BRPI0416532A - 2-quinolinonas e 2-quinoxalinonas substituìdas por 6 como inibidores da poli(adp-ribose) polimerase - Google Patents

2-quinolinonas e 2-quinoxalinonas substituìdas por 6 como inibidores da poli(adp-ribose) polimerase

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Publication number
BRPI0416532A
BRPI0416532A BRPI0416532-2A BRPI0416532A BRPI0416532A BR PI0416532 A BRPI0416532 A BR PI0416532A BR PI0416532 A BRPI0416532 A BR PI0416532A BR PI0416532 A BRPI0416532 A BR PI0416532A
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BR
Brazil
Prior art keywords
quinoxalinones
quinolinones
adp
ribose
poly
Prior art date
Application number
BRPI0416532-2A
Other languages
English (en)
Inventor
Dominique Jean-Pierre Mabire
Jerome Emile George Guillemont
Jacobus Alphonsus Josephus Dun
Maria Victorina Francis Somers
Walter Boudewijn Leopo Wouters
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0416532A publication Critical patent/BRPI0416532A/pt

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    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
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    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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Abstract

"2-QUINOLINONAS E 2-QUINOXALINONAS SUBSTITUìDAS POR 6 COMO INIBIDORES DA POLI(ADP-RIBOSE) POLIMERASE". A presente invenção fornece compostos da fórmula (I), o uso dos mesmos como inibidores de PARP assim como composições farmacêuticas que compreendem os ditos compostos da fórmula (I) em que n, R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬ e X possuem os significados definidos.
BRPI0416532-2A 2003-12-05 2004-11-18 2-quinolinonas e 2-quinoxalinonas substituìdas por 6 como inibidores da poli(adp-ribose) polimerase BRPI0416532A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03078859 2003-12-05
PCT/EP2004/013164 WO2005054210A1 (en) 2003-12-05 2004-11-18 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0416532A true BRPI0416532A (pt) 2007-01-09

Family

ID=34639300

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416532-2A BRPI0416532A (pt) 2003-12-05 2004-11-18 2-quinolinonas e 2-quinoxalinonas substituìdas por 6 como inibidores da poli(adp-ribose) polimerase

Country Status (17)

Country Link
US (2) US7879857B2 (pt)
EP (1) EP1709012B1 (pt)
JP (1) JP4806353B2 (pt)
KR (1) KR101159118B1 (pt)
CN (1) CN1890224B (pt)
AU (1) AU2004295059B2 (pt)
BR (1) BRPI0416532A (pt)
CA (1) CA2546657C (pt)
EA (1) EA010488B1 (pt)
ES (1) ES2551299T3 (pt)
IL (1) IL176060A (pt)
NO (1) NO20063028L (pt)
NZ (1) NZ547193A (pt)
SG (1) SG151249A1 (pt)
UA (1) UA89618C2 (pt)
WO (1) WO2005054210A1 (pt)
ZA (1) ZA200604549B (pt)

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ZA200604549B (en) 2008-04-30
US20110230491A1 (en) 2011-09-22
UA89618C2 (ru) 2010-02-25
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US7879857B2 (en) 2011-02-01
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CA2546657A1 (en) 2005-06-16
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