BRPI0417910A - composto ou um sal ou salvato farmaceuticamente aceitáveis do mesmo, e, uso de um composto - Google Patents

composto ou um sal ou salvato farmaceuticamente aceitáveis do mesmo, e, uso de um composto

Info

Publication number
BRPI0417910A
BRPI0417910A BRPI0417910-2A BRPI0417910A BRPI0417910A BR PI0417910 A BRPI0417910 A BR PI0417910A BR PI0417910 A BRPI0417910 A BR PI0417910A BR PI0417910 A BRPI0417910 A BR PI0417910A
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
hydrogen
solvate
Prior art date
Application number
BRPI0417910-2A
Other languages
English (en)
Inventor
Q Kevin Fang
Seth Hopkins
Steven Jones
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of BRPI0417910A publication Critical patent/BRPI0417910A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"COMPOSTO OU UM SAL OU SOLVATO FARMACEUTICAMENTE ACEITáVEIS DO MESMO, E, USO DE UM COMPOSTO". Os métodos para aumentar a concentração de D-Serina e reduzir a concentração dos produtos tóxicos da oxidação de D-Serina, para intensificar a aprendizagem, memória e/ou cognição, ou para tratar a esquizofrenia, mal de Alzheimer, ataxia ou dor neuropática ou prevenir a perda na função neuronal característica de doenças neurodegenerativas envolvem administrar a um paciente em necessidade de tratamento uma quantidade terapêutica de um composto da fórmula I ou um sal ou solvato deste farmaceuticamente aceitáveis: em que Z¬ 1¬ é N ou CR3; Z¬ 2¬ é N ou CR4; Z¬ 3¬ é O ou S; A é hidrogênio, alquila ou M¬ +¬; M é alumínio, cálcio, lítio, magnésio, potássio, sódio, zinco ou uma mistura destes; R1, R2, R3 e R4 são independentemente selecionados de hidrogênio, alquila, hidróxi, alcóxi, arila, acila, halo, ciano, haloalquila, NHCOOR5 e SO~ 2~NH~ 2~; R5 é arila, arilalquila, heteroarila ou heteroarilalquila; pelo menos um de R1, R2, R3 e R4 é outro que não hidrogênio; e pelo menos um de Z¬ 1¬ e Z¬ 2¬ é outro que não N.
BRPI0417910-2A 2003-12-29 2004-12-28 composto ou um sal ou salvato farmaceuticamente aceitáveis do mesmo, e, uso de um composto BRPI0417910A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53297803P 2003-12-29 2003-12-29
PCT/US2004/043547 WO2005066143A2 (en) 2003-12-29 2004-12-28 Benzo[d]isoxazol-3-ol daao inhibitors

Publications (1)

Publication Number Publication Date
BRPI0417910A true BRPI0417910A (pt) 2007-04-10

Family

ID=34748836

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417910-2A BRPI0417910A (pt) 2003-12-29 2004-12-28 composto ou um sal ou salvato farmaceuticamente aceitáveis do mesmo, e, uso de um composto

Country Status (15)

Country Link
US (1) US7166725B2 (pt)
EP (1) EP1711478A2 (pt)
JP (1) JP2007534657A (pt)
KR (1) KR20060128978A (pt)
CN (3) CN101798291A (pt)
AU (1) AU2004312511A1 (pt)
BR (1) BRPI0417910A (pt)
CA (1) CA2552098A1 (pt)
CZ (1) CZ2006426A3 (pt)
IL (1) IL176607A0 (pt)
NZ (1) NZ548213A (pt)
PL (1) PL380766A1 (pt)
RU (1) RU2384574C2 (pt)
WO (1) WO2005066143A2 (pt)
ZA (1) ZA200605384B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1922149A (zh) * 2003-12-29 2007-02-28 塞普拉科公司 吡咯和吡唑daao抑制剂
CA2472806A1 (en) 2004-05-18 2005-11-18 Petro-Canada Compositions and methods for treating turf insect pests and diseases such as fungal infestations
CA2614282A1 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
KR101381768B1 (ko) 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
EP1976513B1 (en) 2006-01-06 2016-08-24 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
WO2007097279A1 (ja) 2006-02-21 2007-08-30 Toyama Chemical Co., Ltd. 3-{5-[4-(シクロペンチルオキシ)-2-ヒドロキシベンゾイル]-2-[(3-オキソ-2-置換-2,3-ジヒドロ-1,2-ベンズイソオキサゾール-6-イル)メトキシ]フェニル}プロピオン酸エステルの製造法およびその中間体
PT2816024T (pt) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Aminas quirais
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
US9357768B2 (en) 2006-10-05 2016-06-07 Suncor Energy Inc. Herbicidal composition with increased herbicidal efficacy
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP2010516697A (ja) * 2007-01-18 2010-05-20 セプラコール インク. D−アミノ酸オキシダーゼ阻害剤
WO2008151156A1 (en) 2007-05-31 2008-12-11 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
CN102215692B (zh) 2008-06-26 2014-10-22 森科能源公司 含有颜料的改良型草坪草杀真菌制剂
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
ES2731228T3 (es) 2009-01-20 2019-11-14 Los Angeles Biomedical Res Inst Harbor Ucla Medical Ct Acido benzoico o sales del mismo para mejorar la actividad de un producto farmacéutico
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2012031355A1 (en) 2010-09-09 2012-03-15 Suncor Energy Inc. Synergistic paraffinic oil and boscalid fungicides
JP2015522554A (ja) 2012-06-04 2015-08-06 サンコー・エナジー・インコーポレーテッド パラフィン油及び沈降防止剤を含む製剤
WO2014025993A1 (en) 2012-08-08 2014-02-13 The Johns Hopkins University Inhibitors of d-amino acid oxidase
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
CN103435561B (zh) * 2013-08-19 2016-08-10 上海交通大学 一种新型d-氨基酸氧化酶抑制剂及其制备和应用
WO2015147742A1 (en) * 2014-03-24 2015-10-01 Kaohsiung Chang Gung Memorial Hospital Use of benzoic acid salt in the manufactue of a composition for preventing or treating dementia or mild cognitive impairment
CN105801511B (zh) * 2016-04-22 2018-01-02 山西大学 一种1,2‑苯并异恶唑啉‑3‑酮的制备方法
KR102403048B1 (ko) 2016-06-13 2022-05-26 신유알엑스 인터내셔널 (타이완) 코포레이션 벤조산나트륨의 공-결정 및 그의 용도
TWI736635B (zh) 2016-06-13 2021-08-21 心悅生醫股份有限公司 苯甲酸鋰之共晶及其用途
CA2938096C (en) 2016-08-04 2019-02-26 Suncor Energy Inc. Stabilized emulsions
US11369579B2 (en) 2016-10-24 2022-06-28 Syneurx International (Taiwan) Corp. Polymorphic forms of sodium benzoate and uses thereof
US10336679B2 (en) 2016-10-24 2019-07-02 Syneurx International (Taiwan) Corp. Polymorphic forms of sodium benzoate and uses thereof
JP6550426B2 (ja) * 2017-07-26 2019-07-24 カオシュン・チャン・グン・メモリアル・ホスピタル 認知症または軽度認知障害を予防または治療する組成物を製造するための安息香酸塩の使用
WO2019043635A1 (en) 2017-09-01 2019-03-07 Richter Gedeon Nyrt. COMPOUNDS INHIBITING THE ACTIVITY OF D-AMINO ACID OXIDASE
US10336724B2 (en) * 2017-10-18 2019-07-02 Syneurx International (Taiwan) Corp. D-amino acid oxidase inhibitors and therapeutic uses thereof
US10098861B1 (en) 2017-10-24 2018-10-16 Syneurx International (Taiwan) Corp. Pharmaceutical composition comprising sodium benzoate compound and clozapine, and uses thereof
MX2021008944A (es) 2019-01-25 2021-08-24 Suncor Energy Inc Compuestos fotosensibilizadores, metodos de fabricacion y aplicacion a las plantas.
AU2020222515B2 (en) 2019-02-15 2025-10-09 Nutrien Ag Solutions (Canada) Inc. The use of protoporphyrin IX derivatives to improve the health of plants
CN117362246B (zh) * 2023-12-04 2024-03-12 烟台海川化学制品有限公司 一种3-苯基-1,4,2-二恶唑-5-酮的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58177915A (ja) * 1982-04-12 1983-10-18 Green Cross Corp:The 抗血栓剤
US4738709A (en) 1985-01-10 1988-04-19 Ppg Industries, Inc. Herbicidally active substituted benzisoxazoles
JPH0477476A (ja) * 1990-07-19 1992-03-11 Sankyo Co Ltd 抗潰瘍剤
WO1994010158A1 (fr) 1992-10-28 1994-05-11 Toyama Chemical Co., Ltd. Nouveaux derives de 1,2-benzisoxazole ou sel dudit derive, et agent de protection cerebrale contenant ce derive
AU688102B2 (en) * 1994-08-30 1998-03-05 Sankyo Company Limited Isoxazoles
US5484763A (en) 1995-02-10 1996-01-16 American Cyanamid Company Substituted benzisoxazole and benzisothiazole herbicidal agents
US5620997A (en) * 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
DE19960917A1 (de) * 1999-12-17 2001-06-21 Bayer Ag Neue 3-Oxo-2,1-benzisoxazol-1(3H)-carboxamide zur Behandlung von ZNS-Erkrankungen
JP2001247462A (ja) * 2000-03-07 2001-09-11 Otsuka Pharmaceut Co Ltd ウレアーゼ阻害剤
WO2005089753A2 (en) 2004-03-16 2005-09-29 Janssen Pharmaceutica N.V. Daao inhibiting bξnzisoxazoles and their use for the treatment of mental disorders

Also Published As

Publication number Publication date
JP2007534657A (ja) 2007-11-29
RU2384574C2 (ru) 2010-03-20
CZ2006426A3 (cs) 2006-10-11
WO2005066143A2 (en) 2005-07-21
CN1922157B (zh) 2011-01-12
US7166725B2 (en) 2007-01-23
CN102010382A (zh) 2011-04-13
CA2552098A1 (en) 2005-07-21
US20050143434A1 (en) 2005-06-30
AU2004312511A1 (en) 2005-07-21
EP1711478A2 (en) 2006-10-18
KR20060128978A (ko) 2006-12-14
CN101798291A (zh) 2010-08-11
PL380766A1 (pl) 2007-03-19
IL176607A0 (en) 2006-10-31
ZA200605384B (en) 2007-10-31
RU2006127436A (ru) 2008-02-10
CN1922157A (zh) 2007-02-28
NZ548213A (en) 2010-05-28
WO2005066143A3 (en) 2005-10-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]