BRPI0417571A - 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase - Google Patents

2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase

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Publication number
BRPI0417571A
BRPI0417571A BRPI0417571-9A BRPI0417571A BRPI0417571A BR PI0417571 A BRPI0417571 A BR PI0417571A BR PI0417571 A BRPI0417571 A BR PI0417571A BR PI0417571 A BRPI0417571 A BR PI0417571A
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BR
Brazil
Prior art keywords
substituted
quinoxalinones
quinolinones
adp
ribose
Prior art date
Application number
BRPI0417571-9A
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English (en)
Inventor
Dominique Jean-Pierre Mabire
Jacobus Alphonsus Josephus Dun
Maria Victorina Francis Somers
Walter Boudewijn Leopo Wouters
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0417571A publication Critical patent/BRPI0417571A/pt

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    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

"2-QUINOLINONAS E 2-QUINOXALINONAS SUBSTITUìDAS POR 6-CICLOHEXILALQUILA SUBSTITUìDA COMO INIBIDORES DA POLI(ADP-RIBOSE) POLIMERASE". A presente invenção refere-se compostos da fórmula (I), o uso dos mesmos como inibidores de PARP assim como composições farmacêuticas que compreendem os ditos compostos da fórmula (I) 3 em que n, s, R¬ 1¬, R¬ 2¬, R¬ 3¬, Q, X e Y possuem os significados definidos.
BRPI0417571-9A 2003-12-10 2004-11-18 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase BRPI0417571A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03078918 2003-12-10
PCT/EP2004/013165 WO2005058843A1 (en) 2003-12-10 2004-11-18 Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0417571A true BRPI0417571A (pt) 2007-03-20

Family

ID=34684557

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417571-9A BRPI0417571A (pt) 2003-12-10 2004-11-18 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase

Country Status (17)

Country Link
US (1) US7652014B2 (pt)
EP (1) EP1694653B1 (pt)
JP (1) JP4948178B2 (pt)
KR (1) KR101149031B1 (pt)
CN (2) CN102206180B (pt)
AU (1) AU2004299183B2 (pt)
BR (1) BRPI0417571A (pt)
CA (1) CA2548273C (pt)
EA (1) EA010592B1 (pt)
ES (1) ES2565581T3 (pt)
IL (1) IL176199A (pt)
NO (1) NO337621B1 (pt)
NZ (1) NZ547278A (pt)
SG (1) SG151250A1 (pt)
UA (1) UA91007C2 (pt)
WO (1) WO2005058843A1 (pt)
ZA (1) ZA200604774B (pt)

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AU2004299183A1 (en) 2005-06-30
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CN102206180B (zh) 2013-05-29
US7652014B2 (en) 2010-01-26
JP2007513898A (ja) 2007-05-31
EA200601125A1 (ru) 2006-10-27
JP4948178B2 (ja) 2012-06-06
CN102206180A (zh) 2011-10-05
WO2005058843A1 (en) 2005-06-30
CA2548273A1 (en) 2005-06-30
NO337621B1 (no) 2016-05-09
CN1890225A (zh) 2007-01-03
NO20063129L (no) 2006-07-05
ES2565581T3 (es) 2016-04-05
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EP1694653B1 (en) 2016-01-20
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CA2548273C (en) 2013-04-16
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AU2004299183B2 (en) 2010-09-23
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