BRPI0416648A2 - processo para a preparaÇço de sais quirais farmaceuticamente aceitÁveis de amlodipina - Google Patents
processo para a preparaÇço de sais quirais farmaceuticamente aceitÁveis de amlodipinaInfo
- Publication number
- BRPI0416648A2 BRPI0416648A2 BRPI0416648-5A BRPI0416648A BRPI0416648A2 BR PI0416648 A2 BRPI0416648 A2 BR PI0416648A2 BR PI0416648 A BRPI0416648 A BR PI0416648A BR PI0416648 A2 BRPI0416648 A2 BR PI0416648A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- pharmaceutically acceptable
- amlodipine
- amiodipine
- chiral salts
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 4
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical class CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000528 amlodipine Drugs 0.000 title abstract 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- AUONNNVJUCSETH-UHFFFAOYSA-N icosanoyl icosanoate Chemical compound CCCCCCCCCCCCCCCCCCCC(=O)OC(=O)CCCCCCCCCCCCCCCCCCC AUONNNVJUCSETH-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCESSO PARA A PREPARAÇçO DE SAIS QUIRAIS FARMACEUTICAMENTE ACEITÁVEIS DE AMLODIPINA. A presente invenção refere-se a um processo para a preparação de sais farmaceuticamente aceitáveis de Amiodipina quiral, mais especificamente S(-) Amiodipina e R(+) Amiodipina sem isolar a base livre quiral na qual o produto tem uma pureza ótica variando entre 95 e 99% é descrito na presente invenção. O processo compreende resolver uma base RS de Arnlodipina usando ácido tartárico L(+) ou D(-) seguido pela reação do sal de tartrato separado com um ácido orgânico para obter o sal correspondente ao ácido usado com um ee variando a partir de 96 - 99%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1440DE2003 | 2003-11-20 | ||
| PCT/IN2004/000324 WO2005049571A1 (en) | 2003-11-20 | 2004-10-19 | Process for preparation of chiral amlodipine salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416648A2 true BRPI0416648A2 (pt) | 2009-01-13 |
Family
ID=34611190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416648-5A BRPI0416648A2 (pt) | 2003-11-20 | 2004-10-19 | processo para a preparaÇço de sais quirais farmaceuticamente aceitÁveis de amlodipina |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1687273A1 (pt) |
| KR (1) | KR20060086432A (pt) |
| CN (1) | CN1882543A (pt) |
| BR (1) | BRPI0416648A2 (pt) |
| WO (1) | WO2005049571A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2307209T3 (es) * | 2004-10-20 | 2008-11-16 | Emcure Pharmaceuticals Limited | Procedimiento de produccion de un enantiomero de amlodipina con una pureza optica alta. |
| KR101235116B1 (ko) * | 2005-10-17 | 2013-02-20 | 에스케이케미칼주식회사 | 광학활성 암로디핀 겐티세이트 염의 제조방법 |
| KR100843400B1 (ko) * | 2006-11-14 | 2008-07-04 | 씨제이제일제당 (주) | 결정성 ｓ-(-)-암로디핀 말레익산 염 무수물 및 이의제조방법 |
| CN101468986B (zh) * | 2007-12-26 | 2010-12-29 | 香港南北兄弟国际投资有限公司 | 一种二氢嘧啶消旋化合物的拆分方法 |
| KR100979772B1 (ko) * | 2008-06-12 | 2010-09-02 | 에이치 엘 지노믹스(주) | 광학적으로 순수한 에스-(-)-암로디핀 벤젠술폰산염의제조방법 |
| KR101313842B1 (ko) * | 2010-09-15 | 2013-10-01 | 대화제약 주식회사 | 에스-암로디핀 베실레이트 및 그 수화물의 제조방법 |
| CN102516159B (zh) * | 2011-12-15 | 2013-10-09 | 扬子江药业集团江苏海慈生物药业有限公司 | 一种苯磺酸左旋氨氯地平的生产方法 |
| CN104592099A (zh) * | 2014-12-30 | 2015-05-06 | 山东鲁抗医药股份有限公司 | 提高苯磺酸左旋氨氯地平光学纯度的精制方法 |
| CN111689894B (zh) * | 2019-03-13 | 2023-05-02 | 鲁南制药集团股份有限公司 | 一种苯磺酸左旋氨氯地平晶型 |
| CN112110850B (zh) * | 2019-06-20 | 2023-05-02 | 鲁南制药集团股份有限公司 | 一种苯磺酸左旋氨氯地平新晶型 |
| CN115850159B (zh) * | 2022-11-11 | 2025-03-14 | 常州瑞明药业有限公司 | 一种马来酸左旋氨氯地平的制备方法 |
| CN116332832A (zh) * | 2023-03-29 | 2023-06-27 | 安徽美致诚药业有限公司 | 一种马来酸左旋氨氯地平无定型晶型及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9405833D0 (en) * | 1994-03-24 | 1994-05-11 | Pfizer Ltd | Separation of the enantiomers of amlodipine |
| PL362660A1 (en) * | 2000-12-29 | 2004-11-02 | Pfizer Limited | Process for making amlodipine maleate |
| US6608206B1 (en) * | 2002-10-30 | 2003-08-19 | Council Of Scientific & Industrial Research | Process for making S(-) Amlodipine salts |
-
2004
- 2004-10-19 WO PCT/IN2004/000324 patent/WO2005049571A1/en not_active Ceased
- 2004-10-19 CN CNA2004800343754A patent/CN1882543A/zh active Pending
- 2004-10-19 EP EP04791865A patent/EP1687273A1/en not_active Withdrawn
- 2004-10-19 BR BRPI0416648-5A patent/BRPI0416648A2/pt not_active IP Right Cessation
- 2004-10-19 KR KR1020067009616A patent/KR20060086432A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1687273A1 (en) | 2006-08-09 |
| WO2005049571A1 (en) | 2005-06-02 |
| KR20060086432A (ko) | 2006-07-31 |
| CN1882543A (zh) | 2006-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 3A, 4A, 5A, 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |