BRPI0416931A - processo para resolver ácidos mandélicos, e, composto - Google Patents
processo para resolver ácidos mandélicos, e, compostoInfo
- Publication number
- BRPI0416931A BRPI0416931A BRPI0416931-0A BRPI0416931A BRPI0416931A BR PI0416931 A BRPI0416931 A BR PI0416931A BR PI0416931 A BRPI0416931 A BR PI0416931A BR PI0416931 A BRPI0416931 A BR PI0416931A
- Authority
- BR
- Brazil
- Prior art keywords
- mandelic acid
- acid derivatives
- alkyl
- solving
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical class C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 title 1
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 abstract 5
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 229960002510 mandelic acid Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- -1 cyclic amide salts Chemical class 0.000 abstract 1
- 150000003950 cyclic amides Chemical class 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
"PROCESSO PARA RESOLVER ACIDOS MANDéLICOS E COMPOSTO". A presente invenção diz respeito a um novo processo para a resolução de derivados de ácido mandélico a partir de misturas de derivados de ácido mandélico racêmico pela formação de sal com amidas cíclicas de base quiral; para os sais de amida cíclica do ácido mandélico resolvidos (ver, por exemplo, a fórmula IIa) bem como certos outros sais de amina e metálicos dos derivados de ácido mandélico, e ao uso dos derivados de ácido mandélico resolvidos como intermediários apropriados para a fabricação em larga escala de, por exemplo, compostos farmacêuticos; A fórmula IIa, em que R é selecionado a de CHF~ 2~, H, Alquila C~ 1-6~, CH~ 2~F, CHC1~ 2~ e CC1F~ 2~; e em que n é 0, 1 ou 2; R1 é H ou Alquila C~ 1-6~ e X é H, halo ou Alquila C~ 1-6~.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0303220A SE0303220D0 (sv) | 2003-11-28 | 2003-11-28 | New process |
| PCT/GB2004/004964 WO2005054168A2 (en) | 2003-11-28 | 2004-11-25 | A process for resolving, optionally substituted, mandelic acids by salt formation with a chiral base cyclic amide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0416931A true BRPI0416931A (pt) | 2007-01-16 |
Family
ID=29729226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0416931-0A BRPI0416931A (pt) | 2003-11-28 | 2004-11-25 | processo para resolver ácidos mandélicos, e, composto |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7960582B2 (pt) |
| EP (1) | EP1692089A2 (pt) |
| JP (1) | JP4906511B2 (pt) |
| KR (1) | KR101134767B1 (pt) |
| CN (2) | CN100448834C (pt) |
| AU (2) | AU2004295152B2 (pt) |
| BR (1) | BRPI0416931A (pt) |
| CA (1) | CA2546694A1 (pt) |
| IL (1) | IL175488A (pt) |
| NO (1) | NO20062258L (pt) |
| NZ (1) | NZ547354A (pt) |
| SE (1) | SE0303220D0 (pt) |
| SG (2) | SG148212A1 (pt) |
| WO (1) | WO2005054168A2 (pt) |
| ZA (1) | ZA200604192B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0303220D0 (sv) | 2003-11-28 | 2003-11-28 | Astrazeneca Ab | New process |
| GB0510546D0 (en) * | 2005-05-24 | 2005-06-29 | Astrazeneca Ab | New process |
| TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| TW200900033A (en) * | 2007-06-21 | 2009-01-01 | Wen-Qing Li | Automatic brewing machine |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| CN103450008B (zh) * | 2013-09-02 | 2015-02-25 | 江苏宝众宝达药业有限公司 | 一种从废水中回收扁桃酸的方法 |
| CN104447294A (zh) * | 2014-11-24 | 2015-03-25 | 苏州乔纳森新材料科技有限公司 | 一种3-环己烯-1-甲酸的手性拆分方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1867274A (en) * | 1929-11-20 | 1932-07-12 | Lilly Co Eli | Resolution of ephedrine and its homologues and of mandelic acid, and certain intermediates |
| JPS581105B2 (ja) * | 1977-03-24 | 1983-01-10 | 日本化薬株式会社 | 光学活性アミノ酸−マンデル酸複合体及びその製造法 |
| JPS5416442A (en) * | 1977-07-08 | 1979-02-07 | Sumitomo Chem Co Ltd | Optical resolution of 3-pheoxymandelic acid |
