos valores que lhes são definidos na especificação e seus sais farmaceuticamente aceitáveis, que são úteis como agentes no tratamento de doenças e estados, incluindo doenças inflamatórias, doenças cardiovasculares e cânceres. São também proporcionadas composições farmacêuticas compreendendo um ou mais compostos de fórmula (I).
BRPI0415860-1A 2003-10-31 2004-10-19 pirimidinas como inibidores de fosfoinositìdeo 3-quinases (pi3k) BRPI0415860A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51659103P 2003-10-31 2003-10-31
PCT/IB2004/003417 WO2005042519A1 (en) 2003-10-31 2004-10-19 Pyrimidines as inhibitors of phosphoinositide -3-kinases (pi3k)

Publications (1)

Publication Number Publication Date
BRPI0415860A true BRPI0415860A (pt) 2007-01-09

Family

ID=34549554

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415860-1A BRPI0415860A (pt) 2003-10-31 2004-10-19 pirimidinas como inibidores de fosfoinositìdeo 3-quinases (pi3k)

Country Status (9)

Country Link
US (1) US20090227587A1 (pt)
EP (1) EP1682532B1 (pt)
JP (1) JP2007509924A (pt)
AT (1) ATE365732T1 (pt)
BR (1) BRPI0415860A (pt)
CA (1) CA2543608A1 (pt)
DE (1) DE602004007284T2 (pt)
ES (1) ES2285517T3 (pt)
WO (1) WO2005042519A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2552664A1 (en) * 2004-01-08 2005-07-28 Michigan State University Methods for treating and preventing hypertension and hypertension-related disorders
GB0415364D0 (en) 2004-07-09 2004-08-11 Astrazeneca Ab Pyrimidine derivatives
CN102036981B (zh) * 2008-03-18 2015-04-08 默沙东公司 取代的4-羟基嘧啶-5-甲酰胺
MA33501B1 (fr) * 2009-07-02 2012-08-01 Sanofi Sa Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
WO2011065800A2 (ko) * 2009-11-30 2011-06-03 주식회사 오스코텍 피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
KR101301533B1 (ko) 2010-02-09 2013-09-04 한미사이언스 주식회사 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체
US20150258127A1 (en) 2012-10-31 2015-09-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preventing antiphospholipid syndrome (aps)
CA3105657A1 (en) * 2018-07-09 2020-01-16 Lieber Institute, Inc. Pyridine carboxamide compounds for inhibiting nav1.8

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001230426C1 (en) * 2000-01-24 2006-06-22 Astrazeneca Ab Therapeutic morpholino-substituted compounds

Also Published As

Publication number Publication date
JP2007509924A (ja) 2007-04-19
CA2543608A1 (en) 2005-05-12
DE602004007284T2 (de) 2008-02-28
DE602004007284D1 (de) 2007-08-09
US20090227587A1 (en) 2009-09-10
ATE365732T1 (de) 2007-07-15
ES2285517T3 (es) 2007-11-16
EP1682532B1 (en) 2007-06-27
EP1682532A1 (en) 2006-07-26
WO2005042519A1 (en) 2005-05-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.