| US4239912A (en) * | 1978-12-08 | 1980-12-16 | American Cyanamid Company | Process for resolving DL-Mandelic acid with novel 2-benzylamino-1-butanols |
| US4260815A (en) * | 1979-10-09 | 1981-04-07 | American Cyanamid Company | Process for preparing a solution of DL-mandelic acid |
| US4259521A (en) * | 1979-10-09 | 1981-03-31 | American Cyanamid Company | Process for resolving DL-mandelic acid |
| JPH01221345A (ja) * | 1988-02-27 | 1989-09-04 | Ajinomoto Co Inc | マンデル酸誘導体の光学分割方法 |
| DE4137663A1 (de) * | 1991-11-12 | 1993-05-13 | Degussa | Verfahren zur herstellung optisch aktiver 1,3-imidazolidin-4-one und deren verwendung |
| JPH11228546A (ja) * | 1998-02-09 | 1999-08-24 | Koei Chem Co Ltd | 光学活性２−（Ｎ−ｔｅｒｔ−ブチルカルバモイル）ピペラジンの製造法 |
| JP2001002641A (ja) * | 1999-06-24 | 2001-01-09 | Daito Chemix Corp | 光学活性３−アミノピロリジン−２−オン誘導体の製造法 |
| JP2001072644A (ja) * | 1999-09-06 | 2001-03-21 | Yamakawa Yakuhin Kogyo Kk | 光学活性な２−クロロマンデル酸の製造方法および製造の中間体 |
| EP1236714B1 (en) | 1999-11-29 | 2007-01-17 | Mitsubishi Rayon Co., Ltd. | Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative |
| WO2002068391A1 (en) | 2000-11-20 | 2002-09-06 | Eli Lilly And Company | Process for resolving racemic mixtures of piperidine derivatives |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0303220D0 (sv) | 2003-11-28 | 2003-11-28 | Astrazeneca Ab | New process |
| GB0503672D0 (en) | 2005-02-23 | 2005-03-30 | Astrazeneca Ab | New process |
| GB0510546D0 (en) | 2005-05-24 | 2005-06-29 | Astrazeneca Ab | New process |
-
2003
- 2003-11-28 SE SE0303220A patent/SE0303220D0/xx unknown
-
2004
- 2004-11-25 CA CA002546694A patent/CA2546694A1/en not_active Abandoned
- 2004-11-25 JP JP2006540610A patent/JP4906511B2/ja not_active Expired - Fee Related
- 2004-11-25 NZ NZ547354A patent/NZ547354A/en unknown
- 2004-11-25 BR BRPI0416931-0A patent/BRPI0416931A/pt active Search and Examination
- 2004-11-25 CN CNB2004800349394A patent/CN100448834C/zh not_active Expired - Fee Related
- 2004-11-25 CN CNA2008101754369A patent/CN101407453A/zh active Pending
- 2004-11-25 AU AU2004295152A patent/AU2004295152B2/en not_active Ceased
- 2004-11-25 KR KR1020067012985A patent/KR101134767B1/ko not_active Expired - Fee Related
- 2004-11-25 US US10/579,854 patent/US7960582B2/en not_active Expired - Fee Related
- 2004-11-25 SG SG200808873-4A patent/SG148212A1/en unknown
- 2004-11-25 EP EP04819714A patent/EP1692089A2/en not_active Withdrawn
- 2004-11-25 SG SG200808874-2A patent/SG148213A1/en unknown
- 2004-11-25 WO PCT/GB2004/004964 patent/WO2005054168A2/en not_active Ceased
-
2006
- 2006-05-08 IL IL175488A patent/IL175488A/en not_active IP Right Cessation
- 2006-05-19 NO NO20062258A patent/NO20062258L/no not_active Application Discontinuation
- 2006-05-24 ZA ZA200604192A patent/ZA200604192B/en unknown
-
2009
- 2009-08-11 AU AU2009208107A patent/AU2009208107A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2546694A1 (en) | 2005-06-16 |
| SE0303220D0 (sv) | 2003-11-28 |
| KR20060109965A (ko) | 2006-10-23 |
| SG148213A1 (en) | 2008-12-31 |
| JP4906511B2 (ja) | 2012-03-28 |
| KR101134767B1 (ko) | 2012-04-13 |
| EP1692089A2 (en) | 2006-08-23 |
| CN1886359A (zh) | 2006-12-27 |
| WO2005054168A2 (en) | 2005-06-16 |
| CN100448834C (zh) | 2009-01-07 |
| IL175488A (en) | 2012-02-29 |
| NZ547354A (en) | 2010-02-26 |
| ZA200604192B (en) | 2007-11-28 |
| NO20062258L (no) | 2006-08-23 |
| WO2005054168A3 (en) | 2005-10-27 |
| AU2004295152A1 (en) | 2005-06-16 |
| US7960582B2 (en) | 2011-06-14 |
| JP2007513885A (ja) | 2007-05-31 |
| AU2004295152B2 (en) | 2009-07-02 |
| IL175488A0 (en) | 2006-09-05 |
| US20080312457A1 (en) | 2008-12-18 |
| SG148212A1 (en) | 2008-12-31 |
| AU2009208107A1 (en) | 2009-09-03 |
| CN101407453A (zh) | 2009-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |